Tag: 100-200

Gupta, Neerja et al. published their research in International Journal of Pharma and Bio Sciences in 2010 | CAS: 10268-06-1

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Name: 2-(2-Chlorophenyl)acetamide

CAN promoted synthesis of amide derivatives: a green technology for pharmaceuticals was written by Gupta, Neerja;Naaz, Ruby. And the article was included in International Journal of Pharma and Bio Sciences in 2010.Name: 2-(2-Chlorophenyl)acetamide This article mentions the following:

This method displays both economic and environmental advantages. High yields were achieved even on a gram scale, while reaction times are considerably shortened. Ceric ammonium nitrate (CAN) was found to be an efficient catalyst for the solid-phase green synthesis of carboxamides with urea in excellent yields under microwave irradiation Addnl., pharmaceutical applications of the amides were reviewed. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Name: 2-(2-Chlorophenyl)acetamide).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Name: 2-(2-Chlorophenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharghi, Hashem et al. published their research in Tetrahedron in 1996 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-Diethylsalicylamide

BeCl2 as a new highly selective reagent for dealkylation of aryl-methyl ethers was written by Sharghi, Hashem;Tamaddon, Fatemeh. And the article was included in Tetrahedron in 1996.Name: N,N-Diethylsalicylamide This article mentions the following:

An efficient and simple method is introduced for the selective removal of a Me group from poly aryl-Me ethers with BeCl2 in some important derivatives of benzophenones, xanthones, anthraquinones, aryl esters, benzamides, and nitroanisoles. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Name: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hirai, Go et al. published their research in Tetrahedron Letters in 2009 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of N,N-Diethylsalicylamide

Asymmetric synthesis of isobenzofuranone derivatives and their unique character as protein kinase Cα (PKCα) activators was written by Hirai, Go;Ogoshi, Yosuke;Ohkubo, Megumi;Tamura, Yuki;Watanabe, Toru;Shimizu, Tadashi;Sodeoka, Mikiko. And the article was included in Tetrahedron Letters in 2009.Application In Synthesis of N,N-Diethylsalicylamide This article mentions the following:

An efficient enantioselective synthesis of conformationally constrained diacylglycerol analogs, 7-substituted isobenzofuranones, originally developed by the authors as PKCα ligands, was achieved by asym. dihydroxylation and γ-lactone formation via ortho-lithiation and carboxylation. A series of derivatives having straight and/or branched side-chains were synthesized and evaluated, and low-nanomolar-concentration affinity ligands and highly potent PKCα activators were found among them. These potent ligands induced phenotypic change of K562 cells, which is characteristic of PKC activators. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application In Synthesis of N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Van Allan, James A. et al. published their research in Journal of the American Chemical Society in 1947 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C11H15NO2

Salol reaction was written by Van Allan, James A.. And the article was included in Journal of the American Chemical Society in 1947.Formula: C11H15NO2 This article mentions the following:

The salol procedure is very convenient for the preparation of amides of o-HOC6H4CO2H, particularly from the H2NC6H4OH. o-H2NC6H4OH or o-diamines give a cyclic compound The following were prepared from o-HOC6H4CO2Ph (name of amine used, formula of resulting derivative of o-HOC6H4CO2H, m.p. (or b.p.), and yield are given): piperidine, C12H15O2N, m. 142-3°, 69%; cyclohexylamine, C13H17O2N, m. 85-6°, 79%; PhCH2NH2, C14H13O2N, m. 135-6°, 77%; dodecylamine, C19H31O2N, m. 71-2°, 75%; Et2NH, C11H15O2N, b4 146-8°, 68%; (CH2NH2)2, C16H16O4N2, m. 183-4°, 69%; ClC6H4NH2 (isomer not given), C13H11ONCl, m. 155°, 83%; H2NC6H4Ph (isomer not given), C19H15O2N, m. 110°, 85%; o-H2NC6H4OH, C13H9O2N, m. 125°, 22.4%; m-isomer, C13H11O2N, m. 184° 58%; 5-aminoindazole, C14H11O2N3, m. 230°, 37%; 6-isomer, m. 234-5°, 31%; 5-aminobenzotriazole, C13H10O3N4, m. 245°, 42%; 1,2,3,4-tetrahydroquinoline, C16H15O2N, m. 138-9°, 34%. Compounds from 1,2-HOC10H6CO2Ph:Et2NH, C15H17O2N, b1 130-3°, 63%; o-C6H4(NH2)2, C17H12ON2, m. above 265°, 78%; o-H2NC6H4OH, C17H11O2N, m. 188°, 89%. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lin, Dian-Zhao et al. published their research in ChemElectroChem in 2019 | CAS: 119023-25-5

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 119023-25-5

Mn-Catalyzed Electrochemical Synthesis of Quinazolinones from Primary Alcohols/Benzyl Ethers and o-Aminobenzamides was written by Lin, Dian-Zhao;Lai, Yin-Long;Huang, Jing-Mei. And the article was included in ChemElectroChem in 2019.SDS of cas: 119023-25-5 This article mentions the following:

An efficient approach for the synthesis of quinazolinones I [R1 = n-Bu, Ph, 3-pyridyl, etc.; R2 = 4-Me, 3-OMe, 3-Br, etc; R3 = H, Me] from o-aminobenzamides and primary alcs./benzyl ethers using combination of electrochem. and redox-metal catalysis was developed. Taking manganese(II) sulfate as a redox catalyst, this transformation proceeded smoothly under ambient conditions in an undivided cell to afford I in moderate to excellent yields with a wide substrate scope. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5SDS of cas: 119023-25-5).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 119023-25-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kitamura, Mitsuru et al. published their research in Chemistry Letters in 2013 | CAS: 10268-06-1

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C8H8ClNO

Synthesis of α-arylcarboxylic acid amides from silyl enol ether via migratory amidation with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate was written by Kitamura, Mitsuru;Murakami, Kento;Shiratake, Yuichiro;Okauchi, Tatsuo. And the article was included in Chemistry Letters in 2013.Formula: C8H8ClNO This article mentions the following:

α-Arylcarboxylic acid amides were synthesized by reacting silyl enol ethers of aryl ketones and 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP). Silyl enol ethers react with ADMP to give N-(α-arylacyl)guanidines via the migration of aryl groups in enol ethers. The products were transformed to the corresponding α-aryl acetamides by treating with LiAlH4. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Formula: C8H8ClNO).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C8H8ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Fangyuan et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 13255-50-0

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Electric Literature of C11H13NO2

Ni-Catalyzed asymmetric reduction of α-keto-β-lactams via DKR enabled by proton shuttling was written by Wang, Fangyuan;Tan, Xuefeng;Wu, Ting;Zheng, Long-Sheng;Chen, Gen-Qiang;Zhang, Xumu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Electric Literature of C11H13NO2 This article mentions the following:

Chiral α-hydroxy-β-lactams are key fragments of many bioactive compounds and antibiotics, and the development of efficient synthetic methods for these compounds is of great value. The highly enantioselective dynamic kinetic resolution (DKR) of α-keto-β-lactams was realized via a novel proton shuttling strategy. A wide range of α-keto-β-lactams were reduced efficiently and enantioselectively by Ni-catalyzed asym. hydrogenation, providing the corresponding α-hydroxy-β-lactam derivatives with high yields and enantioselectivities (up to 92% yield, up to 94% ee). Deuterium-labeling experiments indicate that phenylphosphinic acid plays a pivotal role in the DKR of α-keto-β-lactams by promoting the enolization process. The synthetic potential of this protocol was demonstrated by its application in the synthesis of a key intermediate of Taxol and (+)-epi-Cytoxazone. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Electric Literature of C11H13NO2).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Electric Literature of C11H13NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Serafim, Ricardo A. M. et al. published their research in Journal of Medicinal Chemistry in 2021 | CAS: 10268-06-1

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 2-(2-Chlorophenyl)acetamide

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold was written by Serafim, Ricardo A. M.;Sorrell, Fiona J.;Berger, Benedict-Tilman;Collins, Ross J.;Vasconcelos, Stanley N. S.;Massirer, Katlin B.;Knapp, Stefan;Bennett, James;Fedorov, Oleg;Patel, Hitesh;Zuercher, William J.;Elkins, Jonathan M.. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 2-(2-Chlorophenyl)acetamide This article mentions the following:

SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) are closely related kinases whose enzymic activity is linked to the regulation of ezrin, radixin, and moesin function and to the regulation of lymphocyte migration and the cell cycle. We identified a series of 3-anilino-4-arylmaleimides as dual inhibitors of SLK and STK10 with good kinome-wide selectivity. Optimization of this series led to multiple SLK/STK10 inhibitors with nanomolar potency. Crystal structures of exemplar inhibitors bound to SLK and STK10 demonstrated the binding mode of the inhibitors and rationalized their selectivity. Cellular target engagement assays demonstrated the binding of the inhibitors to SLK and STK10 in cells. Further selectivity analyses, including anal. of activity of the reported inhibitors against off-targets in cells, identified compound 31 as the most potent and selective inhibitor of SLK and STK10 yet reported. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Recommanded Product: 2-(2-Chlorophenyl)acetamide).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 2-(2-Chlorophenyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hanefeld, Wolfgang et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 1992 | CAS: 13255-50-0

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: 4-Formyl-N-isopropylbenzamide

Nitrosation and hydrazine derivatives. 7. Reactions of phenelzine, endralazine and procorbazine under nitrosation conditions was written by Hanefeld, Wolfgang;Hunz, Ingrid. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1992.Name: 4-Formyl-N-isopropylbenzamide This article mentions the following:

The nitrosation of phenelzine [(2-phenylethyl)hydrazine], endralazine [6-benzoyl-5,6,7,8-tetrahydropyrido[4,3-c]pyridazin-3(2H)-one 3-hydrazone] and procarbazine [N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide] was investigated and the mechanism was discussed. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Name: 4-Formyl-N-isopropylbenzamide).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: 4-Formyl-N-isopropylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ponci, R. et al. published their research in Farmaco, Edizione Scientifica in 1959 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C11H15NO2

Preparation of ο-(n-hexylthio)benzamides and tests for their fungistatic action was written by Ponci, R.;Gialdi, F.;Baruffini, A.. And the article was included in Farmaco, Edizione Scientifica in 1959.Formula: C11H15NO2 This article mentions the following:

Adding to 0.5 mole thiosalicylic acid in 350 cc. EtOH at 60° 1 mole NaOH in 250 cc. water and 0.6 mole n-C6H13Br in 300 cc. EtOH and 1 g. KI in 10 cc. water, heating at 100° 2 hrs. in a steam of N, diluting with 1 l. water, cooling, filtering with a small amount of C, acidifying with dil HCl in the cold, keeping 1 hr. on ice, filtering, and washing with water gave 92% ο-(n-C6H13S)C6H4CO2H (I), m. 96-7° (95% EtOH). Treating 0.2 mole I with 0.5 mole SOCl2 4 hrs. gave the chloride of I, b3 175-8°. Dropping 0.02 mole I chloride in 40 cc. Et2O at 0° into 40 cc. Et2O containing 0.05 mole NH3, keeping some hrs. at room temperature, evaporating to half volume in vacuo, filtering, and washing the solid first with cold. Et2O then with ice water gave I amide, m. 103-4° (95% EtOH). Using BuNH2 in place of NH3 gave the Bu amide (II) of I, m. 49-50° (ligroine). Adding 0.04 mole I chloride in 60 cc. dioxane to 0.08 mole thiourea in 80 cc. dioxane, refluxing 15 min., keeping 1 hr. at room temperature, evaporating in vacuo, and extracting the residue with Et2O gave after washing, drying, and evaporating I thioureide, m. 98-9° (95% EtOH). Using benzylamine and proceeding as for II gave the benzylamide of I, m. 81-2° (EtOH); PhNH2 gave the anilide of I, m. 73-4° (80% EtOH). The β-naphthylamide of I m. 94° (95% EtOH), p-chloroanilide m. 86-7° (EtOH and ligroine), p-methylanilide of I m. 84-5° (AcOH and EtOH). None of the compounds was active against Candida albicans and only I and II were active against Trichophyton mentagrophytes. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics