Tag: 100-200

Hu, Yawen; Chen, Jianzhong; Li, Bowen; Zhang, Zhenfeng; Gridnev, Ilya D.; Zhang, Wanbin published an article in 2020, the title of the article was Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates.SDS of cas: 27115-50-0 And the article contains the following content:

Earth-abundant nickel, coordinated with a suitable chiral bisphosphine ligand was found to be an efficient catalyst for the asym. hydrogenation of 2-amidoacrylates affording the chiral α-amino acid esters in quant. yields and excellent enantioselectivity (up to 96% ee). The active catalyst component was studied by NMR and HRMS, which helped us to realized high catalytic efficiency on a gram scale with a low catalyst loading (S/C=2000). The hydrogenated products could be simply converted into chiral α-amino acids, β-amino alcs. and their bioactive derivatives Furthermore, the catalytic mechanism was investigated using deuterium-labeling experiments and computational calculations The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to amidoacrylate preparation nickel catalyst enantioselective hydrogenation, amido carboxylate preparation, 2-amidoacrylates, asymmetric hydrogenation, chiral α-amino acids, homogeneous catalysis, nickel and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 5, 2018, Kirilova, E. M.; Puckins, A. I.; Romanovska, E.; Fleisher, M.; Belyakov, S. V. published an article.Product Details of 685-91-6 The title of the article was Novel amidine derivatives of benzanthrone: Effect of bromine atom on the spectral parameters. And the article contained the following:

Several new substituted amidine derivatives of benzanthrone were synthesized by condensation reaction from 2-bromo-3-aminobenzo[de]anthracen-7-one and appropriate aromatic or aliphatic amides. The novel benzanthrone derivatives were characterized by TLC anal., NMR, IR, MS, UV/Vis, and fluorescence spectroscopy. The obtained derivatives have yellow or orange fluorescence in organic solvents. The solvent effect on photophys. behaviors of these dyes was investigated, and the results showed that the introduction of a bromine atom causes a blue-shift of the absorption and emission bands and decrease in the fluorescent quantum yield in comparison with unbromated analogs. The difference in the excited state and the ground state dipole moments was estimated by using the variation of Stokes shift and by semiempirical mol. calculations The crystal structure and packing of four novel dyes has been revealed by the X-ray single crystal structure anal. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to bromoaminobenzanthrone aliphatic amide condensation, benzanthrone amidine derivative preparation dye fluorescence crystal mol structure, benzanthrone dyes, crystal structure, dipole moment, fluorescence, solvatofluochromism and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2013, Spasov, A. A.; Yakovlev, D. S.; Suzdalev, K. F.; Kosolapov, V. A.; Kucheryavenko, A. F.; Gurova, N. A.; Grechko, O. Yu.; Naumenko, L. V.; Kolobrodova, N. A.; Mitina, T. M.; Mal’tsev, D. V.; Babakova, M. N. published an article.Category: amides-buliding-blocks The title of the article was Synthesis and pharmacological activity of amides of 2-amino-3-indolylacrylic acid. And the article contained the following:

Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation to the various types of pharmacol. activity typical of this class, including receptor (5-HT2-, 5-HT3-, and P2Y1-ergic, K-opioid), antiaggregant, hemorheol., antiarrhythmic, and antioxidant activities. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to purinoceptor 5ht receptor antiaggregant hemorheol antiarrhythmic antioxidant aminoindolylacrylamide preparation, acrylamide aminoindolyl preparation pharmacol activity, ring opening indolylmethyleneoxazolone aliphatic amine and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2017, Kamila, Mritunjoy; Cosquer, Goulven; Breedlove, Brian K.; Yamashita, Masahiro published an article.Related Products of 685-91-6 The title of the article was Packing structure effects on the slow magnetic relaxation pathways of dysprosium (III) complexes. And the article contained the following:

Three complexes, [Dy{5-(5-methylthiophen-2-yl)-2,2′-bipyridine}(hfac)3] (6), [Dy{5-(4-bromo-5-methylthiophen-2-yl)-2,2′-bipyridine}(hfac)3] (7) and [Dy{5-(4-ethynyl-5-methylthio-phen-2-yl)-2,2′-bipyridine}(hfac)3] (8) (hfac = hexafluoroacetylacetate), were synthesized to investigate the effects of substituents on the ligand far from the metal ion on the magnetic properties of the dysprosium ion. 7 crystallized in two polymorphs (P21/n for 7a and P21/a for 7b), whereas 6 and 8 crystallized in one polymorph (P21/n and P21/a, resp.). All of the complexes have columnar structures, and in 6 and 7a, there are π-π stacking interactions between neighboring aromatic rings in contrast to compounds 7b and 8, which do not show such interactions. Every complex underwent slow magnetic relaxation with a single relaxation time, except for complex 7a, for which there were two relaxation times. In order to clarify the role of distal substitution and crystal packing, the magnetic properties were studied in solution, where all of the complexes show single relaxation times. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6

The Article related to magnetic property susceptibility single mol magnet dysprosium bipyridine thiophenyl, luminescence lifetime dysprosium bipyridine thiophenyl complexes, crystal structure dysprosium bipyridine thiophenyl complex preparation and other aspects.Related Products of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 25, 2009, Liu, Julie published a patent.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of tetrahydroisoquinoline derivatives as orexin receptor antagonists. And the patent contained the following:

This title compounds with general formula I [wherein each Z is independently selected from hydrogen or deuterium; each R is independently selected from CD3, CD2H, CDH2, or CH3, and when each R is CH3 then at least one Z is deuterium] or pharmaceutically acceptable salts thereof were prepared as dual OX-1/OX-2 orexin receptor antagonists for the treatment of obesity, bulimia, anorexia nervosa, insomnia, narcolepsy, sleep apnea, jet-lag syndrome, or memory impairment. For example, compound II·HCl was prepared in a multi-step synthesis, with the last step being the condensation of (1S)-[1,2,3,4-tetrahydro-3,3,4,4-d4]-[6,7-dimethoxy-d6]-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-isoquinoline hydrochloride (preparation given) and toluene-4-sulfonic acid [(S)-1-[(methyl-d3)carbamoyl]-1-phenylmethyl] ester (preparation given). The metabolic stability of compounds I has been tested using pooled liver microsomal incubation. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

The Article related to preparation tetrahydroisoquinoline orexin receptor antagonist treatment eating disorder sleep, treatment obesity bulimia anorexia nervosa insomnia narcolepsy sleep apnea, human jet lag syndrome memory impairment treatment and other aspects.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Jiadi; Ren, Quanlei; Xu, Ning; Wang, Chaodong; Song, Shengjie; Chen, Zhi; Li, Jianjun published an article in 2021, the title of the article was K2S2O8-catalyzed highly regioselective amidoalkylation of diverse N-heteroaromatics in water under visible light irradiation.SDS of cas: 685-91-6 And the article contains the following content:

A K2S2O8-catalyzed versatile C(sp2)-C(sp3) bond formation with N-heteroaromatics and γ-lactams/amides was developed. Quinoxalin-2(1H)-one, quinoline, isoquinoline, phthalazine, and benzothiazole reacted with γ-lactams/amides to give the corresponding C(sp2)-H amidoalkylation products in moderate to good yields with high regioselectivity. This visible-light-induced photocatalyst-free reaction was conducted in H2O at ambient temperature, which comply with the principles of “green chem.”. The new K2S2O8 catalytic mechanism was investigated with control experiments The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6

The Article related to lactam azaarene potassium persulfate catalyst regioselective photochem amidoalkylation, amide azaarene potassium persulfate catalyst regioselective photochem amidoalkylation, amidoalkyl azaarene preparation green chem and other aspects.SDS of cas: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wan, Zhaohua; Wang, Dan; Yang, Zixuan; Zhang, Heng; Wang, Shengchun; Lei, Aiwen published an article in 2020, the title of the article was Electrochemical oxidative C(sp3)-H azolation of lactams under mild conditions.Related Products of 685-91-6 And the article contains the following content:

An electrochem. oxidative direct C(sp3)-H azolation of lactams was reported under metal catalyst-free and external chem. oxidant-free conditions. This electrochem. C(sp3)-H/N-H coupling was characterized by its broad substrate scope of azoles and lactams under mild conditions at room temperature Mechanistic studies suggested that the reaction possibly involves a radical process. Moreover, the site selectivity was explained by DFT calculations More meaningfully, a gram-scale synthesis method of flow electrochem. was employed to show the scaled-up applicability of this transformation. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6

The Article related to azole lactam electrochem oxidative azolation, azolyl lactam preparation, amide azole electrochem oxidative azolation, amido azole preparation, pyrazole urea electrochem oxidative azolation, pyrazolyl urea preparation and other aspects.Related Products of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2015, Subbulakshmi, Karanth N.; Narayana, Badiadka; Yathirajan, Hemmige S.; Akkurt, Mehmet; Celik, Oemer; Ersanli, Cem Cueneyt; Glidewell, Christopher published an article.Category: amides-buliding-blocks The title of the article was Dihydrooxazolones and dihydroimidazolones derived from acylglycines: syntheses, molecular structures and supramolecular assembly. And the article contained the following:

Syntheses and structures are described for some alkylidene-substituted dihydrooxazolones and dihydroimidazoles derived from simple acylglycines. A second, triclinic, polymorph of 4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5(4H)-one, C17H13NO2, (I), has been identified and the structure of 2-methyl-4-[(thiophen-2-yl)methylidene]-1,3-oxazol-5(4H)-one, C9H7NO2S, (II), has been rerefined taking into account the orientational disorder of the thienyl group in each of the two independent mols. The reactions of phenylhydrazine with 2-phenyl-4-[(thiophen-2-yl)methylidene]-1,3-oxazol-5(4H)-one or 2-(4-methylphenyl)-4-[(thiophen-2-yl)methylidene]-1,3-oxazol-5(4H)-one yield, resp., 3-anilino-2-phenyl-5-[(thiophen-2-yl)methylidene]-3,5-dihydro-4H-imidazol-4-one, C10H15N3OS, (III), and 3-anilino-2-(4-methylphenyl)-5-[(thiophen-2-yl)methylidene]-3,5-dihydro-4H-imidazol-4-one, C21H17N3OS, (IV), which both exhibit orientational disorder in their thienyl groups. The reactions of 2-phenyl-4-[(thiophen-2-yl)methylidene]-1,3-oxazol-5(4H)-one with hydrazine hydrate or with water yield, resp., N-[3-hydrazinyl-3-oxo-1-(thiophen-2-yl)prop-1-en-2-yl]benzamide and 2-(benzoylamino)-3-(thiophen-2-yl)prop-2-enoic acid, which in turn react, resp., with thiophene-2-carbaldehyde to form 2-phenyl-5-[(thiophen-2-yl)methylidene]-3-{[(E)-(thiophen-2-yl)methylidene]amino}-3,5-dihydro-4H-imidazol-4-one, C19H13N3OS2, (V), which exhibits orientational disorder in only one of its thienyl groups, and with methanol to give Me (2Z)-2-(benzoylamino)-3-(thiophen-2-yl)prop-2-enoate, C15H13NO3S, (VI). There are no direction-specific intermol. interactions in the crystal structure of the triclinic polymorph of (I), but the mols. of (II) are linked by two independent C-H···O hydrogen bonds to form C 2 2(14) chains. Compounds (III) and (IV) both form centrosym. R 2 2(10) dimers built from N-H···O hydrogen bonds, while compound (V) forms a centrosym. R 2 2(10) dimer built from C-H···O hydrogen bonds. In the structure of compound (VI), a combination of N-H···O and C-H···π(arene) hydrogen bonds links the mols. into sheets. Comparisons are made with some similar compounds The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to dihydrooxazolone dihydroimidazolone acylglycine mol structure supramol assembly, erlenmeyer azlactones, crystal structure, hydrogen bonding, imidazolones, orientational disorder, oxazolones, supramolecular assembly and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 3, 2018, Lamie, Phoebe F.; Philoppes, John N.; Rarova, Lucie published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors. And the article contained the following:

A new series of 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives I (R = H, Me; R1 = H, OMe, Cl; X = O, S) was synthesized. Their cytotoxic activities in vitro were evaluated against breast, ovarian, and liver cancer cell lines and also against normal human skin fibroblasts. Cyclooxygenase (COX)-1, COX-2 and lipoxygenase (LOX) inhibitory activities were measured. The synthesized compounds showed selectivity toward COX-2 rather than COX-1, and the IC50 values (0.25-1.7 μM) were lower than that of indomethacin (IC50 = 9.47 μM) and somewhat higher than that of celecoxib (IC50 = 0.071 μM). The selectivity index for COX-2 of the oxazole derivative I (R = Me; R1 = OMe; X = O) (SI = 3.67) was nearly equal to that of celecoxib (SI = 3.66). For the LOX inhibitory activity, the new compounds showed IC50 values of 0.02-74.03 μM, while the IC50 of the reference zileuton was 0.83 μM. The most active compound I (R = H; R1 = Cl; X = O) was found to have dual COX-2/LOX activity. All the synthesized compounds were docked inside the active site of the COX-2 and LOX enzymes. They linked to COX-2 through the N atom of the azole scaffold, while C=O of the oxazolone moiety was responsible for the binding to amino acids inside the LOX active site. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to benzylidene imidazolone preparation antiinflammatory antitumor mol docking human, cyclooxygenase lipoxygenase inhibitor, anti-inflammatory, cytotoxicity, diaryl imidazolone derivatives, molecular docking study and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dobashi, Yasuo; Dobashi, Akira; Hara, Shoji published an article in 1984, the title of the article was Chiral recognition conducted by tartaric acid derivatives in nonaqueous media.SDS of cas: 65645-88-7 And the article contains the following content:

Chiral recognition of hydroxycarboxylic acids, amino acids and 1,2-diols using diastereomeric complexation based on H bonding with L-(+)-N,N’-diisopropyltartramide is described (liquid-solid chromatog.). The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).SDS of cas: 65645-88-7

The Article related to chiral recognition tartramide, tartaric acid chiral recognition, chromatog tartaric chirality, hydrogen bond tartramide, hydroxycarboxylase enantiomerism chromatog, amino acid enantiomerism, diol enantiomerism and other aspects.SDS of cas: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics