Tag: 100-200

The author of 《Rhodium(III)-Catalyzed Oxidative Annulation of Ketoximes with Sulfonamide: A Direct Approach to Indazoles》 were Wang, Ning; Liu, Lingling; Xu, Wentao; Zhang, Mengye; Huang, Zhibin; Shi, Daqing; Zhao, Yingsheng. And the article was published in Organic Letters in 2019. Synthetic Route of C7H9NO2S The author mentioned the following in the article:

A rhodium(III)-catalyzed intermol. C-H amination of ketoxime and iodobenzene diacetate-enabled N-N bond formation in the synthesis of indazoles has been developed. A variety of functional groups were well tolerated, providing the corresponding products in moderate to good yields. Moreover, the nitro-substituted ketoximes are well compatible in this reaction, leading to the corresponding products in moderate to good yields.4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Enantioselective Construction of Chiral Sulfides via Catalytic Electrophilic Azidothiolation and Oxythiolation of N-Allyl Sulfonamides》 were Liang, Yaoyu; Zhao, Xiaodan. And the article was published in ACS Catalysis in 2019. Reference of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

An efficient and convenient pathway was developed for enantioselective synthesis of chiral sulfides by chiral bifunctional selenide-catalyzed electrophilic azidothiolation and oxythiolation of N-allyl sulfonamides. By this protocol, a variety of chiral vicinal azidosulfides and oxysulfides were obtained in good yields with high enantioselectivities and diastereoselectivities. In this transformation, not only electrophilic arylthiolating reagents but also a wide range of electrophilic alkylthiolating reagents worked very well. The practical application of this method was elucidated by further transformations of the products into the diversified compounds The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Dynamic porous metal-organic frameworks: synthesis, structure and sorption property》 were Hou, Chao; Liu, Qing; Okamura, Taka-aki; Wang, Peng; Sun, Wei-Yin. And the article was published in CrystEngComm in 2012. Recommanded Product: N-(Pyridin-4-yl)isonicotinamide The author mentioned the following in the article:

Three new porous metal-organic frameworks {[Co(L)(PIN)]·dioxane·H2O}n (1), {[Co(L)(DPE)]·0.5DPE}n (2) and {[Co(L)(BPE)]·4H2O}n (3) with the same 2-fold interpenetrating hms topol. based on 5-(pyridin-4-yl)isophthalate (L2-) and different pillar ligands of N-(4-pyridyl)isonicotinamide (PIN), 1,2-di(4-pyridyl)ethylene (DPE) and 1,2-bis(4-pyridyl)ethane (BPE) were prepared and characterized by IR, TGA, single crystal and powder x-ray diffractions. 1 Possesses a flexible framework upon desolvation and H2O/MeOH/EtOH vapor adsorption, and the desolvated sample exhibits a stepwise uptake of CO2 (195 K), H2O (298 K) and MeOH (298 K). More importantly, the desolvated 1 shows high enthalpy of CO2 adsorption and high selectivity for CO2 over N2 as well as H2O/MeOH over EtOH at 298 K. In the experimental materials used by the author, we found N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Recommanded Product: N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Recommanded Product: N-(Pyridin-4-yl)isonicotinamide Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of N-(Pyridin-4-yl)isonicotinamideOn October 7, 2011 ,《Ligand-concentration-dependent self-organization of Hoffman- and PtS-type frameworks from one-pot crystallization》 was published in CrystEngComm. The article was written by Chen, Xin; Zhou, Hu; Chen, Ying-Ying; Yuan, Ai-Hua. The article contains the following contents:

Hoffman- and PtS-type frameworks [ZnL][Ni(CN)4].3H2O (1), ZnNi(CN)4 (2) and ZnNi(CN)4.2CH3CN (3) (L = N-(4-pyridyl)isonicotinamide) were isolated from 1-pot crystallization and characterized structurally. A ligand-concentration effect is proposed in such a self-organized system. In the experimental materials used by the author, we found N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Safety of N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Safety of N-(Pyridin-4-yl)isonicotinamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: 2-Hydroxy-N-phenylacetamideOn September 23, 2015 ,《Vilsmeier reagent initialed sequential one-pot multicomponent synthesis of N,O-disubstituted glycolamides as dipeptidyl peptidase 4 inhibitors》 was published in Tetrahedron. The article was written by Lu, Shi-Han; Yen, Wan-Ping; Tsai, Henry J.; Chen, Chien-Shu; Wong, Fung Fuh. The article contains the following contents:

A series of N,O-disubstituted glycolamide derivatives have been successfully synthesized through Vilsmeier reagent initialed sequential one-pot multicomponent procedure from α-chloro N-arylacetamides with formamide/PBr3 and acid chloride. The three-step synthesis involved Vilsmeier formyloxylation reaction, decarbonylation, and esterification. The strategy was also applicable to α-chloro N-(naphthalenyl)acetamide to prepare the corresponding N,O-disubstituted glycolamide products. All of N,O-disubstituted glycolamides were evaluated against dipeptidyl peptidase 4 inhibitory activity. Based on the inhibitory results, several of O-furan-2-carbonyl and O-quinoline-8-sulfonyl N-aryl glycolamide compounds possessed the better effective inhibition of dipeptidyl peptidase 4. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Name: 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Name: 2-Hydroxy-N-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Formation of Aryl [1-Cyano-4-(dialkylamino)butadienyl] Ketones from Pyridines》 was written by Gim, Hyo Jin; Jung, Michael E.. Safety of N-Methoxy-N-methylacetamideThis research focused onWeinreb amide chloropyridine dialkylamine ring opening addition reaction; carbonyl dialkylamino pentadienenitrile preparation. The article conveys some information:

Treatment of 2-chloropyridine with LDA and the Weinreb amide of benzoic acid afforded three unusual products, namely N-methylbenzamide, 2-chloropyridine-3-methanol and the ring-opened addition product. This same final product could also be obtained from 2-chloro-3-benzoylpyridine on treatment with LDA. Mechanistic insight for the formation of these products is provided. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Safety of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Exploring Pairwise Chemical Crosslinking To Study Peptide-Receptor Interactions》 were Seidel, Lisa; Zarzycka, Barbara; Katritch, Vsevolod; Coin, Irene. And the article was published in ChemBioChem in 2019. Category: amides-buliding-blocks The author mentioned the following in the article:

Pairwise crosslinking is a powerful technique to characterize interactions between G protein coupled receptors and their ligands in the live cell. In this work, the “”thiol trapping”” method, which exploits the proximity-enhanced reaction between haloacetamides and cysteine, is examined to identify intermol. pairs of vicinal positions. By incorporating cysteine into the corticotropin-releasing factor receptor and either a-chloro- or a-bromoacetamide groups into its ligands, it is shown that thiol trapping provides highly reproducible signals and a low background, and represents a valid alternative to classical “”disulfide trapping””. The method is advantageous if reducing agents are required during sample anal. Moreover, it can provide partially distinct spatial constraints, thus giving access to a wider dataset for mol. modeling. Finally, by applying recombinant mini-Gs, GTPS, and Gas-depleted HEK293 cells to modulate Gs coupling, it is shown that yields of crosslinking increase in the presence of elevated levels of Gs. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Category: amides-buliding-blocks)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Suna, Yuki; Himeda, Yuichiro; Fujita, Etsuko; Muckerman, James T.; Ertem, Mehmed Z. published 《Iridium Complexes with Proton-Responsive Azole-Type Ligands as Effective Catalysts for CO2 Hydrogenation》.ChemSusChem published the findings.COA of Formula: C4H9NO2 The information in the text is summarized as follows:

Pentamethylcyclopentadienyl Ir (Cp*Ir) complexes with bidentate ligands consisting of a pyridine ring and an electron-rich diazole ring were prepared Their catalytic activity toward CO2 hydrogenation in 2.0 M KHCO3 aqueous solutions (pH 8.5) at 50°, under 1.0 MPa CO2/H2 (1:1) are reported as an alternative to photo- and electrochem. CO2 reduction Bidentate ligands incorporating an electron-rich diazole ring improved the catalytic performance of the Ir complexes compared to the bipyridine ligand. Complexes 2, 4, and 6, possessing both a hydroxy group and an uncoordinated NH group, which are proton-responsive and capable of generating pendent bases in basic media, recorded high initial turnover frequency values of 1300, 1550, and 2000 h-1, resp. Spectroscopic and computational studies revealed that the reversible deprotonation changes the electronic properties of the complexes and causes interactions between pendent base and substrate and/or solvent H2O mols., resulting in high catalytic performance in basic media. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1COA of Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.COA of Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Kai; Yang, Jianfeng; Li, Xiaoxun published their research in Organic Letters in 2021. The article was titled 《Palladium-Catalyzed Diastereo- and Enantioselective [3 + 2] Cycloaddition of Vinylcyclopropanes with Azadienes: Efficient Access to Chiral Spirocycles》.Reference of 4-Methylbenzenesulfonamide The article contains the following contents:

The first palladium(0)-catalyzed diastereo- and enantioselective [3 + 2] annulation of vinylcyclopropanes (VCPs) I (R = methoxycarbonyl, (2,2,2-trifluoroethoxy)carbonyl, cyano) and BDAs II (R1 = Me, 4-methylphenyl, 4-bromophenyl; R2 = H, 6-Cl, 5-Br, 6-OMe; R3 = Ph, naphthalen-1-yl, thiophen-2-yl, etc.; X = C, O, S) and 2-(phenylmethylidene)-2,3-dihydro-1-benzothiophen-3-one were reported. This transformation is featured with a broad substrate scope III and IV, allowing for facile access to a variety of enantioenriched spirocycles bearing a quaternary stereogenic center in good yields with excellent regio-, diastereo-, and enantioselectivities (up to 93% yield, >20:1 dr, and mostly >99% ee) under mild reaction conditions. Moreover, the spirocyclic products III and IV could be efficiently converted to structurally complex tricyclo[8.3.0.01,5]-azatridecane and tricyclo[7.3.0.01,5]-azadodecane skeletons. The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays》 was written by Kim, Da-Hye; Park, Chang Gyun; Kim, Young Jun. Application In Synthesis of 2-Bromoacetamide And the article was included in Chemosphere in 2020. The article conveys some information:

Exposure to disinfection byproducts (DBPs) is potentially related to cytotoxic, genotoxic, mutagenic, and tumorigenic effects in humans, in addition to their adverse effects on the environment. However, their impacts on endocrine disruption, especially reproductive toxicity, remain largely unknown. In this study, the estrogenic and androgenic activities of DBPs and corresponding antagonistic activities were investigated using a yeast-based reporter assay, focusing on haloacetic acids and haloacetamides. We also examined the cytotoxicity of DBPs and mechanisms of antagonistic activities. Of the DBPs assayed, iodoacetamide (IAM) and bromoacetamide (BAM) were the most cytotoxic, with LC50 values of 0.0462 and 0.0537 mM, resp., followed by chloroacetic acid (CAA; LC50 = 4.87 mM) and chloroacetamide (CAM; LC50 = 5.28 mM). Iodoacetic acid (IAA) and bromoacetic acid (BAA) were the least cytotoxic, with LC50 values of 5.52 and 6.35 mM, resp. IAA (EC10 = 0.00573 mM; EC50 = 0.0215 mM) exhibited most potent estrogenic activity, and CAA (EC10 = 0.0434 mM) and BAM (EC10 = 0.0150 mM) showed weak estrogenic and androgenic activities, resp. By contrast, IAM exhibited anti-estrogenic effects. These results suggest that DBPs interact with hormone receptors. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application In Synthesis of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics