Tag: 100-200

The author of 《Kinetics and mechanistic study of oxidation of paracetamol: an accelerated catalytic approach》 were Negi, Reena; Jain, Bhawana; Singh, Sunita; Singh, Ajaya Kumar; Asthana, Anupama. And the article was published in SN Applied Sciences in 2019. Quality Control of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

In the present paper, a simple, and novel method for the abatement of paracetamol (PA) in aqueous system into environmental friendly compound benzoquinone at 308 K has been described, and was accelerated by simple, and inexpensive catalyst Cu(II)/Ni(II). A comparative assessment between Cu(II) and Ni(II)catalyzed, abatement of PA by CAT was performed. It has been determined that there are very little change in rate of reaction for both Cu(II)/Ni(II) catalyzed degradation of PA. All the kinetics parameters, i.e. the effect of change in concentrations of chloramine-T (CAT), sodium hydroxide, paracetamol, catalyst, added p-toluenesulfonamide, electrolyte etc. have been studied, and measured carefully. Reaction had been studied in the range of temperature 303-323 K. On the basis of kinetic data obtained a satisfactory mechanism has been proposed. And it was deduced that, presently used process was a tenable technique for the degradation of PA. Main abatement product was confirmed by GC-MS anal. technique. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Marcyk, Paul T.; Cook, Silas P.. Safety of 4-Methylbenzenesulfonamide. The article was titled 《Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes》. The information in the text is summarized as follows:

The hydrofunctionalization of alkenes, explored for over 100 years, offers the potential for a direct, atom-economical approach to value-added products. While thermodynamically favored, the kinetic barrier to such processes necessitates the use of catalysts to control selectivity and reactivity. Modern variants typically rely on noble metals that require different ligands for each class of hydrofunctionalization, thereby limiting generality. This Letter describes a general iron-based system that catalyzes the hydroamination and hydroetherification of simple unactivated olefins. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Ge, Jing-Jie; Yao, Chuan-Zhi; Wang, Mei-Mei; Zheng, Hong-Xing; Kang, Yan-Biao; Li, Yadong published 《Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp3)-C(sp2) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes》.Organic Letters published the findings.Formula: C4H9NO2 The information in the text is summarized as follows:

A transition-metal-free deacylative C(sp3)-C(sp2) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and com. abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Miletin, Miroslav; Hartl, J.; Odlerova, Z.; Machacek, M. published an article in Pharmazie. The title of the article was 《Synthesis of some 2,6-bis(alkylthio)-4-pyridinecarboxamides and -carbothioamides and their antimycobacterial and antialgal activity》.Application of 89281-13-0 The author mentioned the following in the article:

Various 2,6-bis(alkylthio)-4-pyridinecarboxamides were prepared by treatment of 2,6-dichloro-4-pyridinecarboxamide with 1-alkanethiols. Subsequent reaction with Lawesson’s reagent gave the corresponding thioamides. The thioamides especially showed antimycobacterial activity; some of them inhibited chlorophyll production of Chlorella vulgaris. In the experiment, the researchers used 2,6-Dichloroisonicotinamide(cas: 89281-13-0Application of 89281-13-0)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 89281-13-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 64479-78-3On November 1, 2018 ,《Synthesis and characterization of one, two and three-dimensional Cu(I) polymers supported by bipyridylamide ligands》 appeared in Polyhedron. The author of the article were Mugenzi, Clement; Powell, Douglas R.; Gerasimchuk, Nikolay N.; Yang, Lei. The article conveys some information:

Reaction of bipyridylamide ligands N-(3-pyridyl)nicotinamide (3-pna), N-(4-pyridyl)nicotinamide (4-pna) and N-(4-pyridyl)isonicotinamide (4-pina) with Cu(I) salts afforded four coordination polymers. The prepared complexes are [Cu(3-pna)2]SbF6 (1), [Cu(4-pna)2]SbF6 (2), [Cu(4-pina)(CH3CN)2]SbF6 (3), {[Cu2(4-pna)4](SbF6)2(H2O)}n (4), and [Cu(4-bpe)2](SbF6) (5). X-ray crystallog. anal. showed one-, two- and three-dimensional networks. The correlation between the pyridyl nitrogen donor disposition and dimensionality of the structures is discussed. Reflectance UV-visible and fluorescence spectroscopic methods were used to characterize the MLCT features of these complexes. Thermal stability of the coordination polymers under nitrogen was also studied. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application of 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 70-55-3In 2019 ,《Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement》 was published in Nature Communications. The article was written by Zhou, Bo; Zhang, Ying-Qi; Zhang, Kairui; Yang, Ming-Yang; Chen, Yang-Bo; Li, You; Peng, Qian; Zhu, Shou-Fei; Zhou, Qi-Lin; Ye, Long-Wu. The article contains the following contents:

Here a metal-free intramol. hydroalkoxylation/[1,3]-rearrangement was reported, leading to the practical and atom-economical assembly of valuable medium-sized lactams such as I [R1 = Me, Et, Ph; R2 = Me, Ph, 2-naphthyl, etc.; R3 = 8-Me, 9-Cl, 8-Br, etc.; R4 = SO2Ph, Ts, Bs] with wide substrate scope and excellent diastereoselectivity. Moreover, such an asym. cascade cyclization was realized by chiral Bronsted acid-catalyzed kinetic resolution In addition, antitumor activity tests revealed that that some of these medium-sized lactams displayed their bioactivity as antitumor agents against melanoma cells, esophageal cancer cells and breast cancer cells. A mechanistic rationale for the reaction was further supported by control experiments and theor. calculations The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 70-55-3In 2019 ,《High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides》 was published in Organic Letters. The article was written by Becica, Joseph; Hruszkewycz, Damian P.; Steves, Janelle E.; Elward, Jennifer M.; Leitch, David C.; Dobereiner, Graham E.. The article contains the following contents:

Through targeted high-throughput experimentation (HTE), authors have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chem. AdBippyPhos is particularly effective for the installation of heteroaromatic groups. Computational steric parametrization of the investigated ligands reveals the potential importance of remote steric demand, where a large cone angle combined with an accessible Pd center is correlated to successful catalysts for C-N coupling reactions. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 70-55-3In 2021 ,《Highly Selective and Catalytic C-N Bond Cleavage of Tertiary Sulfonamides: Scope and Mechanistic Insight》 was published in ACS Omega. The article was written by Bhattacharya, Aditya; Shukla, Pushpendra mani; Maji, Biswajit. The article contains the following contents:

A highly chemoselective C-N bond cleavage reaction of tertiary sulfonamides RN(CH2R1)S(O)2R2 (R = Ph, 3-chlorophenyl, 3,4-dimethoxyphenyl, etc.; R1 = 4-methoxyphenyl, 3,4-dimethoxyphenyl, 2-phenylethenyl, etc.; R2 = 4-methylphenyl, naphthalen-1-yl, 4-nitrophenyl, etc.) in the presence of catalytic Bi(OTf)3 is presented. A wide range of sulfonamide substrates smoothly furnished the corresponding C-N bond cleavage products RNHS(O)2R2 in good to excellent yields. Great efforts have been made to obtain insights into the reaction mechanism based on a series of control experiments and mass spectroscopy. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kong, Minjian; Meng, Yan; Fan, Lei; Yin, Chengxian; Chen, Qibin; Liu, Honglai published an article in 2021. The article was titled 《Experimental Study of Poly(1-Acetamide-3-vinylimidazolium Bromide) as a Corrosion Inhibitor for N80 Carbon Steel in HCl》, and you may find the article in ChemistrySelect.HPLC of Formula: 683-57-8 The information in the text is summarized as follows:

A poly(ionic liquid) (PIL), poly(1-acetamide-3-vinylimidazolium bromide) (PCVIB), was investigated as a potential hydrochloric acid corrosion inhibitor for N80 carbon steel (N80-CS) at 25 °C. In this work, the corrosion inhibition properties of PCVIB were monitored using weight loss, potential dynamic polarization (PDP), electrochem. impedance spectroscopy (EIS), SEM (SEM) and XPS. Results show that the maximum inhibition efficiency (IE, η) of PCVIB can reach up to 95.8 %, whereas its monomer only exhibits a low IE of η=33.6 % under the same conditions. Moreover, PCVIB is characteristic of a mixed type inhibitor, which can effectively impede both cathodic hydrogen evolutions and metal dissolution reactions. Addnl., the adsorption of PCVIB on steel surfaces obeys the Langmuir adsorption isotherm. This finding implies that the polymerization can be a viable and facile method to create the high-efficiency inhibitor from monomeric units that were found or used with the poor IE previously. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.HPLC of Formula: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kubasov, Alexey S.; Turyshev, Evgeniy S.; Novikov, Ivan V.; Gurova, Olga M.; Starodubets, Polina A.; Golubev, Aleksei V.; Zhizhin, Konstantin Yu.; Kuznetsov, Nikolay T. published their research in Polyhedron in 2021. The article was titled 《Theoretical and experimental comparison of the reactivity of the sulfanyl-closo-decaborate and sulfanyl-closo-dodecaborate anions and their mono-S-substituted derivatives》.Application In Synthesis of 2-Bromoacetamide The article contains the following contents:

In this work, we have extended the method proposed by Gabel for the preparation of mono- and di-S,S-substituted derivatives of sulfanyl-closo-dodecaborate anion [B12H11SH]2- to derivatives of the closo-decaborate anion. The method is based on the β-elimination of the propionitrile group of sulfonium derivatives [BnHn-1S(R)CH2CH2CN]- in the presence of bases with the formation of the corresponding mono-S-substituted derivatives and acrylonitrile. We also calculated the Fukui functions for the nucleophilic attack of the S-atom in the [B10H9SH]2- and [B12H11SH]2- anions and their mono-S-substituted derivatives using the Hirshfeld approach. As a result, the calculated value of nucleophilicity in the [B10H9SH]2- anion was found to be 5-10 times lower than in other compounds, which completely agrees with the exptl. data. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application In Synthesis of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics