Tag: 100-200

Liu, Peng; Yang, Jiazhi; Ai, Yao; Hao, Shushu; Chen, Xiaozhong; Li, Feng published their research in Journal of Catalysis in 2021. The article was titled 《Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate》.Category: amides-buliding-blocks The article contains the following contents:

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines RNH2 [R = octyl, adamantan-1-yl, naphthalen-2-yl, 1,3-benzoxazol-2-yl, etc.], 1,2,3,4-tetrahydroisoquinoline and 1,3-bis(4-piperidyl)propane with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products RNHCH3, RN(CH3)2, 2-methyl-1,2,3,4-tetrahydroisoquinoline and 1-methyl-4-(3-(1-methylpiperidin-4-yl)propyl)piperidine/R1S(O)2NH(CH3) (R1 = t-Bu, cyclopropyl, 4-chlorophenyl, thiophen-2-yl, etc.) were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst Cp*Ir@CTF could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalyst Cp*Ir@CTF for hydrogen autotransfer process. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Category: amides-buliding-blocks)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Direct Intramolecular Aminoboration of Allenes》 was written by Yang, Chun-Hua; Han, Meng; Li, Wenyan; Zhu, Ningning; Sun, Zhenzhen; Wang, Junjie; Yang, Zhantao; Li, Yue-Ming. COA of Formula: C7H9NO2S And the article was included in Organic Letters in 2020. The article conveys some information:

Direct intramol. aminoboration of sulfonamidoallenes was realized using BCl3 as a boron source. The reactions benefited from the interaction between BCl3 and sulfonamides and provided a variety of borylvinyl heterocycles, e.g. I, in good isolated yields. When chiral substrates were involved in the reactions, high stereoselectivity was observed, as can be ascertained by single-crystal X-ray diffraction experiments Derivatization of the thus-obtained borylvinyl compounds proceeded readily, and different functionalities could be obtained via oxidation, halogenation, and Suzuki coupling reactions. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation》 was published in Organic Letters in 2020. These research results belong to Lim, Soobin; Cho, Hyungdo; Jeong, Jongheon; Jang, Minjae; Kim, Hyunseok; Cho, Seung Hwan; Lee, Eunsung. Formula: C4H9NO2 The article mentions the following:

Transition-metal-catalyzed transformations of the C-F bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein the authors report a practical Co-catalyzed silylation of aryl fluorides that uses a cheap electrophilic Si source with Mg. This method is compatible with various Si sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic Si source. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Regio- and Diastereoselective Spirocyclopropanation of Benzofuran-Derived Azadienes through 1,4-Addition-Induced Dearomatization Reaction under Mild Conditions》 was published in Organic Letters in 2020. These research results belong to Fang, Qing-Yun; Yi, Meng-Hao; Wu, Xiao-Xia; Zhao, Li-Ming. Recommanded Product: 4-Methylbenzenesulfonamide The article mentions the following:

A Cs2CO3-mediated [2 + 1] cycloaddition of benzofuran-derived azadienes (BDAs) with bromomalonate by using a dearomatization strategy has been developed. Through this process, BDAs serve as a potential 2-atom synthon in the construction of a range of functionalized spirocyclopropane derivatives, such as spirobenzofuran-2-cyclopropanes and spiroindane-2-cyclopropanes. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Trans-Selective hydrocyanation of ynoates, ynones and ynoic acids catalyzed by nucleophilic phosphines》 was written by Schoemberg, Fritz; Peric, Milica; Meyer, Maximilian; Vilotijevic, Ivan. Formula: C4H9NO2This research focused ontrimethylsilyl cyanide phenyl propynoate methyldiphenylphosphine catalyst diastereoselective hydrocyanation; cyano phenyl acrylate regioselective preparation; trimethylsilanecarbonitrile phenyl propynoic acid methyldiphenylphosphine catalyst diastereoselective hydrocyanation; phenyl cyano acrylic acid regioselective preparation. The article conveys some information:

Trans-Selective hydrocyanation of ynoates and ynones in the presence of TMSCN and an alc. additive were catalyzed by nucleophilic phosphines. The trisubstituted E-olefin products of anti-addition of hydrogen cyanide to the alkyne were produced with high regio- and stereoselectivity. The alc. additive reacts with TMSCN to produce hydrogen cyanide in situ. Ynoic acids underwent the phosphine catalyzed hydrocyanation in the presence of TMSCN under aprotic conditions only. In these reactions, TMSCN reacted with the acid to generate hydrogen cyanide and the silyl ester which, unlike the acid, undergoes phosphine catalyzed hydrocyanation and gave the stereo-defined E-2-cyano-acrylic acids after work up.N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Stereoselective organo-catalyzed glycosylation – thiouracil, thioureas and mono-thio-phthalimide act as Bronsted acid catalysts at low loadings》 was written by Bradshaw, G. A.; Colgan, A. C.; Allen, N. P.; Pongener, I.; Boland, M. B.; Ortin, Y.; McGarrigle, E. M.. Synthetic Route of C7H9NO2SThis research focused ontrehalose disaccharide synthesis stereoselective glycosylation catalyst Schreiner thiourea; hydrogen bonding Bronsted acid base catalysis deoxyglycoside glycoconjugate synthesis; stereoselective glycosylation catalyst galactal thiouracil thiophthalimide amino acid. The article conveys some information:

Thiouracil catalyzes stereoselective glycosylations with galactals in loadings as low as 0.1 mol%. It is proposed that in these glycosylation thiouracil, monothiophthalimide, and the previously reported catalyst, Schreiner′s thiourea, do not operate via a double H-bonding mechanism but rather by Bronsted acid/base catalysis. In addition to the synthesis of 2-deoxyglycosides and glycoconjugates, we report the first organo-catalytic synthesis of 1,1′-linked trehalose-type sugars.4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Donor disposition and aliphatic conformation effects on structure in luminescent zinc dicarboxylate coordination polymers with isomeric dipyridylamide coligands》 was published in CrystEngComm in 2013. These research results belong to Uebler, Jacob W.; Wilson, Julie A.; LaDuca, Robert L.. Recommanded Product: N-(Pyridin-4-yl)isonicotinamide The article mentions the following:

Hydrothermal reaction of zinc nitrate, a four-carbon chain dicarboxylic acid, and one of three isomeric dipyridylamide coligands has afforded a family of six new coordination polymers, which were structurally characterized by single-crystal x-ray diffraction. The binding modes and conformations of the dicarboxylate ligands and the nitrogen donor disposition within the dipyridylamide coligands provide crucial structure-directing roles in this system. {[Zn(fum)(3-pina)]·1.5H2O}n (1, fum = fumarate, 3-pina = 3-pyridylisonicotinamide) has a 4-fold interpenetrated 43628 sra topol. [Zn(fum)(4-pna)]n (2, 4-pna = 4-pyridylnicotinamide) possesses a 4-fold interpenetrated 66dia topol., while [Zn(fum)(4-pina)]n (3, 4-pina = 4-pyridylisonicotinamide) has a 2-fold interpenetrated 41263pcu topol. with dimeric cluster nodes. [Zn3(mal)2(OH)2(4-pina)2]n (4, mal = maleate) has neutral [Zn3(mal)2(OH)2]n ribbons linked into a (3,6) triangular layer. [Zn(suc)(4-pina)]n (5, suc = succinate) displays an uncommon 6-connected self-penetrated 446108 mab topol., while instead [Zn(suc)(4-pna)]n (6) has a simple corrugated (4,4) grid structure. Thermal and luminescent properties of these new materials also were studied. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Recommanded Product: N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Recommanded Product: N-(Pyridin-4-yl)isonicotinamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 4-MethylbenzenesulfonamideIn 2019 ,《The N-alkylation of sulfonamides with alcohols in water catalyzed by a water-soluble metal-ligand bifunctional iridium complex [Cp*Ir(biimH2)(H2O)][OTf]2》 was published in New Journal of Chemistry. The article was written by Ai, Yao; Liu, Pengcheng; Liang, Ran; Liu, Yan; Li, Feng. The article contains the following contents:

The iridium complex [Cp*Ir(biimH2)(H2O)][OTf]2 (Cp* = η5-pentamethylcyclopentadienyl, biimH2 = 2,2′-biimidazole) was synthesized and developed as a new-type of water-soluble metal-ligand bifunctional catalyst for the N-alkylation of poorly nucleophilic sulfonamides with alcs. in water. In the presence of catalyst (1 mol%) and Cs2CO3 (0.1 equivalent), a series of desirable products was obtained in 74-91% yields under microwave irradiation Mechanistic experiments revealed that the presence of NH units in the imidazole ligand was crucially important for the catalytic activity of the iridium complex. Notably, this research would facilitate the process of water-soluble metal-ligand bifunctional catalysis for the hydrogen autotransfer process. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Fuhao; Zeng, Jingwen; Gao, Mohan; Wang, Linzhou; Chen, Gen-Qiang; Lu, Yixin; Zhang, Xumu published their research in Nature Chemistry in 2021. The article was titled 《Concise, scalable and enantioselective total synthesis of prostaglandins》.HPLC of Formula: 78191-00-1 The article contains the following contents:

Prostaglandins are among the most important natural isolates owing to their broad range of bioactivities and unique structures. However, current methods for the synthesis of prostaglandins suffer from low yields and lengthy steps. Here, we report a practicability-oriented synthetic strategy for the enantioselective and divergent synthesis of prostaglandins. In this approach, the multiply substituted five-membered rings in prostaglandins were constructed via the key enyne cycloisomerization with excellent selectivity (>20:1 d.r., 98% e.e.). The crucial chiral center on the scaffold of the prostaglandins was installed using the asym. hydrogenation method (up to 98% yield and 98% e.e.). From our versatile common intermediates, a series of prostaglandins and related drugs could be produced in two steps, and fluprostenol could be prepared on a 20-g scale. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1HPLC of Formula: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.HPLC of Formula: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines》 were Akram, Manjur O.; Das, Avishek; Chakrabarty, Indradweep; Patil, Nitin T.. And the article was published in Organic Letters in 2019. Quality Control of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates. The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics