Tag: 100-200

Sun, Bin; Tang, Xiaoli; Shi, Rongcheng; Yan, Zhiyang; Li, Bingqian; Tang, Chen; Jin, Can; Wu, Chunlei L.; Shen, Runpu P. published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Self-photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer》.Recommanded Product: 2-Bromoacetamide The article contains the following contents:

A mild, external photocatalyst- and additive-free protocol for photo-induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl-substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8Recommanded Product: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Recommanded Product: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Engaging Sulfonamides: Intramolecular Cross-Electrophile Coupling Reaction of Sulfonamides with Alkyl Chlorides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Lucas, Erika L.; Hewitt, Kirsten A.; Chen, Pan-Pan; Castro, Anthony J.; Hong, Xin; Jarvo, Elizabeth R.. Recommanded Product: 4-Methylbenzenesulfonamide The article mentions the following:

The application of amine derivatives as coupling partners is rare due to the inherent strength of the C-N bond. Herein, the first cross-electrophile coupling reaction of unstrained benzylic sulfonamides is repoted. Nickel-catalyzed intramol. cross-electrophile coupling reactions of acyclic and cyclic benzylic sulfonamides with pendant alkyl chlorides generate cyclopropane products. Mechanistic experiments and DFT calculations are consistent with initiation of the reaction by magnesium iodide accelerated oxidative addition of the benzylic sulfonamide. This work establishes neutral and unstrained amine derivatives as XEC partners, furnishes structural rearrangement of benzylic sulfonamides, and provides valuable information regarding catalyst design for the development of new cross-electrophile coupling reactions of carbon-heteroatom bonds. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Yu, Chang-Bin; Wang, Jie; Zhou, Yong-Gui published 《Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles》.Organic Chemistry Frontiers published the findings.Name: N-Methoxy-N-methylacetamide The information in the text is summarized as follows:

A concise and enantioselective procedure for the synthesis of optically active indolines I [R = Me, n-Bu, Bn, etc.; R1 = H, 2-Me, 2-OMe, 4-OMe, 2,4-di-Me] was developed through intramol. condensation, deprotection and palladium-catalyzed asym. hydrogenation in a one-pot process with up to 96% ee. A strong Bronsted acid played an important role in both the formation of indoles and asym. hydrogenation process. This strategy could be scaled-up with excellent reactivity and enantioselectivity. The results came from multiple reactions, including the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Name: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Gao, Shang; Wu, Zijun; Wu, Fei; Lin, Aijun; Yao, Hequan published 《Catalyst-Controlled Regiodivergent Dehydrogenative Heck Reaction of 4-Arylthiophene/Furan-3-Carboxylates》.Advanced Synthesis & Catalysis published the findings.Related Products of 78191-00-1 The information in the text is summarized as follows:

A catalyst-controlled regiodivergent dehydrogenative Heck reaction of 4-arylthiophene/furan-3-carboxylates has been realized. Use of a palladium catalyst led to the C-5 alkenylation through electronic palladation to afford, e.g., I, while a ruthenium catalyst favored the C-2 alkenylation with the assistance of a directing group to yield, e.g., II. This reaction exhibited good to excellent regioselectivities. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Related Products of 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Related Products of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 64479-78-3On March 8, 2012, Li, Rongshi; Martin, Mathew P.; Liu, Yan; Wang, Binglin; Patel, Ronil A.; Zhu, Jin-Yi; Sun, Nan; Pireddu, Roberta; Lawrence, Nicholas J.; Li, Jiannong; Haura, Eric B.; Sung, Shen-Shu; Guida, Wayne C.; Schonbrunn, Ernst; Sebti, Said M. published an article in Journal of Medicinal Chemistry. The article was 《Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors》. The article mentions the following:

Using high concentration biochem. assays and fragment-based screening assisted by structure-guided design, we discovered a novel class of Rho-kinase inhibitors. Compound 18 (I) was equipotent for ROCK1 (IC50 = 650 nM) and ROCK2 (IC50 = 670 nM), whereas compound 24 was more selective for ROCK2 (IC50 = 100 nM) over ROCK1 (IC50 = 1690 nM). The crystal structure of the compound 18-ROCK1 complex revealed that 18 is a type 1 inhibitor that binds the hinge region in the ATP binding site. Compounds 18 and 24 inhibited potently the phosphorylation of the ROCK substrate MLC2 in intact human breast cancer cells. In the experiment, the researchers used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Related Products of 64479-78-3 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Systematic evaluation of textural properties, activation temperature and gas uptake of Cu2(pzdc)2L [L = dipyridyl-based ligands] porous coordination pillared-layer networks》 was published in Dalton Transactions in 2012. These research results belong to Garcia-Ricard, Omar J.; Silva-Martinez, Juan C.; Hernandez-Maldonado, Arturo J.. Category: amides-buliding-blocks The article mentions the following:

In situ high temperature x-ray diffraction, nitrogen porosimetry and gas adsorption at room temperature were used to elucidate the effect of the degassing or activation temperature on the long-range and micropore textural properties of a series of coordination polymers with pillared-layer structures. Ramp-and-soak TGA performed at selected activation temperatures were used to verify the thermal stability of a CPL-n series [Cu2(pzdc)2L; H2pzdc = pyrazine-2,3-dicarboxylic acid; L = 4,4′-azopyridine (apy) for CPL-4, 1,2-bis(4-pyridyl)ethylene (bpe) for CPL-5, N-(4-pyridyl)isonicotinamide (pia) for CPL-6, and 1,2-bis(4-pyridyl)glycol (dpyg) for CPL-7]. Although the activation temperatures were far below the decomposition point of the complexes, these resulted in significant and unique changes in micropore surface area and volume, even for CPL-4, -5 and -6, which contained pillar ligands with similar dimensions and similar structural long-range order. For the case of CPL-7, however, the framework appeared to be non-porous at any given activation temperature Pure component equilibrium adsorption data gathered for CO2, CH4, and N2 were used to elucidate the CPL-n materials potential for storage and separations at room temperature All of the materials exhibited considerable selectivity toward CO2, particularly at moderate pressures. Meanwhile, CO2 isosteric heats of adsorption indicated that the pore functionalities arising from the pillar ligands provided similar interactions with the adsorbate in the cases of CPL-4 and -5. For CPL-6, the presence of the carbonyl (C:O) group appeared to enhance interactions with CO2 at low loadings. After reading the article, we found that the author used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Category: amides-buliding-blocks)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Synthesis of 4-Aryl-1,7-naphthyridine-2(1H)-thiones by the Electrocyclic Reaction of 4-(1-Arylalk-1-enyl)-3-isothiocyanatopyridines Generated in situ from the Corresponding Isocyanides》 was written by Kobayashi, Kazuhiro; Kozuki, Taketoshi; Suzuki, Teruhiko. Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide And the article was included in Helvetica Chimica Acta on April 17 ,2012. The article conveys some information:

A convenient synthesis for 4-substituted and 3,4-disubstituted 1,7-naphthyridine-2(1H)-thiones has been developed. The method is based on the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines, generated in situ by the treatment of the resp. isocyanides with S8 in the presence of a catalytic amount of selenium. The isocyanides can be easily prepared from com. available pyridin-3-amine by conventional organic reactions. In the experiment, the researchers used many compounds, for example, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Synthesis of 2-Aryl-2,3-dihydro-1,8-naphthyridin-4(1H)-ones by Deprotective Cyclization of N-{3-[(2E)-3-Arylprop-2-enoyl]pyridin-2-yl}-2,2-dimethylpropanamides in Water》 was published in Helvetica Chimica Acta in 2016. These research results belong to Kobayashi, Kazuhiro; Kosuna, Risa; Imaoka, Ayumi. Electric Literature of C10H14N2O The article mentions the following:

A new and convenient method for the preparation of 2-aryl-2,3-dihydro-1,8-naphthyridin-4(1H)-ones was developed. Thus, N-{3-[(2E)-3-arylprop-2-enoyl]pyridin-2-yl}-2,2-dimethylpropanamides were synthesized from com. available pyridin-2-amine using an easily performed three-step sequence and were subjected to cyclization with deprotection under acidic conditions in H2O to give the desired products. Similarly, 2-aryl-2,3-dihydro-1,7-naphthyridin-4(1H)-ones and 2-aryl-2,3-dihydro-1,6-naphthyridin-4(1H)-ones was prepared from pyridin-3-amine and pyridin-4-amine, resp. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Electric Literature of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Electric Literature of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70-55-3In 2019 ,《Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide》 appeared in Journal of Organic Chemistry. The author of the article were Mahato, Sachinta; Santra, Sougata; Zyryanov, Grigory V.; Majee, Adinath. The article conveys some information:

A novel and efficient approach has been developed to synthesize α-sulfonylamino ketones, e.g., PhCOCH2NHTs, through the reaction between terminal alkynes and sulfonamides under ambient air using diacetoxy iodobenzene. A library of α-sulfonylamino ketone derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and room temperature reaction conditions under ambient air and is operationally simple. A gram-scale synthesis demonstrates the potential applications of the present method. In addition, we have also synthesized α-acetoxy ketones, e.g., PhCOCH2OAc, in the absence of sulfonamide. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Jiafu; Aziz, Tareq Md.; Granger, Caroline O.; Richardson, Susan D. published their research in Environmental Science & Technology in 2021. The article was titled 《Are Disinfection Byproducts (DBPs) Formed in My Cup of Tea? Regulated, Priority, and Unknown DBPs》.Safety of 2-Bromoacetamide The article contains the following contents:

Globally, tea is the second most consumed nonalcoholic beverage next to drinking water and is an important pathway of disinfection byproduct (DBP) exposure. When boiled tap water is used to brew tea, residual chlorine can produce DBPs by the reaction of chlorine with tea compounds In this study, 60 regulated and priority DBPs were measured in Twinings green tea, Earl Gray tea, and Lipton tea that was brewed using tap water or simulated tap water (nanopure water with chlorine). In many cases, measured DBP levels in tea were lower than in the tap water itself due to volatilization and sorption onto tea leaves. DBPs formed by the reaction of residual chlorine with tea precursors contributed ~12% of total DBPs in real tap water brewed tea, with the remaining 88% introduced by the tap water itself. Of that 12%, dichloroacetic acid, trichloroacetic acid, and chloroform were the only contributing DBPs. Total organic halogen in tea nearly doubled relative to tap water, with 96% of the halogenated DBPs unknown. Much of this unknown total organic halogen (TOX) may be high-mol.-weight haloarom. compounds, formed by the reaction of chlorine with polyphenols present in tea leaves. The identification of 15 haloarom. DBPs using gas chromatog.-high-resolution mass spectrometry indicates that this may be the case. Further studies on the identity and formation of these aromatic DBPs should be conducted since haloarom. DBPs can have significant toxicity.2-Bromoacetamide(cas: 683-57-8Safety of 2-Bromoacetamide) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Safety of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics