Tag: 100-200

Yousefinejad, Saeed; Honarasa, Fatemeh; Fararouei, Mohammad; Moosavi-Movahedi, Ali A. published an article in 2019, the title of the article was Structure-electrochemistry relationship for monovalent alkaline metals in non-aqueous solutions.Product Details of 685-91-6 And the article contains the following content:

Electrochem. methods, which deal with the interrelation of chem. and elec. properties, are interesting because of numerous advantages. Here, the electrochem. behavior of three important single-at. metallic monovalent ions (Li+, Na+, K+) were modelled in some organic solvents based on quant. structure electrochem. relationships. Because the inorganic ions have not mol. structure, only structural information of organic solvents was involved in the model. Q2 of cross validation were 0.95, 0.88 and 0.82 in lithium, sodium and potassium models, resp., and the R2test were 0.97, 0.89 and 0.93 in lithium, sodium and potassium models, resp. Various validation approaches were used to evaluate the proposed linear models. The results not only are useful for the prediction and estimation of the voltammetric behavior of the studied cations but also give a way to descript the important features of the utilized organic solvents on the half wave potential of lithium, sodium and potassium. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to structure electrochem relationship monovalent alkanic metal non aqeous solution, Biochemical Methods: Electrical and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Martinho, Nuno; Pires, Rita F.; Zloh, Mire; Bonifacio, Vasco D. B. published an article in 2021, the title of the article was Intrinsic acetamide brush-off by polyurea biodendrimers.Electric Literature of 685-91-6 And the article contains the following content:

The presence of genotoxic impurities in active pharmaceutical ingredients (APIs) is a major concern for the pharmaceutical industry. Acetamide is a common genotoxic byproduct found in synthetic routes of many APIs, mainly due to acetonitrile hydrolysis, and selective scavenging is a still a challenging task. Herein, as a proof-of-concept, we evaluate polyurea (PURE) biodendrimers as strategic nanopolymers to prepare safe drug nanoformulations from mixtures containing acetamide, using (S)-ibuprofen (IBF) as a model drug. Furthermore, computational mol. dynamics (MD) simulations were conducted to rationalize in vitro results and to identify the key intermol. interactions within mixtures Exptl. data were corroborated by MD simulations which showed that acetamide, IBF and carboxyfluorescein interactions with PURE biodendrimers are mostly at the surface. Also, PURE nanoformulations appear to be driven by hydrogen bonding, electrostatic and hydrophobic interactions. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to intrinsic acetamide nanoformulation polyurea biodendrimer, Pharmaceuticals: Pharmaceutics and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Griffin, Laura E.; Kohrt, Sarah E.; Rathore, Atul; Kay, Colin D.; Grabowska, Magdalena M.; Neilson, Andrew P. published an article in 2022, the title of the article was Microbial Metabolites of Flavanols in Urine are Associated with Enhanced Anti-Proliferative Activity in Bladder Cancer Cells In Vitro.SDS of cas: 27115-50-0 And the article contains the following content:

Flavanols are metabolized by the gut microbiota to bioavailable metabolites, and the absorbed fraction is excreted primarily via urine. Uroepithelial cells are thus a potential site of activity due to exposure to high concentrations of these compounds Chemoprevention by flavanols may be partly due to these metabolites. In Vitro work in this area relies on a limited pool of com. available microbial metabolites, and little has been done in bladder cancer. The impact of physiol. relevant mixtures of flavanols and their metabolites remains unknown. Rats were fed various flavanols and urine samples, approximating the bioavailable metabolome, were collected. Urines were profiled by UPLC-MS/MS, and their anti-proliferative activities were assayed In Vitro in four bladder cancer models. Significant interindividual variability was observed for composition and proliferation. Microbial metabolite concentrations (valerolactones, phenylalkyl acids and hippuric acids) were pos. associated with reduced bladder cancer proliferation In Vitro, while native flavanols were poorly correlated with activity. These results suggest that microbial metabolites may be responsible for chemoprevention in uroepithelial cells following flavanol consumption. This highlights the potential to use individual genetics and microbial metabotyping to design personalized dietary interventions for cancer prevention and/or adjuvant therapy to reduce bladder cancer incidence and improve outcomes. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to flavanol microbial metabolite bladder cancer antiproliferative activity, Pharmacology: Drug Metabolism and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nitsche, Johannes M.; Kasting, Gerald B. published an article in 2013, the title of the article was A correlation for 1,9-decadiene/water partition coefficients.Computed Properties of 27115-50-0 And the article contains the following content:

An important series of papers by Xiang, Anderson, and coworkers has established the strong correlation between phospholipid bilayer membrane permeability and the 1,9-decadiene/water partition coefficient over a wide range of compounds, elevating the importance of Kdecadiene/w as a predictor of mol. bioavailability. On the basis of a 58-point dataset developed by these authors, this research note develops an optimal correlation predicting log10Kdecadiene/w in terms of the octanol/water partition coefficient and four of the Abraham solvation parameters, namely A (hydrogen bond acidity), S (polarity/polarizability), E (excess molar refraction), and V (McGowan characteristic volume). The fitted dataset is described to within a root-mean-square error of 0.42, and the probable error in making a prediction for a compound not present therein is 0.49. It is shown that this correlation error for Kdecadiene/w is the dominant source of uncertainty in applying a comprehensive new model of phospholipid bilayer membrane permeability developed in a companion paper (Nitsche and Kasting, submitted for publication), which superposes the effects of mol. size and lipid d. upon the decadiene lipophilicity scale. Thus, more exptl. studies to augment the limited existing database on Kdecadiene/w are called for. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to decadiene water partition coefficient membrane permeability prediction, General Biochemistry: Other and other aspects.Computed Properties of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2018, Duan, Gaigai; Fang, Hong; Huang, Chaobo; Jiang, Shaohua; Hou, Haoqing published an article.Synthetic Route of 685-91-6 The title of the article was Microstructures and mechanical properties of aligned electrospun carbon nanofibers from binary composites of polyacrylonitrile and polyamic acid. And the article contained the following:

High mech. performance carbon nanofibers are highly required for the carbon nanofiber-reinforced composites, and it is necessary to develop novel precursors for the preparation of carbon nanofibers. Blends of poly(acrylonitrile-Bu acrylate mono-Bu itaconate) (co-PAN) and polyamic acid (PAA) were electrospun into aligned nanofibers and the nanofibers were converted to carbon nanofibers by thermal imidization, pre-oxidation, and high-temperature carbonization. FT-IR spectroscopy was applied to monitor the chem. structures of the nanofibers before and after pre-oxidation Tensile tests were used to characterize the mech. properties of electrospun carbon nanofibers (ECNFs). The microstructures of ECNFs were investigated by high-resolution TEM and Raman spectroscopy. The ECNFs derived from blend of co-PAN/PAA with molar ratio of 6/4 and with carbonization temperature of 1400° possessed the highest tensile strength of 1212 MPa, which could be attributed to the ordered graphitic structures in ECNFs. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to microstructure mech property carbon nanofiber polyacrylonitrile polamate, Ceramics: Carbon Products and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2018, Ge, Yang; Wang, Changyuan; Song, Shijie; Huang, Jiaxin; Liu, Zhihao; Li, Yongming; Meng, Qiang; Zhang, Jianbin; Yao, Jihong; Liu, Kexin; Ma, Xiaodong; Sun, Xiuli published an article.Application of 16230-24-3 The title of the article was Identification of highly potent BTK and JAK3 dual inhibitors with improved activity for the treatment of B-cell lymphoma. And the article contained the following:

The BTK and JAK3 receptor tyrosine kinases are two validated and therapeutically amenable targets in the treatment of B-cell lymphomas. Here the authors report the identification of several classes of pyrimidine derivatives as potent BTK and JAK3 dual inhibitors. Among these mols., approx. two thirds displayed strong inhibitory capacity at less than 10 nM concentration, and four compounds could significantly inhibit the phosphorylation of BTK and JAK3 enzymes at concentrations lower than 1 nM. Addnl., these pyrimidine derivatives also exhibited enhanced activity to block the proliferation of B-cell lymphoma cells compared with the representative BTK inhibitor ibrutinib. In particular, two structure-specific compounds I and II displayed stronger activity than reference agents in cell-based evaluation, with IC50 values lower than 10 μM. Further biol. studies, including flow cytometric anal., and a xenograft model for in vivo evaluation, also indicated their efficacy and low toxicity in the treatment of B-cell lymphoma. These findings provide a new insight for the development of novel anti-B-cell lymphoma drugs with multitarget actions. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application of 16230-24-3

The Article related to btk jak3 inhibitor antitumor neoplasm, btk, inhibitor, jak3, lymphoma, pyrimidine, Pharmacology: Structure-Activity and other aspects.Application of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2018, Beloglazkina, A. A.; Skvortsov, D. A.; Tafeenko, V. A.; Majouga, A. G.; Zyk, N. V.; Beloglazkina, E. K. published an article.Recommanded Product: 27115-50-0 The title of the article was Synthesis and cytotoxicity of novel dispiro derivatives of 5-arylidenoxazolones, potential inhibitors of p53-MDM2 protein-protein interaction. And the article contained the following:

Regioselective synthesis of new dispiro indolinones combining both an indolinone and an oxazolone fragment in their structure comprised the 1,3-dipolar cycloaddition of azomethine ylides, generated in situ from isatin and sarcosine, at 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones. When ortho and para halogen atoms were present in the aromatic substituents of the starting oxazolones, complex mixtures containing large amounts of oxazoline ring opening products and their dispiro derivatives were formed. The cytotoxicity of compounds was tested by MTT on LNCaP, PC3, HCT116, MCF7, A549, HEK, and VA13 cell lines. The compound possessing the best cytotoxicity revealed the IC50 = 1.08±0.96 μM towards the p53- expressing LNCaP cells and lower activity (IC50 = 3.21±1.45 μM) towards the non-expressing p53 protein PC3 cells, however, it has proved inactive towards the HCT cells, both expressing (HCT+/+) and non-expressing (HCT-/-) p53. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 27115-50-0

The Article related to preparation dispiro derivative arylidenoxazolone p53 mdm2 interaction cancer, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2018, Liu, Zhuo; Wang, Luhong; Feng, Min; Yi, Yuanyuan; Zhang, Wenhan; Liu, Wenjuan; Li, Lei; Liu, Zhihao; Li, Yanxia; Ma, Xiaodong published an article.HPLC of Formula: 16230-24-3 The title of the article was New acrylamide-substituted quinazoline derivatives with enhanced potency for the treatment of EGFR T790M-mutant non-small-cell lung cancers. And the article contained the following:

A new class of acrylamide-substituted quinazoline derivatives with enhanced inhibitory activity against mutant EGFR T790M enzyme were synthesized. Among them, compound 10b displayed the strongest inhibitory potency to block the phosphorylation of the EGFR T790M enzyme, with an IC50 value of 4.3 nM. Compared with the lead compound gefitinib, compound 10b significantly strengthened the activity against EGFR T790M (194 times higher). Furthermore, compound 10b only exhibited moderate activity against wild type EGFR, with an IC50 of 105.0 nM, suggesting its improved selectivity over the T790M-mutated EGFR. In addition, compound 10b also showed stronger activity against H1975 cells harboring the EGFR T790M mutation than gefitinib. Moreover, compound 10b has low inhibitory activity toward the normal HBE cells (IC50 > 34.04 μM), indicating its low cell cytotoxicity. Overall, this modification provided a new insight to design covalent binding EGFRT790M inhibitors to prevent NSCLC resistance. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).HPLC of Formula: 16230-24-3

The Article related to acrylamide quinazoline synthesis anticancer egfr lung breast cancer, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2011, Kong, Hyesik; Kim, Hyunjeong; Do, Heejeong; Lee, Yonghyun; Hong, Sungchae; Yoon, Jeong-Hyun; Jung, Yunjin; Kim, Young Mi published an article.Synthetic Route of 27115-50-0 The title of the article was Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site. And the article contained the following:

N-aromatic acyl-amino acid conjugates possess a colon-targeted property, implying that such conjugates are stable and are not absorbable until reaching the large intestine in which they are microbially converted (hydrolyzed) to the parent drugs that are therapeutically active. To investigate the structural effect of N-aromatic acyl-amino acid conjugates on the large intestinal deconjugation, the hydrolysis of various N-aromatic acyl-amino acid conjugates was examined in the cecal contents. On incubation of conjugates with glycine, D or/andL forms of alanine or phenylalanine in the cecal contents, the conjugates with D amino acids were not hydrolyzed. The other conjugates are susceptible to the hydrolysis, the rates of which decreased as the size of the substituent on the 2-position of the amino acids increased. The conjugates with alkyl analogs (2-4 carbons) of glycine and taurine were resistant to the hydrolysis, while taurine- and glycine-conjugates were hydrolyzed effectively. The hydrolysis of N-aromatic acyl-glycine conjugates was enhanced by para-substitution of electron withdrawing groups on the aromatic acyl moiety and vice versa for electron-donating groups. While a Me, methoxy or chloro group on the ortho-position retarded the hydrolysis, a hydroxyl group on the position accelerated it. Our data may provide useful information for the design of a colon-specific prodrug with controlled conversion rate in the large intestine. Copyright © 2011 John Wiley & Sons, Ltd. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0

The Article related to n aromatic acylamino acid conjugate hydrolysis cecum sar, Pharmacology: Structure-Activity and other aspects.Synthetic Route of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 25, 2013, Xiao, Run-mei; Sun, Jing-zhi; Mei, Yong; Liu, Jie; Chen, Yong published an article.COA of Formula: C10H11NO3 The title of the article was Simultaneous determination of four urinary metabolites of hippuric acid and methyl hippuric acid by HPLC. And the article contained the following:

A high performance liquid chromatog.(HPLC) method with diode array detection was established for simultaneous determination of hippuric acid (HA), Me hippuric acid(2-MHA, 3-MHA, 4-MHA) in urine. The target analytes in 0.5 mL urine sample were extracted with 0.5 mL Et acetate as extraction solvent in 3 min after the addition of 75 mg NaCL. After centrifugation, the four metabolites in sample were well separated on symmetry C18 (150 mm*4.6 mm, 5μm) column with mobile phase consisting of methanol: water: glacial acetic acid=30:70:0.1, column temperature at 35°C, the wavelength was set at 235 nm. Under the optimal conditions, the calibration curves of the four metabolites were linear in the range of 20mg/L∼500mg/L and the correlation coefficients were not less than 0.9997. The detection limits (S/N=3) were in the range of 21μg/L-200μg/L. The spiked recoveries were in the range of 97%∼104% with relative standard deviations (RSD) less than 5%. The method was sensitive, accurate and it could meet the needs of biol. monitoring on the metabolites of harmful substances in urine. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to urinary metabolite methyl hippuric acid hplc, Food and Feed Chemistry: Analysis and other aspects.COA of Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics