Tag: 100-200

Dornow, Alfred; Siebrecht, Manfred published an article in 1960, the title of the article was Syntheses of nitrogen-containing heterocycles. XXII. The synthesis of some pyrazolo[3,4-b]pyridines.Product Details of 100524-09-2 And the article contains the following content:

5-Amino-3-pyrazolone (I) with β-dicarbonyl compounds gave good yields of pyrazolopyridines. AcMeCHCHO (II) condensed with I gave as the main product the corresponding pyrazolopyrimidine. NCCH2CONHNH2 (99 g.) and 89 g. NaOEt in 400 cc. EtOH heated 1 hr. at 100°-cooled, and filtered gave 116 g. Na salt (III) of I; the concentrated aqueous solution of III acidified with glacial AcOH gave I, m. 204°. III (12.1 g.) in 45 cc. H2O treated with stirring and warming with 13.0 g. AcCH2CO2Et to solution, cooled, filtered, and the residue dissolved in H2O and acidified with AcOH gave 16.2 g. 3,6-dihydroxy-4-methyl-1-pyrazolo [3,4-b]pyridine (IV), m. 335° (decomposition) (MeOH). CH2(CO2Et)2 (8 g.) and 4.95 g. I added to 10.5 g. NaOEt in 100 cc. EtOH, heated 4 hrs. on the water bath and filtered, and the residue dissolved in H2O and acidified with AcOH gave 7.1 g. 4-OH analog of IV, m. 370° (decomposition) (glacial AcOH). III (12.1 g.) in 30 cc. H2O, 11.1 g. AcCH: CHONa in 15 cc. H2O, and 2.5 g. piperidine acetate refluxed 2 hrs., cooled, neutralized with AcOH, and filtered gave 9.9 g. 3-hydroxy-6-methyl-1-pyrazolo[3,4-b]pyridine (V), m. 282° (EtOH). III (6 g.) in 30 cc. H2O treated with 8.5 g. BzCH:CHONa in 20 cc. H2O, heated 2 hrs. with 2 g. piperidine acetate on the water bath, cooled, and acidified with glacial AcOH yielded 6.7 g. 6-Ph analog of V, m. 288° (MeOH). III (6 g.) in 20 cc. H2O treated with 6 g. Na salt of II in 10 cc. H2O, refluxed 2 hrs. with 2 g. piperidine acetate, and worked up gave 5.1 g. orange precipitate; the precipitate extracted with hot EtOH and the extract cooled gave 3.4 g. 2-hydroxy-6,7-dimethylpyrazolo[2,3-a]pyrimidine (VI), m. 239° with sintering from 226° (EtOH); the residue from the extraction gave 1.7 g. 5-Me derivative (VII) of V, m. 343°. I (3 g.) and 3.7 g. Na salt of 1-formyl-2-cyclohexanone in 40 cc. absolute EtOH refluxed 2 hrs., filtered after 2 hrs., and the residue dissolved in H2O and neutralized with glacial AcOH yielded 3.4 g. 3-hydroxy-5,6,7,8-tetrahydro-1-pyrazolo[3,4-b]quinoline (VIII), yellow, m. 297° (EtOH). IV (1 g.) and 10 g. Raney Ni in 230 cc. EtOH refluxed 2 hrs., filtered hot, evaporated, and the residue washed with Et2O gave 0.65 g. 6-hydroxy-2-amino-4-methylnicotinic acid amide (IX), m. 250° (PhMe). V (0.5 g.) and 8 g. Raney Ni in 200 cc. EtOH gave similarly 0.45 g. 2-amino-6-methylnicotinic acid amide (X), m. 219° (PhMe). VII (0.5 g.) and 8 g. Raney Ni refluxed 3 hrs. in 200 cc. EtOH yielded 0.5 g. 5-Me derivative of X, m. 230° (PhMe). VIII (2 g.) and 12 g. Raney Ni in 300 cc. EtOH heated 3 hrs. gave 1.2 g. amide (XI) of 2-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acid (XII), m. 223° (PhMe). XI (0.7 g.) in 5 cc. concentrated HCl refluxed 3 hrs. and neutralized with aqueous NaOH-NaOAc gave 0.6 g. XII. XII (3 g.) distilled at 250° gave with CO2 evolution 2.1 g. 2,4,5-trimethylpyrimidine, b12 107°; picrate m. 198° (EtOH). The experimental process involved the reaction of 2-Amino-6-methylnicotinamide(cas: 100524-09-2).Product Details of 100524-09-2

2-Amino-6-methylnicotinamide(cas:100524-09-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Product Details of 100524-09-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 10, 2021, Yao, Shuyang; Fang, Wei-Hui; Sun, Yayong; Wang, San-Tai; Zhang, Jian published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was Mesoporous assembly of aluminum molecular rings for iodine capture. And the article contained the following:

The effective capture and storage of radioiodine are of worldwide interest for sustainable nuclear energy. However, the direct observation of ambiguous binding sites that accommodate iodine is extremely rare. Here, the authors present a crystallog. visualization of the binding of iodine within mesoporous cages assembled from aluminum mol. rings. These nanocages are formed through 蟺-蟺 interactions between adjacent aluminum mol. rings. Compared with the general nanotubes arrangement, the supramol. nanocage isomer exhibits better iodine adsorption behavior. The robust mol. nanocages demonstrate a high iodine vapor saturation uptake capacity of 50.3 weight% at 80掳C. Furthermore, the resulting adsorbent can be recycled. Single-crystal x-ray diffraction reveals binding sites of mol. I2 within the pores of the phenyl-based linkers stabilized by the strong I路路路蟺 interactions. These compounds represent an excellent model to deduce the trapping mechanism of guest mols. interacting with the host. In addition, this work develops a promising cluster-based aluminum material as iodine adsorbents. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to mesoporous assembly aluminum mol ring radioiodine capture, pyrazole thermal synthesis aluminum oxy cluster radioiodine adsorption, Placeholder for records without volume info and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Fan; Dong, Xin; Ma, Feixiang; Xu, Feng; Liu, Jie; Lu, Jingkun; Li, Chunyan; Bu, Ren; Xue, Peifeng published an article in 2020, the title of the article was The interventional effects of Tubson-2 decoction on ovariectomized rats as determined by a combination of network pharmacology and metabolomics.Reference of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

Post-menopausal osteoporosis (PMOP) is associated with estrogen deficiency and worldwide, is becoming increasingly more prevalent in aging women. Various anti-PMOP drugs have been developed to reduce the burden of PMOP; generally, these drugs are efficacious, but with some adverse side effects. Tubson-2 decoction (TBD), a popular traditional Mongolian medicine, has been used to treat PMOP for centuries. However, the precise mechanisms underlying the action of TBD on PMOP have yet to be fully elucidated. Herein, we combined network pharmacol. with untargeted metabolomics to identify the key targets and metabolic pathways associated with the interventional effects of TBD on ovariectomized (OVX) rats. Furthermore, we investigated the bone histomorphometry of eight different groups of rats to evaluate the therapeutic effect of TBD. First, we established a TBD-target/PMOP network via network pharmacol.; this network identified three key protein targets-vitamin D receptor (VDR), cytochrome P 450 19A1 (CYP19A1), and 11尾-hydroxysteroid dehydrogenase type 1 (HSD11B1). Morphol. anal. showed that severe impairment of the bone micro-architecture in OVX rats could be improved by TBD administration. The TBD-treated rats had a significantly lower bone surface-to-tissue volume (BS/TV) and a significantly smaller trabecular separation (Tb路Sp.) (P<0.05) than the OVX rats; in contrast, bone volume fraction (BVF), trabecular thickness (Tb路Th.), trabecular number (Tb路N.), and bone mineral d. (BMD) were significantly higher in the TBD-treated rats (P<0.05). Multivariate and univariate anal. showed that OVX resulted in significant alterations in the concentrations of 105 metabolites and 11 metabolic pathways (P<0.05); in addition, 26 potential biomarkers were identified to investigate the progression of PMOP. Network pharmacol. showed that major alterations in vitamin B6 metabolism were associated with the VDR target. Next, we validated the three crucial targets (VDR [P<0.01], HSD11B1 [P<0.01], and CYP19A1 [P<0.05]) by enzyme-linked immunosorbent assays (ELISAs) and demonstrated that the levels of these targets were elevated in the OVX group but reduced in the TBD-treatment group. Collectively, our results suggest that the interventional effects of TBD on OVX rats are likely to be associated with the down regulation of VDR. Our findings enhance our mol. understanding of the interventional effects of TBD on PMOP and will allow us to develop further TBD studies. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to tubson network pharmacol metabolomic, tubson-2, metabolomics, network pharmacology, ovariectomized, post-menopausalosteoporosis, Placeholder for records without volume info and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Fent, Kenneth W.; Mayer, Alexander C.; Toennis, Christine; Sammons, Deborah; Robertson, Shirley; Chen, I-Chen; Bhandari, Deepak; Blount, Benjamin C.; Kerber, Steve; Smith, Denise L.; Horn, Gavin P. published an article.Product Details of 27115-50-0 The title of the article was Firefighters鈥?urinary concentrations of VOC metabolites after controlled-residential and training fire responses. And the article contained the following:

Firefighters are exposed to volatile organic compounds (VOCs) during structural fire responses and training fires, several of which (e.g., benzene, acrolein, styrene) are known or probable carcinogens. Exposure studies have found that firefighters can absorb chems. like benzene even when self-contained breathing apparatus (SCBA) are worn, suggesting that dermal absorption contributes to potentially harmful exposures. However, few studies have characterized VOC metabolites in urine from firefighters. We quantified VOC metabolites in firefighters urine following live firefighting activity across two field studies. In two sep. controlled field studies, spot urine was collected before and 3 h after firefighters and firefighter students responded to simulated residential and training fires. Urine was also collected from instructors from the training fire study before the first and 3 h after the last training scenario for each day (instructors led three training scenarios per day). Samples were analyzed for metabolites of VOCs to which firefighters may be exposed. In the residential fire study, urinary metabolites of xylenes (2MHA), toluene (BzMA), and styrene (MADA) increased significantly (at 0.05 level) from pre- to post-fire. In the training fire study, MADA concentrations increased significantly from pre- to post-fire for both firefighter students and instructors. Urinary concentrations of benzene metabolites (MUCA and PhMA) increased significantly from pre- to post-fire for instructors, while metabolites of xylenes (3MHA+4MHA) and acrolein (3HPMA) increased significantly for firefighter students. The two highest MUCA concentrations measured post-shift from instructors exceeded the BEI of 500 渭g/g creatinine. Some of the metabolites that were significantly elevated post-fire are known or probable human carcinogens (benzene, styrene, acrolein); thus, exposure to these compounds should be eliminated or reduced as much as possible through the hierarchy of controls. Given stringent use of SCBA, it appears that dermal exposure contributes in part to the levels measured here. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Product Details of 27115-50-0

The Article related to volatile organic compound firefighter urinary concentration fire response, acrolein, benzene, biomarker, fire, styrene, urine, Placeholder for records without volume info and other aspects.Product Details of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Balic, Ivan; Olmedo, Patricio; Zepeda, Baltasar; Rojas, Barbara; Ejsmentewicz, Troy; Barros, Miriam; Aguayo, Daniel; Moreno, Adrian A.; Pedreschi, Romina; Meneses, Claudio; Campos-Vargas, Reinaldo published an article.Computed Properties of 685-91-6 The title of the article was Metabolomic and biochemical analysis of mesocarp tissues from table grape berries with contrasting firmness reveals cell wall modifications associated to harvest and cold storage. And the article contained the following:

Tissue texture influences the grape berry consumers acceptance. We studied the biol. differences between the inner and outer mesocarp tissues in hard and soft berries of table grapes cv NN107. Texture anal. revealed lower levels of firmness in the inner mesocarp as compared with the outer tissue. HPAEC-PAD anal. showed an increased abundance of cell wall monosaccharides in the inner mesocarp of harder berries at harvest. Immunohistochem. anal. displayed differences in homogalacturonan methylesterification and cell wall calcium between soft and hard berries. This last finding correlated with a differential abundance of calcium measured in the alc.-insoluble residues (AIR) of the inner tissue of the hard berries. Anal. of abundance of polar metabolites suggested changes in cell wall carbon supply precursors, providing new clues in the identification of the biochem. factors that define the texture of the mesocarp of grape berries. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Computed Properties of 685-91-6

The Article related to table grape mesocarp cell wall metabolomic harvest cold storage, calcium, pectin, polar metabolites, texture, vitis vinifera, Placeholder for records without volume info and other aspects.Computed Properties of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dornow, Alfred; Neuse, Eberhard published an article in 1951, the title of the article was The reaction of amidines with β-dicarbonyl compounds.Application In Synthesis of 2-Amino-6-methylnicotinamide And the article contains the following content:

cf. C.A. 34, 6629.3.-β-Dicarbonyl compounds react with RO2CCH2C(:NH)OR (Ia) via an amidine derivative, RCOCH2CR’:C(CO2R)C(:NH)N:C(OR)CH2CO2R, to form pyridine derivatives This reaction is studied further. MeCOCHNaCHO (23 g.) and 30 g. H2NCOCH2C(:NH)NH2.HCl (I) are refluxed in 80 cc. absolute EtOH 12 h. and the hot filtered solution is cooled, giving 56% 2-amino-6-methylnicotinamide (II), long needles, m. 220° [picrate, yellow leaflets, m. 253-4° (decomposition)]. Refluxing 1 g. II with concentrated HCl 10 h. and neutralizing the mixture with NH4OH give 100% free acid, m. 296°. Treating 0.35 g. II in 20 cc. dilute H2SO4 with 0.45 g. NaNO2 and warming the mixture on a water bath give 2-hydroxy-6-methylnicotinic acid, m. 227° (decomposition), which, decarboxylated, gives 6-methyl-2-pyridone, m. 157°. Refluxing 17.5 g. PhCOCHNaCHO and 13.5 g. I in 50 cc. absolute EtOH and 30 g. anhydrous KOAc 2 h., distilling off the solvent, extracting the residue with H2O, and refluxing the residue several hrs. with concentrated HCl give 11.6 g. 2-amino-6-phenylnicotinic acid-HCl, sintering at 219-20°, m. 240° (decomposition); free acid (III), m. 243° [picrate, m. 189-90° (decomposition)]. Only in 1 experiment was the amide, thick yellowish crystals, m. 220-1°, obtained; it shows strong blue fluorescence in alc. solution [picrate, yellow needles, m. 229-30° (decomposition)]. Diazotization of 0.22 g. III in 20 cc. dilute H2SO4 with 0.3 g. NaNO2 and boiling the mixture give 2-hydroxy-6-phenylnicotinic acid, m. 304° (decomposition), which, heated above its m.p., gives 6-phenyl-2-pyridone, m. 197°. Condensation of 20 g. EtCOCHNaCHO (IV) with 22 g. I in 100 cc. 50% MeOH gives 66% 2-amino-5,6-dimethylnicotinamide (V), fine yellowish crystals, m. 230-1° [picrate, m. 269-70° (decomposition)]. Diazotization of 2.5 g. V with 1.7 g. NaNO2 and boiling the mixture give 59% 2-hydroxy-5,6-dimethylnicotinic acid (VI) needles, m. 306° (decomposition) (cf. Barat, C.A. 26, 2979), also obtained on saponification of the cyanopyridone obtained on condensation of NCCH2CONH2 with IV. Heating VI above its m.p. gives 5,6-dimethyl-2-pyridone, m. 205-6°. Keeping 6.95 g. I in 50 cc. N NaOH with 5.1 cc. Ac2CH2 overnight at 20° gives 60% 2-amino-4,6-dimethylnicotinamide, m. 156.5°; from the aqueous mother liquor a compound, m. 295-300°, is isolated. 2-Hydroxy-4,6-dimethylnicotinic acid, prepared in 60% yield like VI, m. 254°. Refluxing 15 g. I 24 h. in 100 cc. EtOH containing 2.3 g. Na with 16 g. BzCH2COMe gives 21% 2-amino-4-methyl-6-phenylnicotinamide, yellowish crystals, m. 227°; from the mother liquor some CH2(CONH2)2, m. 166°, is isolated. Adding 11 g. EtO2CCH2C(:NH)OEt.HCl to 40 cc. satd Na2CO3 overlayered with ether and heating the residue of the dried ether solution with 5 g. BzCH2COMe 16 h. on a water bath give 52% Et 2-amino-4-methyl-6-phenylnicotinate (VII), cubelike crystals, m. 129°; its alc. solution fluoresces strongly blue [HCl salt, m. 205° (decomposition)]. Refluxing 1.1 g. VII 8 h. with 10 cc. concentrated HCl gives 90% HCl salt (VIII) of the free acid, needles, m. 171-2° (decomposition), from which, with NH4OH and AcOH, the free acid, m. 267° (decomposition), is obtained. Treating 0.9 g. VIII in dilute H2SO4, with 0.5 g. NaNO2 with warming gives 90% 2-hydroxy-4-methyl-6-phenylnicotinic acid (IX), crystals from AcOH, m. 278°, which is also obtained in 92% yield from the acid amide, m. 227°. Treating 0.9 g. VII in 15 cc. warm AcOH with 0.3 g. NaNO2 and boiling the mixture give 78% Et ester (X) of IX, broad leaflets, m. 163°; its aqueous solution shows weak bluish fluorescence. Heating 0.4 g. IX 10 min. at 300-5° gives 62% 4-methyl-6-phenyl-2-pyridone, m. 180°, which is also formed on heating IX or X with 80% H2SO4 or concentrated HCl. Refluxing 27.3 g. I and 29.5 g. 2-hydroxymethylenecyclohexanone (XI) 2 h. in 100 cc. absolute MeOH and keeping the mixture 12 h. in the cold give 51% 2-amino-5,6,7,8-tetrahydro-3-quinolinecarboxamide (XII), needles, m. 224-5°, soluble in concentrated H2SO4 with strong blue-violet fluorescence [picrate, yellow needles, m. 259-60° (decomposition)]. Refluxing Ia (R = Et) from 200 g. HCl salt 30 h. with 52 g. XI on a water bath gives 20 g. Et 2-amino-5,6,7,8-tetrahydro-3-quinolinecarboxylate (XIII), m. 127°. Distillation of the residue of the mother liquor gives addnl. XIII, b12 185°, bringing the total yield to 36%. XIII dissolves in concentrated H2SO4 or EtOH with strong blue-violet fluorescence [picrate, yellow needles, m. 212-13° (decomposition)]. Refluxing 5 g. XIII 10 h. with 30 cc. concentrated HCl gives 70% HCl salt of the acid, m. 232-4° (decomposition); free acid (XIV), needles from AcOH, m. 291-2° (decomposition), also obtained on refluxing 0.9 g. XII 10 h. with 20 cc. concentrated HCl. 2-OH analog (XV) of XIV, m. 268-9° (decomposition). Heating 0.15 g. XV 15 min. above its m.p. gives 5,6,7,8-tetrahydro-2-quinolone, needles, m. 201°. Treating 18 g. BzCH2C(:NH)OEt. HCl (XVI) in ether with 10 g. Na2CO3 in 100 cc. H2O, adding 3.1 g. Ac2CH2 to the dried ether solution, evaporating the ether, heating the residue 15 h. at 140-150°, and acidifying the mixture with concentrated HCl give 50% 4,6-dimethyl-2-phenacylpyrimidine-HCl (XVII), crystals from 6 N HCl, m. 201° (free base, yellow leaflets, m. 74°; picrate, yellow needles, m. 203°). Treating 1 g. XVII in 30 cc. 3 N HCl at 40-5° with 0.5 g. NaNO2 in 10 cc. H2O gives 80% 2-(α-isonitrosophenacyl) derivative (XVIII), leaflets, m. 212°. Hydrogenation of 0.8 g. XVIII in 200 cc. absolute EtOH with 0.15 g. PtO2 gives 4,6-dimethyl-2-(β-hydroxy-α-aminophenethyl)pyrimidine, which is converted into its picrate, m. 175-80° (decomposition). Refluxing 2 g. CHCCHO with BzCH2C(:NH)OEt from 25 g. XVI gives 54% 2-phenacylpyrimidine, m. 150°. The experimental process involved the reaction of 2-Amino-6-methylnicotinamide(cas: 100524-09-2).Application In Synthesis of 2-Amino-6-methylnicotinamide

2-Amino-6-methylnicotinamide(cas:100524-09-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Application In Synthesis of 2-Amino-6-methylnicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2015, Jain, Ram B. published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Distributions of selected urinary metabolites of volatile organic compounds by age, gender, race/ethnicity, and smoking status in a representative sample of U.S. adults. And the article contained the following:

Data from National Health and Nutrition Examination Survey for the years 2011-2012 were used to evaluate variability in the observed levels of 19 urinary metabolites of 15 parent volatile organic compounds (VOCs) by age, gender, race/ethnicity, and smoking status. Smokers were found to have statistically significantly higher adjusted levels than nonsmokers for selected urinary metabolites of acrolein, acrylamide, acrylonitrile, 1,3-butadiene, carbon-disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene-styrene, propylene oxide, styrene, and xylene. Female nonsmokers were found to have lower adjusted levels of selected metabolites of acrolein, carbon-disulfide, and N,N-dimethylformamide than male nonsmokers but female smokers had higher levels of each of these metabolites than male smokers. In addition, female smokers also had higher adjusted levels of selected metabolites of 1,3-butadiene, crotonaldehyde, cyanide, and ethylbenzene-styrene. Thus, constituents other than VOCs in tobacco smoke affect excretion of certain VOC metabolites differently among males and females. Non-Hispanic whites (NHW) had higher adjusted levels than non-Hispanic blacks (NHB) for 8 metabolites. NHB had statistically significantly lower adjusted levels than Hispanics for 5 VOC metabolites and lower levels than non-Hispanic Asians (NHAS) for 6 metabolites. Hispanics had statistically significantly higher levels than NHAS for 5 metabolites. Levels of 11 of the 19 metabolites analyzed increased with increase in age. Exposure to environmental tobacco smoke at home was associated with increased levels of 9 metabolites. Increase in the number of days tobacco products were used during the last five days was associated with increased levels of 12 of the 19 VOC metabolites. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to volatile organic compound urine metabolite human adult smoking, lifestyles, nhanes, smoking, urinary metabolites of volatile organic compounds, Toxicology: Tobacco and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 7, 2014, Mueller, Daniel C.; Piller, Markus; Niessner, Reinhard; Scherer, Max; Scherer, Gerhard published an article.Category: amides-buliding-blocks The title of the article was Untargeted Metabolomic Profiling in Saliva of Smokers and Nonsmokers by a Validated GC-TOF-MS Method. And the article contained the following:

A GC-TOF-MS method was developed and validated for a metabolic fingerprinting in saliva of smokers and nonsmokers. The authors validated the method by spiking 37 different metabolites and 6 internal standards to saliva between 0.1 μM and 2 mM. Intraday coefficients of variation (CVs) (accuracies) were on average, 11.9% (85.8%), 8.2% (88.9%), and 10.0% (106.7%) for the spiked levels 25, 50, and 200 μM, resp. (N = 5). Interday CVs (accuracies) were 12.4% (97%), 18.8% (95.5%), and 17.2% (105.9%) for the resp. levels of 25, 50, and 200 μM (N = 5). The method was applied to saliva of smokers and nonsmokers, obtained from a 24 h diet-controlled clin. study, to identify biomarkers of endogenous origin, which could be linked to smoking related diseases. Automated peak picking, integration, and statistical anal. were conducted by the software tools MZmine, Metaboanalyst, and PSPP. The authors could identify 13 significantly altered metabolites in smokers by matching them against MS libraries and authentic standard compounds Most of the identified metabolites, including tyramine, adenosine, and glucose-6-phosphate, could be linked to smoking-related perturbations and may be associated with established detrimental effects of smoking. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to tobacco smoking saliva metabolomics biomarker, Toxicology: Tobacco and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wahlang, Banrida; Gripshover, Tyler C.; Gao, Hong; Krivokhizhina, Tatiana; Keith, Rachel J.; Sithu, Israel D.; Rai, Shesh N.; Bhatnagar, Aruni; McClain, Craig J.; Srivastava, Sanjay; Cave, Mathew C. published an article in 2022, the title of the article was Associations between residential exposure to volatile organic compounds and liver injury markers.Formula: C10H11NO3 And the article contains the following content:

Occupational exposures to volatile organic compounds (VOCs) have been associated with numerous health complications including steatohepatitis and liver cancer. To address this knowledge gap, the objective of this cross-sectional study is to investigate associations between VOCs and liver injury biomarkers in community residents. Subjects were recruited from six Louisville neighborhoods, and informed consent was obtained. Exposure biomarkers included 16 creatinine-adjusted urinary metabolites corresponding to 12 parent VOCs. Serol. disease biomarkers measured included cytokertain-18 (K18 M65 and M30), liver enzymes, and direct bilirubin. The population comprised of approx. 60% females and 40% males; White persons accounted 78% of the population; with more nonsmokers (n = 413) than smokers (n = 250). In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene, and xylene were pos. associated with alk. phosphatase. These associations persisted in smokers, with the exception of crotonaldehyde, and addition of N,N-dimethylformamide and propylene oxide metabolites. Although no pos. associations were observed for K18 M30, the benzene metabolite was pos. associated with bilirubin, irresp. of smoking status. Taken together, the results demonstrated that selected VOCs were pos. associated with liver injury biomarkers. These findings will enable better risk assessment and identification of populations vulnerable to liver disease. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to volatile organic compound liver injury, alp, vocs, liver injury, residential, smoking, Toxicology: Other and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2016, Beloglazkina, Anastasia A.; Wobith, Birgit; Barskaia, Elena S.; Zefirov, Nikolay A.; Majouga, Alexander G.; Beloglazkina, Elena K.; Zyk, Nikolay V.; Kuznetsov, Sergei A.; Zefirova, Olga N. published an article.Application of 27115-50-0 The title of the article was Synthesis and biological testing of (5Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones as antimitotic agents. And the article contained the following:

Compounds interacting with cell protein tubulin and microtubules represent an important type of antimitotic agents. A series of tubulin-targeted 2-aryl-4-benzoyl-imidazoles were reported to possess high cytotoxicity, and so, the authors prepared a series of structural isomers of these to be evaluated as antimitotic agents. The synthesis of the novel (Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones involved coupling of substituted hippuric acids with aromatic aldehydes. Subsequent conversion of the resulting oxazolones to the corresponding imidazolones was carried out under microwave irradiation in the presence of urea and ammonium acetate. The cytotoxicity of the majority of the compounds to human epithelial carcinoma cancer cell line A549 was in the sub-micromolar range and was found to be more sensitive to the substituents on the 5-arylmethylidene fragment than on the 2-aryl ring in general. The cytotoxicities of the synthesized compounds were lower than those of the previously reported isomeric 2-aryl-4-benzoyl-imidazoles, and the basic structure-activity relationships in the isomeric pairs were different. Synthesized (5Z)-5-[(4-bromophenyl)methylidene]-2-(4-methylphenyl)-3,5-dihydro-4H-imidazol-4-one, which had the highest cytotoxicity (IC50 ∼ 440 nM) in the series of novel compounds, had a definite cytostatic effect on the A549 cells, but its antiproliferative properties were not linked to action on the microtubules. This would be an interesting lead compound for addnl. investigation into the mechanism of cytostatic action, and further structural optimization. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application of 27115-50-0

The Article related to antimitotic antitumor neoplasm, Pharmacology: Structure-Activity and other aspects.Application of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics