Tag: 100-200

On December 29, 2017, Lunn, Daniel B.; Yun, Young J.; Jorgenson, James W. published an article.Product Details of 27115-50-0 The title of the article was Retention and effective diffusion of model metabolites on porous graphitic carbon. And the article contained the following:

The study of metabolites in biol. samples is of high interest for a wide range of biol. and pharmaceutical applications. Reversed phase liquid chromatog. is a common technique used for the separation of metabolites, but it provides little retention for polar metabolites. An alternative to C18 bonded phases, porous graphitic carbon has the ability to provide significant retention for both non-polar and polar analytes. The goal of this work is to study the retention and effective diffusion properties of porous graphitic carbon, to see if it is suitable for the wide injection bands and long run times associated with long, packed capillary-scale separations The retention of a set of standard metabolites was studied for both stationary phases over a wide range of mobile phase conditions. Porous graphitic carbon benefits from significantly increased retention (often >100 fold) under initial gradient conditions for these metabolites, suggesting much improved ability to focus a wide injection band at the column inlet. The effective diffusion properties of these columns were studied using peak-parking experiments with the standard metabolites under a wide range of retention conditions. Under the high retention conditions, which can be associated with retention after injection loading for gradient separations, Deff/Dm ∼ 0.1 for both the C18-bonded and porous graphitic carbon columns. As C18 bonded particles are widely, and successfully used for long gradient separations without issue of increasing peak width from longitudinal diffusion, this suggests that porous graphitic carbon should be amenable for long runtime gradient separations as well. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Product Details of 27115-50-0

The Article related to metabolite retention diffusion porous graphitic carbon chromatog, effective diffusion, metabolites, porous graphitic carbon, sample pre-concentration, Biochemical Methods: Chromatographic and other aspects.Product Details of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghamari, Farhad; Bahrami, Abdulrahman; Yamini, Yadollah; Shahna, Farshid Ghorbani; Moghimbeigi, Abbas published an article in 2017, the title of the article was Hollow-fiber liquid-phase microextraction based on carrier-mediated transport for determination of urinary methyl hippuric acids.Reference of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

Hollow-fiber liquid-phase microextraction based on carrier-mediated transport for anal. of Me hippuric acids in aqueous samples is described. Under optimized conditions, relative recoveries of 83%-98% and limits of detection of 2-3μg L-1 were obtained, with linear calibration curves for the three isomers in the range of 10-50,000μg L-1. The method was applied for the determination of urine samples of volunteers at various working environments. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to urinary methyl hippuric acid microextraction, Biochemical Methods: Chromatographic and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 20, 2013, Liu, Jie; Mei, Yong; Wang, Ya-nan; Gu, Ying-ying; Wang, Qian; Jiang, Jin-feng published an article.Category: amides-buliding-blocks The title of the article was Standardized study on determination of methylhippuric acids in urine by HPLC. And the article contained the following:

The aim of this paper is to get a better separation of methylhippuric acid isomers and establish a standardized method for the determination of methylhippuric acids in urine by HPLC. C18 column was used to determine the methylhippuric acid. The mobile phase was methanol-0.1% acetic acid (33:67). The detector was performed at λ=230 nm, at 0.7 mVmin. Calibration curves of three methylhippuric acids were linear in the range of 25μg/mL∼1000μg/mL, with a correlation coefficient more than 0.999. The average recovery was in the range of 91.36%∼101.36% and the average RSD was in the range of 2.0%∼9.6%. The min. detection concentrations of 2-MHA, 3-MHA, 4-MHA were resp. 0.47μg/mL, 0.46μg/mL, 0.41μg/mL. The separation of 4-methylhippuric acid and 3-methylhippuric acid was up to 1.44. The method is able to make 3-methylhippuric acid and 4-methylhippuric acid baseline separated, and the methodol. indicators are in line with the relevant requirements of the method for determination of chems. in the occupational health standard-setting Guide Part V. So it can be used to determine methylhippuric acids in urine of xylene exposure workers. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to hplc methylhippuric acid determination, Biochemical Methods: Chromatographic and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gika, Helen G.; Ji, Cheng; Theodoridis, Georgios A.; Michopoulos, Filippos; Kaplowitz, Neil; Wilson, Ian D. published an article in 2012, the title of the article was Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling.SDS of cas: 27115-50-0 And the article contains the following content:

Alc. consumption in man, when seen in its extreme form of alcoholism, is a complex and socially disruptive disorder that can result in significant levels of liver injury. Here the rodent “intragastric feeding model” was used together with UHPLC-TOFMS anal. to determine changes in global metabolite profiles for plasma and urine from alc. treated rats and mice compared to control animals. Multivariate statistical anal. (using principal components anal., PCA) revealed robust differences between profiles from control and alc.-treated animals from both species. A large number of metabolites were seen to differ between control and alc.-treated animals, for both biofluids. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to investigation chronic alc consumption rodents ultra high performance liquid, Toxicology: Ethanol and Alcoholism and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 20, 2022, Pal, Vineet Kumar; Li, Adela Jing; Zhu, Hongkai; Kannan, Kurunthachalam published an article.HPLC of Formula: 27115-50-0 The title of the article was Diurnal variability in urinary volatile organic compound metabolites and its association with oxidative stress biomarkers. And the article contained the following:

Volatile organic compounds (VOCs) are ubiquitous environmental pollutants that are associated with birth defects, leukemia, neurocognitive deficits, reproductive impairment and cancer in humans exposed to these compounds Exposure to VOCs can be assessed by measuring their metabolites in urine. Little is known, however, about the temporal variability in urinary VOC metabolite (VOCM) concentrations within- and between-individuals. In this study, we determined the variability in the concentrations of 38 VOCMs in urine samples collected from 19 healthy individuals across a period of 44 days. We also measured seven biomarkers of oxidative stress (lipid, protein and DNA damage) in urine to assess the relationship of VOC exposure to oxidative stress. Seventeen VOCMs had detection frequencies (DFs) of >60% in urine, and we limited further data anal. to those compounds The creatinine-adjusted geometric mean concentrations of VOCMs ranged from 2.70 渭g/g to 327 渭g/g in spot and 2.60 渭g/g to 551 渭g/g in first morning void (FMV) urine samples. Calculation of the intra-class correlation coefficients (ICCs) for 17 VOCM concentrations to assess their predictability and repeatability in urinary measurements showed ranges of 0.080-0.425 in spot and 0.050-0.749 in FMV urine samples, revealing notable within-individual variability. Our results suggest that taking only single measurements of VOCM concentrations in urine in epidemiol. investigations may lead to exposure misclassification. In addition, VOCM concentrations were significantly and pos. correlated with oxidative stress biomarkers. This study thus provides important information for formulating sampling strategies in the biomonitoring of VOC exposure in human populations. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to volatile organic compound metabolite oxidative stress biomarker, benzene, biomonitoring, intra-class correlation coefficients, oxidative stress, voc, variability, Placeholder for records without volume info and other aspects.HPLC of Formula: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Dehghan Haghighi, Javid; Hormozi, Maryam; Payandeh, Abolfazl published an article.Electric Literature of 27115-50-0 The title of the article was Blood serum levels of selected biomarkers of oxidative stress among printing workers occupationally exposed to low-levels of toluene and xylene. And the article contained the following:

Printing workers (PWs) are exposed to a mixture of solvents, yet the health risks associated with such exposuer are unknown. This study aimed to compare the serum levels of selected biomarkers of oxidative stress among occupationally exposed PWs to low-level of toluene and xylenes and unexposed controls. Associations between levels of such biomarkers and occupational exposures to toluene and xylene were also investigated. Urinary levels of hippuric acid (HA) and Me hippuric acids (MHAs) as exposure biomarkers of toluene and xylenes, resp., and serum levels of oxidative stress biomarkers, including total antioxidant capacity (TAC), malondialdehyde (MDA), and the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were measured among the 84 subjects, comprising 44 PWs and 40 unexposed subjects. Mean concentrations of urinary HA and MHAs of PWs showed a significant increase compared with the unexposed controls. Although levels of urinary biomarkers of exposure to toluene (HA) and xylenes (MHAs) were well below the biol. exposure indexes (BEIs; ACGHI), PWs presented significantly increased serum levels of MDA, and significantly decreased serum activities of SOD and GPx compared to the unexposed controls. However, for serum TAC and CAT activity, no significant difference was observed between the two groups. Correlation analyses indicated that urinary levels of HA and MHAs were pos. correlated with MDA levels and neg. correlated with GPx and SOD. Our study suggested that the alterations evidenced in serum levels of MDA, SOD, and GPx could be involved in the oxidative stress caused by co-exposure to low levels of toluene and xylene. Further investigation is needed to clarify the effect of low-level occupational exposure to solvents among PWs. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to toluene xylene blood serum printing worker biomarker oxidative stress, occupational exposure, antioxidants, oxidative stress, printing workers, toluene, xylene, Placeholder for records without volume info and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 1, 2021, Liu, Limin; Wang, Zhengjie; Gao, Chao; Dai, Honglin; Si, Xiaojie; Zhang, Yang; Meng, Yaqi; Zheng, Jiaxin; Ke, Yu; Liu, Hongmin; Zhang, Qiurong published an article.Reference of N-(3-Aminophenyl)acrylamide The title of the article was Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives. And the article contained the following:

In order to find efficient new antitumor drugs, a series of novel trifluoromethyl-substituted pyrimidine derivatives were designed and synthesized and the bioactivity against four human tumor cells (PC-3, MGC-803, MCF-7 and H1975) was evaluated by MTT assay. Compound I displayed potent anti-proliferative activity on H1975 (IC50 = 2.27 渭M), which was better than the pos. control 5-FU (IC50 = 9.37 渭M). Further biol. evaluation studies showed that compound I apoptosis of H1975 cells and arrested the cell cycle at G2/M phase. Furthermore, compound I induced H1975 cells apoptosis through increasing the expression of pro-apoptotic proteins Bax and p53 and down-regulating the anti-apoptotic protein Bcl-2. In addition, compound I was able to be tightly embedded in the active pocket of EGFR. These results demonstrated that compound I has a potential as a lead compound for further investigation. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Reference of N-(3-Aminophenyl)acrylamide

The Article related to trifluoromethyl benzyl thio pyrimidin preparation sar antitumor mol docking, antitumor activity, pyrimidine derivatives, synthesis, trifluoromethyl moiety, Placeholder for records without volume info and other aspects.Reference of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2017, Gui, Yong-Yuan; Chen, Xiao-Wang; Zhou, Wen-Jun; Yu, Da-Gang published an article.Recommanded Product: N,N-Diethylacetamide The title of the article was Arylation of Amide and Urea C(sp3)-H Bonds with Aryl Tosylates Generated In Situ from Phenols. And the article contained the following:

The arylation of amide and urea C(sp3)-H bonds with aryl tosylates generated in situ from phenols has been realized at room temperature by combining visible-light-photoredox catalysis, hydrogen-atom-transfer catalysis, and nickel catalysis. This streamlined protocol permits rapid functionalization of phenols and direct transformation of 伪-amino C(sp3)-H bonds. The C(sp3)-H arylation products are obtained in high yields with good functional-group tolerance at low catalyst loadings. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: N,N-Diethylacetamide

The Article related to amide urea arylation aryl tosylate, photoredox hydrogen atom transfer nickel catalysis, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chatterjee, Puranjan; Wang, Hsin; Manzano, J. Sebastian; Kanbur, Uddhav; Sadow, Aaron D.; Slowing, Igor I. published an article in 2022, the title of the article was Surface ligands enhance the catalytic activity of supported Au nanoparticles for the aerobic 伪-oxidation of amines to amides.Name: N,N-Diethylacetamide And the article contains the following content:

The catalytic aerobic 伪-oxidation of amines in water is an atom economic and green alternative to current methods of amide synthesis. The reaction uses O2 as terminal oxidant, avoids hazardous reactants and gives water as the only byproduct. Here we report that the catalytic activity of silica-supported Au nanoparticles for the aerobic 伪-oxidation of amines can be improved by tethering pyridyl ligands to the support. In contrast, immobilization of thiol groups on the material gives activities comparable to Au supported on bare silica. Our studies indicate that the ligands affect the electronic properties of the Au nanoparticles and thereby determine their ability to activate O2 and mediate C-H cleavage in the amine substrate. The reaction likely proceeds via an Au catalyzed 尾-hydride elimination enabled by back donation from electron-rich metal to the orbital. O2, which is also activated on electron-rich Au, acts as a scavenger to remove H from the metal surface and regenerate the active sites. The mechanistic understanding of the catalytic conversion led to a new approach for forming C-C bonds 伪 to the N atoms of amines. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Name: N,N-Diethylacetamide

The Article related to amide preparation amine aerobic alpha oxidation, supported au nanoparticle catalysis, General Organic Chemistry: Synthetic Methods and other aspects.Name: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2013, Barati, Behjat; Moghadam, Majid; Rahmati, Abbas; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj published an article.Recommanded Product: 27115-50-0 The title of the article was Direct oxidation of alcohols to carboxylic acids over ruthenium hydride catalyst with diphenyl sulfoxide oxidant. And the article contained the following:

Direct oxidation of alcs. to their corresponding carboxylic acids with di-Ph sulfoxide oxidant over RuHCl(CO)(PPh3)3 catalyst was investigated. Mild reaction conditions, short reaction times and excellent yields make this method as an appealing way for preparation of carboxylic acids. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 27115-50-0

The Article related to alc diphenyl sulfoxide oxidation ruthenium catalyst, carboxylic acid preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics