Tag: 100-200

Azizi, Kobra; Madsen, Robert published an article in 2020, the title of the article was Radical condensation between benzylic alcohols and acetamides to form 3-arylpropanamides.Electric Literature of 685-91-6 And the article contains the following content:

A new radical condensation reaction was developed where benzylic alcs. and acetamides were coupled to generate 3-arylpropanamides ArCH2CH2C(O)NR1R2 [Ar = Ph, 4-ClC6H4, 1-naphthyl, etc.; R1 = R2 = Me, Et; R1 = H; R2 = Me; R1R2 = (CH2)5, (H2C)2O(CH2)2] with water as the only byproduct. The transformation was performed with potassium tert-butoxide as the only additive and gave a variety of 3-arylpropanamides ArCH2CH2C(O)NR1R2 in good yields. The mechanism was investigated exptl. with labeled substrates, trapping experiments and spectroscopic measurements. The findings indicated a radical pathway where potassium tert-butoxide was believed to serve a dual role as both base and radical initiator. The radical anion of the benzylic alc. was proposed as the key intermediate, which undergoes coupling with the enolate of the amide to form the new C-C bond. Subsequent elimination to the corresponding cinnamamide and olefin reduction then afforded the 3-arylpropanamides ArCH2CH2C(O)NR1R2. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to arylpropanamide preparation, benzylic alc acetamid condensation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Peiyuan; Naduthambi, Devan; Mosley, Ralph T.; Niu, Congrong; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J. published an article in 2011, the title of the article was Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.Electric Literature of 27115-50-0 And the article contains the following content:

Phenylpropenamides have been reported to be a class of non-nucleoside inhibitors of the hepatitis B virus (HBV). This class of compounds was explored with the objective of developing potent anti-HBV agents, with a novel mechanism of action, that could be combined with nucleos(t)ide analogs currently used to treat HBV infection. To accomplish this objective a series of substituted arylpropenamides I (X = Br, Cl; R1 = Ph, 2-MeOC6H4, 1,3-dioxolan-4-yl, 2-FC6H4, 4-MeC6H4; R2 = Ph, 4-O2NC6H4, 4-MeO2SC6H4, etc.; R3R4N = 1-piperidinyl, 4-morpholinyl, 4-methyl-1-piperazinyl, etc.) was prepared and the E and Z geometrical isomers were separated The structural identity of each of the E and Z isomers of I (X = Cl; R1 = R2 = Ph; R3R4N = 1-piperidinyl) was determined by single crystal X-ray crystallog. Contrary to previous reports, the activity of this class of mols. resides in the Z isomer. Further structure-activity relationship studies around the active Z isomer identified compounds that displayed potent antiviral activity against HBV with EC90 value of approx. 0.5 μM in vitro. Attempts to develop ring constrained analogs did not lead to active HBV inhibitors. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to propenamide aryl aroylamino preparation antiviral hepatitis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Blanco-Lomas, Marina; Funes-Ardoiz, Ignacio; Campos, Pedro J.; Sampedro, Diego published an article in 2013, the title of the article was Oxazolone-Based Photoswitches: Synthesis and Properties.SDS of cas: 27115-50-0 And the article contains the following content:

The synthesis, photophysics and photochem. of a family of mol. switches inspired by the green fluorescent protein (GFP) chromophore is presented. These compounds can be synthesized in one step and good yields, their photophys. properties may be tuned by the substituents, solvent and wavelength of irradiation, and they show very efficient and fast photoisomerization. Furthermore, their high thermal stability and limited photodecomposition could allow these switches to be used in a range of applications. Finally, oxazolone photoswitches may be activated by the use of light and deactivated by either heat or light of a different wavelength. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to photophysics photochem oxazolone based photoswitch, mol switch oxazolone derivative photoisomerization, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cohen, Irit; Mishra, Abhaya K.; Parvari, Galit; Edrei, Rachel; Dantus, Mauricio; Eichen, Yoav; Szpilman, Alex M. published an article in 2017, the title of the article was Sunlight assisted direct amide formation via a charge-transfer complex.Reference of N,N-Diethylacetamide And the article contains the following content:

We report on the use of charge-transfer complexes between amines and carbon tetrachloride, as a novel way to activate the amine for photochem. reactions. This principle is demonstrated in a mild, transition metal free, visible light assisted, dealkylative amide formation from feedstock carboxylic acids and amines. The low absorption coefficient of the complex allows deep light penetration and thus scale(coating process) up to a gram scale. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to sunlight amide charge transfer complex, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Raheem, Islam Ali Abdel; Razek, Amro Abdul; Elgendy, Abeer Abdelaziz; Saleh, Noha Mohamed; Shaaban, Mona Ibrahem; Abd El-Had, Faten K. published an article in 2019, the title of the article was Design, evaluation and antimicrobial activity of egyptian propolis-loaded nanoparticles: intrinsic role as a novel and naturally based root canal nanosealer.Synthetic Route of 685-91-6 And the article contains the following content:

Propolis is a unique natural adhesive product collected by honeybees. It contains a diversity of bioactive compounds with reported functional properties such as antioxidants, antibacterial, antifungal, anti-inflammatory, antiviral and anticancer activity. Dental caries is a worldwide problem that caused by microbial growth usually progress from tooth enamel to the underlying pulpal tissues and root canal. This situation could be controlled by a sequence of steps to remove microorganisms and fill root canal with a suitable long-lasting root canal sealer. Unfortunately, leachable and degradation products of the currently used sealers compromised their antimicrobial activity by inflammatory modulation associated with irritation and toxicity of periapical tissues. Hence, propolis was selected to be designed as a natural root canal sealer due to its amazing functional properties. Moreover, its handling properties were enhanced and potentiated by its incorporation in polymeric nanoparticles (NPs). Frist, propolis was collected, extracted and analyzed for its bioactive compounds After that, propolis-loaded NPs of PLGA (ProE-loaded NPs) were developed and fully characterized regarding physicochem. properties, in vitro release and in vitro cytotoxicity. Then, root canal sealers were fabricated and assayed for their antimicrobial activity. Both cytotoxicity and antimicrobial activity were compared to those of a model sealer; AH Plus. The results revealed that spherical nanoscopic NPs with narrow size distribution were obtained. ProE-loaded NPs exhibited accepted entrapment efficiency (>80) and prolonged release. In vitro cytotoxicity study confirmed the safety of ProE-loaded NPs. Also, the developed sealers showed antimicrobial activity vs. bacterial strains of Enterococcus faecalis and Streptococcus mutans and antifungal activity against Candida albicans. ProE-loaded NPs could be incorporated in and represented as a root canal sealer with prolonged release and enhanced cytocompatibility as well as antimicrobial activities. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to egyptian propolis nanoparticle antimicrobial activity root canal nanosealer, plga, antimicrobial activity, in vitro cytotoxicity, polymeric nanoparticles, propolis, sealer and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 4, 2015, Zhou, Xiaomeng; Wang, Qing; Zhao, Weihua; Xu, Songsong; Zhang, Wei; Chen, Junmin published an article.Electric Literature of 27115-50-0 The title of the article was Palladium-catalyzed ortho-arylation of benzoic acid derivatives via C-H bond activation using an aminoacetic acid bidentate directing group. And the article contained the following:

A highly efficient protocol for the palladium-catalyzed ortho-arylation of benzoic acid derivatives by aryl iodides is described with an aminoacetic acid based N,O bidentate directing group. This protocol can be applied to various benzoyl aminoacetic acids and aryl iodides with both electron-donating and electron-withdrawing groups. Remarkably, the nature of a new directing group drives selective C-H bond activation to afford only monoarylation products in good to excellent yields. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to benzoyl aminoacetic acid aryl iodide ortho arylation palladium catalyst, arylbenzoic amide acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ghafouri, Moloud; Moghadam, Majid; Mehrani, Kheirollah; Daneshvar, Anahita published an article in 2018, the title of the article was Supported ruthenium hydride catalysts for direct conversion of alcohols to carboxylic acids using styrene oxide as oxidant.Formula: C10H11NO3 And the article contains the following content:

In the present work, the ability of two ruthenium hydride catalysts supported on multiwall carbon nanotubes, [Ru-H@EDT-MWCNT], and gold nanoparticles cored triazine dendrimer, [Ru-H@AuNPs-TD], in the direct conversion of alcs. to carboxylic acids via transfer hydrogenation using styrene oxide as oxidant is reported. Different alcs. were successfully converted to their corresponding carboxylic acids. The results showed that these two heterogeneous catalysts are more efficient than the homogeneous counterpart. In addition, the catalysts were reused several times. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to ruthenium hydride catalyst supported alc styrene oxide, carboxylic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 22, 2021, Li, Yanxiong; Xu, Liang; Meng, Faming; Yu, Yonghai published a patent.Recommanded Product: 65645-88-7 The title of the patent was Preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine and chiral catalyst thereof. And the patent contained the following:

The invention relates to preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine and chiral catalyst thereof, which has the advantages of high yield and simple method, low cost, environmentally friendly and safety. The (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine was prepared by the following steps: mixing 1-(3-ethoxy-4-methoxy Phenyl)-2-(methylsulfonyl)vinylamine, chiral catalyst I, acid and solvent, performing isomerization to obtain the final product; where R=hydrogen atom, C1-20 linear alkyl, C3-20 branched chain alkyl, C3-10 cycloalkyl, C3-10 heterocyclyl, C1-20 alkoxy, trifluoromethyl, halogen, amino, cyano, hydroxyl, nitro, ester, amide, substituted or unsubstituted C6-20 aryl, substituted or unsubstituted C5-20 heteroaryl. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: 65645-88-7

The Article related to preparation ethoxymethoxyphenylmethylsulfonylethylamine chiral catalyst isomerization, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Recommanded Product: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Polonski, T. published an article in 1983, the title of the article was Optical activity of lactones and lactams – II. Chiroptical properties of 4-oxazolidinones.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide And the article contains the following content:

Several optically active 4-oxazolidinones (e.g., I) were obtained from amides or N-methylamides of α-hydroxy acids. Solvent and substituent effects on their CD were studied. The predominance of the envelope conformation was established for these compounds, the degree of puckering being enhanced by polar solvents. The folded form with the aromatic ring facing the oxazolidinone ring was observed for 5-benzyloxazolidinone derivatives The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to cd oxazolidinone conformation, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vallejo-Sanchez, Daniel; Amo-Ochoa, Pilar; Beobide, Garikoitz; Castillo, Oscar; Froeba, Michael; Hoffmann, Frank; Luque, Antonio; Ocon, Pilar; Perez-Yanez, Sonia published an article in 2017, the title of the article was Chemically Resistant, Shapeable, and Conducting Metal-Organic Gels and Aerogels Built from Dithiooxamidato Ligand.Application of 685-91-6 And the article contains the following content:

Metal-organic gels (MOGs) appear as a blooming alternative to well-known metal-organic frameworks (MOFs). Porosity of MOGs has a microstructural origin and not strictly crystalline like in MOFs; therefore, gelation may provide porosity to any metal-organic system, including those with interesting properties but without a porous crystalline structure. The easy and straightforward shaping of MOGs contrasts with the need of binders for MOFs. In this contribution, a series of MOGs based on the assembly of 1D-coordination polymer nanofibers of formula [M(DTA)]n (MII: Ni, Cu, Pd; DTA: dithiooxamidato) are reported, in which properties such as porosity, chem. inertness, mech. robustness, and stimuli-responsive elec. conductivity are brought together. The strength of the M-S bond confers an unusual chem. resistance, withstanding exposure to acids, alkalis, and mild oxidizing/reducing chems. Supercritical drying of MOGs provides ultralight metal-organic aerogels (MOAs) with densities as low as 0.03 g cm-3 and plastic/brittle behavior depending on the nanofiber aspect ratio. Conductivity measurements reveal a semiconducting behavior (10-12 to 10-7 S cm-1 at 298 K) that can be improved by doping (10-5 S cm-1). Moreover, it must be stressed that conductivity of MOAs reversibly increases (up to 10-5 S cm-1) under the presence of acetic acid. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application of 685-91-6

The Article related to metal organic aerogel built dithiooxamidato ligand chem resistant, Electric Phenomena: Conduction and Conductivity, Semiconductivity, Resistance, Current Carriers, Galvanomagnetic and Acoustoelectric Effects and other aspects.Application of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics