Tag: 100-200

On December 7, 2018, Baghdady, Yehia Z.; Schug, Kevin A. published an article.Electric Literature of 27115-50-0 The title of the article was A novel diagnostic in situ derivatization kit for the simultaneous determination of 14 biomarkers of exposure to benzene, toluene, ethyl benzene and xylenes in human urine by isotope dilution liquid chromatography tandem mass spectrometry and kit optimization using response surface methodology. And the article contained the following:

Metabolite profiling can be used as a diagnostic measure for both short and long term co-exposure by individuals to benzene, toluene, ethylbenzene and xylenes (BTEX). A novel one pot derivatization in situ kit (OPDISK) was developed and optimized using a multivariate approach based on central composite design. The OPDISK was designed to simultaneously derivatize, in a urine sample matrix, a series of fourteen carboxylic acid and phenol-bearing urinary metabolites of BTEX to enhance their chromatog. anal. and sensitivity for detection by liquid chromatog. – electrospray ionization – tandem mass spectrometry (LC-ESI-MS/MS). Using the reagent kit, the less responsive functional units on the mols. were converted to permanently pos.-charged functional units. The kit was composed of three components, 2-fluoro-1-methylpyridinium p-toluenesulfonate (FMP), 3-carbinol-1-methylpyridinium iodide (CMP) and triethylamine (TEA) as a basic catalyst and, only after diluting a urine sample 20-fold with acetonitrile, was applied under mild conditions of room temperature and short reaction time of 20 min. The derivatized biomarkers were then directly analyzed using isotope dilution LC-ESI-MS/MS. The method was sensitive (limit of detection on column ranged from 1.4 pg to 3.1 ng), accurate (mean accuracy from 85% to 114%), and precise (mean coefficient of variation from 1% to 14%). The method results indicated a good linearity (R2 ≥0.990) for all metabolites. ClinChek urine control samples were used successfully to demonstrate the accuracy of the method. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to benzene toluene ethylbenzene xylene exposure biomarker determination urine, btex exposure biomarker determination human urine lc ms opdisk, btex, biomarkers, central composite design, in situ derivatization, metabolites, occupational exposure and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 2010, Fun, Hoong-Kun; Yeap, Chin Sing; Mange, Yatin; Isloor, Arun M.; Hegde, Chitrakar published an article.Application of 27115-50-0 The title of the article was N-[(4-Amino-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-4-methylbenzamide. And the article contained the following:

In N-[(4-amino-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-4-methylbenzamide, C11H13N5OS, the dihedral angle between the triazole ring and the benzene ring is 84.21(7)°. The amino group adopts a pyramidal configuration. An intramol. N-H···O H bond stabilizes the mol. structure and generates an S(8) ring. In the crystal, mols. are linked by intermol. N-H···O, N-H···S, N-H···N and C-H···S H bonds into layers lying parallel to the bc plane. The crystal structure is further stabilized by aromatic π-π stacking interactions [centroid-centroid distance = 3.3330(7) Å]. Crystallog. data are given. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application of 27115-50-0

The Article related to crystal structure aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, mol structure aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, hydrogen bond aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, pi stacking aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, triazolylmethylmethylbenzamide aminosulfanylidenedihydro crystal mol structure and other aspects.Application of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 15, 2020, Teng, Yu; Li, Xinyu; Ren, Shengnan; Cheng, Yu; Xi, Kun; Shen, Hongtao; Ma, Wenzhuo; Luo, Guoshun; Xiang, Hua published an article.Quality Control of N-(3-Aminophenyl)acrylamide The title of the article was Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity. And the article contained the following:

Herein, a series of quinazoline derivatives I [R1 = Br, 3-pyridyl, (6-fluoro-3-pyridyl), (6-chloro-3-pyridyl), 3-quinolyl; R2 = vinyl, Et, HC=CH2CH3, C≡CCH3; R3 = H, Me] bearing acrylamide fragment were prepared using skeleton-deconstruction strategy. The preliminary bioactivity evaluation resulted in the discovery of lead compound I [R1 = 3-quinolyl; R2 = vinyl; R3 = Me]. Compound I [R1 = 3-quinolyl; R2 = vinyl; R3 = Me] exhibited excellent enzyme activity against PI3Kδ (IC50 = 27.5 nM) compared with BEZ235 as well as the significant anti-proliferation activities. With the high selectivity over other PI3K isoforms and potent effects on PI3K/Akt pathway, compoundI [R1 = 3-quinolyl; R2 = vinyl; R3 = Me] could be identified as a promising PI3Kδ inhibitor worthy of further profiling. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Quality Control of N-(3-Aminophenyl)acrylamide

The Article related to quinazoline preparation pi3k delta inhibitor docking human, bromoquinazolinyl amino phenyl boric acid suzuki coupling catalyst palladium, boric acid bromoquinazolinyl oxy phenyl suzuki coupling catalyst palladium, quinolineboronic acid bromoquinazolinyl amino phenyl suzuki coupling catalyst palladium, b-cell malignancies, pi3kδ, quinazoline derivatives and other aspects.Quality Control of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 9, 2021, Zhang, Xin; Geng, Peiyu; Liu, Guixia; Huang, Zheng published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Ru-Catalyzed Site-Selective Aliphatic C-H Bond Silylation of Amides and Carbamides. And the article contained the following:

Hydrido Ru complexes (POCNP)RuH(NBD) (NBD = norbornadiene) supported by N/O-bridged pincer ligands were synthesized and characterized. The Ru complex containing a pincer ligand with an indolol scaffold exhibits high catalytic activity for the intermol. aliphatic C-H bond silylation of amides and carbamides. The reaction proceeds selectively at the C-H bonds adjacent to the N atom to efficiently afford α-silyl amides and carbamides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to hydridoruthenium pincer complex containing diphosphinated indolol ligand preparation catalyst, crystal structure hydridoruthenium pincer complex containing diphosphinated indolol ligand, mol structure hydridoruthenium pincer complex containing diphosphinated indolol ligand, diphosphinated indolol ligand preparation cyclometalation ruthenium complex and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2020, Tong, Dan; Chen, Jiangyao; Qin, Dandan; Ji, Yuemeng; Li, Guiying; An, Taicheng published an article.Related Products of 685-91-6 The title of the article was Mechanism of atmospheric organic amines reacted with ozone and implications for the formation of secondary organic aerosols. And the article contained the following:

Organic amines are a most important N-containing compounds in the atm.; their reactions with tropospheric O3 significantly contribute to secondary organic aerosols (SOA) formation. But the chem. pathways of their reaction with atm. O3 are poorly understood. This work examined the atm. ozonolysis mechanism for two typical organic amines (diethylamine, triethylamine) using exptl. and theor. methods. Intermediate gas chromatog./mass spectrometry and proton transfer reaction /time-of-flight mass spectrometry anal. results confirmed formation of 8 and 11 N- and O-containing products during diethylamine and triethylamine ozonolysis, resp. N-ethylethanimine (average 56.5%) or acetaldehyde (average 64.9%) was formed as the dominant product from ozonolysis of each organic amine. Ozonolysis pathway results indicated conversion to N-ethylethanimine was the dominant pathway for diethylamine ozonolysis. Simultaneously, triethylamine preferred an initial transformation to diethylamine with discharge of acetaldehyde then conversion to N-ethylethanimine. Higher SOA mass concentrations were obtained from triethylamine vs. diethylamine ozonolysis, probably because the former released a larger amount of intermediate products, particularly acetaldehyde. Results provided a deep insight into atm. processing of organic amines via ozonolysis and implications of this mechanism for SOA formation. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6

The Article related to atm ozonolysis organic amine secondary organic aerosol formation, diethylamine triethylamine atm ozonolysis secondary organic aerosol formation, reaction pathway transformation mechanism organic amine atm ozonolysis, ozonolysis intermediate byproduct organic amine reaction, atmospheric organic amine, carbonyl intermediate and other aspects.Related Products of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 15, 2021, Wang, Zhiguo; Li, Shijiang; Li, Ronghao; Luo, Chunyan published a patent.Formula: C6H11NO The title of the patent was Preparation of indoline-5-methylamine dihydrochloride from indole. And the patent contained the following:

The present invention relates to the preparation of indoline-5-methylamine dihydrochloride from indole. In particular, the preparation method comprises of following steps: (1) using indole as a raw material, and reacting with an acid to obtain a formyl-protected indoline; (2) carrying out Friedel-Crafts reaction of the formyl protected indoline with an amination reagent to obtain 5-[(1,3-dioxoisoindolin-2-yl)methyl]indole-1-carbaldehyde; (3) the obtained intermediate compound is treated with hydrazine hydrate to obtain 5-(aminomethyl)indole-1-aminoaldehyde; and (4) carrying out the deprotection reaction of 5-(aminomethyl)indole-1-aminoaldehyde to obtain the target product indoline-5-methylamine dihydrochloride. The inventive method has a short process route, low cost, easy availability of raw materials and auxiliary materials, high reactivity, simple operation, easy control, and has high yield of the target product, which is convenient for industrial scale-up. The experimental process involved the reaction of Azepan-2-one(cas: 105-60-2).Formula: C6H11NO

The Article related to indole formic acid formylation reduction, formylindoline preparation hydroxymethyl phthalimide compound friedel crafts reaction, dioxyisoindolinyl methylindole formaldehyde preparation amination, aminomethyl dihydro indole carboxaldehyde preparation deprotection, indoline methylamine dihydrochloride preparation and other aspects.Formula: C6H11NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 27, 2017, Mancini, Alessandra; Chelini, Alessia; Di Capua, Angela; Castelli, Loretta; Brogi, Simone; Paolino, Marco; Giuliani, Germano; Cappelli, Andrea; Frosini, Maria; Ricci, Lorenzo; Leonelli, Erminia; Giorgi, Gianluca; Giordani, Antonio; Magistretti, Jacopo; Anzini, Maurizio published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents. And the article contained the following:

The synthesis of differently functionalized 4H-3,1-benzothiazine I and 2H-1,4-benzothiazine II [X = CH2, S; Y = CH2, S; R = H, OCF3; R1 = R2 = H, Me, Et, n-Pr] series as superior homologs of rizuline were reported. Biol. evaluation demonstrated that amidine 4H-3,1-benzothiazine derivatives I [R1 = R2 = H, Et, n-Pr] reduces glutamate and LDH release in the oxygen/glucose deprivation and reperfusion model (OGD/R) applied to brain slices with a higher potency than rizuline. Moreover the mentioned compounds significantly reduced glutamate- and 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in neuroblastoma cells. In addition, the same compounds limit ROS formation in both neuronal preparations Finally, compound I [R1 = R2 = Et] proved effective in inhibiting neuronal voltage-dependent Na+ and Ca2+-channels, showed a profile comparable with that of rizuline. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to benzothiazinyl acetamidine preparation neuroprotective agent antioxidant sar, propylthiourea benzothiazinyl preparation neuroprotective agent antioxidant sar, benzothiazine derivatives, neurodegenerative diseases, neuronal voltage-dependent na(+) and ca(2+) currents, neuroprotective agents, sh-sy5y cells and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Xiang; Nguyen, Edward T.; Hong, Anh N.; Feng, Pingyun; Bu, Xianhui published an article in 2018, the title of the article was Chiral Isocamphoric Acid: Founding a Large Family of Homochiral Porous Materials.Safety of N,N-Diethylacetamide And the article contains the following content:

Homochiral metal-organic frameworks (MOFs) are an important class of chiral solids with potential applications in chiral recognition; however, relatively few are available. Of great importance is the availability of low-cost, racemization-resistant, and versatile enantiopure building blocks. Among chiral building blocks, D-camphoric acid is highly prolific, yet, its trans-isomer, L-isocamphoric acid, has remained unknown in the entire field of solid-state materials. Its rich yet totally untapped synthetic and structural chem. has now been studied through the synthesis of a large family of homochiral metal isocamphorates. The 1st observation of diastereoisomerism in isostructural MOFs is presented. Isocamphorate has a powerful ability to create framework topologies unexpected from common inorganic building blocks, and isocamphoric acid should allow access to hundreds of new homochiral materials. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Safety of N,N-Diethylacetamide

The Article related to chiral isocamphorate preparation homochiral porous material, transition metal isocamphorate camphorate mof preparation, crystal structure magnesium cobalt copper isocamphorate camphorate mof, camphoric acid, chiral ligands, homochiral porous materials, isocamphoric acid, metal-organic frameworks and other aspects.Safety of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 8, 2021, Kumar, Vishal; Dhawan, Sanjeev; Girase, Pankaj Sanjay; Singh, Parvesh; Karpoormath, Rajshekhar published an article.Application of 685-91-6 The title of the article was An Environmentally Benign, Catalyst-Free N-C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides. And the article contained the following:

An operationally simple, cheap and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol was environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy was implied in the chemoselective synthesis of a pharmaceutical mol., paracetamol, on a gram-scale with excellent yield. Anticipated that this was universally applicable strategy will be of great interest in drug discovery, biochem., and organic synthesis. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application of 685-91-6

The Article related to formamide amine hydrochloride n formylation transamidation green chem, arylformamide preparation, acetamide amine hydrochloride n acylation transamidation green chem, arylacetamide preparation, benzamide amine hydrochloride n benzoylation transamidation green chem, arylbenzamide preparation and other aspects.Application of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2019, Hu, Cong; Yang, Zhen; Yan, Fuhua; Sun, Biancheng published an article.Formula: C10H11NO3 The title of the article was Extraction of the toluene exposure biomarkers hippuric acid and methylhippuric acid using a magnetic molecularly imprinted polymer, and their quantitation by LC-MS/MS. And the article contained the following:

A magnetic polymer was molecularly imprinted with hippuric acid (HA) to obtain a nanomaterial with an architecture of type Fe3O4@SiO2@MIP. It was used as a sorbent for magnetic solid phase extraction of HA and methylhippuric acids (2-MHA, 3-MHA, 4-MHA) from urine samples. The resp. imprinting factor are 4.6, 2.7, 2.0 and 1.8, resp., and the selectivity coefficients are 1.7, 2.3 and 2.6. The effects of adsorbent amount, extraction time, pH value, ionic strength, desorption solvent and desorption time on the extraction of HA and MHA were investigated. Following elution with 1 mM NaOH solution, the 4 HAs were quantified by ultra-performance liquid chromatog. with mass spectrometric detection. Under the optimal exptl. conditions, the limits of detection (at S/N = 3) range between 89 ng·L-1 (for HA) and 170 ng·L-1 (for 4-MHA), the limits of quantification (at S/N = 10) range between 300 ng·L-1 (for HA) and 570 ng·L-1 (for 4-MHA), the linear range extends from 500 ng·L-1 to 10 mg·L-1, the relative standard deviations of intra-day range between 6.4 and 9.6% (for n = 6 at 10μg·L-1) and inter-day range between 9.2 and 11.5% (for n = 6 at 10μg·L-1). The method was successfully applied to the anal. of HA and MHA in (spiked) urine, and good recoveries were obtained. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to lc ms toluene biomarker hippuric methylhippuric acid polymer china, fourier transform infrared spectrometry, magnetic solid phase extraction, transmission electron microscopy, ultrasonic liquid desorption, urine analysis, vortex-assisted extraction, x-ray photoelectron spectroscopy and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics