Tag: 100-200

On December 21, 2018, Jang, Yoon Kyung; Krueckel, Tobias; Rueping, Magnus; El-Sepelgy, Osama published an article.Formula: C6H13NO The title of the article was Sustainable Alkylation of Unactivated Esters and Amides with Alcohols Enabled by Manganese Catalysis. And the article contained the following:

In the presence of a bench-stable manganese pincer complex of a PNN ligand, acetamides and tert-Bu acetate underwent chemoselective and green monoalkylation with primary alcs. to yield amides and tert-Bu esters. Under similar conditions, alkylation of N-methyloxindole with benzyl alc. yielded 3-benzyl-3-hydroxy-N-methyloxindole. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Formula: C6H13NO

The Article related to amide ester chemoselective green preparation, hydroxyoxindole preparation, manganese pincer complex catalyst alkylation acetamide acetate primary alc, oxindole alkylation hydroxylation benzyl alc manganese pincer complex catalyst and other aspects.Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 10, 2015, Salami-Ranjbaran, Elmira; Khosropour, Ahmad R.; Mohammadpoor-Baltork, Iraj; Moghadam, Majid; Tangestaninejad, Shahram; Mirkhani, Valiollah published an article.Category: amides-buliding-blocks The title of the article was A Novel pseudo-Four-Component Domino Reaction for the Synthesis of Naphtho[2,1-b]furan-2(1H)-ones Using a Nanocatalyst. And the article contained the following:

In this article, an original one-pot method is utilized to synthesize a variety of derivatives of naphtho[2,1-b]furan-2(1H)-one via a pseudo-four-component domino reaction of aryl aldehydes, acetic anhydride, hippuric acids, and 2-naphthols catalyzed by HSW@SPIONs. This reaction illustrates an array of attractive features including, with particular interest in this report, a convenient and unique process of creating and utilizing a powerful recyclable nanocatalyst. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to aryl aldehyde hippuric acid naphthol four component domino nanocatalyst, naphtho furanone preparation green chem, domino reaction, heterocycles, multicomponent reaction, nanocatalyst, naphthofuran, tungstosilicic acid hydrate and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2015, Chen, Shijie; He, Long; Wang, Xuewei; Gong, Xianfeng; Zhang, Hua published an article.HPLC of Formula: 27115-50-0 The title of the article was Synthesis and cytotoxic activity of imatinib derivatives. And the article contained the following:

Fourteen derivatives of imatinib were prepared by condensation of (L)-N-acylation amino acid with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine (6), which was prepared from 3-acetyl-pyrimidin and 2-methyl-5-nitroaniline through the reactions of addition, condensation, cyclization and reduction, resp. The structures of all target compounds were characterized by IR, 1H NMR, 13C NMR and HRMS techniques. They were evaluated for cytotoxic activity against human Leukemia cells (K562), human non-small-cell-lung cancer cells lines (A549) and human hepatoma cell lines (HepG-2) by Me thiazolyl tetrazolium (MTT) method. The results showed the cytotoxic activities of compounds I, 7i, 7j, 7k, 7l, 7n against human Leukemia cells (K562) and human non-small-cell-lung cancer cell lines (A549), compounds 7a, I, 7e against human hepatoma cell lines (HepG-2) were comparable to those of imatinib. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to imatinib derivative preparation antitumor cytotoxic activity leukemia lung cancer, amino acid aminomethylphenylpyridylpyrimidine amine acylation, acetylpyrimidin methylnitroaniline addition condensation cyclization reduction and other aspects.HPLC of Formula: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cavallo, Delia; Ursini, Cinzia Lucia; Fresegna, Anna Maria; Ciervo, Aureliano; Maiello, Raffaele; Buresti, Giuliana; Paci, Enrico; Pigini, Daniela; Gherardi, Monica; Carbonari, Damiano; Sisto, Renata; Tranfo, Giovanna; Iavicoli, Sergio published an article in 2021, the title of the article was Occupational exposure in industrial painters: sensitive and noninvasive biomarkers to evaluate early cytotoxicity, genotoxicity and oxidative stress.Electric Literature of 27115-50-0 And the article contains the following content:

This study aimed to identify sensitive and noninvasive biomarkers of early cyto-genotoxic, oxidative and inflammatory effects for exposure to volatile organic compounds (VOCs) in shipyard painters. On 17 (11 spray and 6 roller) painters (previously characterized for VOCs exposure to toluene, xylenes, ethylbenzene, Et acetate) and on 18 controls, we performed buccal micronucleus cytome (BMCyt) assay; Fpg-comet assay on lymphocytes; detection of urinary 8-oxoGua (8-oxo-7,8-dihydroguanine), 8-oxodGuo (8-oxo-7,8-dihydro-2′-deoxyguanosine) and 8-oxoGuo (8-oxo-7,8-dihydroguanosine), and cytokines release on serum. We found induction of cyto-genotoxicity by BMCyt assay and inflammatory effects (IL-6 and TNFα) in roller painters exposed to lower VOC concentrations than spray painters. In contrast, in both worker groups, we found direct and oxidative DNA damage by comet assay (with slightly higher oxidative DNA damage in roller) and significant increase of 8-oxoGuo and decrease of 8-oxodGuo and 8-oxoGua in respect to controls. The cyto-genotoxicity observed only on buccal cells of roller painters could be related to the task’s specificity and the different used protective equipment. Although limited by the small number of subjects, the study shows the usefulness of all the used biomarkers in the risk assessment of painters workers exposed to complex mixtures The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to volatile organic compound biomarker cytotoxicity genotoxicity oxidative stress, bmcyt assay, fpg comet assay, biological monitoring, occupational vocs exposure, oxidative stress biomarkers, painters, proinflammatory effects and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 15, 2015, Xu, Xiao; Wang, Xiaobo; Mao, Long; Zhao, Li; Xi, Biao published a patent.Related Products of 16230-24-3 The title of the patent was Preparation of pyrimidine compounds as Btk and Jak kinase inhibitors. And the patent contained the following:

The present invention relates to heterocyclic compounds [I; R1 = H, NRcRd, or 3-7 member cyclic ring substituted with C1-5 alkyl optionally substituted with halo; Rc = H, C1-4 alkyl or 3-7 member cyclic ring; Rd = H or C1-4 alkyl optionally substituted with OZ; Z = H or C1-4 alkyl; R2 = H, halo, C1-4 alkyl, or C1-4 alkoxy; R3 = H, halo, C1-4 alkyl, or C1-4 alkoxy; R5 = H, halo, C1-4 alkyl, or C1-4 alkoxy; R6 = H, halo, C1-4 alkyl, or C1-4 alkoxy; or R1 and R5 are part of 3-7 member cyclic ring, optionally substituted with C1-4 alkyl substituted with OZ; or R1 and R2 are part of 3-7 member cyclic ring, optionally substituted with C1-4 alkyl substituted with OZ; or R2 and R6 are part of 3-7 member cyclic ring, optionally substituted with C1-4 alkyl substituted with OZ; R4 = C2 alkenyl optionally substituted with C1-4 alkyl, CH2OMe, or -CH2NMe2; X = O, C1-4 alkyl optionally substituted with halo, or NRb; Rb = H, or C1-5 alkyl optionally substituted with halo; Y = CH optionally substituted with halo, or N, wherein at least one of R2, R3, R5 and R6 is not H] or pharmaceutically acceptable salts thereof. It also relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, cancer, tumor, inflammatory disease, autoimmune disease, psoriasis, dry eye or immunol. related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the resp. pathways. Thus, etherification of 2,4-dichloro-5-methoxypyrimidine with 3-nitrophenol in the presence of K2CO3 in DMF at 30 ° for 24 h gave 2-chloro-5-methoxy-4-(3-nitrophenoxy)pyrimidine which was coupled with 4-(4-methylpiperazin-1-yl)aniline in the presence of X-Phos and Pd2(dba)3, and K2CO3 in tert-Bu alc. at refluxing for 4 h to give 5-methoxy-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-(3-nitrophenoxy)pyrimidin-2-amine (II; R = NO2). Hydrogenation of II (R = NO2) in the presence of 10% Pd-C in THF under hydrogen pressure of 15 MPa gave II (R = NH2) which was acylated by acryloyl chloride in the presence of diisopropylethylamine in a mixture of MeOH and THF at 0° with stirring for 1 h to give II (R = acryloylamino), namely N-[3-[[5-methoxy-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]oxy]phenyl]acrylamide. II (R = acryloylamino) showed IC50 of ≤200 nM against Jak3 phosphorylation in NK-92 cells and that of ≤10 nM against Btk Tyr223 phosphorylation in Ramos cells. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Related Products of 16230-24-3

The Article related to piperazinylphenylaminopyrimidine preparation btk jak kinase inhibitor, pyrimidine preparation btk jak kinase inhibitor, piperazinylphenylaminopyrimidinyloxyphenylacrylamide preparation btk jak kinase inhibitor, proliferative disorder cancer tumor treatment pyrimidine preparation and other aspects.Related Products of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jain, Isha; Sharma, Ramandeep; Malik, Payal published an article in 2019, the title of the article was Manganese-mediated acetylation of alcohols, phenols, thiols, and amines utilizing acetic anhydride.Application of 685-91-6 And the article contains the following content:

Manganese(II) chloride-catalyzed acetylation of alcs., phenols, thiols and amines RXH (R = Ph, n-octyl, cyclohexyl, etc.; X = O, S, NH), morpholine with acetic anhydride is reported. This method is environment-friendly and economically viable as it involves inexpensive, relatively benign catalyst, mild reaction condition, and simple workup. Acetylation is performed under the solvent-free condition at ambient temperature and acetylated products RXAc, N-acetylmorpholine obtained in good to excellent yields. Primary, secondary heterocyclic amines, and phenols with various functional groups are smoothly acetylated in good yields. This method exhibits exquisite chemoselectivity, and the amino group is preferentially acetylated in the presence of a hydroxyl/thiol group. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application of 685-91-6

The Article related to acetate preparation green chem solventless, aliphatic alc acetic anhydride acetylation manganese catalyst, phenol acetic anhydride acetylation manganese catalyst, thiophenol acetic anhydride acetylation manganese catalyst, aniline acetic anhydride acetylation manganese catalyst and other aspects.Application of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 22, 2021, Hu, Zhiyong; Wei, Xiao-Jing; Handelmann, Jens; Seitz, Ann-Katrin; Rodstein, Ilja; Gessner, Viktoria H.; Goossen, Lukas J. published an article.SDS of cas: 685-91-6 The title of the article was Coupling of Reformatsky reagents with aryl chlorides enabled by ylide-functionalized phosphine ligands. And the article contained the following:

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6

The Article related to aryl ester synthesis steric hindrance natural product drug, reformatsky reagent negishi coupling aryl chloride ylide phosphine ligand, arylation catalyst palladium aryl bromide chloride, reformatsky reagent, aryl chlorides, cross-coupling, phosphine ligands, selectivity and other aspects.SDS of cas: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mao, Yu; Liu, Yeqing; Yu, Lei; Ni, Shengyang; Wang, Yi; Pan, Yi published an article in 2021, the title of the article was Uranyl-catalysed C-H alkynylation and olefination.Product Details of 685-91-6 And the article contains the following content:

A strategy to utilize uranyl for direct alkynylation and olefination of amides was described. The uranyl cation (UO22+) was identified as a highly oxidizing agent to abstract hydrogen atoms from C-H bonds for the formation of carbon-centered radicals. The photoexcitation of uranyl cations provides a range of carbon-centered radicals via hydrogen atom transfer, which can be successfully applied in cross-coupling reactions with a broad range of alkynyl and alkenyl bromides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to amide bromoalkyne uranyl catalyst regioselective alkynylation, alkynyl amide preparation, alkenylbromide amide uranyl catalyst regioselective alkenylation, alkenyl amide preparation, allylbromide amide uranyl catalyst regioselective allylation, allyl amide preparation and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 18, 2019, Hardy, Jeanne A.; Meka, Penchala Narasimhara published a patent.Formula: C9H10N2O The title of the patent was Preparation of furoxan-based compounds for treating neurodegenerative diseases. And the patent contained the following:

This invention relates to the title compounds I [R1 = H or aryl; R2 = H or aryl; X1 and X2 = (independently) N, N+-O- or CR3 (wherein R3 = H or alkyl and only one of X1 and X2 can be N+-O-); with the proviso] or pharmaceutically acceptable salts, polymorphs, prodrugs, solvates or clathrates thereof, as well as to pharmaceutical compositions comprising such compounds, and to methods for using such compounds/pharmaceutical compositions for treating neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis (MS). Over fifty compounds I were prepared E.g., a multi-step synthesis of II, starting from cyclohexanone, was described. A method for inhibiting caspase-6 with a compound that reacts with the sulhydryl group (SH) on cysteine 246 of caspase-6 was disclosed (no biol. data given). The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Formula: C9H10N2O

The Article related to furoxan derivative preparation neurodegenerative alzheimer’s parkinson’s huntington’s disease treatment, caspase 6 inhibitor furoxan derivative triazolobenzooxadiazole preparation, multiple sclerosis treatment furoxan derivative triazolobenzooxadiazole preparation and other aspects.Formula: C9H10N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 14, 1996, Roucoux, Alain; Thieffry, Laurent; Carpentier, Jean-Francois; Devocelle, Marc; Meliet, Catherine; Agbossou, Francine; Mortreux, Andre; Welch, Alan J. published an article.Recommanded Product: 65645-88-7 The title of the article was Amidophosphine-Phosphinites: Synthesis and Use in Rhodium-Based Asymmetric Hydrogenation of Activated Keto Compounds. Crystal Structure of Bis[(μ-chloro)((S)-2-((diphenylphosphino)oxy)-2-phenyl- N-(diphenylphosphino)-N-methylacetamide)rhodium(I)]. And the article contained the following:

Amidophosphine-phosphinite ligands (AMPP) derived from (S)-N-benzylmandelamide ((S)-R,R’-benzylmandelNOP (S)-1 (R = R’ = phenyl) and (S)-7 (R = Ph, R’ = cyclopentyl)), (S)-N-methylmandelamide ((S)-R,R’-methylmandelNOP (S)-2 (R = R’ = phenyl) and (S)-8 (R = Ph, R’ = cyclopentyl)), (S)-N-methyllactamide ((S)-R,R’-methyllactaNOP (S)-3 (R = R’ = phenyl) and (S)-9 (R = Ph, R’ = cyclopentyl)), and (S)-2-(hydroxymethyl)-2-pyrrolidinone ((S)-R,R’-oxoProNOP (S)-4-6 and (S)-10 (R, R’ = Ph, cyclohexyl, cyclopentyl)) have been prepared in high yields (60-94%) and reacted with rhodium precursors to prepare neutral “Rh{AMPP}” complexes of general formula [Rh{AMPP}X]2, where X = Cl, I, OCOCH3, OCOCF3, and OCOC3F7. The crystal structure of [Rh{(S)-Ph,Ph-methylmandelNOP}Cl]2 (12) has been determined The rhodium atom has a cis square-planar coordination, and the seven-membered chelate ring has a boat conformation with the nitrogen atom in the mean plane RhP2. Complexes have been used as catalyst precursors for the asym. hydrogenation of dihydro-4,4-dimethyl-2,3-furandione (27) and N-benzylbenzoylformamide (29) giving the corresponding optically active hydroxy compounds in high yields and low to high enantiomeric excesses (28-98.7% ee and 13-87% ee, resp.). Catalytic activities (turnover frequency at 50% conversion at room temperature up to 3300 h-1) as well as the enantioselectivities depended strongly on the nature of the substituents on phosphorus as well as on the nature of the non chiral ligands. Catalyst precursor [Rh{(S)-Cp,Cp-oxoProNOP}OCOCF3]2 afforded (R)-pantolactone in 98.7% ee. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: 65645-88-7

The Article related to amidophosphine phosphinite preparation reaction rhodium complex, asym hydrogenation catalyst rhodium amidophosphine phosphinite, mandelamide lactamide phosphino preparation reaction rhodium, crystal mol structure amidophosphine phosphinite rhodium and other aspects.Recommanded Product: 65645-88-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics