Tag: 100-200

Computed Properties of C11H9N3OOn October 31, 2007 ,《Conformation dependent network structures in the coordination polymers derived from pyridylisonicotinamides, carboxylates and Co(II): entrapment of (H2O)14 water cluster of an unprecedented topology》 appeared in CrystEngComm. The author of the article were Kumar, D. Krishna; Das, Amitava; Dastidar, Parthasarathi. The article conveys some information:

Four coordination polymers, [{(H2O)4Co(μ-L1)}·fumarate·2H2O]n (1), [{(H2O)3(μ-fumarate)Co(μ-L1)}·fumarate·2H2O]n (2), [{(H2O)4Co(μ-L2)}·terephthalate·3H2O]n (3) and [{(H2O)4Co(μ-L2)}·terephthalate·5H2O]n (4, L1 = N-(3-pyridyl)nicotinamide, L2 = N-(4-pyridyl)isonicotinamide) were synthesized and structurally characterized mainly by single crystal x-ray diffraction techniques to explore the effect of H bond functionalized backbone and ligating topologies on the resultant supramol. architectures in mixed ligand systems containing dicarboxylates as counter bridging anions. The counter bridging anions fumarate and terephthalate failed to coordinate to the metal centers in 1 and 3-4, resp.; fumarate, however, terminally connects to the metal centers in 4 resulting in the ladder topol. A (H2O)14 water cluster, having unprecedented topol., was found entrapped in the lattice of 4. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Computed Properties of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Computed Properties of C11H9N3OAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: 4-MethylbenzenesulfonamideIn 2020 ,《A New Endoplasmic Reticulum (ER)-Targeting Fluorescent Probe for the Imaging of Cysteine in Living Cells》 appeared in Journal of Fluorescence. The author of the article were Zhou, Lei; Li, Yunxia; Zhou, Aiqin; Zhang, Guanghui; Cheng, Zhi-Qiang; Ge, Yong-Xi; Liu, Shan-Kui; Azevedo, Ricardo Bentes; Zhang, Juan; Jiang, Shenglin; Jiang, Cheng-Shi. The article conveys some information:

A review. Abstract: Cysteine (Cys) is an important endogenous amino acid and plays critical physiol. roles in living systems. Herein, an endoplasmic reticulum (ER)-targeting fluorescent probe (FER-Cys) was designed and prepared for imaging of Cys in living cells. The probe FER-Cys consists of a fluorescein framework as the fluorescent platform, acrylate group as the response site for the selective recognition of Cys, and ER-specific p-toluenesulfonamide fragment. After the response of probe FER-Cys to Cys, a turn-on fluorescence signal at 546 nm could be detected obviously. The probe FER-Cys further shows desirable selectivity to Cys. Finally, the probe FER-Cys was proven to selectively detect Cys in live cells and successfully image the changes of Cys level in the cell models of H2O2-induced redox imbalance. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Epton, Ryan G.; Unsworth, William P.; Lynam, Jason M. published an article in Organometallics. The title of the article was 《Selectivity, Speciation, and Substrate Control in the Gold-Catalyzed Coupling of Indoles and Alkynes》.SDS of cas: 78191-00-1 The author mentioned the following in the article:

A convenient and mild protocol for the Au-catalyzed intermol. coupling of substituted indoles with carbonyl-functionalized alkynes to give vinyl indoles is reported. This reaction affords 3-substituted indoles in high yield, and in contrast to the analogous reactions with simple alkynes which give bisindolemethanes, only a single indole is added to the alkyne. The protocol is robust and tolerates substitution at a range of positions of the indole and the use of ester-, amide- and ketone-substituted alkynes. The use of 3-substituted indoles as substrates results in the introduction of the vinyl substituent at the 2-position of the ring. A combined exptl. and computational mechanistic study revealed that the Au catalyst has a greater affinity to the indole than the alkyne, despite the C-C bond formation step proceeding through an η2(π)-alkyne complex, which helps to explain the Stark differences between the intra- and intermol. variants of the reaction. Also the addition of a 2nd indole to the carbonyl-containing vinyl indole products is both kinetically and thermodynamically less favored than in the case of more simple alkynes, providing an explanation for the observed selectivity. Finally, a highly unusual Au-promoted alkyne dimerization reaction to form a substituted Au pyrylium salt was identified and studied. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hess, Andreas; Prohaska, Jan P.; Doerrich, Sabrina B.; Trauner, Florian; Lutter, Ferdinand H.; Lemaire, Sebastien; Wagschal, Simon; Karaghiosoff, Konstantin; Knochel, Paul published an article in 2021. The article was titled 《Directed regioselective ortho,ortho’-magnesiations of aromatics and heterocycles using sBu2Mg in toluene》, and you may find the article in Chemical Science.Synthetic Route of C4H9NO2 The information in the text is summarized as follows:

The development of a toluene-soluble dialkylmagnesium base sec-Bu2Mg was reported. This new reagent allows mild and regioselective ortho-magnesiations of various N-arylated pyrazoles as well as arenes bearing oxazolines, phosphorodiamidate or amide directing groups e.g., I. The resulting diarylmagnesium reagents e.g., II were further functionalized either by Pd-catalyzed arylation or by trapping reactions with a broad range of electrophiles e.g., allyl bromide. Furthermore, several double ortho,ortho;-magnesiations were realized in the case of aryl oxazolines, N-aryl pyrazoles as well as 2-aryl-2H-1,2,3-triazoles e.g., IIIby simply repeating the magnesiation/electrophile trapping sequence allowing the preparation of valuable 1,2,3-functionalized arenes e.g., IV. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl-O-(tert-butyl)hydroxylamine, t-BuONSO》 was written by Davies, Thomas Q.; Tilby, Michael J.; Skolc, David; Hall, Adrian; Willis, Michael C.. Related Products of 70-55-3 And the article was included in Organic Letters in 2020. The article conveys some information:

Sulfonamides have played a defining role in the history of drug development and continue to be prevalent today. In particular, primary sulfonamides are common in marketed drugs. Here we describe the direct synthesis of these valuable compounds from organometallic reagents and a novel sulfinylamine reagent, t-BuONSO. A variety of (hetero)aryl and alkyl Grignard and organolithium reagents perform well in the reaction, providing primary sulfonamides in good to excellent yields in a convenient one-step process. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gaskin, Gabrielle J.; LaDuca, Robert L. published an article in IUCrData. The title of the article was 《Poly[diaqua[μ4-2-(carboxylatomethoxy)benzoato][μ2-2-(carboxylatomethoxy)benzoato]dicadmium(II)]》.Electric Literature of C11H9N3O The author mentioned the following in the article:

In the title compound, [Cd2(C9H6O5)2(H2O)2]n, the crystallog. distinct CdII cations are coordinated in pentagonal-bipyramidal and octahedral fashions. The 2-(carboxymethoxy)benzoate (cmb) ligands connect the Cd atoms into [Cd2(cmb)2(H2O)2)]n coordination polymer ribbons that are oriented along the a-axis direction. Supramol. layers are formed parallel to (01 [inline formula omitted] ) by O-H···O hydrogen bonding between the ribbons. The supramol. three-dimensional crystal structure of the title compound is then constructed by π-π stacking interactions with a centroid-centroid distance of 3.622 (2) Å between cmb ligands in adjacent layer motifs. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Electric Literature of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Electric Literature of C11H9N3OAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocksOn September 16, 2016 ,《Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids》 was published in Organic Letters. The article was written by Zhu, Yan-Ping; Sergeyev, Sergey; Franck, Philippe; Orru, Romano V. A.; Maes, Bert U. W.. The article contains the following contents:

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with com. reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols. In the experimental materials used by the author, we found 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Category: amides-buliding-blocks)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 2-Hydroxy-N-phenylacetamideOn May 31, 2008, Gomez, Maria J.; Sirtori, Carla; Mezcua, Milagros; Fernandez-Alba, Amadeo R.; Agueera, Ana published an article in Water Research. The article was 《Photodegradation study of three dipyrone metabolites in various water systems: Identification and toxicity of their photodegradation products》. The article mentions the following:

The photochem. behavior of 3 relevant metabolites of the analgesic and antipyretic drug dipyrone, 4-methylaminoantipyrine (4-MAA), 4-formylaminoantipyrine (4-FAA) and 4-acetylaminoantipyrine (4-AAA), was evaluated under simulated solar irradiation (Suntest system). For 4-MAA, different aqueous solutions (synthetic seawater, freshwater and Milli-Q water) as well as different operational conditions were compared. According to the exptl. results, 4-MAA resulted as being an easily degraded mol. by direct photolysis, with half-life times (t1/2) ranging from 0.12 to 0.58 h, depending on the irradiation conditions. Faster degradation was observed in synthetic waters, suggesting that the photolysis was influenced by the salt composition of the waters. However, no effect on the degradation rate was observed by the presence of natural photosensitizers (dissolved organic matter, nitrate ions). 4-FAA and 4-AAA showed slower photodegradation kinetics, with t1/2 of 24 and 28 h, resp. A study of photoproduct identification was carried out by gas chromatog.-mass spectrometry (GC-MS) and liquid chromatog.-time-of-flight mass spectrometry (LC-TOF-MS) (ESI pos. mode), which allowed us to propose a tentative photodegradation pathway for 4-MAA and the identification of persistent byproducts in all the cases. The application of an acute toxicity test (Daphnia magna) showed an increase in toxicity during the photolytic process, a consequence of the formation of toxic photoproducts. The results came from multiple reactions, including the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Recommanded Product: 2-Hydroxy-N-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Unexpected right-handed helical nanostructures co-assembled from L-phenylalanine derivatives and achiral bipyridines》 was published in Chemical Science in 2017. These research results belong to Liu, Guofeng; Liu, Jinying; Feng, Chuanliang; Zhao, Yanli. Application of 64479-78-3 The article mentions the following:

The construction of chiral supramol. systems with desirable handedness is of great importance in materials science, chem., and biol. since chiral nanostructures exhibit fascinating photophys. properties and unique biol. effects. Herein, we report that achiral bipyridines can co-assemble with L-phenylalanine derivatives into unexpected right-handed helical nanostructures rather than a left-handed helix via intermol. hydrogen bonding interactions formed between the pyridyl and carboxylic groups. This study opens up a route to develop chiral nanostructures with desirable handedness via the co-assembly of simple mol. building blocks and provides a straightforward insight into the chirality control of nanostructures in supramol. systems. In addition to this study using N-(Pyridin-4-yl)isonicotinamide, there are many other studies that have used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application of 64479-78-3) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Application of 64479-78-3 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Novel primary amide-based cationic metal complexes: green synthesis, crystal structures, Hirshfeld surface analysis and solvent-free cyanosilylation reaction》 was written by Markad, Datta; Khullar, Sadhika; Mandal, Sanjay K.. SDS of cas: 683-57-8This research focused ontransition metal bispyridinylmethyldiacetamideethylene complex preparation thermal stability; crystal structure transition metal bispyridinylmethyldiacetamideethylene complex. The article conveys some information:

A new sym. and flexible primary amide functionalized ligand, 2,2′-(ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))diacetamide (2-BPEG), was synthesized and structurally characterized. Using this multidentate ligand, four novel metal complexes, [Cu(2-BPEG)](ClO4)2·0.5H2O (1), [Zn(2-BPEG)](ClO4)2 (2), [Zn(2-BPEG)](ZnCl4)·H2O (3) and [Cd(2-BPEG)(H2O)](ClO4)2·H2O (4), were synthesized under ambient conditions and characterized by elemental, spectroscopic and thermal anal., and single and powder x-ray diffraction. Complexes 1-3 are hexacoordinated with an N4O2 donor set (provided by the hexadentate 2-BPEG ligand), while complex 4 is heptacoordinated with an addnl. coordinated water mol. In all cases, the 2-BPEG ligand acts as a hexadentate ligand. A change in the starting metal salt gave 2 and 3 with different tetrahedral anions, ClO4- and ZnCl4-, resp. This provided an opportunity to showcase anion-directed supramol. networks for these compounds Compounds 1, 2 and 4 with perchlorate anions show similar and comparable intermol. interactions in their 3-dimensional networks. However, the supramol. self-assembly of 3 is dominated by a variety of intermol. interactions such as C-H···Cl, N-H···Cl, O-H···Cl and C-H···O due to the presence of a tetrachlorozincate(II) ion. Also, the role of weak intermol. interactions in the crystal packing was analyzed and quantified using Hirshfeld surface anal. Also, compound 4 exhibiting an open Lewis acid site is a very efficient and recyclable heterogeneous catalyst for the solvent-free cyanosilylation of various aldehydes with trimethylsilyl cyanide (TMSCN) producing the corresponding trimethylsilyl ether in high yields. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8SDS of cas: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.SDS of cas: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics