Tag: 100-200

On May 21, 2021, Xu, Chang; Shen, Fang-Qi; Feng, Gaofeng; Jin, Jian published an article.COA of Formula: C6H13NO The title of the article was Visible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes. And the article contained the following:

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, was disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in N,N-diethylethanamide in the presence of Cs2CO3 afforded α-arylated amines in good to excellent yields. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).COA of Formula: C6H13NO

The Article related to tertiary amine benzonitrile photochem regioselective arylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2017, Zhang, Yinsheng; Gao, Yong; Ren, Jing; Wang, Qinglin; Wang, Zhao published a patent.Related Products of 16230-24-3 The title of the patent was 2,4-Disubstituted pyrimidine compounds as EGFR or/and ALK inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention relates to 2,4-disubstituted pyrimidine compounds of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and application thereof in treating diseases induced by EGFR or/and ALK. Compounds of formula I wherein X and Y are independently N and CH; R1 is H, halo, CF3, CN; R2 and R6 are independently H, C1-6 alkoxy; R3 and R5 are independently H, acroylamino; R4 is (un)substituted 3- to 8-membered heterocyclic ring, -Z-(CH2)1-4-NR9R10; R7 is H, C1-6 alkoxy, -Z-(CH2)1-4-NR9R10, (un)substituted piperazinyl; R9 and R10 are independently H and C1-4 alkyl; Z is O, S, NH and derivatives; and their pharmaceutically acceptable salts as EGFR or/and ALK inhibitors in the treatment of diseases thereof, are claimed. Compounds of formula I were prepared by using condensation and reduction as the key steps. All the invention compounds were evaluated for their EGFR or/and ALK inhibitory activity. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Related Products of 16230-24-3

The Article related to pyrimidine preparation egfr alk inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Related Products of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 8, 2014, Xu, Yong; Wang, Xuehai; Li, Lie; Huang, Lu; Tian, Hua; Yang, Zhongwen; Xia, Qingfeng; Xiao, Qiang; Guo, Diliang; Tu, Ronghua; Yu, Yanping; Yu, Jing; Huang, Xiang; Fan, Zhaoze; He, Zhenyu; Zhang, Yi; Yang, Jing published a patent.Name: N-(3-Aminophenyl)acrylamide The title of the patent was Purine compounds as kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention provides purine compounds of formula I and their preparing method and application. The inventive compounds can serve as Bruton’s tyrosine kinase (BTK) inhibitors. Compound of formula I wherein X is (un)substituted Ph, (un)substituted 3- to 7-membered saturated or unsaturated carbon ring, (un)substituted 8- to 10-membered saturated or unsaturated bicyclic ring or aryl ring, etc.; R1 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R2 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R is H, (un)substituted C1-6 alkyl, (un)substituted Ph, (un)substituted 4- to 7-membered heterocycle having 1-2 heteroatoms, (un)substituted 5- to 6-membered monocyclic heteroaryl ring including 1-4 heteroatoms, and the heteroatoms are selected from N, O, and S; and their stereoisomers, tautomers, pharmaceutically active metabolites, pharmaceutically acceptable salts, hydrates, solvates, or prodrugs as kinase inhibitors in the treatment of diseases thereof, are claimed. Compound of formula I were prepared via condensation of 2-chloro-9H-purin-6-amine with 4-hydroxypiperidine; the resulting 2-chloro-9-(4-piperidinyl)-9H-purin-6-amine underwent acylation with acryloyl chloride to give to give 2-chloro-6-(acryloylamino)-9-(1-acryloylamino-4-piperidinyl)-9H-purine, which underwent condensation with amines to give I. All the invention compounds were evaluated for their BTK inhibitory activity. From the assay, it was determined that two of the tested compounds exhibited the IC50 value of 0.016 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Name: N-(3-Aminophenyl)acrylamide

The Article related to purine preparation btk kinase inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 10, 2015, Xu, Yong; Wang, Xuehai; Li, Li’e; Huang, Lu; Tian, Hua; Yang, Zhongwen; Xia, Qingfeng; Xiao, Qiang; Guo, Diliang; Tu, Ronghua; Yu, Yanping; Yu, Jing; Huang, Xiang; Fan, Zhaoze; He, Zhenyu; Zhang, Yi; Yang, Jing published a patent.Category: amides-buliding-blocks The title of the patent was Purine compounds as kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention provides purine compounds of formula I and their preparing method and application. The inventive compounds can serve as Bruton’s tyrosine kinase (BTK) inhibitors. Compound of formula I wherein X is (un)substituted Ph, (un)substituted 3- to 7-membered saturated or unsaturated carbon ring, (un)substituted 8- to 10-membered saturated or unsaturated bicyclic ring or aryl ring, etc.; R1 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R2 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R is H, (un)substituted C1-6 alkyl, (un)substituted Ph, (un)substituted 4- to 7-membered heterocycle having 1-2 heteroatoms, (un)substituted 5- to 6-membered monocyclic heteroaryl ring including 1-4 heteroatoms, and the heteroatoms are selected from N, O, and S; and their stereoisomers, tautomers, pharmaceutically active metabolites, pharmaceutically acceptable salts, hydrates, solvates, or prodrugs as kinase inhibitors in the treatment of diseases thereof, are claimed. Compound of formula I were prepared via condensation of 2-chloro-9H-purin-6-amine with 4-hydroxypiperidine; the resulting 2-chloro-9-(4-piperidinyl)-9H-purin-6-amine underwent acylation with acryloyl chloride to give to give 2-chloro-6-(acryloylamino)-9-(1-acryloylamino-4-piperidinyl)-9H-purine, which underwent condensation with amines to give I. All the invention compounds were evaluated for their BTK inhibitory activity. From the assay, it was determined that two of the tested compounds exhibited the IC50 value of 0.016 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Category: amides-buliding-blocks

The Article related to purine preparation btk kinase inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 24, 2017, Chen, Wenteng; Liu, Xingyu; Shao, Jiaan; Chen, En; Yu, Yongping published a patent.Application of 16230-24-3 The title of the patent was Preparation of 2-aminooimidazole pyridine derivatives as antitumor agents. And the patent contained the following:

The invention provides 2-aminooimidazole pyridine derivatives and method for preparing them, therfore. Experiments prove that the derivative has obvious proliferation inhibition effect on tumor cells (human epidermal carcinoma cell strain A431 overexpressing wild type EGFR, and Gefitinib-resistant human lung adenocarcinoma cell strain H1975) related with activity of EGFR tyrosine kinase activity at mol. level, particularly has preferable inhibition on drug-resistant cell strain H1975, has weak inhibitory activity on human colon cancer cell strain SW620 low expressing EGFR, and can be applied to prepare corresponding tumor cell-resistant drugs. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application of 16230-24-3

The Article related to aminooimidazole pyridine preparation antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 1999, Park, Kyung Jae; Oh, In Hwan; Mun, Jae Jun; Jung, Shin Hae published a patent.Formula: C9H10N2O The title of the patent was Method for the preparation of polymeric pigment. And the patent contained the following:

A process for preparing an acrylic based polymer pigment polymerized with a pigment itself by polymerizing an acrylic/azo based pigment monomer with a vinyl monomer is provided, which has excellent coloring property and workability for general plastic and engineering plastic as substantial matrix resin. This process comprises the steps of: preparing raw material for synthesizing 3-nitroacrylanilide by using 3-nitroaniline and acryloyl chloride in acetone as a solvent and sodium hydroxide as a catalyst; reducing 3-nitroacrylanilide using iron/hydrochloric acid in 50% methanol as a solvent; preparing an acrylic/azo based color monomer by reacting 3-aminoacrylanilide with sodium nitrate and coupling with a coupler; and polymerizing the acrylic/azo based color monomer and Me methacrylate. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Formula: C9H10N2O

The Article related to acrylic azo polymer pigment preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Other Dyes and Pigments and other aspects.Formula: C9H10N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 20, 2020, Persson, Ingmar; Lundberg, Daniel; Bajnoczi, Eva G.; Klementiev, Konstantin; Just, Justus; Sigfridsson Clauss, Kajsa G. V. published an article.Computed Properties of 685-91-6 The title of the article was EXAFS Study on the Coordination Chemistry of the Solvated Copper(II) Ion in a Series of Oxygen Donor Solvents. And the article contained the following:

The structures of the solvated Cu(II) ion in H2O and nine organic oxygen donor solvents with similar electron-pair donor ability, but with different space-demanding properties at coordination, were studied by EXAFS. N,N’-Dimethylpropyleneurea and N,N,N’,N’-tetramethylurea are sufficiently space demanding at coordination to make the axial positions not accessible, resulting in square-planar Cu(II) solvate complexes with an intense green color. The mean Cu-O bond distances in these two solvate complexes are 1.939(3) and 1.935(3) Å, resp. The best fits of the remaining solvates, which are light blue in different hues, were obtained with a Jahn-Teller distorted-octahedral model consisting of four strongly bound solvent mols. in the equatorial positions at 1.96(2) Å and two in the axial positions but with different Cu-Oax bond distances: ∼2.15 and 2.32 Å. This is in agreement with observations in solid-state structures of compounds containing hexaaquacopper(II) complexes crystallizing in noncentrosym. space groups and all reported crystal structures containing a [Cu(H2O)5(O-ligand)] complex with Jahn-Teller distortion. Such a structure is in agreement with previous EPR and EXAFS studies proving the hydrated Cu(II) ion to be a noncentrosym. complex in aqueous solution The refinements of the EXAFS data of the solids [Cu(H2O)6](ClO4)2, [Cu(H2O)6](BrO3)2, [Cu(H2O)6]SiF6, Cu(NO3)2·2.5H2O, and CuSO4·5H2O gave Cu-O bond distances significantly different from those reported in the crystallog. studies but similar to the configuration and bond distances in the hydrated Cu(II) ion in aqueous solution This may depend on whether the orientation of the axial positions is random in one or three dimensions, giving a mean structure of the solid with symmetry higher than that of the individual complexes. This study presents the very 1st exptl. data from the new x-ray absorption spectroscopy beamline Balder at the MAX IV synchrotron radiation facility in Lund, Sweden, as well as the used properties of the beamline. The coordination chem. of the solvated Cu(II) ion was studied in 10 solvents, including H2O. The Cu(II) ion has a noncentrosym. Jahn-Teller distorted-octahedral geometry with the axial Cu-O bond distances differing by ∼0.2 Å. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Computed Properties of 685-91-6

The Article related to crystal structure copper dimethylpropyleneurea complex, exafs copper aqua solvated oxygen donor solvent, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Electron, X-Ray, and Photoelectron Spectroscopy and other aspects.Computed Properties of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Tan, Tian; Cheng, Hongye; Chen, Guzhong; Song, Zhen; Qi, Zhiwen published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Prediction of infinite-dilution activity coefficients with neural collaborative filtering. And the article contained the following:

Accurate prediction of infinite dilution activity coefficient (γ∞) for phase equilibrium and process design is crucial. In this work, an exptl. γ∞ dataset containing 295 solutes and 407 solvents (21,048 points) is obtained through data integrating, cleaning, and filtering. The dataset is arranged as a sparse matrix with solutes and solvents as columns and rows, resp. Neural collaborative filtering (NCF), a modern matrix completion technique based on deep learning, is proposed to fully fill in the γ∞ matrix. Ten-fold cross-validation is performed on the collected dataset to test the effectiveness of the proposed NCF, proving that NCF outperforms the state-of-the-art phys. model and previous machine learning model. The completed γ∞ matrix makes solvent screening and extension of UNIFAC parameters possible. Taking two typical hard-to-sep. systems (benzene/cyclohexane and Me cyclopentane/n-hexane mixtures) as examples, the NCF-developed database provides high-throughput screening for separation systems in terms of solvent selectivity and capacity. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to prediction infinite dilution activity coefficient neural collaborative filtering, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bi, Wen-Zhu; Zhang, Wen-Jie; Li, Chen-Yu; Shao, Lu-Hao; Liu, Qing-Pu; Feng, Su-Xiang; Geng, Yang; Chen, Xiao-Lan; Qu, Ling-Bo published an article in 2022, the title of the article was Photoexcited sulfenylation of C(sp3)-H bonds in amides using thiosulfonates.Product Details of 685-91-6 And the article contains the following content:

A photoexcited sulfenylation of C(sp3)-H bonds in amides was developed for the synthesis of sulfenyl amides R1C(O)NR2CHR3SR4 [R1 = Me, Et, Ph; R2 = Me, Et; R3 = H, Me; R4 = Ph, Bn, 4-MeOC6H4, etc.] using thiosulfonates as a sulfur source. In the presence of easily available and inexpensive Na2-eosin Y, TBHP and potassium carbonate, various sulfenyl amides R1C(O)NR2CHR3SR4 could be obtained under the irradiation of blue light at room temperature The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to alkyl arylsulfanylmethyl amide preparation, benzenesulfonylsulfanyl aryl amide sulfenylation catalyst disodium eosin yellow, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Delgado, Gerzon E.; Guillen, Marilia; Ramirez, Jeans W.; Mora, Asiloe J.; Contreras, Jines E.; Chacon, Cecilia published an article in 2016, the title of the article was X-ray powder diffraction data for the N-acylamino acids: ortho, meta, and para-methyl hippuric acids.Recommanded Product: 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

N-acylamino acid isomers: ortho, meta, and para-methylhippuric acids, are specific xylene metabolites. Here, we report X-ray powder diffraction data, unit-cell parameters, and space groups for the three isomer (C10H11NO3), [ortho-methylhippuric acid 2 mHA, monoclinic P21/n cell, a = 8.522(1), b = 10.443(1), c = 10.734(1) Å, β = 92.43(1)°, V = 954.5(1) Å3; meta-methylhippuric acid 3 mHA, monoclinic C2/c cell a = 20.0951(2), b = 10.485(1), c = 10.074(2) Å, β = 119.08(1)°, V = 1933.9(1) Å3; para-methylhippuric acid 4 mHA, orthorhombic P212121 cell, a = 5.1794(7), b = 8.279(1), c = 22.276(2) Å, V = 955.2(2) Å3], space group. In each case, all measured diffraction peaks were indexed and are consistent with the corresponding space group. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 2-(4-Methylbenzamido)acetic acid

The Article related to xray powder diffraction methyl hippuric acylamino acid, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.Recommanded Product: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics