Tag: 100-200

On August 4, 2017, Matsuzawa, Akinobu; Noda, Hidetoshi; Kumagai, Naoya; Shibasaki, Masakatsu published an article.Reference of N,N-Diethylacetamide The title of the article was Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates. And the article contained the following:

Direct asym. aldol addition of an α-CF3 amide to arylglyoxal hydrates was promoted by a chiral catalyst comprising a soft Lewis acidic Cu(I), a chiral bisphosphine ligand, and DBU. The 7-azaindoline moiety of the amide facilitates its enolization and stabilizes the thus-generated Cu enolate, furnishing enantioenriched aldol adducts. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to asym aldol addition alpha trifluoromethyl amide arylglyoxal hydrate, copper catalyzed addition azaindoline moiety enantioenriched aldol adduct preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vracko, M.; Stanojevic, M.; Sollner Dolenc, M. published an article in 2022, the title of the article was Comparison of predictions of developmental toxicity for compounds of solvent data set.Safety of N,N-Diethylacetamide And the article contains the following content:

We have considered a series of 235 compounds tech. classified as solvents. Chem., they belong to different classes. Their potential developmental toxicity was evaluated using two models available on platform VEGA HUB; model CAESAR and the Developmental/ Reproductive Toxicity library (PG) model. Models provide beside the prediction of developmental toxicity addnl. information on similar compounds from models training sets. In the report, first, we compare the predictions. Second, the sets of similar compounds have been used to implement the clustering scheme. The Kohonen artificial neural network method has been applied as a clustering method. The clusters obtained have been discussed for both models. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Safety of N,N-Diethylacetamide

The Article related to developmental toxicity solvents data set artificial neural network, developmental toxicity, kohonen artificial neural network, vega hub caesar model, vega hub pg model, solvents and other aspects.Safety of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2022, Riggs, Daniel W.; Malovichko, Marina V.; Gao, Hong; McGraw, Katlyn E.; Taylor, Breandon S.; Krivokhizhina, Tatiana; Rai, Shesh N.; Keith, Rachel J.; Bhatnagar, Aruni; Srivastava, Sanjay published an article.HPLC of Formula: 27115-50-0 The title of the article was Environmental exposure to volatile organic compounds is associated with endothelial injury. And the article contained the following:

Volatile organic compounds (VOCs) are airborne toxicants abundant in outdoor and indoor air. High levels of VOCs are also present at various Superfund and other hazardous waste sites; however, little is known about the cardiovascular effects of VOCs. We hypothesized that ambient exposure to VOCs exacerbate cardiovascular disease (CVD) risk by depleting circulating angiogenic cells (CACs). In this cross-sectional study, we recruited 603 participants with low-to-high CVD risk and measured 15 subpopulations of CACs by flow cytometry and 16 urinary metabolites of 12 VOCs by LC/MS/MS. Associations between CAC and VOC metabolite levels were examined using generalized linear models in the total sample, and sep. in non-smokers. In single pollutant models, metabolites of ethylbenzene/styrene and xylene, were neg. associated with CAC levels in both the total sample, and in non-smokers. The metabolite of acrylonitrile was neg. associated with CD45dim/CD146+/CD34+/AC133+ cells and CD45+/CD146+/AC133+, and the toluene metabolite with AC133+ cells. In anal. of non-smokers (n = 375), multipollutant models showed a neg. association with metabolites of ethylbenzene/styrene, benzene, and xylene with CD45dim/CD146+/CD34+ cells, independent of other VOC metabolite levels. Cumulative VOC risk score showed a strong neg. association with CD45dim/CD146+/CD34+ cells, suggesting that total VOC exposure has a cumulative effect on pro-angiogenic cells. We found a non-linear relationship for benzene, which showed an increase in CAC levels at low, but depletion at higher levels of exposure. Sex and race, hypertension, and diabetes significantly modified VOC associated CAC depletion. Low-level ambient exposure to VOCs is associated with CAC depletion, which could compromise endothelial repair and angiogenesis, and exacerbate CVD risk. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to volatile organic compound environmental exposure endothelial injury, benzene, circulating angiogenic cells, endothelial injury, ethylbenzene, vocs, volatile organic compounds and other aspects.HPLC of Formula: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Elliott, Rory; Ryan, Aoife A.; Aggarwal, Aviral; Zhu, Nianyong; Steuber, Friedrich W.; Senge, Mathias O.; Schmitt, Wolfgang published an article in 2021, the title of the article was 2D porphyrinic metal-organic frameworks featuring rod-shaped secondary building units.Application In Synthesis of N,N-Diethylacetamide And the article contains the following content:

Metal-organic frameworks (MOFs) encompass a rapidly expanding class of materials with diverse potential applications including gas storage, mol. separation, sensing and catalysis. So-called ‘rod MOFs’, which comprise infinitely extended 1D secondary building units (SBUs), represent an underexplored subclass of MOF. Further, porphyrins are considered privileged ligands for MOF synthesis due to their tunable redox and photophys. properties. In this study, the CuII complex of 5,15-bis(4-carboxyphenyl)-10,20-diphenylporphyrin (H2L-CuII, where H2 refers to the ligand’s carboxyl H atoms) is used to prepare two new 2D porphyrinic rod MOFs PROD-1 and PROD-2. Single-crystal X-ray anal. reveals that these frameworks feature 1D MnII- or CoII-based rod-like SBUs that are coordinated by labile solvent mols. and photoactive porphyrin moieties. Both materials were characterised using IR (IR) spectroscopy, powder X-ray diffraction (PXRD) spectroscopy and thermogravimetric anal. (TGA). The structural attributes of PROD-1 and PROD-2 render them promising materials for future photocatalytic investigations. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to porphyrinic metal organic framework secondary building unit, 2d mof, 2d materials, mof, porphyrin mof, porphyrinoids, coordination chemistry, metal-organic framework, rod mof and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2020, Wang, Dong; Fu, Zhifei; Xing, Yanchao; Tan, Yao; Han, Lifeng; Yu, Haiyang; Wang, Tao published an article.Synthetic Route of 27115-50-0 The title of the article was Rapid identification of chemical composition and metabolites of Pingxiao Capsule in vivo using molecular networking and untargeted data-dependent tandem mass spectrometry. And the article contained the following:

Pingxiao capsule (PXC) is a herbal medicine used for adjuvant therapy in breast cancer. However, the constituents and absorbed components of the formula and their related metabolites have not been elucidated to date. PXC is a typical traditional Chinese medicine formula consisting of Strychnos nux-vomica L., Curcuma wenyujin Y. H., Agrimonia pilosa Ledeb., Toxicodendron vernicifluum, Trogopterus dung, alumen, potassium nitrate (saltpeter) and Citrus aurantium L. In this study, a ultra-high performance liquid chromatog. system equipped with high resolution Q-Orbitrap mass spectrometry (MS) and comparative Global Natural Product Social mol. networking together with the Compound Discoverer software were used to identify metabolites of PXC in vitro and in vivo. Based on untargeted data-dependent MS2 and data-mining techniques, 89 peaks of alkaloids, flavonoids, organic acid and phenolic compounds were identified in a PXC 70% methanol extract Furthermore, 15 absorbed prototype compounds and their metabolites were rapidly confirmed in rat blood. Glucuronidation, oxidation, methylation and hydroxylation were the main metabolic pathways. We fully clarified the chem. constituents of PXC and provided a scientific and efficient strategy for rapid discovery and identification of prototypes and their metabolites in rat plasma using high-resolution MS aided by Global Natural Product Social and Compound Discoverer software. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0

The Article related to pingxiao capsule chem composition metabolite mol networking mass spectrometry, pingxiao capsule, chemical constituents, mass spectrometry, metabolites, molecular networking and other aspects.Synthetic Route of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 14, 2017, Loubert, Gael; Volkringer, Christophe; Henry, Natacha; Arab-Chapelet, Benedicte; Delahaye, Thibaud; Loiseau, Thierry published an article.COA of Formula: C6H13NO The title of the article was Structural studies of a series of uranyl alkylacetamides and piracetam complexes obtained in nitric acid aqueous solution. And the article contained the following:

Three uranyl amide complexes have been isolated from slow evaporation technique from an aqueous solution of nitric acid (0.5 M), in the presence of N’,N-diethylacetamide (noted dam; compound 1), N-ethylacetamide (noted eam; compound 2) and 2-(2-oxopyrrolidino)acetamide (or piracetam, noted pam; compound 3). It results in the formation of crystalline mol. assemblies of UO2(L)2(NO3)2 neutral moieties (L = amide ligand), in which the uranyl center is coordinated to two chelating nitrate groups either in cis positions (1) or trans positions (2 and 3) and two organic ligands, through the amide functionality. The corresponding coordination geometry for uranyl is a hexagonal bipyramid, with the two typical trans U:O bondings. Single-crystal x-ray diffraction anal. revealed the bond lengths of U-Oamide are for 2.362(3), 2.363(3) and 2.374(2) Å for 1, 2 and 3, resp. The three complexes have been further characterized by IR spectroscopy and their thermal behavior has been evaluated by thermogravimetry. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).COA of Formula: C6H13NO

The Article related to uranyl alkylacetamide piracetam complex preparation crystal mol structure, diethylacetamide ethylacetamide oxopyrrolidinoacetamide reaction uranium nitrate aqueous solution and other aspects.COA of Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 12, 2019, Zamani, Parisa; Phipps, Joshua; Hu, Jiyun; Cheema, Faizan; Amiri Rudbari, Hadi; Bordbar, Abdol-Khalegh; Khosropour, Ahmad R.; Beyzavi, Hudson published an article.Safety of 2-(4-Methylbenzamido)acetic acid The title of the article was Multicomponent Synthesis of Diversified Chromeno[3,2-d]oxazoles. And the article contained the following:

A practical and efficient synthetic procedure to novel chromeno[3,2-d]oxazoles through a one-pot sequential multistep process is presented. This procedure proceeds efficiently in propylene carbonate (PC) as a green solvent and affords a wide range of the chromenooxazole scaffolds. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Safety of 2-(4-Methylbenzamido)acetic acid

The Article related to chromeno oxazole diversity oriented synthesis multistep cyclization, chromenooxazoles, one-pot multicomponent reaction, propylene carbonate, sequential annulation reactions and other aspects.Safety of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 14, 2022, Nishioka, Kiho; Tanaka, Mizuki; Fujimoto, Hayato; Amaya, Toru; Ogoshi, Sensuke; Tobisu, Mamoru; Nakanishi, Shuji published an article.Electric Literature of 685-91-6 The title of the article was Overlooked Factors Required for Electrolyte Solvents in Li-O2 Batteries: Capabilities of Quenching 1O2 and Forming Highly-Decomposable Li2O2. And the article contained the following:

Although sufficient tolerance against attack by superoxide radicals (O2-) has been mainly recognized as an important property for Li-O2 battery (LOB) electrolytes, recent evidence has revealed that other critical factors also govern the cyclability, prompting a reconsideration of the basic design guidelines of LOB electrolytes. Here, we found that LOBs equipped with a N,N-dimethylacetamide (DMA)-based electrolyte exhibited better cyclability compared with other standard LOB electrolytes. This superior cyclability is attributable to the capabilities of quenching 1O2 and forming highly decomposable Li2O2. The1O2 quenching capability is equivalent to that of a tetraglyme-based electrolyte containing a several millimolar concentration of a typical chem. quencher. Based on these overlooked factors, the DMA-based electrolyte led to superior cyclability despite its lower O2- tolerance. Thus, the present work provides a novel design guideline for the development of LOB electrolytes. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to lithium oxygen battery electrolyte solvent electrochem stability current density, electrochemistry, electrolyte, lithium-air battery, lithium-oxygen battery, singlet oxygen and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Leimbacher, Markus; Zhang, Yixin; Mannocci, Luca; Stravs, Michael; Geppert, Tim; Scheuermann, Joerg; Schneider, Gisbert; Neri, Dario published an article in 2012, the title of the article was Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library.Synthetic Route of 27115-50-0 And the article contains the following content:

Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0

The Article related to dna encoded chem library drug discovery protein ligand, interleukin 2 inhibitor dna encoded chem library, tumor antigen carbonic anhydrase ix inhibitor dna encoded library and other aspects.Synthetic Route of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2013, Mange, Yatin J.; Isloor, Arun M.; Malladi, Shridhar; Isloor, Shrikrishna; Fun, Hoong-Kun published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis and antimicrobial activities of some novel 1,2,4-triazole derivatives. And the article contained the following:

In the present investigation, a series of new Schiff bases were synthesized by the condensation of N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides with various substituted aromatic aldehydes in ethanol-dioxane mixture using catalytic amount of sulfuric acid. The starting materials N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides were in turn synthesized by the fusion of (4-H/Me-benzoyl)-glycines with thiocarbohydrazide. Newly synthesized compounds were characterized by IR, NMR, mass spectra and elemental analyses. All the compounds were evaluated for their antibacterial and antifungal activity using the Min. Inhibition Concentration (MIC) method by serial dilution technique. Few of the compounds were found to be biol. active. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to thiocarbohydrazide aroylglycine cyclocondensation, aminomercaptotriazole arylamidomethyl preparation condensation aryl aldehyde, schiff base triazolethiol preparation antibacterial antifungal and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics