Tag: 100-200

The analgesic properties of some substituted salicylamide derivatives was written by Carron, M.;Tabart, J.;Jullien, Mrs.. And the article was included in Therapie in 1952.Related Products of 19311-91-2 This article mentions the following:

Derivatives of salicylamide (I) were prepared; they had general formulas C₆H₄OH.CONRR’ or C₆H₄CONH₂. OR”. Their lethal doses (per os) and analgesic effects were determined by the Armour and Smith method (J. Pharm. Exptl. Therap. 72, 74, 1941). Introduction of hydrosol. groups, methoxylation, and acetylation of the phenolic function lowered the analgesic power; ethoxylation of the same increased it. Substitution of amide H by alkyls activated the analgesic effect from Et to iso-Pr, but Me and Bu derivatives had low activities. Hydrosol. functions introduced on the amide did not modify the effect of the products. Joining 2 I mols by a C₃ chain increased its effect, but a C₁ or C₂ linkage lowered the activity of the compounds Min. analgesic doses and lethal doses of the most active derivatives compared with acetylsalicylic acid (II) were: I 0.3, 0.6; N-diethyl-I 0.15, 0.85; o-ethoxybenzamide 0.2, 0.7; o-acetylsalicylureide 0.2, 0.3; methylol-I 0.24, 0.85; N-isopropyl-I 0.25, 0.65; propylenebis-I 0.26, 0.95; and II 0.4, 0.83 g./kg. weight of mice. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Related Products of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reactions of OH-radicals with procarbazine. A pulse radiolysis and computer simulation study was written by Delipetar-Grudl, A.;Solar, S.;Getoff, N.. And the article was included in Anticancer Research in 2006.Recommanded Product: 13255-50-0 This article mentions the following:

Pulse radiolysis was applied to study the reactivity of ^·OH radicals with procarbazine (PC), a cytostatic agent widely used in radiation- and chemotherapy. An overall rate constant of k(^·OH+PC)=3.7×10⁹ l.mol^-1.s^-1 was determined The thereby formed transients had a strong absorption at 350 nm, ε₃₅₀=4.46×10³ l.mol^-1.cm^-1, and a weak absorption band around 530 nm. Computer simulation studies to elucidate the most probable sites of ^·OH attack on the PC mol. showed that ^·OH radical addition to the aromatic ring had the highest probability. These transients decayed by a first order reaction, k=1.75×10³ s^-1, whereby species having a maximum absorption at 300 nm and broad shoulder at 340-380 nm were formed. Similar absorptions were observed after gamma radiolysis of PC. A reaction mechanism is suggested. For the reaction of H-atoms with PC, a rate constant k(^·H+PC)=6.4×10⁸ l.mol^-1.s^-1 was determined In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Recommanded Product: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors was written by Zhang, Han;Liu, Huan;Luo, Xiao;Wang, Yuxi;Liu, Yuan;Jin, Hongwei;Liu, Zhenming;Yang, Wei;Yu, Peilin;Zhang, Liangren;Zhang, Lihe. And the article was included in European Journal of Medicinal Chemistry in 2018.Electric Literature of C7H7ClN2O This article mentions the following:

In this study, a series of novel 2,3-dihydroquinazolin-4(1H)-one derivatives, e.g. I was subsequently synthesized and characterized. Their inhibitory activity against the TRPM2 channel was evaluated by calcium imaging and electrophysiol. approaches. Some of the compounds exhibited significant inhibitory activity, especially 6-bromo-8-methyl-2-[3-(2-naphthyl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-quinazolin-4-one which showed an IC₅₀ of 3.7μM against TRPM2 and did not affect the TRPM8 channel. The summarized structure-activity relationship (SAR) provided valuable insights for further development of specific TRPM2 targeted inhibitors. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Electric Literature of C7H7ClN2O).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Electric Literature of C7H7ClN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper porphyrin-catalyzed C(sp²)-O bond construction via coupling phenols with formamides was written by Yang, Shuang;Chen, Xiao-Yan;Xiong, Ming-Feng;Zhang, Hao;Shi, Lei;Lin, Dong-Zi;Liu, Hai-Yang. And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2021.SDS of cas: 19311-91-2 This article mentions the following:

Copper porphyrin-catalyzed construction of C(sp²)-O bond via coupling formamides with phenols was achieved firstly. A broad range of substrates afforded various carbamates R¹R²NC(O)OR [R¹ = 4-FC₆H₄, 3-CHOC₆H₄, 2-F₃CC₆H₄, etc.; R¹ = Me, Et; R² = Me, Et; R¹R² = CH₂CH₂OCH₂CH₂] in moderate to good yields with good functional group tolerance at low catalyst loading. Intermol. competing kinetic isotope effect experiment indicated that the generation of formamide radical was the rate-determining step of current cross-dehydrogenative coupling (CDC) reaction. The research extended the application of metalloporphyrin in CDC reaction. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2SDS of cas: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil was written by Bouteiller, Cedric;Becerril-Ortega, Javier;Marchand, Patrice;Nicole, Olivier;Barre, Louisa;Buisson, Alain;Perrio, Cecile. And the article was included in Organic & Biomolecular Chemistry in 2010.Product Details of 19311-91-2 This article mentions the following:

An operationally simple and concise synthesis of anilinoethanolamines, as NMDA NR2B receptor antagonist ifenprodil analogs, was developed via a copper-catalyzed amination of the corresponding bromoarene. Coupling was achieved with linear primary alkylamines, α,ω-diamines, hexanolamine and benzophenone imine, as well as with aqueous ammonia, in good yields using CuI and N,N-diethylsalicylamide, 2,4-pentadione or 2-acetylcyclohexanone as catalytic systems. Amination with ethylene diamine was efficient even in the absence of an additive ligand, whereas no reaction occurred with ethanolamine whatever the conditions used. The anilinoethanolamines were evaluated as NR2B receptor antagonists in a functional inhibition assay. Aminoethylanilines displayed inhibition effects close to that of ifenprodil. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Product Details of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

α₁-Adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines was written by Hodson, Stephen J.;Bigham, Eric C.;Garrison, Deanna T.;Gobel, Michael J.;Irving, Paul E.;Liacos, James A.;Navas, Frank;Saussy, David L.;Sherman, Bryan W.;Speake, Jason D.;Bishop, Michael J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Recommanded Product: N,N-Diethylsalicylamide This article mentions the following:

Literature reports suggest that disruption of an interhelical salt bridge is critical for α₁-adrenoceptor activation, and the basic amine found in adrenergic receptor ligands is responsible for the disruption. Novel 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles are agonists of the cloned human α₁-adrenoceptors in vitro, and potent, selective α_1A-adrenoceptor agonists have been identified in this series. These imidazoles demonstrate similar potencies and α₁-subtype selectivities as the corresponding 2-substituted imidazolines. The extremely close SAR suggests that, in spite of the large difference in basicity, these imidazoles and imidazolines may establish the same interactions to activate α₁-adrenoceptors. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An efficient synthesis of 3-cyano-1(3H)-isobenzofuranones was written by Okazaki, Kousuke;Nomura, Keiichi;Yoshii, Eiichi. And the article was included in Synthetic Communications in 1987.Formula: C11H15NO2 This article mentions the following:

Salicylamides I (R¹ = H, OMe, OCH₂OMe; R² = H, OMe, F; R³ = H, OMe; R⁴ = H, OMe, OCH₂OMe, F) were converted to phthalides II in two steps. I were treated with MeSiCN, KCN, and 18-crown-6 to yield cyanohydrin derivatives III, and the latter were kept in HOAc to give II. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Versatile and chemoselective transformation of aliphatic and aromatic secondary amides to nitriles was written by Geng, Hui;Huang, Pei-Qiang. And the article was included in Tetrahedron in 2015.Name: 4-Formyl-N-isopropylbenzamide This article mentions the following:

Triflic anhydride in combination with 2-fluoropyridine effectively dehydrates secondary amides to afford nitriles under mild reaction conditions. The reaction is general in scope and compatible with the use of aliphatic, α,β-unsaturated, aromatic and heteroaromatic amides bearing either secondary, tertiary, or benzylic N-alkyl groups. The reaction also shows good to excellent chemoselectivity for the secondary amide and tolerates several labile functional groups. Under optimized conditions the synthesis of the target compounds was achieved using amides as starting materials, such as N-(isopropyl)benzenebutanamide, N-(isopropyl)benzenepropanamide, adamantanecarboxamide derivatives, N-(tert-butyl)benzamide, 3-(phenyl)-2-propenamide derivatives (unsaturated amides), 1,3-benzodioxole-5-carboxamide, 2-thiophenecarboxamide (thiophene), benzo[b]thiophene-2-carboxamide derivatives, (aminocarbonyl)benzoic acid derivatives In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Name: 4-Formyl-N-isopropylbenzamide).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: 4-Formyl-N-isopropylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Metal-Free Thermal Activation of Molecular Oxygen Enabled Direct α-CH₂-Oxygenation of Free Amines was written by Ghosh, Santanu;Jana, Chandan K.. And the article was included in Journal of Organic Chemistry in 2018.Category: amides-buliding-blocks This article mentions the following:

Direct oxidation of α-CH₂ group of free amines is hard to achieve due to the higher reactivity of amine moiety. Therefore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence or absence of hazardous oxidants under sensitive reaction conditions. A novel method for direct C-H oxygenation of aliphatic amines through a metal-free activation of mol. oxygen has been developed. Both activated and unactivated free amines were oxygenated efficiently to provide a wide variety of amides (primary, secondary) and lactams under operationally simple conditions without the aid of metallic reagents and toxic oxidants. The method has been applied to the synthesis of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol and -buclosamide. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Category: amides-buliding-blocks).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita was written by Zhang, Ruifeng;Guo, Wei;Wang, Gaolei;Chen, Xiulei;Li, Zhong;Xu, Xiaoyong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Application In Synthesis of 2-Amino-4-fluorobenzamide This article mentions the following:

Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, I and II showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, resp. The influence of substituent type and position was studied. The relation between structure and activity was also preliminary analyzed. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Application In Synthesis of 2-Amino-4-fluorobenzamide).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application In Synthesis of 2-Amino-4-fluorobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics