Tag: 100-200

The author of 《Making Carbonyls of Amides Nucleophilic and Hydroxyls of Alcohols Electrophilic Mediated by SO2F2 for Synthesis of Esters from Amides》 were Fang, Wan-Yin; Zha, Gao-Feng; Qin, Hua-Li. And the article was published in Organic Letters in 2019. Electric Literature of C4H9NO2 The author mentioned the following in the article:

The promotion of sulfuryl fluoride, the carbonyl groups of amides performed as nucleophiles while the hydroxyl groups of alcs. were activated to functionalize as electrophiles is reported. This study displayed that the amide C-N bonds could be easily cleaved with delicate nucleophiles to form the ester C-O bonds at room temperature without using transition metals. The broad substrate scope and excellent functional group compatibility were proved with 44 examples in up to 99% yields. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Electric Literature of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Electric Literature of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stockmann, Vegar; Fiksdahl, Anne published their research in Tetrahedron on August 4 ,2008. The article was titled 《Preparation of new pyrido[3,4-b]thienopyrroles and pyrido[4,3-e]thienopyridazines》.Category: amides-buliding-blocks The article contains the following contents:

Two new types of pyrido-fused tris-heterocycles (1a,b and 2a,b) were prepared from 3-aminopyridine in five/six steps. A synthetic strategy for the preparation of the novel pyrido[3,4-b]thieno[2,3- and 3,2-d]pyrroles (1a,b) and pyrido[4,3-e]thieno[2,3- and 3,2-c]pyridazines (2a,b) was studied. The Suzuki cross coupling of the appropriate 2- and 3-thienoboronic acids (3,4) and 4-bromo-3-pyridylpivaloylamide (9) afforded the biaryl coupling products (10,11) in high yields (85%). Diazotization of the hydrolyzed (2-thienyl)-coupling product (12) and azide substitution gave the 3-azido-4-(2-thienyl)pyridine intermediate (72%, 14). 3-Azido-4-(3-thienyl)pyridine (15) was prepared by exchanging the previous order of reactions. The desired β-carboline thiophene analogs (1a,b) were obtained via the nitrene by thermal decomposition of the azido precursors (14,15). By optimizing conditions for intramol. diazocoupling, the corresponding pyridazine products (72-83%, 2a,b) were afforded. After reading the article, we found that the author used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Category: amides-buliding-blocks)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2015,CrystEngComm included an article by Forgan, Ross S.; Marshall, Ross J.; Struckmann, Mona; Bleine, Aurore B.; Long, De-Liang; Bernini, Maria C.; Fairen-Jimenez, David. Synthetic Route of C11H9N3O. The article was titled 《Structure-directing factors when introducing hydrogen bond functionality to metal-organic frameworks》. The information in the text is summarized as follows:

The introduction of H-bond donor/acceptor functionality into metal-organic frameworks (MOFs) can have a beneficial effect on their mol. recognition, uptake selectivity and catalytic properties. The changes in ligand geometry induced by incorporation of functional groups may also affect the topol. and composition of the resultant MOFs. Herein, the authors present a comprehensive study of functional group incorporation into MOFs, linked by either Zn2+ paddlewheel units or monomeric Zn2+ corners, which exhibit pcu and dia topol., resp. Crystallog. anal. shows that amide groups can be easily incorporated into isoreticular pcu pillared-MOFs, while integration of urea units results in materials with dia topol. Mol. simulations allow the examination of hypothetical structures with differing constitutions and topologies, and highlight the influence of the urea units in generating the exptl. observed topologies. Noncovalent interactions between independent nets may be significant structure-directing influences, a finding which has great implications for the design of MOFs containing more complex functional groups. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Synthetic Route of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Synthetic Route of C11H9N3O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C10H14N2OOn March 15, 2011, Metro, Thomas-Xavier; Fayet, Christine; Arnaud, Florian; Rameix, Nathalie; Fraisse, Pierre; Janody, Simon; Sevrin, Mireille; George, Pascal; Vogel, Rachel published an article in Synlett. The article was 《Synthesis of 2,2-disubstituted azaindolines by intramolecular cyclization in acidic media》. The article mentions the following:

The synthesis of a diverse array of 2,2-disubstituted azaindolines, e.g. I, is reported. The bicyclic core is built by a simple acidic treatment of conveniently substituted aminopyridines. The results came from multiple reactions, including the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Synthetic Route of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn May 2, 2009 ,《Formation of new 4-isocyanobut-2-enenitriles by thermal ring cleavage of 3-pyridyl azides》 appeared in Tetrahedron. The author of the article were Stockmann, Vegar; Bakke, Jan M.; Bruheim, Per; Fiksdahl, Anne. The article conveys some information:

A new thermal ring cleavage of 3-pyridyl nitrenes for the formation of 4-isocyanobut-2-enenitrile products is reported. Thermolysis of 4-(thien-3-yl)-3-pyridyl azide and 3-azido-4-(1-TIPS-1H-pyrrol-3-yl)pyridine afforded two new isonitrile-nitrile products by ring cleavage; 4-isocyano-2-(thiophen-3-yl)but-2-enenitrile (I, 27%) and 4-isocyano-2-(1-TIPS-1H-pyrrol-3-yl)but-2-enenitrile (II, 20%), in addition to the previously reported pyrido[3,4-b]thienopyrrole (29%) and pyrido[3,4-b]pyrrolo[3,2-d]pyrrole (71%) products. Minor amounts of 2-(thien-3-yl)-1H-pyrrole-3-carbonitrile (III, 6%), formed by ring contraction, were also isolated after thermolysis of 4-(thien-3-yl)-3-pyridyl azide. Isonitriles I and II underwent degradation into amine and formamide, resp., by acidic hydrolysis. The nature and chem. of compounds I, III and II were investigated.2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of N-Methoxy-N-methylacetamideIn 2019 ,《Asymmetric synthesis of natural cis-dihydroarenediols using tetrahydroxynaphthalene reductase and its biosynthetic implications》 was published in Organic Letters. The article was written by Saha, Nirmal; Muller, Michael; Husain, Syed Masood. The article contains the following contents:

Asym. reduction of hydroxynaphthoquinones to secondary metabolites, (3S,4R)-3,4,8- and (2S,4R)-2,4,8-trihydroxy-1-tetralone, a putative biosynthetic diketo intermediate and a probable natural analog, (3S,4R)-7-acetyl-3,4,8-trihydroxy-6-methyl-3,4-dihydronaphthalene-1(2H)-one, using NADPH-dependent tetrahydroxynaphthalene reductase (T4HNR) of Magnaporthe grisea is described. This work implies the involvement of T4HNR or related enzymes during the (bio)synthesis of other dihydroarenediols by reduction of the hydroxynaphthoquinone scaffold containing substrates. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Reference of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C2H4BrNOIn 2021 ,《Semaphorin 3A-glycosaminoglycans interaction as therapeutic target for axonal regeneration》 was published in Pharmaceuticals. The article was written by Perez, Yolanda; Bonet, Roman; Corredor, Miriam; Domingo, Cecilia; Moure, Alejandra; Messeguer, Angel; Bujons, Jordi; Alfonso, Ignacio. The article contains the following contents:

Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance mol., inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with Sema3A signaling is proposed as a therapeutic target for achieving functional recovery after CNS injuries. It has been shown that Sema3A adheres to the proteoglycan component of the extracellular matrix (ECM) and selectively binds to heparin and chondroitin sulfate-E (CS-E) glycosaminoglycans (GAGs). We hypothesize that the biol. relevant interaction between Sema3A and GAGs takes place at Sema3A C-terminal polybasic region (SCT). The aims of this study were to characterize the interaction of the whole Sema3A C-terminal polybasic region (Sema3A 725-771) with GAGs and to investigate the disruption of this interaction by small mols. Recombinant Sema3A basic domain was produced and we used a combination of biophys. techniques (NMR, SPR, and heparin affinity chromatog.) to gain insight into the interaction of the Sema3A C-terminal domain with GAGs. The results demonstrate that SCT is an intrinsically disordered region, which confirms that SCT binds to GAGs and helps to identify the specific residues involved in the interaction. NMR studies, supported by mol. dynamics simulations, show that a new peptoid mol. (CSIC02) may disrupt the interaction between SCT and heparin. Our structural study paves the way toward the design of new mols. targeting these protein-GAG interactions with potential therapeutic applications. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8COA of Formula: C2H4BrNO) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.COA of Formula: C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: N-Methoxy-N-methylacetamideIn 2016 ,《A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives》 appeared in Tetrahedron. The author of the article were Gilbert, Eric J.; Brunskill, Andrew; Cai, Jiaqiang; Cai, Yaxian; Chu, Xin-Jie; Dai, Xing; Hao, Jinsong; Kuethe, Jeffrey T.; Lai, Zhong; Liu, Hong; Mu, Cuizhi; Qi, Yan; Scott, Jack D.; Taoka, Brandon; Truong, Quang; Walsh, Shawn P.; Wu, Wen-Lian; Cumming, Jared N.. The article conveys some information:

A novel domino reaction for the preparation of non-racemic β-proline derivatives is reported. The addition of a Me 2-(oxetan-3-yl)acetate titanium enolate to chiral tert-butanesulfinyl ketimines followed by an intramol. oxetane ring-opening provides the highly-substituted pyrrolidine ring systems with three contiguous stereogenic centers. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Name: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Tilby, Michael J.; Dewez, Damien F.; Pantaine, Loic R. E.; Hall, Adrian; Martinez-Lamenca, Carolina; Willis, Michael C. published an article in ACS Catalysis. The title of the article was 《Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates》.Reference of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

A plethora of drug mols. and agrochems. contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates. This methodol. exploits a metal-free photocatalytic approach to access radical chem., which is harnessed by combining pharmaceutically relevant sulfonamides with an assortment of alkene fragments. Addnl., the sulfinate anion can be readily obtained, further broadening the options for sulfonamide functionalization. Mechanistic studies suggest that energy-transfer catalysis (EnT) is in operation. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C11H9N3OOn October 7, 2013 ,《Metastable Interwoven Mesoporous Metal-Organic Frameworks》 was published in Inorganic Chemistry. The article was written by He, Yabing; Guo, Zhiyong; Xiang, Shengchang; Zhang, Zhangjing; Zhou, Wei; Fronczek, Frank R.; Parkin, Sean; Hyde, Stephen T.; O’Keeffe, Michael; Chen, Banglin. The article contains the following contents:

Three isostructural interwoven 3,4-connected mesoporous metal-organic frameworks of pto-a topol. [M3(BTN)2(H2O)3]·x(solv) (H3BTN = 6,6′,6”-benzene-1,3,5-triyl-2,2′,2”-trinaphthoic acid; solv = DMF or DEF) (UTSA-28-Cu, UTSA-28-Zn, and UTSA-28-Mn) were prepared and structurally characterized. Because of their metastable nature, their gas sorption properties are highly dependent on the metal ions and activation profiles. The most stable acetone activated MOF, UTSA-28a-Cu, exhibits promising gas storage and separation capacities. In the part of experimental materials, we found many familiar compounds, such as N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Formula: C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Formula: C11H9N3O The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics