Tag: 100-200

Alsudairi, Amell; Lajami, Amal; Kendrick, Ian; Mukerjee, Sanjeev; Abraham, K. M. published an article in 2019, the title of the article was Correlating ionic conductivity, oxygen transport and ORR with structure of dialkylacetamide-based electrolytes for lithium-air batteries.Category: amides-buliding-blocks And the article contains the following content:

Chem. structures of lithium and tetrabutylammonium (TBA) salt solutions in N,N-dimethylacetamide (DMAc) and N,N-diethylacetamide (DEAc), two high Donor Number organic solvents, were studied. In LiX salt solutions (where X = PF6-, CF3SO3-, ClO4- and NO3-), solvation occurs when the Li+ bonds with the solvent’s carbonyl group forming Li+[O=C(CH3)N(CH3)2]nX- ion pairs. IR and 13C-NMR spectra are consistent with the ion pair being solvent-separated when the anion is PF6-, ClO4- or NO3-, and a contact ion pair in the case of CF3SO3-. Chem. interactions between TBA+ and the solvents to form conducting solutions appeared to be dipolar in nature. Ionic conductivities of TBA+ and Li+ electrolytes were measured and correlated with their viscosities. In 0.1M TBAPF6/DMAc, the O2 solubility and diffusion coefficient (3.09 × 10-6 mol/cm-3 and 5.09 × 10-5 cm2s-1, resp.) measured using microelectrode technique are typical of values measured in several TBA+ solutions Microelectrode voltammetry revealed steady-state limiting current behavior for oxygen reduction reactions (ORR) in TBAX/DMAc electrolytes indicating a reversible ORR process. Conversely, microelectrode current-voltage data for ORR in LiX/DMAc electrolytes revealed irreversible behavior mainly ascribed to the blockage of the electrode surface by insoluble ORR products. The ORR in DMAc correlated with its high Donor Number and the overall process conformed to the Hard-Soft Acid-Base theory. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to ionic conductivity oxygen transport dialkylacetamide electrolyte lithium battery, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 28, 2016, Chen, Yi published a patent.Safety of N-(3-Aminophenyl)acrylamide The title of the patent was Preparation of substituted [(6-phenyl-4-methyl-3-oxo-3,4-dihydropyrazin-2-yl)amino]benzene derivatives as selective Bruton’s tyrosine kinase inhibitors. And the patent contained the following:

The invention provides compounds I [R0 and R1 = independently H, alkyl, alkenyl, alkynyl, cycloalkyl, etc.; L = N(Rd)(CH2)m; Rd = H, alkyl, alkenyl, alkynyl, cycloalkyl or heterocycloalkyl; m = 0-4; R2 = H or alkyl; R3 = H, halo, alkyl, or hydroxyalkyl; R4 = W, X, Y or Z; R5, R6, R7, R8, R9, R10, R11 and R12 = independently H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, halo, or alkoxy], or their N-oxides, pharmaceutically acceptable salts, solvates, polymorphs or tautomers. For example, compound II was prepared by coupling of compound III (preparation given) with compound IV (preparation given) followed by hydrolysis. The Kd value of compound II for Bruton’s tyrosine kinase (BTK) was 0.86 nM, which clearly shows that compound II is a highly potent BTK inhibitor. The invention compounds are useful as inhibitors of Bruton’s tyrosine kinase for the treatment of neoplastic disease, autoimmune disease and inflammatory disorder. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Safety of N-(3-Aminophenyl)acrylamide

The Article related to phenylmethyloxodihydropyrazinylaminobenzene compound preparation bruton tyrosine kinase inhibitor, neoplastic disease autoimmune disease inflammatory disorder treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 9, 2015, Chen, Yi published a patent.Recommanded Product: 16230-24-3 The title of the patent was Preparation of substituted [(6-phenyl-4-methyl-3-oxo-3,4-dihydropyrazin-2-yl)amino]benzene derivatives as inhibitors of bruton’s tyrosine kinase. And the patent contained the following:

The present invention provides compounds I [R0 and R1 = independently H, alkyl, alkenyl, alkynyl, cycloalkyl, etc.; L = N(Rd)(CH2)m; Rd = H, alkyl, alkenyl, alkynyl, cycloalkyl or heterocycloalkyl; m = 0-4; R2 = H or alkyl; R3 = H, halo, alkyl, or hydroxyalkyl; R4 = W, X, Y or Z; R5, R6, R7, R8, R9, R10, R11 and R12 = independently H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, halo, or alkoxy], or their N-oxides, pharmaceutically acceptable salts, solvates, polymorphs or tautomers. For example, compound II was prepared by coupling of compound III (preparation given) with compound IV (preparation given) followed by hydrolysis. The Kd value of compound II for bruton’s tyrosine kinase (BTK) was 0.86 nM, which clearly shows that compound II is a highly potent BTK inhibitor. The invention compounds are useful as inhibitors of bruton’s tyrosine kinase for the treatment of neoplastic disease, autoimmune disease and inflammatory disorder. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Recommanded Product: 16230-24-3

The Article related to phenylmethyloxodihydropyrazinylaminobenzene compound preparation bruton tyrosine kinase inhibitor, neoplastic disease autoimmune disease inflammatory disorder treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 5, 2017, Ma, Dawei; Yu, Qiang; Yuan, Junying; Xia, Hongguang; Cai, Dongpo; Wang, Kailiang; Zhang, Chen; Xia, Shanghua published a patent.Application In Synthesis of N-(3-Aminophenyl)acrylamide The title of the patent was 2,4-Diamino-5-(trifluoromethyl)pyridine-1,3-diaminobenzene-acrylamide derivatives as EGFR kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. And the patent contained the following:

The invention provides EGFR kinase inhibitor and its preparation method and application.Specifically, the invention provides a compound shown in formula (I), wherein the definition of each group is as noted in the instruction book.Described compound is the effective EGFR inhibitor. The invention provides 2,4-diamino-5-(trifluoromethyl)pyridine-1,3-diaminobenzene-acrylamide derivatives of formula I as EGFR kinase inhibitors and the preparation method and use thereof. Compounds of formula I wherein X and Y are independently N, CH; provided that X and Y are not CH at the same time; R is (un)substituted 5- to 7-membered heterocyclic ring, -NH-(un)substituted 5- to 7-membered heterocyclic ring, etc.; and their preparation method, as well as their use as EGFR kinase inhibitors in the treatment of cancer thereof, are claimed. Compounds of formula I were prepared by using condensation and deacylation as the key steps. All the invention compounds were evaluated for their EGFR inhibitory activity. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application In Synthesis of N-(3-Aminophenyl)acrylamide

The Article related to trifluoromethyl pyridine diaminobenzene acrylamide preparation egfr inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application In Synthesis of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Moglie, Yanina; Buxaderas, Eduardo; Mancini, Agustina; Alonso, Francisco; Radivoy, Gabriel published an article in 2019, the title of the article was Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions.Application In Synthesis of N,N-Diethylacetamide And the article contains the following content:

A series of catalysts based on supported copper nanoparticles were prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-Bu hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some com. available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodol. was successfully scaled-up to a gram scale with no detriment to the yield. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to reusable zeolite support copper nanoparticle preparation surface area, tertiary amine caboxylic anhydride copper nanocatalyst amidation, aryl alkyl amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Pinheiro, Danielle L. J.; Nielsen, Martin published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Chemoselective Transfer Hydrogenation of Enamides Using Ru Pincer Complexes for the Synthesis of α-Amino Acids. And the article contained the following:

The chemoselective reduction of enamides to α-amino acids with iPrOH and EtOH as H-donors and solvents catalyzed by Ru pincer complexes was demonstrated. A range of α-amino acids was synthesized in good to excellent yields. Applications, large scale and a one-pot experiment was also reported. Finally, deuterium-labeling experiments show high regioselectivity between the α- and β-positions of the alkene unit. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to aryl phenyl formamidopropenoate alkanol ruthenium catalyst chemoselective transfer hydrogenation, alkyl benzamido aryl propanoate preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2021, Gu, Xiaoke; Zhang, Yinpeng; Zou, Yueting; Li, Xin; Guan, Mingyu; Zhou, Qingqing; Qiu, Jingying published an article.Electric Literature of 27115-50-0 The title of the article was Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents. And the article contained the following:

As a continuation of our previous work, a series of new Ph acrylamide derivatives were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound I could potently inhibit HBV DNA replication in wild-type and lamivudine (3TC)/entecavir resistant HBV mutant strains with IC50 values of 0.19 and 0.18μM, resp. Notably, the selective index value of I was above 526, indicating the favorable safety profile. Interestingly, unlike nucleoside analog 3TC, I could significantly inhibit 3.5 kb pgRNA expression. Mol. docking study revealed that I could fit well into the dimer-dimer interface of HBV core protein by hydrophobic, π-π and H-bond interactions. Considering the potent anti-HBV activity, low toxicity and diverse anti-HBV mechanism from that of nucleoside anti-HBV agent 3TC, compound I might be a promising lead to develop novel non-nucleoside anti-HBV therapeutic agents, and warranted further investigation. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to ph acrylamide preparation potent non nucleoside antihbv agent safety, anti-hbv agents, non-nucleoside, phenyl acrylamide derivatives, synthesis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 4, 2020, Lv, Ningning; Yu, Shuling; Hong, Chao; Han, De-Man; Zhang, Yuhong published an article.Quality Control of N,N-Diethylacetamide The title of the article was Selectively Oxidative C(sp2)-H/C(sp3)-H Cross-Coupling of Benzamides with Amides by Nickel Catalysis. And the article contained the following:

The oxidative cross-coupling between the α-C(sp3)-H bond of amide in DMAc and the inert ortho-C(sp2)-H bond of benzamides is achieved for the first time by nickel catalysis, with the assistance of 8-aminoquinolyl group in the presence of a silver oxidant. Notably, the selectivity of conversion can be perfectly controlled by modulating the oxidant additives, and the products from the coupling of the C(sp3)-H bond adjacent to nitrogen of amides with benzamides are approached through the use of peroxide. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Quality Control of N,N-Diethylacetamide

The Article related to benzamide amide nickel catalyst regioselective dehydrogenative oxidative cross coupling, functionalized benzamide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Quality Control of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2018, Laha, Joydev K.; Patel, Ketul V.; Tummalapalli, K. S. Satyanarayana; Hunjan, Mandeep Kaur published an article.Recommanded Product: 685-91-6 The title of the article was Palladium-Catalyzed Serendipitous Synthesis of Arylglyoxylic Amides from Arylglyoxylates and N,N-Dialkylamides in the Presence of Halopyridines. And the article contained the following:

A palladium-catalyzed synthesis of arylglyoxylic amides by the reaction of arylglyoxylates and N,N-dialkylamides in the presence of a 2,3-dihalopyridine has been realized for the first time. An anticipated 2,3-diaroylpyridine did not form in this reaction. The current study unveils an unprecedented role of 2,3-dihalopyridine toward this amidation. Our mechanistic study reveals that the arylglyoxylate could react with halopyridine to form a traceless activated pyridyl ester of arylglyoxylic acid, which upon subsequent reaction with amino surrogate, N,N-dialkylamides could form the arylglyoxylic amides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: 685-91-6

The Article related to arylglyoxylate dialkylamide dihalopyridine palladium amidation catalyst, arylglyoxylic amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Barham, Joshua P.; Tamaoki, Souma; Egami, Hiromichi; Ohneda, Noriyuki; Okamoto, Tadashi; Odajima, Hiromichi; Hamashima, Yoshitaka published an article in 2018, the title of the article was C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor.Product Details of 685-91-6 And the article contains the following content:

C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording mol. complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chem. toolbox. Reaction scalability (up to 65 g h-1 product) was demonstrated using a microwave flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to arylbutanamide preparation microwave flow reactor, alkylamide styrene alkylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics