Tag: 100-200

《Pd-catalyzed oxidative C-H/C-H cross-coupling of pyridines with heteroarenes》 was published in Chemical Science in 2013. These research results belong to Liu, Bo; Huang, Yumin; Lan, Jingbo; Song, Feijie; You, Jingsong. Electric Literature of C10H14N2O The article mentions the following:

The authors have developed for the first time a general, concise and highly selective method for the C2-heteroarylation of pyridines and related azines with a broad range of heteroarenes via a two-fold C-H activation, which streamlines the previous approaches that require the activated azine N-oxide as the coupling partner. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Electric Literature of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C7H9NO2SIn 2022 ,《Fluorogenic detection of sulfite in water by using copper(II) azacyclam complexes》 was published in Molecules. The article was written by Ciarrocchi, Carlo; Sacchi, Donatella; Boiocchi, Massimo; Weththimuni, Maduka Lankani; Orbelli Biroli, Alessio; Licchelli, Maurizio. The article contains the following contents:

Copper(II) azacyclam complexes (azacyclam = 1,3,5,8,12-pentaazacyclotetradecane) containing naphthyl or dansyl subunits can be prepared by template synthesis involving proper sulfonamide derivatives as locking fragments. The macrocyclic complexes are very poorly emissive due to the fluorescence-quenching behavior displayed by Cu2+ ions. However, the fluorescence can be recovered as a result of the decomposition of the complexes, which induces the release of free light-emitting subunits to the solution This reaction takes place very slowly in neutral water but its rate is increased by the presence of sulfite. Therefore, [Cu(azacyclam)]2+ derivatives have been investigated as simple chem. probes for the fluorogenic detection of sulfite both on laboratory and real samples. Preliminary tests performed on samples of white wine provided sulfite concentration values that are in agreement with those obtained by a standard anal. method. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 4-MethylbenzenesulfonamideIn 2021 ,《Bronsted Acid Promoted N-Dealkylation of N-Alkyl(sulfon)amides》 appeared in ChemistrySelect. The author of the article were Gu, Linghui; Wang, Yang; Cheng, Zemin; Sun, Yanan; Gong, Xin; Li, Zheyu; Ma, Wenbo. The article conveys some information:

A simple and efficient Bronsted-acid-promoted N-dealkylation of N-alkylsulfonamides RS(O)2NHR1 (R = 4-chlorophenyl, 1-naphthyl, thiophen-2-yl, etc.; R1 = t-Bu, cyclopropyl) and N-alkylamides R2C(O)NHR3 (R2 = benzyl, 1-naphthyl, biphenyl-2-yl, thiophen-3-yl, etc.; R3 = t-Bu, cyclopropyl) has been developed. This strategy features an ample substrate scope with excellent chem. selectivity, affording primary (sulfon)amide derivatives RS(O)2NH2 and R2C(O)NH2 in moderate to good yields without the need for transition-metal catalysts. After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Comparative studies on polysaccharides, triterpenoids, and essential oil from fermented mycelia and cultivated sclerotium of a medicinal and edible mushroom, Poria cocos》 was written by Wang, Dongdong; Huang, Chonggui; Zhao, Ye; Wang, Lin; Yang, Yongcheng; Wang, Anhua; Zhang, Yang; Hu, Gaosheng; Jia, Jingming. Product Details of 78191-00-1 And the article was included in Molecules in 2020. The article conveys some information:

Poria cocos, an important medicinal and edible fungus, is well known in East Asia. The main active components are water-soluble polysaccharides (WPS) and triterpenoids. Due to the growing market demand, long cultivation period, and consumption of pine trunk during cultivation, alternative methods for producing P. cocos or its active components should be investigated. In this study, WPS, triterpenoids, monosaccharide composition, and essential oil in fermented mycelia and cultivated sclerotium were analyzed using UV spectrophotometry, HPLC, pre-column derivatization, and HS-GC/MS, resp. Our results showed that the WPS and triterpenoids in mycelia are several times higher than those in sclerotium. Among the 62 compounds identified by HS-GC/MS anal. from the essential oil obtained from the fermentation media and a fresh external layer, the two main fragrances in common were linalool and Me phenylacetate. Our results suggested that it is applicable to produce polysaccharides and triterpenoids by the fermentation of P. cocos, and a strategy to improve triterpenoid production in the fermentation process was proposed. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Product Details of 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Product Details of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Gold-Catalyzed Synthesis of Chiral Cyclopentadienyl Esters via Chirality Transfer》 was written by Zhao, Ke; Hsu, Yu-Chen; Yang, Ziguang; Liu, Rai-Shung; Zhang, Liming. Application In Synthesis of N-Methoxy-N-methylacetamide And the article was included in Organic Letters in 2020. The article conveys some information:

Efficient access to chiral cyclopentadienyl esters from readily accessible chiral enynyl ester substrates is developed. Typically high levels of chirality transfer realized in this homogeneous gold catalysis are attributed to the intermediacy of a chiral bent allene gold complex. Cyclopentadienyl esters can be prepared in good yields and with excellent enantiomeric excesses. The synthetic utilities of the chiral cyclopentadienyl esters are demonstrated by the Diels-Alder reactions, fluorination, alkylation, and epoxidation without any notable erosion of enantiopurity. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Oxidative sulfamidation of vinyl silanes: A route to diverse silylated N-Heterocycles》 were Astakhova, Vera V.; Shainyan, Bagrat A.; Moskalik, Mikhail Yu.; Sterkhova, Irina V.. And the article was published in Tetrahedron in 2019. Product Details of 70-55-3 The author mentioned the following in the article:

The reaction of trimethyl(vinyl)silane 1 and dimethyl(divinyl)silane 2 with various sulfonamides in the oxidative system (tert-BuOCl + NaI) has been studied and shown to be an efficient approach for the synthesis of silylated N-heterocycles. Triflamide demonstrated the reactivity principally different from that of arenesulfonamides. With silane 1, it afforded the products of iodochlorination and bis(triflamidation) (major), whereas arenesulfonamides gave N-arenesulfonylaziridines in up to 91% yield. Silane 2 with arenesulfonamides yielded the products of mono and bis(iodochlorination), mono and bis(aziridination), and 3,5-diiodo-4,4-dimethyl-1-(arylsulfonyl)-1,4-azasilinanes. By contrast, triflamide, apart from the products of halogenation and iodotriflamidation, unexpectedly gave 3-(trifluoromethylsulfonyl)-5-(triflamido)oxazolidine as the main product. The structure of most heterocyclic products is proved by X-ray anal. The effect of the silyl group in the substrate and of the substituent in the reagent on the course of oxidative sulfamidation is discussed by comparing with all-carbon analogs.4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis of Imides, Imidates, Amidines, and Amides by Intercepting the Aryne-Isocyanide Adduct with Weak Nucleophiles》 were Ghorai, Sourav; Lee, Daesung. And the article was published in Organic Letters in 2019. Computed Properties of C7H9NO2S The author mentioned the following in the article:

New aryne-based multicomponent coupling reactions for the formation of functionalized aromatic compounds have been developed. Arynes generated from triynes or tetraynes through the hexadehydro Diels-Alder reaction readily react with isocyanide to generate nitrilium intermediate. Intercepting this nitrilium species with various weak nucleophile including carboxylic acids, alcs., sulfonamides, or water generated the corresponding imides, imidates, amidines, or amides. The high regioselectivity of these transformations was mainly controlled by the substituents of the arynes. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《A tandem coupling/Smiles rearrangement/cyclization approach to 1,4-benzoxazinone or 1,4-pyridooxazinones under mild conditions》 were Zhan, Chunjing; Jia, Jiong; Yang, Bingchuan; Huang, Aiping; Liu, Yanli; Ma, Chen. And the article was published in RSC Advances in 2012. Related Products of 4746-61-6 The author mentioned the following in the article:

A facile and efficient approach to 1,4-benzoxazinone or 1,4-pyridooxazinone scaffolds is developed by a Smiles rearrangement tandem reaction. 1,4-Benzoxazinone derivatives or 1,4-pyridooxazinone derivatives with diversity at two substituents on their scaffolds were synthesized conveniently in the presence of cesium carbonate at room temperature in good to excellent yields. The reaction mechanism is assumed by a tandem coupling/Smiles rearrangement/cyclization process. The synthesis of the target compounds was achieved using fluoro(nitro)benzene derivatives and chloro(nitro)benzene derivatives and 2-hydroxyacetamide derivatives as starting materials. The title compounds thus formed included 3,4-dihydro-3-oxo-4-phenyl-2H-1,4-benzoxazine-7-carbonitrile (I), 4-(phenylmethyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (II), 5-chloro-4-(phenylmethyl)-2H-1,4-benzoxazin-3(4H)-one (III) and related substances. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Related Products of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Related Products of 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rocca, Patrick; Marsais, Francis; Godard, Alain; Queguiner, Guy published an article in Tetrahedron. The title of the article was 《Connection between metalation and cross-coupling strategies. A new convergent route to azacarbazoles》.Computed Properties of C10H14N2O The author mentioned the following in the article:

New convergent synthesis of azacarbazoles through metalation, cross-coupling reaction, and intramol. substitution via (2-aminobenzene)boronic acid and ortho-fluoroiodopyridines are presented. Thus, 2-(HO)2BC6H4NHCOCMe3 coupled with pyridines I (X = F, Cl, Y = iodo, Z = H; X = H, Y = F, Z = iodo; X = H, Y = iodo, Z = F; X = iodo, Y = F, Z = H) to give the corresponding (pyridylphenyl)propanamides II (R = F, Cl). The 3-fluoro-4-pyridyl derivative of II was treated with pyridinium chloride under reflux to give β-carboline III. The α-, γ-, and δ-carbolines were prepared similarly. In the experiment, the researchers used many compounds, for example, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Computed Properties of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Computed Properties of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy published their research in Perkin 1 on December 21 ,2000. The article was titled 《Reaction of magnesiated bases on substituted pyridines: deprotonation or 1,4-addition?》.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide The article contains the following contents:

N-(tert.-Butyl)pyridine-2-carboxamide, N-phenylpyridine-2-carboxamide, and 2,2-dimethyl-N-(2-pyridyl)propanamide are readily deprotonated at C-3 with a stoichiometric amount of iso-PrMgCl or Bu2Mg in THF under reflux. Subsequent trapping with various electrophiles (deuterated water, aldehydes, iodine and di-Me disulfide) gives 2,3-disubstituted pyridines carrying a useful carboxylic acid- or amino-derived function at C-2. When N-(tert.-butyl)pyridine-3-carboxamide and 2,2-dimethyl-N-(3-pyridyl)propanamide are subjected to the same reaction conditions, 1,4-addition to the pyridine ring occurs, giving 4-alkyl derivatives Starting from N-(tert-butyl)pyridine-4-carboxamide, 1,2-addition and deprotonation reactions occur simultaneously. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics