Tag: 100-200

Weinreb Amide Directed Versatile C-H Bond Functionalization under (η⁵-Pentamethylcyclopentadienyl)cobalt(III) Catalysis was written by Kawai, Kentaro;Bunno, Youka;Yoshino, Tatsuhiko;Matsunaga, Shigeki. And the article was included in Chemistry – A European Journal in 2018.Recommanded Product: 3-Fluoro-N-methoxy-N-methylbenzamide This article mentions the following:

The (η⁵-pentamethylcyclopentadienyl)cobalt(III) (Cp*Co^III)-catalyzed C-H bond functionalization of aromatic, heteroaromatic and α,β-unsaturated Weinreb amides was explored. The C-H allylation using allyl carbonate and a perfluoroalkene/oxidative alkenylation with Et acrylate/iodination using N-iodosuccinimide and amidation with dioxazolones were catalyzed by Cp*Co(CO)I₂ in presence of cationic silver salt and silver acetate to afford various synthetically useful building blocks like RC(O)N(Me)(OMe) [R = 2-H₂C=CHCH₂C₆H₄, MeC=CHCH=CHCO₂Et, 2-I-C₆H₄, etc.]. Mechanistic studies of C-H allylation disclosed that the C-H activation step was rate determining and virtually irreversible. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Recommanded Product: 3-Fluoro-N-methoxy-N-methylbenzamide).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 3-Fluoro-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and pharmacological properties of some 2,5-substituted isopropyl and hydroxyethylpiperazinylpyridines was written by Thunus, L.. And the article was included in Annales Pharmaceutiques Francaises in 1977.Name: 6-Chloro-N,N-dimethylnicotinamide This article mentions the following:

Pyridylpiperazines I (R = CONR2R3, SO2NR2R3; R1 = CHMe2, CH2CH2OH; R2 = H, R3 = H, Me, Et, CHMe2; NR2R3 = NMe2, NEt2, pyrrolidino, piperidino, morpholino, 4-methylpiperazino) were obtained in 65-95% yield by treating piperazines with chloropyridines. I are devoid of pharmacol. activity. In the experiment, the researchers used many compounds, for example, 6-Chloro-N,N-dimethylnicotinamide (cas: 54864-83-4Name: 6-Chloro-N,N-dimethylnicotinamide).

6-Chloro-N,N-dimethylnicotinamide (cas: 54864-83-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: 6-Chloro-N,N-dimethylnicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Expanding Pd-Catalyzed C-N Bond-Forming Processes: The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions. [Erratum to document cited in CA139:117168] was written by Huang, Xiaohua;Anderson, Kevin W.;Zim, Danilo;Jiang, Lei;Klapars, Artis;Buchwald, Stephen L.. And the article was included in Journal of the American Chemical Society in 2003.Computed Properties of C11H15NO2 This article mentions the following:

An important reference pertinent to the Pd-catalyzed amination in water was omitted on page 6655. The work by Boche and co-workers (Wullner, G.; Jansch, H.; Kannenberg, S.; Schubert, F.; Boche, G. Chem. Commun. 1998, 1509-1510) describes one example of aryl amination in water and several examples of aryl amination in aqueous solvent mixtures using NaOH as base. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Computed Properties of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quantitative structure activity relationship of the aromatic carboxylic acid derivatives was written by Xue, Feiqun;Wang, Hanqing;Zhao, Rongcai. And the article was included in Zhongguo Shouyi Xuebao in 1996.Synthetic Route of C11H15NO2 This article mentions the following:

The repellency and QSAR of forty aromatic carboxylic acid derivatives were analyzed using Hansch’s method in the study. The results indicated that the repellency of a series of the compounds is significantly correlated with the boiling coefficient The size of substituent of the compounds should not be larger than benzene, the most appropriate value of the partition coefficient (logP) is about 3.50. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Structural studies of organoboron compounds. XXXIV. 4-(N-Methoxymethylimino)-2,2-diphenyl-1,3-dioxa-2-borata-1,2,3,4-tetrahydronaphthalene and 4-diethylimino-2,2-diphenyl-1,3-dioxa-2-borata-1,2,3,4-tetrahydronaphthalene was written by Kliegel, Wolfgang;Tajerbashi, Mahmood;Rettig, Steven J.;Trotter, James. And the article was included in Canadian Journal of Chemistry in 1989.Formula: C11H15NO2 This article mentions the following:

Cyclocondensation of 2-HOC₆H₄CONRR¹ (R = Me, R¹ = OMe; R = R¹ = Et) with Ph₂BOBPh₂ in EtOH gave 88 and 86% title compounds I, resp. The crystal structures of both I were reported. In both structures the N,N-dialkylsalicylamidate ligands coordinate the Ph₂B moieties via the phenolate O and amide O atoms, forming 6-membered O-B-O chelate rings. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Phosphates and thiophosphates with a heterocyclic substituent. 9. Aza analogs. I. Aza analogs of phthalimide, benzotriazole, and 1,2,3,-benzotriazin-4(3H)-one derivatives was written by Ruefenacht, Kurt. And the article was included in Helvetica Chimica Acta in 1975.Application In Synthesis of 3-Aminopicolinamide This article mentions the following:

Thiophosphates RCH2SP(S)(OR1)2 (I, R = 2,3-pyridinedicarboximido, 3,4-pyridinedicarboximido, 2,3-pyrazinedicarboximido, 1-triazolo[4,5-b]pyridyl, 4-oxopyrido[2,3-e]-1,2,3-triazin-3-yl) were prepared by methylolating RH, chlorinating RCH2OH, and treating RCH2Cl with NH4SP(S)(OMe)2 or KSP(S)(OEt)2. I were approx. equal in toxicity and pesticidal activity to their known analogs. In the experiment, the researchers used many compounds, for example, 3-Aminopicolinamide (cas: 50608-99-6Application In Synthesis of 3-Aminopicolinamide).

3-Aminopicolinamide (cas: 50608-99-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of 3-Aminopicolinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The ortho effect in pyridines. Part XI. Substituent effects on basicity of 2- and 4-substituted 3-aminopyridines was written by Rasala, D.. And the article was included in Bulletin de la Societe Chimique de France in 1992.Safety of 3-Aminopicolinamide This article mentions the following:

The substituent effects on the pK_a values corresponding to the first protonation site of thirty 2- and 4-substituted 3-aminopyridines have been studied. The relative localized and delocalized effects are apparently sensitive to the variation of substituent position in the pyridine ring. An interaction of the 2-substituent with the protonation center has mainly inductive character, whereas, the pK_a values of 4-substituted 3-aminopyridines are highly affected by through-resonance. The steric effect was insignificant. In the experiment, the researchers used many compounds, for example, 3-Aminopicolinamide (cas: 50608-99-6Safety of 3-Aminopicolinamide).

3-Aminopicolinamide (cas: 50608-99-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Safety of 3-Aminopicolinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fe^III-Catalyzed Synthesis of Primary Amides from Aldehydes was written by Gowda, Ravikumar R.;Chakraborty, Debashis. And the article was included in European Journal of Organic Chemistry in 2011.Category: amides-buliding-blocks This article mentions the following:

A direct synthetic route for the transformation of aldehydes into primary amides in the presence of catalytic amounts of FeCl₃ in water is described. Hydroxylamine hydrochloride acts as the nitrogen source in this transformation, and reaction kinetics are investigated. The application of the methodol. to D-ribofuranose derivatives is demonstrated. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Category: amides-buliding-blocks).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Catalyst-free oxidative N-N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO was written by Cai, Yue-Ming;Zhang, Xin;An, Cui;Yang, Ye-Fei;Liu, Wei;Gao, Wen-Xia;Huang, Xiao-Bo;Zhou, Yun-Bing;Liu, Miao-Chang;Wu, Hua-Yue. And the article was included in Organic Chemistry Frontiers in 2019.SDS of cas: 119023-25-5 This article mentions the following:

A catalyst-free method was developed to synthesize 1,2,3-benzotriazinones I [R = H, 6-Cl, 6-Br, etc.] and 1,2,3-benzothiadiazoles II [R¹ = H, 6-Cl, 6-Br, etc.] from 2-amino-benzamides and 2-amino thiols. Of particular note was that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines III [R² = H, Ph, 4-ClC₆H₄; R³ = H, 7-Me, 7-Br] from pyridin-2-ylmethanamine was reported for the first time. This approach featured no use of catalyst, extremely mild conditions and excellent efficiency. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5SDS of cas: 119023-25-5).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 119023-25-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Regio- and stereoselective synthesis of γ-alkylidenebutenolides by cyclization of dilithiated 1,3-dicarbonyl compounds with N,N’-dimethoxy-N,N’-dimethylethanediamide was written by Langer, Peter;Stoll, Martin. And the article was included in Angewandte Chemie, International Edition in 1999.SDS of cas: 106675-70-1 This article mentions the following:

In most cases the title reactions gave (E)-alkylidenebutenolides [I; R¹ = H, Me; R² = H, Me, Et; R³ = OEt, OCMe₃, Me, NEt₂, Ph; R²R³ = CH₂CH₂O, (CH₂)₄, CH₂CHMeO, etc.]. In two cases the Z isomers predominated. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1SDS of cas: 106675-70-1).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.SDS of cas: 106675-70-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics