Tag: 100-200

《Preparation of Primary Amides from Functionalized Organozinc Halides》 was written by Schade, Matthias A.; Manolikakes, Georg; Knochel, Paul. Quality Control of 2,6-Dichloroisonicotinamide And the article was included in Organic Letters on August 20 ,2010. The article conveys some information:

Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly with com. available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dichloroisonicotinamide(cas: 89281-13-0Quality Control of 2,6-Dichloroisonicotinamide)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Quality Control of 2,6-Dichloroisonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 70-55-3In 2020 ,《Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines》 was published in Journal of Organic Chemistry. The article was written by Gou, Quan; Liu, Zining; Cao, Tuanwu; Tan, Xiaoping; Shi, Wenbing; Ran, Man; Cheng, Feixiang; Qin, Jun. The article contains the following contents:

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Dalton Transactions included an article by Pradhan, Rabindra N.; Chakraborty, Subhayan; Bharti, Pratibha; Kumar, Janesh; Ghosh, Arindam; Singh, Akhilesh K.. SDS of cas: 683-57-8. The article was titled 《Seven coordinate Co(II) and six coordinate Ni(II) complexes of an aromatic macrocyclic triamide ligand as paraCEST agents for MRI》. The information in the text is summarized as follows:

We are reporting Co(II) and Ni(II) complexes of a pyridine containing aromatic macrocyclic triamide ligand, 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetamide (TPTA), as paramagnetic chem. exchange saturation transfer (paraCEST) MRI contrast agents. The synthesis and characterization of TPTA and its complexes are reported. The solution chem. and solid-state structure of Co(II) and Ni(II) complexes are studied. Crystallog. data show that the [Co(TPTA)]·Cl2·2H2O complex (seven-coordinate, all four N atoms of ring and three amide O atoms) has a distorted pentagonal bipyramidal geometry, however the [Ni(TPTA)Cl]·Cl·0.25H2O complex (six-coordinate, all four N atoms of the ring, one amide O and one chloride ion) adopts a distorted octahedral geometry. Notably the two pendent amide arms are not coordinated in the [Ni(TPTA)Cl]+ complex and one chloride ion fulfils its sixth coordination. The CEST effect of [Co(TPTA)]2+ and [Ni(TPTA)Cl]+ amide protons is observed at 57 ppm and 78 ppm downfield of the bulk water proton resp. in a buffer solution containing 20 mM N-(2-hydroxyethyl)piperazine-N’-ethanesulfonic acid and 100 mM NaCl at pH 7.4 at 37 °C on a 9.4 T NMR spectrometer. The effects of CEST intensity and exchange rate constant with variation of pH of the solution were studied. The CEST effect and exchange rate constant for the amide protons of the [Co(TPTA)]2+ complex have been monitored in HEPES buffer, fetal bovine serum (FBS), rabbit serum and 4% agarose gel (weight/weight). The stability of the [Co(TPTA)]2+ complex in aqueous solution towards oxidation was verified by cyclic voltammetry measurement. The stability of [Co(TPTA)]2+ has further been monitored in the presence of biol. relevant ions including HPO42-, CO32-, and Zn2+ and under acidic conditions. The experimental process involved the reaction of 2-Bromoacetamide(cas: 683-57-8SDS of cas: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.SDS of cas: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocksOn November 3, 2014 ,《Large Thermal Hysteresis for Iron(II) Spin Crossover Complexes with N-(Pyrid-4-yl)isonicotinamide》 appeared in Inorganic Chemistry. The author of the article were Lochenie, Charles; Bauer, Wolfgang; Railliet, Antoine P.; Schlamp, Stephan; Garcia, Yann; Weber, Birgit. The article conveys some information:

Fe(II) 1-dimensional coordination polymers [FeL1(pina)]·xsolvent with L1 being a tetradentate N2O22- coordinating Schiff-base-like ligand [([3,3′]-[1,2-phenylenebis(iminomethylidyne)]bis(2,4-pentanedionato)(2-)-N,N’,O2,O2′], and pina being a bridging axial ligand N-(pyrid-4-yl)isonicotinamide, are discussed. The x-ray crystal structure of [FeL1(pina)]·2MeOH was solved for the low-spin state. The compound crystallizes in the monoclinic space group P21/c, and the anal. of the crystal packing reveals the formation of a H bond network where addnl. MeOH mols. are included. Different magnetic properties are observed for the seven samples analyzed, depending on the nature of the included solvent mols. The widest hysteresis loop is observed for a fine crystalline sample [FeL1(pina)]·xH2O/MeOH. The 88 K wide thermal hysteresis loop (T1/2↑ = 328 K and T1/2↓ = 240 K) is centered around room temperature and can be repeated without of a loss of the spin transition properties. For the single crystals of [FeL1(pina)]·2MeOH, a 51 K wide hysteresis loop is observed (T1/2↑ = 296 K and T1/2↓ = 245 K) that is also stable for several cycles. For a powder sample of [FeL1(pina)]·0.5H2O·0.5MeOH a cooperative spin transition with a 46 K wide hysteresis loop around room temperature is observed (T1/2↑ = 321 K and T1/2↓ = 275 K). This compound was further studied using Mossbauer spectroscopy and DSC. Both methods reveal that, in the cooling mode, the spin transition is accompanied by a phase transition while in the heating mode a loss of the included MeOH is observed that leads to a loss of the spin transition properties. The pina ligand was used successfully in a crystal-engineering-like approach to generate 1-dimensional coordination polymers and improve their spin crossover properties. In addition to this study using N-(Pyridin-4-yl)isonicotinamide, there are many other studies that have used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Category: amides-buliding-blocks) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Category: amides-buliding-blocks In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Development of carboxylic acid search prefilters for spectral library matching》 was published in Microchemical Journal in 2012. These research results belong to Lavine, Barry K.; Nuguru, Kadambari; Mirjankar, Nikhil; Workman, Jerome. Quality Control of 2-Hydroxy-N-phenylacetamide The article mentions the following:

435 IR absorbance spectra of 140 carboxylic acids and 295 noncarboxylic acids which included aldehydes, ketones, esters, amides as well as compounds containing both carbonyls and alcs. were preprocessed using the wavelet packet tree to enhance subtle but important features in the data. Wavelet coefficients that optimized the separation of the spectra by functional group in a plot of the two largest principal components of the data were identified using a genetic algorithm (GA) for pattern recognition anal. Because principal components maximize variance, the bulk of the information encoded by the wavelet coefficients selected by the pattern recognition GA is characteristic of the carboxylic acid functional group. The carboxylic acid search prefilter developed as part of this study was successfully validated using two external validation sets. The 1st validation set consisted of 24 carboxylic acids and 61 noncarboxylic acids and the 2nd validation set consisted of 264 carboxylic acids and 72 noncarboxylic acids. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Quality Control of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Quality Control of 2-Hydroxy-N-phenylacetamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C7H9NO2SIn 2020 ,《N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal-Ligand Bifunctional Dinuclear Iridium Catalyst》 was published in Journal of Organic Chemistry. The article was written by Meng, Chong; Liu, Peng; Nguyen, Thanh Tung; Han, Xingyou; Li, Feng. The article contains the following contents:

The N-methylation of amines with methanol in aqueous solution was proposed and accomplished by using a water-soluble metal-ligand bifunctional dinuclear iridium catalyst. In the presence of [(Cp*IrCl)2(thbpym)][Cl]2 (1 mol%), a range of desirable products were obtained in high yields under environmentally benign conditions. Notably, this research exhibited the potential of transition metal-catalyzed the activation of methanol as a C1 source for the construction of C-N bond in aqueous solution The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mohammadi, Susan; Mohammadi, Somayeh; Salimi, Abdollah; Ahmadi, Rezgar published an article in 2022. The article was titled 《A Chelation-enhanced Fluorescence Assay using Thiourea Capped Carbonaceous Fluorescent Nanoparticles for As (III) Detection in Water Samples》, and you may find the article in Journal of Fluorescence.Safety of 4-Methylbenzenesulfonamide The information in the text is summarized as follows:

Herein, we designed a sensitive and selective “”Turn-On”” fluorescence nanosensor using water-soluble carbonaceous fluorescent nanomaterials (CFNs) functionalized with thiourea (CFNs-Thiourea) for efficient detection of trace concentrations of arsenic (III) in aqueous samples. The CFNs and CFNs-Thiourea were characterized by transmission electron microscopy (TEM), UV-visible spectroscopy (UV-vis) and fourier transformed IR spectroscopy (FTIR). The emission peak intensity of proposed nanosensor at 425 nm was gradually enhanced on arsenite addition in a wide detection range (3.3-828.5μg L-1) attributed to the binding of arsenite species with sulfur groups of CFNs-Thiourea. The limit of detection (LOD) was 0.48μg L-1 being much lower than the World Health Organization (WHO) recommended threshold value of 10μg L-1. Furthermore, the as-prepared CFNs-Thiourea exhibited a superb selectivity for As (III) compared to various cations and anions, such as; NO3-, NO2-, F-, Ni2+, Fe3+, Cu2+, Ca2+, Mg2+, Zn2+, Fe2+, Hg2+, Pb2+, F-, Cl-, Mn2+, Cr3+, Co2+, Cd2+, Bi3+, Al3+ and As (V) at 100 folds concentration of As (III). The turn on fluorescence nanosensor was successfully exploited for quantification of arsenic in spiked water samples with acceptable efficiencies. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Safety of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《AuCl3-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis》 was published in Chemistry – A European Journal in 2020. These research results belong to Wang, Rui; Chen, Yi; Shu, Mao; Zhao, Wenwen; Tao, Maoling; Du, Chao; Fu, Xiaoya; Li, Ao; Lin, Zhihua. SDS of cas: 70-55-3 The article mentions the following:

A highly efficient AuCl3-catalyzed intramol. ring-closing carbonyl-olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes I (R = C(O)OEt, Ph, COPh, CONHPh; Ar = Ph, 3-methoxyphenyl, furan-2-yl, etc.), polycycles e.g., II, benzocarbocycles e.g., III, and N-heterocycle derivatives IV (R1 = Ph, 4-fluorophenyl, naphthalen-2-yl, etc.) in good to excellent yields.4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: N-Methoxy-N-methylacetamideIn 2018 ,《Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Yu, Tao; Li, Ning; Wu, Chengde; Guan, Amy; Li, Yi; Peng, Zhengang; He, Miao; Li, Jie; Gong, Zhen; Huang, Lei; Gao, Bo; Hao, Dongling; Sun, Jikui; Pan, Yan; Shen, Liang; Chan, Chichung; Lu, Xiulian; Yuan, Hongyu; Li, Yongguo; Li, Jian; Chen, Shuhui. The article conveys some information:

The identification and lead optimization of a series of pyridopyrimidinone derivatives are described as a novel class of efficacious dual PI3K/mTOR inhibitors, resulting in the discovery of (I). Compound I exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation in cell assays and good pharmacokinetic profile. Furthermore, compound I demonstrated in vivo efficacy in a PC-3M tumor xenograft model. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hu, Xiao-Qiang; Hou, Ye-Xing; Liu, Zi-Kui; Gao, Yang published an article in 2021. The article was titled 《Ruthenium-catalyzed C-H/C-N bond activation: facile access to isoindolinones》, and you may find the article in Organic Chemistry Frontiers.Name: 4-Methylbenzenesulfonamide The information in the text is summarized as follows:

A facile ruthenium-catalyzed C-H/C-N bond activation and the subsequent annulation of readily available benzoic acids with in situ generated formaldimines was reported. The choice of solvent and base was critical for this reaction. This protocol allowed the efficient synthesis of a wide range of biol. important isoindolinones I [R = Ts, 4-ClC6H4SO2, 4-t-BuC6H4SO2, 4-F3COC6H4SO2; R1 = H, Me, Ph, etc.; R2 = H, Br, OPh, etc.; R3 = H, n-Bu, Cl, etc.; R4 = H, Cl, Br; R1R2 = (CH2)4; R2R3 = CH=CH-CH=CH] in useful to excellent yields without the use of any external oxidants. The late-stage modification of bioactive acids such as adapalene, bexarotene and flufenamic acid demonstrated the synthetic utility of this methodol. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics