Tag: 100-200

On October 31, 2010, Mannocci, Luca; Melkko, Samu; Buller, Fabian; Molnar, Ilona; Gapian Bianke, Jean-Paul; Dumelin, Christoph E.; Scheuermann, Jorg; Neri, Dario published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Isolation of Potent and Specific Trypsin Inhibitors from a DNA-Encoded Chemical Library. And the article contained the following:

Collections of chem. compounds, individually attached to unique DNA fragments serving as amplifiable identification bar codes, are generally referred to as “DNA-encoded chem. libraries”. Such libraries can be used for the de novo isolation of binding mols. against target proteins of interest. Here, we describe the synthesis and use of a DNA-encoded library based on benzamidine analogs, which allowed the isolation of a trypsin inhibitor with an IC50 value of 3.0 nM, thus representing a >10 000-fold potency improvement compared to the parental compound The novel trypsin inhibitor displayed an excellent selectivity toward other serine proteases. This study indicates that DNA-encoded libraries can be used for the facile “affinity maturation” of suboptimal binding compounds, thus facilitating drug development. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to trypsin inhibitor benzamidine derivative dna encoded library, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 19, 2017, Naya, Masami; Hamano, Yoshimi; Kokado, Kenta; Sada, Kazuki published an article.Formula: C6H13NO The title of the article was Organic Reaction as a Stimulus for Polymer Phase Separation. And the article contained the following:

Mol. design of stimuli-sensitive polymers has been attracting considerable interest of chemists because of their latent ability to achieve smart materials. Heat, light, pH, and chems. have been often utilized as a stimuli-inducing polymer phase transition from solution to aggregation and vice versa. In this report, as a new trigger for lower critical solution temperature (LCST)-type polymer phase transition, we introduce organic reaction of small organic mols., not to the polymer chain itself. The addition of the reactant for the “effector”, which can interact with the polymer chain for increasing the compatibility of the polymer chain with the media, caused a polymer phase separation, due to reduction of the solvation ability of the effector to the polymer chain. In other words, decrease of the “effector” concentration induced the polymer phase separation Within our knowledge, this is the first report to connect a polymer phase separation with organic reaction dynamics. This process will be the first step for the development of artificial allosteric enzyme mimics from a combination of a simple synthetic polymer and a product or reactant in organic reactions. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Formula: C6H13NO

The Article related to organic polymer stimuli sensitive phase separation, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2015, Suhasini, K. P.; Christopher, V.; Kumar, Ch. Praveen; Rao, S. Rama Mohana; Murthy, Y. L. N. published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis, characterisation and antimycobacterial screening of 5(4H)-oxazolone derivatives against M. tuberculosis H37Rv. And the article contained the following:

A series of 4-(substituted benzylidene)-2-p-tolyloxazol-5(4H)-ones I [R = H, 4-Cl, 2,5-(OCH3)2, etc.] has been designed, synthesized and subjected to evaluate their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in comparison with standard drugs Rifampicin and Isoniazid. The out-put of these studies disclosed that all the synthesized target mols. of the series displayed good to moderate activity with MIC values ranging 8-64 U+03BCg/mL. The compound I [R = 2,4,6-(OCH3)3] is the most distinctive compound identified, amongst the series because of its remarkable in vitro antimycobacterial activity and thus may act as a promising lead mol. for further explorations. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to oxazolone preparation antimycobacterial, methylbenzamido acetic acid preparation aldehyde aryl erlenmeyer plochl azlactone, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Huang, Wenhua; Dong, Guangping; Mijiti, Zumureti published an article in 2012, the title of the article was One-pot synthesis of 2,4,5-trisubstituted oxazoles from N-acyl amino acids by a combination of cyclodehydration with N,N’-diisopropylcarbodiimide and Wittig olefination.Quality Control of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

By a combination of cyclodehydration of N-acyl amino acids with N,N’-diisopropylcarbodiimide (DIC) and non-classical Wittig olefination of the resultant 5(4H)-oxazolones with Ph3P=CHCN and Ph3P=CHCOOEt, 5-oxazoleacetonitriles and 5-oxazoleacetates were synthesized in one-pot in 41-85% and 57-70% yields, resp. E.g., reaction of 4-MeC6H4CONHCH2CO2H with Ph3P:CHCN in presence of DIC gave 85% 5-oxazoleacetonitrile (I). The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Quality Control of 2-(4-Methylbenzamido)acetic acid

The Article related to acyl amino acid cyclodehydration wittig olefination, oxazoleacetonitrile preparation, oxazoleacetate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Quality Control of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 16, 2019, Yan, Dingyuan; Jiang, Heming; Sun, Wenxue; Wei, Wei; Zhao, Jing; Zhang, Xinhao; Wu, Yun-Dong published an article.HPLC of Formula: 685-91-6 The title of the article was Synthesis of Benzofurans and Benzoxazoles through a [3,3]-Sigmatropic Rearrangement: O-NHAc as a Multitasking Functional Group. And the article contained the following:

The synthesis of heterocycles relies heavily on diverse sigmatropic rearrangements triggered by the cleavage of X-Y (X, Y = C, O, N, S, I) bonds. However, a unified rearrangement approach for constructing heterocyclic libraries is highly desirable. Encouraged by computational anal. of [3,3]-sigmatropic rearrangements, we can now rapidly synthesize oxa-heterocycles by treating N-phenoxyacetamides (Ph-ONHAc) with compounds containing an sp-hybridized carbon. The generality of the process is illustrated by the late-stage diversification of natural products, including estrone and an approved drug. A combination of exptl. and computational studies revealed that the reactions proceed through a facile Claisen-like [3,3]-sigmatropic rearrangement/annulation process. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).HPLC of Formula: 685-91-6

The Article related to synthesis benzofuran benzoxazole, sigmatropic rearrangement mol modeling, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.HPLC of Formula: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2015, Suhasini, K. P.; Christopher, V.; Rao, S. Rama Mohana; Kumar, Ch. Praveen; Murthy, Y. L. N. published an article.COA of Formula: C10H11NO3 The title of the article was Synthesis, characterisation and antitubercular screening of 5(4H)-oxazolone derivatives. And the article contained the following:

In search of new antitubercular agents, a new series of 4-(substituted benzylidene)-2-p-tolyloxazol-5(4H)-ones I [R = C6H5, 4-H3CC6H4, 4-CH3OC6H4, 2,5-(CH3O)2C6H3, 2,4,6-(CH3O)3C6H2, 4-ClC6H4, 4-BrC6H4, O2NC6H4] has been designed, synthesized and subjected to evaluate their antitubercular activity for the first time against Mycobacterium tuberculosis H37Rv, in comparison with standard drugs Rifampicin and Isoniazid. The out-put of these studies disclosed that all the synthesized target mols. I of the series displayed good to moderate activity with MIC values ranging 8-64 U+03BCg/mL. Compound I [R = 2,4,6-(CH3O)3C6H2] having three methoxy groups, is the most distinctive compound identified, amongst the series because of its remarkable in vitro antitubercular activity and thus may act as a promising lead mol. for further explorations. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to oxazolone preparation antitubercular, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.COA of Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 8, 2021, Chen, Yan-Ru; Chung, Hsiao-Wei; Tung, Shih-Huang published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was On the Formation Mechanism of Nonsolvent-Induced Porous Polylactide Electrospun Fibers. And the article contained the following:

Polylactide (PLA) fibers were electrospun from the solutions of PLA dissolved in the mixtures of its good and poor solvents, and the formation mechanism of the poor solvent-induced porous structure on the fibers was investigated. From a systematic study using the pairs of a variety of good/poor solvents for electrospinning, the conditions, specifically the solvent properties, for producing uniform fibers with controllable pores that appear not only on the surface but also throughout the fibers were proposed. The water miscibility of the good/poor solvents is crucial, which is because the ambient moisture that condenses during electrospinning plays an important role in the formation of the pores. Furthermore, the evaporation rate of the good/poor solvents is another key factor that affects the pore size and pore distribution on fibers because the solvent evaporation rate regulates the moisture condensation and the phase-separated scale that are closely related to fiber morphol. The principles generalized in this work can be applied to other low-polar polymers for controlling the porosity of fibers. In addition, this work demonstrates that the porous PLA fibers can be electrospun from low-toxic solvents and that with a large surface area and storage space provided by the pores, the PLA porous fibers are highly capable of adsorbing oils, with a capacity double that of the smooth counterpart. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to porous polylactide electrospun fiber, Textiles and Fibers: Fiber and Yarn Processing and Processing Materials and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 9, 2009, Bappert, Erhard; De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Nazir, Zarghun; Skranc, Wolfgang; Spindler, Felix; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Computed Properties of 65645-88-7 The title of the patent was Process for the preparation of an enantiomeric trisubstituted 3,4-dihydroisoquinoline derivative. And the patent contained the following:

The invention relates to a process for the preparation of the compound of formula I by enantioselective hydrogenation of the corresponding imine intermediate catalyzed by bis[chloro-1,5-cyclooctadiene-iridium] and (S)-1-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]ferrocene. Reaction conditions, such as additives, ratios of substrate/catalyst and solvent systems, play roles respect to enantioselectivity and yields therefore were examined Other metal/chiral ligand catalyst systems were evaluated for the enantioselective hydrogenation of the substrate. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Computed Properties of 65645-88-7

The Article related to dihydroisoquinoline derivative hydrogenation iridium chiral ligand, tetrahydroisoquinoline derivative asym preparation, iridium chiral ligand asym hydrogenation catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Computed Properties of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 20, 2012, Bappert, Erhard; De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Nazir, Zarghun; Skranc, Wolfgang; Spindler, Felix; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Related Products of 65645-88-7 The title of the patent was Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative. And the patent contained the following:

The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Related Products of 65645-88-7

The Article related to dihydroisoquinoline derivative hydrogenation iridium chiral ligand, tetrahydroisoquinoline derivative asym preparation, iridium chiral ligand asym hydrogenation catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Related Products of 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2021, Giroux, Simon; Nuhant, Philippe Marcel; Bandarage, Upul Keerthi; Garcia Barrantes, Pedro Manuel; Liao, Yusheng; Gale-Day, Zachary; Gu, Wenxin; Karns, Alexander S.; Zhang, Hu; Allen, Emily Elizabeth; Xu, Jinwang; Deninno, Michael Paul; Tang, Qing; Boucher, Diane Marie; Fanning, Lev T.D.; Hall, Amy B.; Hurley, Dennis James; Johnson, Mac Arthur, Jr.; Maxwell, John Patrick; Swett, Rebecca Jane; Tapley, Timothy Lewis; Thomson, Stephen A.; Damagnez, Veronique; Cottrell, Kevin Michael published a patent.Quality Control of 2-Fluoro-4-hydroxybenzamide The title of the patent was Preparation of 1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency. And the patent contained the following:

1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives(I) as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD). Compounds I wherein Z1-Z3 each independently -N, -NH, or -CH; V1 and V2 are each selected from C and N; W1 and W2 are each selected from -C=O, -CR2, N, etc.; etc., are claimed. The example compound II was prepared via 4-steps synthesis using (4-chlorophenyl)boronic acid as starting material reacting with intermediate (also prepared)(procedure given). Compounds I were evaluated for alpha-1-antitrypsin modulating activity (data given). Compounds I can be used for the treatment of α1-antitrypsin deficiency. The experimental process involved the reaction of 2-Fluoro-4-hydroxybenzamide(cas: 1133122-96-9).Quality Control of 2-Fluoro-4-hydroxybenzamide

The Article related to pyrazoloquinoline preparation alpha1 antitrypsin deficiency treatment, pyrazoloisoquinoline preparation alpha1 antitrypsin modulator deficiency treatment, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Quality Control of 2-Fluoro-4-hydroxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics