Tag: 100-200

On March 5, 2021, Laurence, Christian; Mansour, Sergui; Vuluga, Daniela; Planchat, Aurelien; Legros, Julien published an article.Synthetic Route of 685-91-6 The title of the article was Hydrogen-Bond Acceptance of Solvents: A 19F Solvatomagnetic β1 Database to Replace Solvatochromic and Solvatovibrational Scales. And the article contained the following:

A variety of physicochem. properties and several hydrogen-bond donors have been used to define methods and to build scales aiming at measuring the hydrogen-bond acceptance of solvents. There is a great deal of confusion in these scales and methods. Solvatochromic, solvatocalorimetric, solvatovibrational, and 19F solvatomagnetic comparison methods are critically reviewed. Only two methods, the solvatomagnetic and the solvatocalorimetric ones, are able to yield reliable solvent hydrogen-bond acceptance scales. The solvatomagnetic β1 scale defined from the 19F chem. shift of 4-fluorophenol is extended to many solvents including ionic liquids and green solvents. The results for about 240 hydrogen-bond acceptor solvents are organized in a numerical β1 database. The comparison of β1 with solvatochromic scales highlights their shortcomings, in particular for the important class of amphiprotic solvents. Therefore, the use of the 19F solvatomagnetic comparison method and of the solvatomagnetic β1 scale is recommended in solvent effect studies. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to solvent hydrogen bond acceptor solvatomagnetic scale database, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 15, 2020, Zhu, Yanming; Zheng, Xu; Wang, Changyuan; Sun, Xiuli; Sun, Huijun; Ma, Tengyue; Li, Yanxia; Liu, Kexin; Chen, Lixue; Ma, Xiaodong published an article.Product Details of 16230-24-3 The title of the article was Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis. And the article contained the following:

Idiopathic pulmonary fibrosis (IPF) is a serious and fatal lung disease, with a median survival of only 3-5 years from diagnosis. Janus kinase 3 (JAK3) has a well-established role in the pathogenesis of various autoimmune diseases, including rheumatoid arthritis (RA) and autoimmune-related pulmonary fibrosis. In this study, through the use of a conformationally-constrained design strategy, a series of thieno[3,2-d]pyrimidines were synthesized as potent JAK3 inhibitors for the treatment of IPF. Among them, the most potent JAK3 inhibitor, namely 8e (IC50 = 1.38 nM), significantly reduced the degree of airsacculitis and fibrosis according to hematoxylin-eosin (HE) staining assay for the lung tissue in the bleomycin (BLM)-induced pulmonary fibrosis mouse model. The clear reduction of the lung collagen deposition by the determination of Masson and hydroxyproline (HYP) content also demonstrated its efficacy in the treatment of fibrosis. In addition, 8e also reduced the expression of the inflammatory markers IL-6, IL-17A, TNF-α and malondialdehyde (MDA) in lung tissue, which indicated its higher anti-inflammatory activity compared with that of the reference agents (nintedanib and gefitinib). Furthermore, it possessed low cytotoxicity against normal human bronchial epithelia (HBE) cells (IC50 > 39.0μM) and C57BL mice. All these evaluated biol. properties suggest that 8e may be a potential JAK3 inhibitor for the treatment of IPF. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Product Details of 16230-24-3

The Article related to thieno pyrimidine derivative preparation jak3 inhibitors idiopathic pulmonary fibrosis, idiopathic pulmonary fibrosis, jak inhibitors, thieno[3,2-d]pyrimidines, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Product Details of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sun, Bo; Liu, Xiaowen; Zheng, Xu; Wang, Changyuan; Meng, Qiang; Sun, Huijun; Shu, Xiaohong; Liu, Kexin; Sun, Xiuli; Li, Yanxia; Ma, Xiaodong published an article in 2020, the title of the article was Novel Pyrimidines as Multitarget Protein Tyrosine Kinase Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis (IPF).Recommanded Product: 16230-24-3 And the article contains the following content:

A new class of pyrimidine derivatives were identified as potent protein tyrosine kinase (PTK) inhibitors for the treatment of idiopathic pulmonary fibrosis (IPF). Most of these small-mol. inhibitors displayed strong enzymic activity against BTK and JAK3 kinases at concentrations lower than 10 nM. The representative compound N-(3-((5-chloro-2-(4-((1-morpholino)acetylamino)phenylamino)-4-pyrimidinyl)amino)phenyl)acrylamide (6 a) also exhibited high inhibitory potency toward both BTK and JAK kinase families, as well as ErbB4, at a concentration of 10 nM, achieving rates of inhibition higher than 57%. Addnl., in vivo biol. evaluations showed that 6 a can remarkably decrease the severity of IPF disease. All these investigations suggested that the multi-PTK inhibitor 6 a may serve as a promising agent for the treatment of IPF. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Recommanded Product: 16230-24-3

The Article related to pyrimidine derivative preparation tyrosine kinase inhibitor idiopathic pulmonary fibrosis, ipf, ptk, inhibitors, multitarget, pyrimidine, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Recommanded Product: 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Amaral, Miriam C. S.; Moravia, Wagner G.; Lange, Lisete C. published an article in 2017, the title of the article was Characterization of residual organic compounds of aerobic degradation of landfill leachate.Synthetic Route of 685-91-6 And the article contains the following content:

The purpose of this article is to characterize and compare the residual COD of raw landfill leachate and its low and high mol. weight fractions before and after aerobic degradation process. The low and high mol. weight fractions (<10 kDa and >10 kDa, resp.) were obtained by the use of an ultrafiltration cell. Samples of the fractions with mol. weights 10 kDa, as well as the raw leachate, were characterized in terms of COD, protein, carbohydrate and lipid concentration and by biodegradability test. The compound identification of all samples was carried out using gas chromatog. coupled with mass spectrometry (GC/MS). The results show that the landfill leachate studied is constituted of approx. 60% of compounds with mol. weight <10 kDa. Approx. 80% of the compounds identified in the leachate had been degraded. This is an indication that most of the compounds that constitute the significant fraction of residual COD correspond to intermediate products and products of condensation of affluent compounds or had been generated during the degradation (SMP). Similar compounds were identified in all effluents of the degradation assay, suggesting the presence of SMP. These compounds, predominantly aliphatic and esters, are characterized by high mol. weight and probable refractory nature. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to residual organic compound aerobic degradation landfill leachate, compounds identifications, smp, leachate, residual cod, Waste Treatment and Disposal: Chemical Treatment Of Aqueous Wastes and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Tianlong; Lu, Maojian; Lin, Zhaowei; Huang, Mingqiang; Cai, Shunyou published an article in 2019, the title of the article was Visible-light-promoted oxidation/condensation of benzyl alcohols with dialkylacetamides to cinnamides.Reference of N,N-Diethylacetamide And the article contains the following content:

Oxidative cross-coupling reactions of benzyl alcs. with N,N-dialkylacetamides were developed only employing oxygen as the terminal oxidant, efficiently providing a new, novel protocol for the construction of multifunctionalized cinnamides with the synergistic effects of KOH, organic photocatalyst eosin Y, and visible light irradiation at room temperature A broad substrate scope and mild reaction conditions are the prominent features of this transformation. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to cinnamide preparation visible light promoted oxidation condensation reaction, oxidative cross coupling benzyl alc diarylacetamide organic photocatalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: General and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 25, 2019, Zhou, Qilin; Zhang, Fenghua; Xie, Jianhua; Wang, Lixin published a patent.Related Products of 65645-88-7 The title of the patent was Chiral spiro phosphine-amino-oxazoline tridentate ligand, its preparation method and application. And the patent contained the following:

A chiral spiro phosphine-amino-oxazoline tridentate ligand having ruthenium complex exhibits high catalytic activity (TON to 10,000) and enantioselectivity (up to 98% ee) in the asym. hydrogenation of α-ketoamide, which has practical value is provided. The chiral spiro phosphine-amino-oxazoline tridentate ligand comprises a compound of formula I or an enantiomer, racemate, or a catalytically acceptable salt thereof, and having a main structural feature of having a chiral spiroindoline skeleton and having a chiral oxazoline group. The method for preparing a chiral spiro phosphine-amino-oxazoline tridentate ligand by racemic or optically active 7-diaryl/alkylphosphino-7/-aminospiroindole represented by formula 1 having a chiral spiroindoline skeleton used as a starting material. The chiral spiro phosphine-amino-oxazoline tridentate ligand forms a complex with the transition metal salt and can be used to catalyze the asym. catalytic hydrogenation of the carbonyl compound The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Related Products of 65645-88-7

The Article related to chiral spiro phosphine amino oxazoline preparation enantioselective hydrogenation catalyst, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Related Products of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 19, 2017, Ma, Xiaodong; Ge, Yang; Song, Zhendong; Huang, Shanshan; Wang, Changyuan; Zhang, Jianbin; Tang, Zeyao; Liu, Kexin published a patent.Application In Synthesis of N-(3-Aminophenyl)acrylamide The title of the patent was Phosphoryl pyrimidine compound, and its composition and application. And the patent contained the following:

The title phosphoryl pyrimidine compound is shown in formula I, wherein, X is Cl or F; L is -CH2- or -O(CH2)2CH2-; R1 is selected from H, Me, methoxy, and Cl; R2 is selected from methoxy, ethoxy, etc.; R3 is methoxy, ethoxy, etc. The phosphoryl pyrimidine compound is capable of inhibiting Brutons tyrosine kinase, so as to treat tumor diseases, such as Burkitts lymphoma, diffuse large B cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application In Synthesis of N-(3-Aminophenyl)acrylamide

The Article related to phosphoryl pyrimidine compound preparation antitumor activity, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application In Synthesis of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Krais, Annette M.; Essig, Julie Y.; Gren, Louise; Vogs, Carolina; Assarsson, Eva; Dierschke, Katrin; Nielsen, Joern; Strandberg, Bo; Pagels, Joakim; Broberg, Karin; Lindh, Christian H.; Gudmundsson, Anders; Wierzbicka, Aneta published an article in 2021, the title of the article was Biomarkers after controlled inhalation exposure to exhaust from Hydrogenated vegetable oil (HVO).Recommanded Product: 27115-50-0 And the article contains the following content:

Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicol. properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatog. tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM1 ~1μg/m3 and ~90μg/m3 for vehicles with and without exhaust aftertreatment systems, resp.) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM1 ~300μg/m3) increased urinary 4-MHA, a biomarker for p-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, p < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 27115-50-0

The Article related to hydrogenated vegetable oil inhalation exposure biomarker, hvo, aerosol, biomarkers, exposure studies, lipid peroxidation, renewable diesel, Fossil Fuels, Derivatives, and Related Products: Crude-Oil Refining and other aspects.Recommanded Product: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 15, 2005, Weller, Thomas; Koberstein, Ralf; Aissaoui, Hamed; Clozel, Martine; Fischli, Walter published a patent.Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of substituted 1,2,3,4-tetrahydroisoquinolines as orexin receptor antagonists. And the patent contained the following:

Title compounds I [R1-2 = H, alkoxy; R3 = alkyl; X = CH, N] are prepared For instance, II is prepared from a Ru-catalyzed enantioselective alkylation of 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline with 1-bromomethyl-4-trifluoromethylbenzene followed by alkylation of the resulting isoquinoline with (S)-α-(4-toluenesulfonyloxy)-N-methylphenylacetamide (preparation given). Compounds of the invention are orexin antagonists with activity in the nanomolar range. I are useful for the treatment of, e.g., anxiety and depression. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to tetrahydroisoquinoline orexin receptor antagonist process preparation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Name: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 21, 2019, Morrow, Benjamin Joseph; Camerino, Michelle Ang; Walker, Scott Raymond; Stevenson, Graeme Irvine; Stupple, Paul Anthony published a patent.Category: amides-buliding-blocks The title of the patent was Substituted condensed thiophenes as modulators of STING protein and their preparation. And the patent contained the following:

The invention relates to substituted benzothiophenes, thienopyridines and thienopyrimidines of formula I and their use as pharmaceuticals for treating diseases ameliorated by modulation of STING protein. Compound of formula I wherein R1 is H, C3-6 cycloalkyl, (un)substituted C3-7 heterocyclyl and (un)substituted (un)branched C1-4 alkyl; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD are H; Y is O, NH or CH2; R’ is (un)substituted arylcarboxamide, (un)substituted heteroarylcarboxamide and (un)substituted 3-aminobenzisoxazol-6-yl; are claimed. Example compound II was prepared by hydrolysis of Et 3-((4-carbamoylphenoxy)methyl)-4-fluorobenzo[b]thiophene-2-carboxylate. The invention compounds were evaluated for their STING modulatory activity (data given). The experimental process involved the reaction of 2-Fluoro-4-hydroxybenzamide(cas: 1133122-96-9).Category: amides-buliding-blocks

The Article related to condensed thiophene preparation sting modulator, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics