Tag: 100-200

Application of 70-55-3In 2019 ,《A Practical Method for the Preparation of Sulfonyl Chlorides and Sulfonamides from Thiols using H2O2-TAPC Reagent System》 was published in ChemistrySelect. The article was written by Parnian, Rouhallah; Soleimani, Ebrahim; Bahrami, Kiumars. The article contains the following contents:

H2O2 in the presence of TAPC (1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-chloride) as an effective and chemoselective reagent system was described for the direct conversion of thiols to sulfonyl chlorides. Upon reaction with amines, the desired sulfonamides were produced in excellent yields and in short reaction times. Mild conditions, metal-free process, and excellent selectivity are some of the advantages of this method. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Application of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C4H9NO2In 2020 ,《Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Jin, Ru-Yi; Tang, Tian; Zhou, Sha; Long, Xu; Guo, Hui; Zhou, Jing; Yan, Hao; Li, Zhi; Zuo, Zheng-Yu; Xie, Hong-Lei; Tang, Yu-Ping. The article conveys some information:

PI3Kα has been identified as an ideal target to treat with PIK3CA gene mutation disease, including drugs such as Alpelisib and Copanlisib. Five purine analogs and four thiazole analogs were designed and synthesized. Their enzymic activity against PI3Ka/β/γ/δ were tested, resp. All compounds showed excellent selectivity in modulating PI3Ka activity, and parts of the compounds showed good inhibition. Meanwhile, Autodock 4.2 was used to explore the binding mode of I (X = CH2), the most potent compound, with the target protein. In addition, DFT was used to calculate the HOMO-LUMO maps of the compounds I (X = CH2, O)and pos. control. This paper will provide some useful information for further drug design of PI3Kα inhibitors. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Jaskolski, Mariusz; Wlodawer, Alexander; Dauter, Zbigniew; Minor, Wladek; Rupp, Bernhard published an article in Protein Science. The title of the article was 《Group depositions to the Protein Data Bank need adequate presentation and different archiving protocol》.Electric Literature of C7H9NO2S The author mentioned the following in the article:

A polemic in response to Berman H et al is given. Accurate exptl. determined structure models of biol. macromols. are used by a large and diverse community of researchers. It is an established practice to base the assessment of the structure model quality on both, expectations of correct stereochem. and, most importantly, on examination of the model’s fit to the primary exptl. evidence. In the case of Xray crystallog., the primary evidence is provided by the electron d. map. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Ingham, Aidan; Wharton, Luke; El Sayed, Tarek; Southcott, Lily; McNeil, Brooke L.; Ezhova, Maria B.; Patrick, Brian O.; Jaraquemada-Pelaez, Maria de Guadalupe; Orvig, Chris published an article in Inorganic Chemistry. The title of the article was 《H2ampa-Versatile Chelator for [203Pb]Pb2+, [213Bi]Bi3+, and [225Ac]Ac3+》.Recommanded Product: 683-57-8 The author mentioned the following in the article:

A new decadentate chelator, H2ampa, was designed to be a potential radiopharmaceutical chelator component. The chelator involves both amide and picolinate functional groups on a large non-macrocyclic, ether-bridged backbone. With its large scaffold, H2ampa was paired with [nat/203Pb]Pb2+, [nat/213Bi]Bi3+, and natLa3+/[225Ac]Ac3+ ions. NMR spectroscopy and high-resolution mass spectrometry were used to study the non-radioactive metal complexes. A single crystal of [Bi(ampa)](NO3) was obtained; its asym., 10-coordinate complex structure was revealed by X-ray diffraction. Optimal conformations of the metal complexes were assessed by d. functional theory studies to provide further structural information. Solution studies providing thermodn. insights into metal complex formation revealed H2ampa coordinated Bi3+, Pb2+, and La3+ ions to obtain pM values of 26, 14.8, and 15.1, resp. Preliminary concentration-dependent radiolabeling experiments were carried out between H2ampa and three different radiometals to evaluate their compatibility for radiopharmaceutical applications. The chelator radiolabeled [203Pb]Pb2+, [213Bi]Bi3+, and [225Ac]Ac3+ in short reaction times (7-30 min), at dilute concentrations, and under mild conditions. Thus, H2ampa was proven to be a versatile chelator able to well coordinate a small range of radiometals frequently considered to be alpha therapeutic candidates.2-Bromoacetamide(cas: 683-57-8Recommanded Product: 683-57-8) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Recommanded Product: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ingham, Aidan; Kostelnik, Thomas I.; McNeil, Brooke L.; Patrick, Brian O.; Choudhary, Neha; Jaraquemada-Pelaez, Maria de Guadalupe; Orvig, Chris published their research in Dalton Transactions in 2021. The article was titled 《Getting a lead on Pb2+-amide chelators for 203/212Pb radiopharmaceuticals》.Computed Properties of C2H4BrNO The article contains the following contents:

Amide-based chelators DTPAm, EGTAm and ampam were synthesized to investigate which chelator most ideally coordinates [nat/203Pb]Pb2+ ions for potential radiopharmaceutical applications. 1H NMR spectroscopy was used to study each metal-ligand complex in the solution state. The 1H NMR spectrum of [Pb(DTPAm)]2+ revealed minimal isomerization and fluxional behavior compared to [Pb(EGTAm)]2+ and [Pb(ampam)]2+, both of which showed fewer spectral changes indicative of less static behavior. The solid-state coordination properties of each complex were also examined from single crystal structures that were studied by X-ray diffraction (XRD). In the solid-state, octadentate DTPAm coordinated Pb2+ to form an eight-coordinate hemidirected complex; octadentate EGTAm coordinated Pb2+ forming a ten-coordinate holodirected complex with a bidentate NO3- ion also coordinated to the metal center; decadentate ampam completely encapsulated the Pb2+ ion to form a ten-coordinate holodirected complex with a C2 axis of symmetry. Potentiometric titrations were carried out to assess the thermodn. stability of each metal-ligand complex. The pM values obtained for [Pb(DTPAm)]2+, [Pb(EGTAm)]2+ and [Pb(ampam)]2+ were 9.7, 7.2 and 10.2, resp. The affinity of each chelator for Pb2+ ions was tested by [203Pb]Pb2+ radiolabeling studies to evaluate their prospects as chelators for [203/212Pb]Pb2+-based radiopharmaceuticals. DTPAm radiolabeled [203Pb]Pb2+ ions achieving molar activities as high as 3.5 MBq μmol-1 within 15 min, at 25°C, whereas EGTAm and ampam produced lower molar activities of 0.25 MBq μmol-1 within 30 min, at 37°C. EGTAm and ampam were therefore deemed unsuitable for [203/212Pb]Pb2+-based radiopharmaceutical applications, while DTPAm warrants further studies. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Computed Properties of C2H4BrNO)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Computed Properties of C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Vanadium-Catalyzed Coupling of Allenols with Electrophilic Halide Sources for the Formation of α-Halo-α’,β’-unsaturated Ketones》 were Trost, Barry M.; Tracy, Jacob S.; Yusoontorn, Tas. And the article was published in Organic Letters in 2019. Product Details of 78191-00-1 The author mentioned the following in the article:

In the presence of tris(triarylsiloxy)oxovanadium complexes, allenyl alcs. such as PhCH(OH)CH:C:CHMe underwent chemoselective and diastereoselective fluorination, chlorination, and bromination (coupling reactions) with electrophilic halogen sources to yield α’-halo-α,β-unsaturated ketones such as (E)-PhCH:CHCOCHRMe (R = F, Cl, Br)(I) as single olefin diastereomers. Nucleophilic substitution reactions of I (R = Br) yielded I (R = N3, NC, PhS, I).N-Methoxy-N-methylacetamide(cas: 78191-00-1Product Details of 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Papamicael, Cyril; Dupas, Georges; Queguiner, Guy; Bourguignon, Jean published their research in Heterocycles on December 31 ,1998. The article was titled 《Regioselective metalation of γ-carbolines》.SDS of cas: 70298-88-3 The article contains the following contents:

The synthesis of new 3-substituted γ-carbolines is described, and these products were subjected to ortho-lithiation experiments Whereas 3-carboxamido derivatives [I; R = CONHCMe3, CON(CHMe2)2] were cleanly lithiated at the 4-position, the 3-amino derivatives (I; R = NHCOOCMe3, NHCOCMe3) gave only small amounts of addition products. The results were compared to those previously published in the α-carboline series, and semiempirical calculations were performed. Various 3,4-disubstituted γ-carbolines were obtained in acceptable yields. The experimental part of the paper was very detailed, including the reaction process of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3SDS of cas: 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.SDS of cas: 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nguyen, Trang T.; Hull, Kami L. published their research in ACS Catalysis on December 2 ,2016. The article was titled 《Rhodium-Catalyzed Oxidative Amidation of Sterically Hindered Aldehydes and Alcohols》.Related Products of 70298-88-3 The article contains the following contents:

In the presence of Rh(cod)2BF4, either 1,4-bis(diphenylphosphino)butane, tricyclohexylphosphine, or Xantphos, and either styrene, Me methacrylate, or α,α,α-trifluoroacetophenone with cesium acetate in THF, pivaldehyde or β,β-disubstituted alcs. underwent oxidative amidation with aliphatic and aromatic amines to yield hindered α,α-disubstituted amides in 25-94% yields. Mechanistic studies were performed to gain insight into the catalytic cycles for aldehyde and alc. amidation. The results came from multiple reactions, including the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Related Products of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Zafon, Elisenda; Echevarria, Igor; Barrabes, Silvia; Manzano, Blanca R.; Jalon, Felix A.; Rodriguez, Ana M.; Massaguer, Anna; Espino, Gustavo published an article in Dalton Transactions. The title of the article was 《Photodynamic therapy with mitochondria-targeted biscyclometallated Ir(III) complexes. Multi-action mechanism and strong influence of the cyclometallating ligand》.Formula: C2H4BrNO The author mentioned the following in the article:

Photodynamic therapy is an alternative to classical chemotherapy due to its potential to reduce side effects by a controlled activation of a photosensitizer through local irradiation with light. The photosensitizer then interacts with oxygen and generates reactive oxygen species. Iridium biscyclometallated complexes are very promising photosensitizers due to their exceptional photophys. properties and their ability to target mitochondria. Four Ir(III) biscyclometallated complexes of formula [Ir(C^N)2(N^N′)]Cl, where N^N′ is a ligand containing a benzimidazolyl fragment, have been synthesized and characterized. The C^N ligands were 2-phenylpyridinate (ppy) and 2-(2,4-difluorophenyl)pyridinate (dfppy). The complexes exhibited high photostability. The electrochem. and photophys. properties were modulated by both the cyclometallating and the ancillary ligands. The dfppy derivatives yielded the highest emission energy values, quantum yields of phosphorescence and excited state lifetimes. All complexes generated 1O2 in aerated solutions upon irradiation Biol. studies revealed that these complexes have a moderate cytotoxicity in the dark against different human cancer cell lines: prostate (PC-3), colon (CACO-2) and melanoma (SK-MEL-28), and against non-malignant fibroblasts (CCD-18Co). However, derivatives with ppy ligands ([1a]Cl, [2a]Cl) yielded a relevant photodynamic activity upon light irradiation (450 nm, 24.1 J cm-2), with phototoxicity indexes (EC50,dark/EC50,light) of 20.8 and 17.3, resp., achieved in PC-3 cells. Mechanistic studies showed that these complexes are taken up by the cells through endocytosis and preferentially accumulate in mitochondria. Upon photoactivation, the complexes induced mitochondrial membrane depolarization and DNA damage, thus triggering cell death, mainly by apoptosis. Complex [1a]Cl is also able to oxidize NADH. This mitochondria-targeted photodynamic mechanism greatly inhibited the reproductive capacity of cancer cells and provides a valuable alternative to traditional chemotherapy for the controlled treatment of cancer.2-Bromoacetamide(cas: 683-57-8Formula: C2H4BrNO) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Formula: C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Castro, Goretti; Wang, Gaoji; Gambino, Tanja; Esteban-Gomez, David; Valencia, Laura; Angelovski, Goran; Platas-Iglesias, Carlos; Perez-Lourido, Paulo published an article in 2021. The article was titled 《Lanthanide(III) Complexes Based on an 18-Membered Macrocycle Containing Acetamide Pendants. Structural Characterization and paraCEST Properties》, and you may find the article in Inorganic Chemistry.HPLC of Formula: 683-57-8 The information in the text is summarized as follows:

We report a detailed investigation of the coordination properties of macrocyclic lanthanide complexes containing a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane scaffold functionalized with four acetamide pendant arms. The X-ray structures of the complexes with the large Ln3+ ions (La and Sm) display 12- and 10-coordinated metal ions, where the coordination sphere is fulfilled by the six N atoms of the macrocycle, the four O atoms of the acetamide pendants, and a bidentate nitrate anion in the La3+ complex. The analogous Yb3+ complex presents, however, a 9-coordinated metal ion because one of the acetamide pendant arms remains uncoordinated. 1H NMR studies indicate that the 10-coordinated form is present in solution throughout the lanthanide series from La to Tb, while the smaller lanthanides form 9-coordinated species. 1H and 89Y NMR studies confirm the presence of this structural change because the two species are present in solution Anal. of the 1H chem. shifts observed for the Tb3+ complex confirms its D2 symmetry in aqueous solution and evidences a highly rhombic magnetic susceptibility tensor. The acetamide resonances of the Pr3+ and Tb3+ complexes provided sizable paraCEST effects, as demonstrated by the corresponding Z-spectra recorded at different temperatures and studies on tube phantoms recorded at 22°C. A 10-coordinated Tb3+ complex shows remarkably a chem. exchange saturation transfer response with a temperature-sensitive chem. shift. In the experimental materials used by the author, we found 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.HPLC of Formula: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics