Tag: 100-200

On June 4, 2022, Kumar, Vishal; Dhawan, Sanjeev; Bala, Renu; Girase, Pankaj Sanjay; Singh, Parvesh; Karpoormath, Rajshekhar published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Metal-free direct annulation of 2-aminophenols and 2-aminothiophenols with unactivated amides through transamidation: Access to polysubstituted benzoxazole and benzothiazole derivatives. And the article contained the following:

Simple yet novel oxidant, metal and solvent-free green protocol for synthesizing differently 2-substituted 1,3-benzoxazoles I [R1 = Me, Ph, Bn, etc.; R2 = H, 6-Me, 5-Cl, etc.; X = O] and benzothiazoles I [R1 = Me; R2 = H, 5-Cl; X = S] from 2-aminophenol hydrochloride salt, unactivated amide as in situ carbon source was reported. Further, the hydrogen ion of hydrochloride played a crucial role in amide activation followed nucleophilic attack that through eliminations of amine as a side product, and de-hydrolysis step leads to final annulation. This versatile strategy was applicable to a wide variety of differently substituted o-aminophenols, unactivated aliphatic and aromatic amides, yielding the corresponding product in good to excellent yields in a single step. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to benzoxazole green preparation, aminophenol hydrochloride salt unactivated amide annulation, benzothiazole green preparation, aminothiophenol hydrochloride salt unactivated amide annulation and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boscari, Carolina Nasser; Mazzuia, Giovanna Rodrigues; Wisniewski, Celio; Borges, Keyller Bastos; Figueiredo, Eduardo Costa published an article in 2017, the title of the article was Molecularly imprinted probe for solid-phase extraction of hippuric and 4-methylhippuric acids directly from human urine samples followed by MEKC analysis.SDS of cas: 27115-50-0 And the article contains the following content:

Hippuric acid (HA) and 4-methylhippuric acid (4-MHA) are metabolites as well as biol. indicators for toluene and xylenes, resp., and their determination in urine samples is very important, in order to monitor the occupational exposition to these solvents, ensuring a safe working environment. Thus, this paper describes the synthesis and characterization of a probe impregnated with molecularly imprinted polymers (MIPs) for the solid-phase extraction of HA and 4-MHA directly from untreated urine samples followed by micellar electrokinetic chromatog. (MEKC) analyses. The MIP probe selectivity was compared to the non-imprinted polymer probe. The MEKC separations were carried out in 50 mmol/L sodium tetraborate pH 10.0/0.5 mmol/L cetyltrimethylammonium bromide aqueous solution, with a constant voltage of -15 kV. The system variables were optimized to provide ideal conditions for the extraction and desorption of the analytes, as well as for the MEKC analyses. The method was linear from 0.5 to 5.0 g/L for both analytes, with correlation coefficients > 0.994. Precisions and accuracies, expressed as relative standard deviation and relative error, were < 20.0 and within -15.4 to 16.6%, resp., in accordance with the United States Food and Drug Administration recommendation. The MIP probe has proven to be simple, cheap, resistant, and synthetically reproducible, being successfully used to analyze both HA and 4-MHA from real samples. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to hippurate methylhippurate molecularly imprinted polymer solid phase extraction mekc, capillary electrophoresis, hippuric acid, methylhippuric acid, molecularly imprinted polymer, urine and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 7, 2015, Lill, Andreas P.; Roedl, Carmen B.; Steinhilber, Dieter; Stark, Holger; Hofmann, Bettina published an article.Computed Properties of 27115-50-0 The title of the article was Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy. And the article contained the following:

Different inflammatory diseases and allergic reactions are mediated by leukotrienes, which arise from the oxygenation of arachidonic acid catalyzed by 5-lipoxygenase (5-LO). One promising approach for an effective anti-leukotriene therapy (leukotriene antagonists) is the inhibition of this key enzyme. This study presents the synthesis and development of a potent and direct 5-LO inhibitor based on the well characterized 5-benzylidene-2-phenylthiazolone C06, whose further pharmacol. investigation was precluded due to its low solubility Through optimization of C06, evaluation of a structure-activity relationship including profound assessment of the thiazolone core and consideration of the solubility, the 5-benzyl-2-phenyl-4-hydroxythiazoles represented by ST-1829 [i.e., 5-(4-chlorobenzyl)-2-p-tolyl-4-thiazolol] were developed. ST-1829 showed an improved 5-LO inhibitory activity in cell-based (IC50 values 0.14 μM) and cell-free assays (IC50 values 0.03 μM) as well as a prominent enhanced solubility Furthermore, ST-1829 kept its promising inhibitory potency in the presence of blood serum, excluding excessive binding to serum proteins. These facts combined with the non-cytotoxic profile mark a major step towards an effective anti-inflammatory therapy. The synthesis of the target compounds was achieved using 2-thioxo-4-thiazolidinone, 4-methylbenzoic acid, aldehydes, nitriles as simple starting materials. The title compounds thus formed included 2-(4-chlorophenyl)-5-[(4-methoxyphenyl)methyl]-4-thiazolol, 5-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-4-thiazolone and related substances. Analogs included (3E)-3-[(4-methoxyphenyl)methylene]-5-(4-methylphenyl)-2(3H)-furanone, (4Z)-4-[(4-methoxyphenyl)methylene]-2-(4-methylphenyl)-5(4H)-oxazolone. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to thiazole thiazolone thiazolol preparation leukotriene antagonist, 5-lipoxygenase, anti-leukotriene therapy, hydroxythiazoles, inflammation, solubility, structure–activity relationship and other aspects.Computed Properties of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2021, Jokioja, Johanna; Percival, Jasmine; Philo, Mark; Yang, Baoru; Kroon, Paul A.; Linderborg, Kaisa M. published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was Phenolic Metabolites in the Urine and Plasma of Healthy Men After Acute Intake of Purple Potato Extract Rich in Methoxysubstituted Monoacylated Anthocyanins. And the article contained the following:

Structurally stable acylated anthocyanins have potential in various food applications but the effects of acylation and methoxysubstitution on anthocyanin metabolism are poorly understood. This is the first study thoroughly investigating phenolic metabolites, their time-wise changes, and pharmacokinetics following an acute intake of methoxysubstituted monoacylated anthocyanins. Healthy male volunteers (n = 17) consumed a yellow potato meal with and without purple potato extract rich in acylated anthocyanins (152 mg) and hydroxycinnamic acid conjugates (140 mg). Ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) is used for identification and quantification of metabolites from serially collected urine and plasma. While the parent anthocyanins are not detected, 28 phenolic metabolites from urine and 14 from plasma are quantified, including hydroxybenzoic and hydroxycinnamic acids and protocatechuic acid sulfates and glucuronides; three (catechol, gallic acid-4-O-glucuronide, and 2-methoxybenzoic acid) are detected for the first time after anthocyanin-rich food. Urinary hippuric acid is the most abundant with an increase of 139 μM mM-1 creatinine after the treatment. A large addnl. set of tentatively identified phenolic metabolites are detected. Late urinary peak time values suggest colonic degradation Acylated anthocyanins are more bioavailable than earlier reported after extensive degradation in human and/or colonial metabolism to phenolic metabolites, which may be further conjugated and demethylated. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to phenolic metabolite urine plasma purple potato extract anthocyanin, solanum tuberosum l., acylated anthocyanins, mass spectrometry, postprandial metabolites, purple-fleshed potatoes and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Konkle, Stacey L.; Zierold, Kristina M.; Taylor, Kira C.; Riggs, Daniel W.; Bhatnagar, Aruni published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. And the article contained the following:

Exposure to air pollution is a leading cause of global mortality. Volatile organic compounds (VOCs) are constituents of ambient air that could exert adverse health effects. To examine the relationship between VOC levels in ambient air and individual-level exposure to VOCs, as assessed by urinary VOC metabolites. Secular trends in 11 ambient air VOCs (2005-2013) and individual-level metabolites of 14 VOCs (2005-2014) were assessed using National Monitoring Programs (NMP) and National Health and Nutrition Examination Survey (NHANES) data, resp. To isolate environmental exposure, individuals reporting exposure to tobacco smoke were excluded. Quantile regression models were used to assess secular trends in VOC exposure, and survey-weighted regression models were built to identify factors associated with VOC exposure. All annual levels of ambient VOCs decreased from 2005 to 2013 (Range: 12.5%-77.2%). However, 11 of the corresponding VOC metabolites increased during the same time (Range: 0.3%-53.6%). There was a proportional change in patterns of VOC exposure across NHANES waves, with the middle quantiles of exposure showing the largest increase. VOC exposures were significantly associated with age, sex, race, education, and phys. inactivity, but not with secular VOC trends. In the United States, individual-level exposure to several VOCs increased between 2005 and 2014 despite a decline in ambient air VOC levels. This inverse relationship suggests that ambient VOCs are not the primary source of VOC exposure, therefore, decreasing ambient VOCs alone may not be sufficient to protect against the adverse health effects associated with VOC exposure. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to ambient air volatile organic compound biomarker united states, air pollution, biomarkers of exposure, environmental health, nhanes, secular trends, vocs, volatile organic compounds and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boyle, Elizabeth Barksdale; Viet, Susan M.; Wright, David J.; Merrill, Lori S.; Alwis, K. Udeni; Blount, Benjamin C.; Mortensen, Mary E.; Moye, John Jr.; Dellarco, Michael published an article in 2016, the title of the article was Assessment of exposure to VOCs among pregnant women in the National Children’s study.Computed Properties of 27115-50-0 And the article contains the following content:

Epidemiol. studies can measure exposure to volatile organic compounds (VOCs) using environmental samples, biomarkers, questionnaires, or observations. These different exposure assessment approaches each have advantages and disadvantages; thus, evaluating relationships is an important consideration. In the National Children’s Vanguard Study from 2009 to 2010, participants completed questionnaires and data collectors observed VOC exposure sources and collected urine samples from 488 third trimester pregnant women at in-person study visits. From urine, we simultaneously quantified 28 VOC metabolites of exposure to acrolein, acrylamide, acrylonitrile, benzene, 1-bromopropane, 1,3-butadiene, carbon disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene, ethylene oxide, propylene oxide, styrene, tetrachloroethylene, toluene, trichloroethylene, vinyl chloride, and xylene exposures using ultra high performance liquid chromatog. coupled with an electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS) method. Urinary thiocyanate was measured using an ion chromatog. coupled with an electrospray ionization tandem mass spectrometry method (IC-ESI/MSMS). We modeled the relationship between urinary VOC metabolite concentrations and sources of VOC exposure. Sources of exposure were assessed by participant report via questionnaire (use of air fresheners, aerosols, paint or varnish, organic solvents, and passive/active smoking) and by observations by a trained data collector (presence of scented products in homes). We found several significant (p < 0.01) relationships between the urinary metabolites of VOCs and sources of VOC exposure. Smoking was pos. associated with metabolites of the tobacco constituents acrolein, acrylamide, acrylonitrile, 1,3-butadiene, crotonaldehyde, cyanide, ethylene oxide, N,N-dimethylformamide, propylene oxide, styrene, and xylene. Study location was neg. associated with the toluene metabolite N-acetyl-S-(benzyl)-L-cysteine (BMA), and paint use was pos. associated with the xylene metabolites 2-methylhippuric acid (2MHA) and 3-Methylhippuric acid & 4-methylhippuric acid (3MHA + 4MHA). A near-significant (p = 0.06) relationship was observed between acrylamide metabolites and observation of incense. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to environmental exposure volatile organic compound pregnancy, national children’s study, birth cohort study, pregnant women, tobacco, urinary metabolites, volatile organic compounds and other aspects.Computed Properties of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 2022, Chatterjee, Nabanita; Oliver, Clive L. published an article.Product Details of 685-91-6 The title of the article was Ligated Solvent Influence on Interpenetration and Carbon Dioxide and Water Sorption Hysteresis in a System of 2D Isoreticular MOFs. And the article contained the following:

Four two-dimensional (2D), fluorinated metal-organic frameworks (MOFs), [Cu(hfipbb)(DMF)]n·0.5(DMF)n (1), [Cu(hfipbb)(DEF)]n (2), [Cu3(hfipbb)3(DMA)3]n·6(DMA)n·2(H2O)n (3), and [Cu2(hfipbb)2(DEA)2]n·2(DEA)n·2(H2O)n (4), were synthesized where hfipbb = 4,4′-(hexafluoroisopropylidene)bis(benzoate), DMF = N,N’-DMF, DEF = N,N’-diethylformamide, DMA = N,N’-dimethylacetamide, and DEA = N,N’-diethylacetamide. The choice of a formamide or acetamide solvent ligand leads to 2-dimensional, doubly interpenetrated (1,2) or noninterpenetrated (3,4) MOF structures. Despite their lower potential void spaces, the doubly interpenetrated structures have superior CO2 and hydrogen sorption properties. Their 195 K CO2 sorption isotherms display inflection points, followed by 3̃-fold increases in sorption capacities and very large hysteretic behavior. Small changes in the identity of the ligated solvent ligand can affect whether the resulting MOF is interpenetrated or noninterpenetrated and so drastically affect the sorption properties. The activated phase of a 5th MOF, synthesized through DMF ligand exchange with H2O in 1 (1W), does not display an inflection point and subsequent increased CO2 sorption at 195 K, despite having the same degree of interpenetration, showing that even more subtle differences in the desolvated phases can lead to marked differences in their sorption behavior. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to copper fluoroisopropylidenebenzoate mof preparation sorption hysteresis gas adsorption, crystal structure copper fluoroisopropylidenebenzoate formamide acetamide isoreticular mof and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2020, Rodriguez, Frederic; Saffon, Nathalie; Sammartino, Jose Camilla; Degiacomi, Giulia; Pasca, Maria Rosalia; Lherbet, Christian published an article.Safety of N-(3-Aminophenyl)acrylamide The title of the article was First triclosan-based macrocyclic inhibitors of InhA enzyme. And the article contained the following:

Two macrocyclic derivatives based on the triclosan frame were designed and synthesized as inhibitors of Mycobacterium tuberculosis InhA enzyme. One of the two mols. M02 displayed promising inhibitory activity against InhA enzyme with an IC50 of 4.7μM. Mol. docking studies of these two compounds were performed and confirmed that M02 was more efficient as inhibitor of InhA activity. These mols. are the first macrocyclic direct inhibitors of InhA enzyme able to bind into the substrate pocket. Furthermore, these biaryl ether compounds exhibited antitubercular activities comparable to that of triclosan against M. tuberculosis H37Rv strain. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Safety of N-(3-Aminophenyl)acrylamide

The Article related to preparation triclosan derivative macrocyclic inhibitor inha enzyme tuberculosis, enoyl-acp-reductase, inha, macrocycle, marchantin analogue, mycobacterium tuberculosis, triclosan and other aspects.Safety of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2022, Zhou, Hao-long; Su, Guan-hua; Zhang, Ru-yi; Di, Dong-sheng; Wang, Qi published an article.COA of Formula: C10H11NO3 The title of the article was Association of volatile organic compounds co-exposure with bone health indicators and potential mediators. And the article contained the following:

Limited evidence was found in the associations of volatile organic compound (VOC) exposure with bone health indicators. This study aimed to explore the associations of individual and combined metabolites of VOCs (mVOCs) in urine, a representative of the internal exposure level of VOCs, with bone mineral d. (BMD), osteoporosis (OP) and fracture, and potential mediators. Data of the National Health Examination and Nutrition Survey 2005-2006 and 2013-2014 was used. Multiple linear and logistic regression modeling were performed to analyze the associations of individual mVOC with bone health indicators. The least absolute shrinkage and selection operator (LASSO) regression was adopted to select mVOCs that were more relevant to bone health indicators for further weight quantile sum (WQS) anal. used for analyzing the associations between multiple VOC co-exposure and bone health indicators. Mediation anal. was used to identify potential mediators. Seventeen mVOC members with detection rate of >50% in urine of all 3478 participants aged ≥20 years (1829 females) were involved. Levels of most mVOCs were higher in women than men. Eight mVOCs were neg. associated with BMDs, and two and four mVOCs were pos. associated with OP and fracture risks, resp. WQS regression revealed decreased femoral neck BMD ( β= -0.010 g/cm2, 95% CI: -0.020, -0.0001) and total spine BMD (β = -0.015 g/cm2, 95% CI: -0.028, -0.002) in response to increasing mVOC mixture levels. And alk. phosphatase (ALP), body mass index (BMI), fasting insulin (FI) and high-d. lipoprotein (HDL), were mediators in the associations with proportions of mediating effect ranging from 4.6% to 10.2%. Individual and combined VOC (co-)exposure were associated with reduced BMDs in American adults. ALP, BMI, FI and HDL were demonstrated to be mediators in the association of multiple VOC co-exposure with BMD. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to volatile organic compound bone health indicator body mass index, bone mineral density, co-exposure, mediation, metabolite of volatile organic compound, osteoporosis, weighted quantile sum regression and other aspects.COA of Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 14, 2010, De Vries, Maria Andreas Hendrikus; Domin, Doris; Helms, Matthias; Imboden, Chistoph; Koberstein, Ralph; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Maria Gerardus Karel; Stichler, Juergen published a patent.Formula: C9H11NO2 The title of the patent was Process and intermediates for preparation of almorexant hydrochloride.. And the patent contained the following:

(S)-6,7-Dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydroisoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), taniaphos, and I2 in a solvent at 1-200 bar H2. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Formula: C9H11NO2

The Article related to almorexant hydrochloride preparation, methoxytrifluoromethylphenylethyldihydroisoquinoline acetate chiral preparation, hydroisoquinoline asym hydrogenation taniaphos cyclopentadiene iridium chloride and other aspects.Formula: C9H11NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics