Tag: 100-200

Macsim, Ana-Maria; Georgescu, Emilian; Georgescu, Florentina; Filip, Petru; Nicolescu, Alina; Deleanu, Calin published an article in 2021. The article was titled 《Benzimidazolium salts as starting materials or intermediates in 1,3-dipolar cycloadditions》, and you may find the article in Monatshefte fuer Chemie.Name: 2-Bromoacetamide The information in the text is summarized as follows:

Several new benzimidazolium salts was synthesized and fully characterized by multinuclear NMR spectroscopy. The benzimidazolium salts occurred as intermediates in various 1,3-dipolar cycloadditions and they were also useful as starting materials in such cycloadditions In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Jiaxin; Wei, Yin; Shi, Min published an article in 2021. The article was titled 《Visible light mediated synthesis of 4-aryl-1,2-dihydronaphthalene derivatives via single-electron oxidation or MHAT from methylenecyclopropanes》, and you may find the article in Organic Chemistry Frontiers.Computed Properties of C4H9NO2 The information in the text is summarized as follows:

A direct single-electron oxidation of methylenecyclopropanes (MCPs) I (R = H, 2-Me, 3-OMe, 4-F, etc.; R1 = H, 2-Me, 3-Cl, 4-F, etc.) for the rapid construction of 4-aryl-1,2-dihydronaphthalene derivatives II (R2 = H, 5-Me, 6-OMe, 7-F, etc.; R3 = H, F) and III (R4 = R5 = H, F) by merging visible light photoredox catalysis and cobalt catalysis was reported. In MeCN with Et3N·3HF (1.0 equivalent), the fluorination of MCPs I can be realized in the presence of 9-mesityl-10-methylacridinium perchlorate and Co(dmgH)2PyCl, affording fluorinated 4-aryl-1,2-dihydronaphthalene derivatives II (R3 = F) in moderate yields. In MeCN/HFIP (7 : 3), 4-aryl-1,2-dihydronaphthalene derivatives II (R3 = H) and III were obtained in good yields through a metal-catalyzed hydrogen atom transfer process under similar conditions. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Computed Properties of C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Yang; Liu, Jian; Kamounah, Fadhil S.; Ciancaleoni, Gianluca; Lee, Ji-Woong published their research in Journal of Organic Chemistry in 2021. The article was titled 《A CO2-Catalyzed Transamidation Reaction》.SDS of cas: 78191-00-1 The article contains the following contents:

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Herein, a report on the use of CO2 as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular, N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation vs. a N2 atmosphere. Comparative Hammett studies and kinetic anal. were conducted to elucidate the catalytic activation mechanism of mol. CO2, which was supported by DFT calculations The pos. effect of CO2 in the transamidation reaction was attributed to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.SDS of cas: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Targeted Synthesis of Trimeric Organic-Bromoplumbate Hybrids That Display Intrinsic, Highly Stokes-Shifted, Broadband Emission》 was written by Febriansyah, Benny; Neo, Chong Shern Daniel; Giovanni, David; Srivastava, Shivani; Lekina, Yulia; Koh, Teck Ming; Li, Yongxin; Shen, Ze Xiang; Asta, Mark; Sum, Tze Chien; Mathews, Nripan; England, Jason. Name: 2-Bromoacetamide And the article was included in Chemistry of Materials in 2020. The article conveys some information:

Zero-dimensional (0D) hybrid organic-inorganic lead halides have been shown to display efficient broadband photoluminescence and are, therefore, of significant interest for artificial lighting applications. However, work that investigates the formability of the materials as a function of templating organic cation structure are rare. This severely limits our ability to rationally design new materials displaying specific structural and photophys. properties. With the goal of accessing rare 0D trimeric bromoplumbates, we have systematically varied templating N-alkylpyridinium cations and examined their impact upon inorganic lattice structure. Whereas comparatively short and flexible N-alkyl substituents (Et, 2-hydroxyethyl, and pentyl) yield one-dimensional (1D) inorganic chains, more rigid substituents (benzyl, acetamidyl, and cyanomethyl) afford hybrids composed of lead-bromide face-sharing trimers ([Pb3Br12]6-). Of the rigid substituents studied, benzyl groups were found to enforce the highest level of distortion of the [PbBr6]4- octahedra that comprise their trimeric structures. Upon exposure to ultra-violet (UV) light, N-benzylpyridinium lead-bromide (1)6[Pb3Br12] exhibits a broadband emission, centered at 571 nm, which spans from 400 to 800 nm. More specifically, it displays a large Stokes shift of ca. 1.39 eV and a full width at half maximum (FWHM) of ca. 146 nm. This broadband emission decays with a comparatively long lifetime of 426 ns at room temperature, which increases to 5.8μs at 77 K. The reduced size and dimensionality of its inorganic lattice also results in a photoluminescence quantum yield (at least 10%) that is approx. one order magnitude higher than that of its 1D congeners. Mechanistically, broadband emission in (1)6[Pb3Br12] is believed to originate from triplet excited state(s) obtained from excited-state structural reorganization of the [Pb3Br12]6- moiety. In the experimental materials used by the author, we found 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Oxidation of acetanilides to glycolanilides and oxanilic acids in rabbits》 were Kiese, Manfred; Lenk, Werner. And the article was published in Biochemical Pharmacology in 1969. Recommanded Product: 4746-61-6 The author mentioned the following in the article:

In the urine of rabbits injected with various acetanilides, the corresponding glycol-anilides were found. Approx. 5% of the given acetanilides appeared in the urine as 4-chloroglycolanilide, 4-bromoglycolanilide and 4-propionylglycolanilide. They were isolated and their structures were established by uv, ir and N.M.R. spectra. Less than 1% of acetanilide and phenacetin were excreted as glycolanilides. No 4-propylglycolanilide was found in the urine after the administration of 4-propylacetanilide. The effect of various substituents in the 4-position on the biochem. hydroxylation of AcOH in acetanilides is discussed. Rabbits given 4-chloroacetanilide or 4-propionylacetanilide excrete several per cent as the corresponding oxanilic acids. In addition to this study using 2-Hydroxy-N-phenylacetamide, there are many other studies that have used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 4746-61-6) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Recommanded Product: 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70298-88-3On June 10, 1988, Estel, L.; Marsais, F.; Queguiner, G. published an article in Journal of Organic Chemistry. The article was 《Metalation/SRN1 coupling in heterocyclic synthesis. A convenient methodology for ring functionalization》. The article mentions the following:

Sequential lithiation and iodination of 2-fluoropyridine gave 85% 2-fluoro-3-iodopyridine, which underwent nucleophilic aromatic substitution with NaOMe, NH3, and MeNH2 to give 70-96% 2-substituted 3-iodopyridines I (R = iodo; R1 = OMe, NH2, NHMe). Radical nucleophilic substitution reactions of these compounds with the enolates of MeCOCMe3 or Me2CO gave pyridylmethyl ketones I (R = CH2COCMe3, CH2COMe; same R1). Intramol. cyclocondensation of I (R = CH2COCMe3, CH2COMe; R1 = NH2, NHMe) gave pyrrolo[2,3-b]pyridines II (R2 = H, Me; R3 = CMe3, Me). Similar iodination, radical nucleophilic enolate substitution, and cyclocondensation starting from 2-, 3-, and 4-(pivaloylamino)pyridines gave 2-substituted pyrrolo[2,3-b]-, -[2,3-c]-, and -[3,2-c]pyridines [e.g., II (R2 = H, R3 = CMe3, Me), III]. The experimental part of the paper was very detailed, including the reaction process of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Design, synthesis, and insecticidal and fungicidal activities of quaternary ammonium salt derivatives of a triazolyphenyl isoxazoline insecticide》 was written by Huang, Shi-sheng; Zhu, Bin-bing; Wang, Kai-hua; Yu, Mo; Wang, Zi-wen; Li, Yongqiang; Liu, Yu-xiu; Zhang, Peng-li; Li, Shou-jun; Li, Ya-ling; Liu, Ai-ling; Wang, Qing-min. Recommanded Product: 683-57-8This research focused ontriazolyphenyl isooxazoline ammonium salt derivative insecticidal fungicidal activity; DP-9; fungicidal activity; insecticidal activity; isoxazoline; quaternary ammonium; structure optimization. The article conveys some information:

Insect pests seriously decrease the yield and quality of agricultural crops. Resistance to commonly used insecticides is increasingly undermining their effectiveness, and therefore the development of agents with novel modes of action is desirable. Isoxazolines are a new class of insecticides that act on γ-aminobutyric acid (GABA) gated chloride channels. In this work, we used the highly active 4-triazolyphenyl isoxazoline DP-9 as a parent structure to design and synthesize a series of quaternary ammonium salt (QAS) derivatives, and we systematically evaluated their insecticidal and antifungal activities. RESULTS : Many of the synthesized QASs exhibit insecticidal activities equivalent to or higher than that of DP-9. In particular, compounds I-31 (93%, 0.00005 mg/L) and I-34 (80%, 0.00001 mg/L) showed insecticidal activities against diamondback moth larvae that were 2-10 times higher than those of fluralaner (70%, 0.0001 mg/L) and DP-9 (80%, 0.0001 mg/L), in addition to showing excellent activities against oriental armyworm, fall armyworm, cotton bollworm, corn borer, and mosquito larvae. Furthermore, all of the synthesized compounds also showed broad-spectrum fungicidal activities. The insecticidal activities of QAS derivatives of DP-9 were the same as or better than the activity of DP-9. Compounds I-31 and I-34 showed better insecticidal activities against diamondback moth larvae than fluralaner and DP-9, and thus are promising new candidates for insecticide research. In the experimental materials used by the author, we found 2-Bromoacetamide(cas: 683-57-8Recommanded Product: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Recommanded Product: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 683-57-8In 2021 ,《Allosteric binding properties of a 1,3-alternate thiacalix[4]arene-based receptor having phenylthiourea and 2-pyridylmethyl moieties on opposite faces》 was published in New Journal of Chemistry. The article was written by Rahman, Shofiur; Tomiyasu, Hirotsugu; Wang, Chuan-Zeng; Georghiou, Paris E.; Alodhayb, Abdullah; Carpenter-Warren, Cameron L.; Elsegood, Mark R. J.; Teat, Simon J.; Redshaw, Carl; Yamato, Takehiko. The article contains the following contents:

The synthesis of three new heteroditopic receptors (5a-c) which are based on thiacalix[4]arenes in the 1,3-alternate conformation is reported herein. These new receptors each have two thiourea moieties linking Ph groups, two of which are substituted with electron-withdrawing groups at their para-positions, and at the opposite side of the thiacalix[4]arene cavity, with two 2-pyridylmethyl groups. One example (5a) was also characterized by X-ray crystallog. A limited 1H-NMR and UV-vis anion complexation study was conducted. DFT computational determinations indicated that 5c, which has strongly electron-withdrawing NO2 groups, had the most effective recognition ability towards the selected anions. The binding of Ag+ at the 2-pyridyl moieties, and the binding of the anions at the two thiourea NH groups of the p-substituted phenylthioureido moieties, resp., was also investigated. The appearance of a pos. allosteric effect with receptor 5b was also found using 1H-NMR titration experiments In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Recommanded Product: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Recommanded Product: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Perez-Lourido, Paulo; Madarasi, Eniko; Antal, Fanni; Esteban-Gomez, David; Wang, Gaoji; Angelovski, Goran; Platas-Iglesias, Carlos; Tircso, Gyula; Valencia, Laura published an article in Dalton Transactions. The title of the article was 《Stable and inert macrocyclic cobalt(II) and nickel(II) complexes with paraCEST response》.Category: amides-buliding-blocks The author mentioned the following in the article:

We report the synthesis of the macrocyclic ligands 3,9-PC2AMH (2,2′-(3,6,9-triaza-1(2,6)-pyridinacyclodecaphane-3,9-diyl)diacetamide) and 3,9-PC2AMtBu (2,2′-(3,6,9-triaza-1(2,6)-pyridinacyclodecaphane-3,9-diyl)bis(N-tert-butyl)acetamide) which contain a pyclen platform functionalized with acetamide or tert-butylacetamide pendant arms at positions 3 and 9 of the macrocyclic unit. The corresponding Co(II) and Ni(II) complexes were prepared, isolated and characterized as potential paramagnetic chem. exchange saturation transfer (paraCEST) agents. The X-ray structures of the Ni(II) complexes reveal six-coordination of the ligands to the metal ion. The Co(II) complex with 3,9-PC2AMtBu shows a similar six-coordinate structure in the solid state, while the Co(II) complex with 3,9-PC2AMH contains a seven-coordinate metal ion, seventh coordination being completed by the presence of an inner-sphere water mol. The structure of the Co(II) complexes was investigated using 1H NMR spectroscopy and computational methods. The complexes present a seven-coordinate structure in solution, as demonstrated by the anal. of the paramagnetic shifts using d. functional theory. Ligand protonation constants and stability constants of the complexes with 3,9-PC2AMH were determined using potentiometric titrations (I = 0,15 M NaCl). The Co(II) complex was found to be more stable than the Ni(II) analog (log KCoL = 14.46(5) and log KNiL = 13.15(3)). However, the Ni(II) and Co(II) complexes display similar rate constants characterizing the proton-assisted dissociation mechanism. The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analog at 25°C. In the experiment, the researchers used many compounds, for example, 2-Bromoacetamide(cas: 683-57-8Category: amides-buliding-blocks)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Han, Lu; Zhang, Xue-Ting; Xie, Dong; Tian, Shi-Kai published an article in 2021. The article was titled 《Aryne-mediated [2,3]-sigmatropic rearrangement of tertiary 2,3-allenylamines bearing an electron-withdrawing group at the α-position》, and you may find the article in Organic & Biomolecular Chemistry.Product Details of 683-57-8 The information in the text is summarized as follows:

An unprecedented [2,3]-sigmatropic rearrangement reaction of quaternary 2,3-allenylammonium ylides, generated in-situ from tertiary 2,3-allenylamines and arynes, was established. With 2-(trimethylsilyl)aryl triflates as aryne precursors, a range of tertiary 2,3-allenylamines bearing an electron-withdrawing group at the α-position smoothly participated in the aryne-mediated [2,3]-sigmatropic rearrangement at room temperature, delivering structurally diverse 2-vinylallyamines or 1-amino-1,3-dienes in moderate to excellent yields. The reaction proceeded in the absence of strong bases and transition metals, was compatible with moisture and air and tolerated a wide variety of functional groups. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Product Details of 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Product Details of 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics