Tag: 100-200

Identification of toxic substances by means of Feldstein’s extraction method, thin-layer chromatography, and uv spectrometry. I. Basic substances was written by Drost, R. H.;Reith, Jan F.. And the article was included in Pharmaceutisch Weekblad in 1967.Quality Control of N,N-Diethylsalicylamide This article mentions the following:

Biol. material was extracted with 1,2-dichloroethane, according to Feldstein, and separated into strongly acid, weakly acid, neutral, basic, and basic substances with a phenol group. The basic substances were separated by thin-layer chromatog. on activated kieselgel G with CHCl3-Et2NH (90:10), CHCl3-Me2CO-Et2NH (50:40:10), CHCl3-cyclohexane-Et2NH (40:50:10), cyclohexane-Et2NH (90:10), and C6H6-EtOAc-Et2NH (70:20:10). The spots were located with uv light and the compounds identified by their reaction with a platinic chloride-KI spray and by the uv spectrum of a dichloroethane extract The Rf values, color reactions, and spectral data are given for 32 substances. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Quality Control of N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Quality Control of N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Direct transformation of amides: a one-pot reductive Ugi-type three-component reaction of secondary amides was written by Zheng, Jian-Feng;Qian, Xiang-Yang;Huang, Pei-Qiang. And the article was included in Organic Chemistry Frontiers in 2015.Recommanded Product: 13255-50-0 This article mentions the following:

An efficient reductive Ugi-type reaction has been established. The method employs common secondary amides as starting materials. The reaction exhibited a broad substrate scope, good chemoselectivity and functional group tolerance and provides rapid access to a variety of functionalized α-acetamidoamides. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Recommanded Product: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Exploiting a “Beast” in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy was written by Parisi, Giovanna;Colella, Marco;Monticelli, Serena;Romanazzi, Giuseppe;Holzer, Wolfgang;Langer, Thierry;Degennaro, Leonardo;Pace, Vittorio;Luisi, Renzo. And the article was included in Journal of the American Chemical Society in 2017.Formula: C9H10FNO2 This article mentions the following:

The first direct and straightforward nucleophilic fluoromethylation of organic compounds is reported. The tactic employs a “fleeting” lithium fluorocarbenoid (LiCH₂F) generated from com. available fluoroiodomethane. Precise reaction conditions were developed for the generation and synthetic exploitation of such a labile species. The versatility of the strategy is showcased in ca. 50 examples involving a plethora of electrophiles. Highly valuable chems. such as fluoroalcs., fluoroamines, and fluoromethylated oxygenated heterocycles could be prepared in very good yields through a single synthetic operation. The scalability of the reaction and its application to complex mol. architectures (e.g., steroids) are documented. PhSOCH₂F. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Formula: C9H10FNO2).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C9H10FNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some examples of the Schmidt rearrangement was written by Edwards, W. G. H.;Petrow, V.. And the article was included in Journal of the Chemical Society in 1948.Safety of 6-Chloro-2-aminobenzamide This article mentions the following:

The Schmidt rearrangement is carried out in 10 volumes concentrated H₂SO₄ at 0° by adding dropwise 1.1 equivalents NaN₃ in a min. quantity of H₂O and allowing the mixture to stand overnight. Isatin (I) gives ο-H₂NC₆H₄CONH₂ (II); the 5-NO₂ derivative of II results in 42% yield; the 6-Cl derivative of I gives 80% of the 4-Cl derivative of II; the 4-Cl derivative of I gives 40% 6,2-Cl(H₂N)C₆H₃CO₂H. Isatin-7-carboxylic acid fails to react, as do oxindole and its N-HO and 5-NO₂ derivatives 1-Acetylindoxyl gives a dark amorphous solid which could not be purified. Benzisoxazolone & and coumaranone are recovered unchanged. Acenaphthenone gives a tarry product that could not be purified. Acenaphthenequinone gives naphthalic anhydride. 3-Acetylacenaphthene gives a mixture of 3-aminoacenaphthenesulfonic acid and the Ac derivative; the latter forms an S-benzylisothiuronium salt, m. 226° (decomposition, corrected); in H₃PO₄, unchanged ketone was recovered. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Safety of 6-Chloro-2-aminobenzamide).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Safety of 6-Chloro-2-aminobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rearrangement of aldoximes to amides in water under air atmosphere catalyzed by water-soluble iridium complex [Cp*Ir(H₂O)₃][OTf]₂ was written by Sun, Chunlou;Qu, Panpan;Li, Feng. And the article was included in Catalysis Science & Technology in 2014.Recommanded Product: 3,4-Dichlorobenzamide This article mentions the following:

In the presence of the water-soluble iridium complex [Cp*Ir(H₂O)₃][OTf]₂, a variety of aldoximes, including aromatic, aliphatic, conjugated unsaturated and non-conjugated unsaturated, were converted into their corresponding amides in water with good to excellent yields. Further, the one-pot synthesis of amides from aldehydes, hydroxylamine hydrochloride and sodium carbonate via a tandem condensation-rearrangement reaction in water was also accomplished. Compared with the reported organometallic catalysts for the rearrangement of aldoximes to amides in water, the present catalyst exhibited some advantages such as being phosphorus ligand-free, having low catalyst loading, and operational convenience under air atm. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 3,4-Dichlorobenzamide).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 3,4-Dichlorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models was written by Shen, Sida;Hadley, Melissa;Ustinova, Kseniya;Pavlicek, Jiri;Knox, Tessa;Noonepalle, Satish;Tavares, Mauricio T.;Zimprich, Chad A.;Zhang, Guiping;Robers, Matthew B.;Barinka, Cyril;Kozikowski, Alan P.;Villagra, Alejandro. And the article was included in Journal of Medicinal Chemistry in 2019.SDS of cas: 2670-38-4 This article mentions the following:

Isoxazole is a five-membered heterocycle that is widely used in drug discovery endeavors. Here, the authors report the design, synthesis, and structural and biol. characterization of SS-208, a novel HDAC6-selective inhibitor containing the isoxazole-3-hydroxamate moiety as a zinc-binding group as well as a hydrophobic linker. A crystal structure of the Danio rerio HDAC6/SS-208 complex reveals a bidentate coordination of the active-site zinc ion that differs from the preferred monodentate coordination observed for HDAC6 complexes with phenylhydroxamate-based inhibitors. While SS-208 has minimal effects on the viability of murine SM1 melanoma cells in vitro, it significantly reduced in vivo tumor growth in a murine SM1 syngeneic melanoma mouse model. These findings suggest that the antitumor activity of SS-208 is mainly mediated by immune-related antitumor activity as evidenced by the increased infiltration of CD8+ and NK+ T cells and the enhanced ratio of M1 and M2 macrophages in the tumor microenvironment. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4SDS of cas: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.SDS of cas: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel and Direct Transformation of Methyl Ketones or Carbinols to Primary Amides by Employing Aqueous Ammonia was written by Cao, Liping;Ding, Jiaoyang;Gao, Meng;Wang, Zihua;Li, Juan;Wu, Anxin. And the article was included in Organic Letters in 2009.Recommanded Product: 3,4-Dichlorobenzamide This article mentions the following:

A novel and direct transformation of aryl, heteroaryl, vinyl, or ethynyl Me ketones or carbinols to corresponding primary amides has been developed. An iodine-NH₃·H₂O system was proven to be efficient for this reaction and afforded the expected products with good yields in aqueous media. A tandem Lieben-Haller-Bauer reaction mechanism was involved in this type of reaction and is proposed for the first time. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 3,4-Dichlorobenzamide).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 3,4-Dichlorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines was written by Kwong, Fuk Yee;Buchwald, Stephen L.. And the article was included in Organic Letters in 2003.Electric Literature of C11H15NO2 This article mentions the following:

An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses com. available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 °C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Electric Literature of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Microwave-Assisted Beckman Rearrangement by Cu(II)/Triazine-Based Dendrimer as an Efficacious Recoverable Nano-Catalyst Under Solvent-Free Conditions was written by Ghoreishi, Somayeh;Moeinpour, Farid. And the article was included in Polycyclic Aromatic Compounds.Product Details of 2670-38-4 This article mentions the following:

An efficient solvent-less procedure has been expanded to synthesis primary amides through Beckman rearrangement using Cu(II)/hydroxyl terminated triazine-based dendrimer (Cu(II)/TD) as a proficient heterogeneous nano-catalyst. The Cu(II)/TD nano-catalyst was recognized using TEM, FT-IR, TGA, SEM, EDS, XRD and ICP techniques. The deploying of this new nano-catalyst provides the synthesis of assorted primary amides in outstanding yields through a simple working-up method in a short-term reaction under green conditions in the absence of dangerous and poisonous organic solvents. The Cu(II)/TD catalyst was able to reprocessed and recovered many times without considerable failure of its performance. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Product Details of 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot construction of diverse and functionalized isochromenoquinolinediones by Rh(III)-catalyzed annulation of unprotected arylamides with 3-diazoquinolinediones and their application for fluorescence sensor was written by Shrestha, Rajeev;Khanal, Hari Datta;Lee, Yong Rok. And the article was included in RSC Advances in 2019.Recommanded Product: 3,4-Dichlorobenzamide This article mentions the following:

A facile and efficient Rh(III)-catalyzed annulation of arylamides with 3-diazoquinolinediones for the construction of diverse and highly functionalized isochromenoquinolinediones was described. Furthermore, the methodol. was applicable for delivering various relevant mols. such as pyridopyranoquinolindiones, thienopyranoquinolinones, and indolopyranoquinolinone. The reaction proceeds via cascade C-H activation, carbene insertion and intramol. lactonization. The reaction exhibits highed atom economy, good functional group tolerance and high regioselectivity. The synthesized compound can also behave as a potent fluorescence sensor for Fe³⁺ ion. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 3,4-Dichlorobenzamide).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 3,4-Dichlorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics