Tag: 100-200

Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant was written by Muraglia, Ester;Kinzel, Olaf D.;Laufer, Ralph;Miller, Michael D.;Moyer, Gregory;Munshi, Vandna;Orvieto, Federica;Palumbi, Maria Cecilia;Pescatore, Giovanna;Rowley, Michael;Williams, Peter D.;Summa, Vincenzo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Computed Properties of C7H10N2O2S This article mentions the following:

A series of aryltetrazolylacetanilides was synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors on wild-type virus and on the clin. relevant K103N mutant strain. Extensive SAR investigation led to potent compounds, with nanomolar activity on K103N, and orally bioavailable in rats. In the experiment, the researchers used many compounds, for example, 4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4Computed Properties of C7H10N2O2S).

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C7H10N2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists was written by Shen, Lan;Zhang, Yan;Wang, Aihua;Sieber-McMaster, Ellen;Chen, Xiaoli;Pelton, Patricia;Xu, June Z.;Yang, Maria;Zhu, Peifang;Zhou, Lubing;Reuman, Michael;Hu, Zhiyong;Russell, Ronald;Gibbs, Alan C.;Ross, Hamish;Demarest, Keith;Murray, William V.;Kuo, Gee-Hong. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Electric Literature of C7H5Cl2NO This article mentions the following:

Replacement of the methyl-thiazole moiety of GW501516 (a PPARδ selective agonist) with [1,2,4]thiadiazole gave compound 21 (I) which unexpectedly displayed submicromolar potency as a partial agonist at PPARα in addition to the high potency at PPARδ. A structure-activity relationships study of 21 resulted in the identification of 40 as a potent and selective PPARα/δ dual agonist. Compound 40 and its close analogs represent a new series of PPARα/δ dual agonists. The high potency, high selectivity, significant gene induction, excellent PK profiles, low P 450 inhibition or induction, and good in vivo efficacy in four animal models support 40 being selected as a pre-clin. study candidate, and may render 40 as a valuable pharmacol. tool in elucidating the complex roles of PPARα/δ dual agonists, and the potential usage for the treatment of metabolic syndrome. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Electric Literature of C7H5Cl2NO).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C7H5Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex was written by Sutherell, Charlotte L.;Tallant, Cynthia;Monteiro, Octovia P.;Yapp, Clarence;Fuchs, Julian E.;Fedorov, Oleg;Siejka, Paulina;Muller, Suzanne;Knapp, Stefan;Brenton, James D.;Brennan, Paul E.;Ley, Steven V.. And the article was included in Journal of Medicinal Chemistry in 2016.Recommanded Product: 54166-95-9 This article mentions the following:

Bromodomain containing proteins PB1, SMARCA4, and SMARCA2 are important components of SWI/SNF chromatin remodeling complexes. We identified bromodomain inhibitors that target these proteins and display unusual binding modes involving water displacement from the KAc binding site. The best compound (I) binds the fifth bromodomain of PB1 with a K_D of 124 nM, SMARCA2B and SMARCA4 with K_D values of 262 and 417 nM, resp., and displays excellent selectivity over bromodomains other than PB1, SMARCA2, and SMARCA4. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Recommanded Product: 54166-95-9).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 54166-95-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-Pot Assembly and Synthetic Applications of Geminal Acyl/Alkoxy Tetrasubstituted Allenes was written by Bergstrom, Benjamin D.;Toth-Williams, Garrett;Lo, Anna;Toman, Jeffrey W.;Fettinger, James. C.;Shaw, Jared T.. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: 226260-01-1 This article mentions the following:

Polysubstituted allenes are useful synthetic intermediates in many applications, offering structural complexity, modularity, and their axial chirality in further transformations. While acyl and alkoxy-substituted allenes are known, there are currently few examples of allenes containing both functionalities and no reports of geminally substituted acyl/alkoxy allenes being isolated and characterized. Herein, authors report the synthesis of tetrasubstituted allenes featuring a novel geminal acyl/alkoxy substitution. These unique “push-pull” allenes are bench-stable and exhibit interesting reactivity in several applications. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Recommanded Product: 226260-01-1).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 226260-01-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and biological evaluation of a series of substituted 4,5-diphenylpyridine-2,6(1H,5H)-diones was written by Andrews, Peter R.;Brinkworth, Ross I.;Partridge, Ashton C.;Reiss, James A.. And the article was included in Australian Journal of Chemistry in 1988.Reference of 10268-06-1 This article mentions the following:

Esters R¹CCCO₂Et (R¹ = Ph, anisyl, ClC₆H₄) reacted with R²CH₂CONH₂ (R² = Ph, ClC₆H₄) and Na to give pyridinediones I. I (R¹ = 4-ClC₆H₄, R² = Ph) and I (R¹ = 2-ClC₆H₄, R² = 4-ClC₆H₄) showed some antipsychotic activity. Phosphoranes R¹COC(CO₂Et):PPh₃ were heated to give the resp. arylpropiolate esters. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Reference of 10268-06-1).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 10268-06-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lithiation of a silyl ether: Formation of an ortho-Fries hydroxy ketone was written by Lo, Hong-Jay;Lin, Chin-Yin;Tseng, Mei-Chun;Chein, Rong-Jie. And the article was included in Angewandte Chemie, International Edition in 2014.COA of Formula: C11H15NO2 This article mentions the following:

A hydroxy-directed alkylation of an N,N-di-Et aryl amide using CIPE-assisted α-silyl carbanions (CIPE = complex-induced proximity effect) was developed using a simple reagent combination of LDA [LiN(CHMe₂)₂] and Me₃SiCl. A study on the mechanism, and the application of the procedure to an anionic Snieckus-Fries rearrangement for a highly efficient synthesis of the potent phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 are reported. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2COA of Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.COA of Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effect of plasticizers on the properties of polycaprolactam was written by Poludennaya, V. M.;Volkova, N. S.;Arkhangel’skii, D. N.;Konkin, A. A.. And the article was included in Khimicheskie Volokna in 1969.Reference of 5339-69-5 This article mentions the following:

High-mol.-weight polycaprolactam (I) gives stronger cord, but it has increased viscosity (η) and presents difficulties in spinning. The addition of ≤20% PhSO2NHPr-iso, p-EtC6H4SO2NHPr-iso, or 2,4-Et2C6H3SO2NHPr-iso to ε-caprolactam, prior to the polymerization, decreased η of I melt without decreasing its mol. weight Thus I of mol. weight 30,000 without the plasticizer had η = 11,000 poises; the addition of 5-7% plasticizer decreased η to 6000-5000 poises, which is sufficient for spinning I melt in standard equipment. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Reference of 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stereoselective sulfoxide directed reduction of 1,2-diketo-derivatives to enantiomerically pure syn and anti 1,2-diols: correction of the relative configuration by X-ray and chemical correlation to goniobutenolides A and B was written by Solladie, Guy;Hanquet, Gilles;Rolland, Catherine. And the article was included in Tetrahedron Letters in 1999.COA of Formula: C6H12N2O4 This article mentions the following:

In a report [G. Solladie; 1997] on the enantioselective synthesis of syn and anti 1,2-diols from oxalyldi(N-methyl-N-methoxyamide), a sample inversion for ¹³C NMR anal. led to an incorrect attribution of relative configurations. Correction of the configurations of these diols, I and II (R = Me, Ph, allyl, CH:CH₂), was made by x-ray anal. and chem. correlation to two known natural products, goniobutenolides A and B. Thus, the relative configuration of diols obtained by stereoselective sulfoxide directed reduction of β-hydroxy-γ-keto sulfoxides of type III is erythro with DIBAL-H or DIBAL-H/Yb(O₂CCF₃)₃ and threo with DIBAL-H/ZnI₂. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1COA of Formula: C6H12N2O4).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.COA of Formula: C6H12N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper(II)-Catalyzed Enantioselective Intramolecular Carboamination of Alkenes was written by Zeng, Wei;Chemler, Sherry R.. And the article was included in Journal of the American Chemical Society in 2007.HPLC of Formula: 19311-91-2 This article mentions the following:

The enantioselective oxidative cyclizations of γ-alkenyl arenesulfonamides, e.g. I [R¹ = H, Me, Ph; R¹₂ = (CH₂)₄, (CH₂)₅; R² = H, Me, Cl, MeO], and a δ-alkenyl arylsulfonamide for the synthesis of nitrogen heterocycles are presented. The reactions are catalyzed by chiral copper(II) complexes, and MnO₂ is used as the inexpensive stoichiometric oxidant. A variety of five-membered heterocycles, e.g. II, and a tetrahydroisoquinoline have been synthesized in good to excellent yields with good to excellent levels of enantioselectivity. This is the first reported copper-catalyzed enantioselective carboamination of alkenes. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2HPLC of Formula: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemo- and Regioselective Anionic Fries Rearrangement Promoted by Lithium Amides under Aerobic Conditions in Sustainable Reaction Media was written by Ghinato, Simone;De Nardi, Federica;Bolzoni, Paola;Antenucci, Achille;Blangetti, Marco;Prandi, Cristina. And the article was included in Chemistry – A European Journal in 2022.Recommanded Product: 19311-91-2 This article mentions the following:

A straightforward and efficient protocol to promote the metalation/anionic Fries rearrangements of O-aryl carbamates, using for the first time a lithium amide as metalating agent under aerobic/ambient-friendly reaction conditions, was reported. This approach enabled the sustainable preparation of salicylamide derivatives such as I [R = Et, i-Pr; R¹ = H, 5-MeO, 3-Ph, etc.] with high levels of chemoselectivity within ultrafast reaction times, working at room temperature in the presence of air/moisture, and using environmentally responsible cyclopentyl Me ether as a solvent. Furthermore, the regioselective manipulation of O-2-tolyl carbamates had been accomplished using interchangeably alkyllithiums or lithium amides, with an unexpected beneficial contribution from the employment of biorenewable protic eutectic mixtures as non-innocent reaction media. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics