Tag: 100-200

《Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects》 was written by Pflimlin, Elsa; Zhou, Zhihong; Amso, Zaid; Fu, Qiangwei; Lee, Candy; Muppiddi, Avinash; Joseph, Sean B.; Nguyen-Tran, Van; Shen, Weijun. HPLC of Formula: 683-57-8 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

The effects of oxytocin on food intake and body weight reduction have been demonstrated in both animal models and human clin. studies. Despite being efficacious, oxytocin is enzymically unstable and thus considered to be unsuitable for long-term use in patients with obesity. Herein, a series of oxytocin derivatives were engineered through conjugation with fatty acid moieties that are known to exhibit high binding affinities to serum albumin. One analog (OT-12) in particular was shown to be a potent full agonist at the oxytocin receptor (OTR) in vitro with good selectivity and long half-life (24 h) in mice. Furthermore, OT-12 is peripherally restricted, with very limited brain exposure (1/190 of the plasma level). In a diet-induced obesity mouse model, daily s.c. administration of OT-12 exhibited more potent anorexigenic and body weight reducing effects than carbetocin. Thus, our results suggest that the long-acting, peripherally restricted OTR agonist may offer potential therapeutic benefits for obesity. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.HPLC of Formula: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis and Antimicrobial and Antioxidant Activities of Sulfonamide Derivatives Containing Tetrazole and Oxadiazole Rings》 were Ozkan, Hamdi; Demirci, Bayram. And the article was published in Journal of Heterocyclic Chemistry in 2019. Recommanded Product: 4-Methylbenzenesulfonamide The author mentioned the following in the article:

A new sulfonamide derivative with 1,3,4-oxadiazole moiety and tetrazole ring. I [R = 4-FC6H4S(O)2NH, 4-H3CC6H4S(O)2NH, (4-sulfamoylphenyl)aminyl, etc.] have been synthesized. The biol. activities of resulting compound were also investigated and observed that the compounds reveal strong antimicrobial activity over some important bacterial strains including Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and Staphylococcus aureus ATCC 29213. The in vitro antifungal properties of synthesized compounds I, II and III [R1 = H, 2,2-dimethyl-2-((1-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methyl]-1H-1,2,3,4-tetrazol-5-yl)carbamoyl)ethyl] were also a target using Candida albicans NRRL Y-477 and Saccharomyces cerevisiae fungal strains. A useful guideline for future studies about the effect of the chem. structures of sulfonamide compounds on the biol. activities have been provided. Among the target compounds, I (R = 4-FC6H4S(O)2NH, 4-ClC6H4S(O)2NH, 4-BrC6H4S(O)2NH, 4-IC6H4S(O)2NH) demonstrated surprisingly high antimicrobial activities than did others. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《An insight into the synergistic and mechanistic aspects of (IrCl3 + PdCl2) bimetallic and IrCl3, PdCl2 individual catalysts on oxidation-kinetics of kojic acid with alkaline chloramine-T》 were Radhakrishnan, Ramya; Puttaswamy. And the article was published in Chemical Data Collections in 2019. Related Products of 70-55-3 The author mentioned the following in the article:

The kinetics of (IrCl3+PdCl2) bimetallic catalytic mixture as well as individual IrCl3 and PdCl2 catalyzed and uncatalyzed oxidation of kojic acid by sodium-N-chloro-p-toluenesulfonamide (chloramine-T or CAT) in the presence of NaOH has been explored at 298 K. Under identical exptl. conditions, the kinetics for the catalyzed and uncatalyzed reactions was found to unveil varied orders. The rates of catalyzed reactions were found to be 9-38 folds faster than the uncatalyzed reaction. The observed rates of catalyzed reactions called for the existence of synergistic effect in an equimolar mixture of IrCl3+PdCl2. Justifications for the observed results have been provided by plausible mechanisms. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Chemistry – A European Journal included an article by Moore, Lucas C.; Lo, Anna; Fell, Jason S.; Duong, Matthew R.; Moreno, Jose A.; Rich, Barry E.; Bravo, Martin; Fettinger, James C.; Souza, Lucas W.; Olmstead, Marilyn M.; Houk, Kendall N.; Shaw, Jared T.. Name: 4-Methylbenzenesulfonamide. The article was titled 《Acyclic Stereocontrol in the Additions of Nucleophilic Alkenes to α-Chiral N-Sulfonyl Imines》. The information in the text is summarized as follows:

Diastereoselective Lewis acid-mediated additions of nucleophilic alkenes R(R1)C=CH2 (R = H, Me, OTMS; R1 = Ph, CH2BF3K, CH2TMS) to N-sulfonyl imines (S,E)-R2CH(OR3)CH=NTs (R2 = Me, Ph, Bn; R3 = Me, Bn, TBDPS) are reported. The canonical polar Felkin-Anh model describing additions to carbonyls does not adequately describe analogous additions to N-sulfonyl imines. The development of conditions to produce both syn and anti products syn-R2CH(OR3)CH(NTs)CH2R4 [R4 = CH=CH2, C(O)Ph, CH2=CMe] with high diastereoselectivity and good yields has been described. A stereoelectronic model consistent with exptl. outcomes is also proposed. After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kobayashi, Kazuhiro; Kozuki, Taketoshi; Konishi, Manami; Suzuki, Teruhiko; Tanmatsu, Miyuki; Konishi, Hisatoshi published an article in Helvetica Chimica Acta. The title of the article was 《Synthesis of 2,3-Diaryl-3H-pyrrolo[2,3-c]pyridin-3-ol Derivatives by the Reaction of Aryl(3-isocyanopyridin-4-yl)methanones with Aryl Grignard Reagents》.Application of 70298-88-3 The author mentioned the following in the article:

The reaction of aryl(3-isocyanopyridin-4-yl)methanones, e.g., I, easily prepared from com. available pyridin-3-amine, with aryl Grignard reagents gave, after aqueous workup, 2,3-diaryl-3H-pyrrolo[2,3-c]pyridin-3-ols. These rather unstable alcs. were O-acylated with Ac2O in pyridine in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) to afford the corresponding 2,3-diaryl-3H-pyrrolo[2,3-c]pyridin-3-yl acetates, e.g., II, in relatively good yields. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1999,Journal of Molecular Modeling included an article by Wang, Jiansuo; Lai, Luhua; Tang, Youqi. HPLC of Formula: 4746-61-6. The article was titled 《Data mining of toxic chemicals: structure patterns and QSAR》. The information in the text is summarized as follows:

The authors take a two-step strategy to explore non-congeneric toxic chems. from the database RTECS: the screening of structure patterns and the generation of a detailed relationship between structure and activity. An efficient similarity comparison is proposed to screen chem. patterns for further QSAR anal. Then CoMFA study is carried out on one structure pattern as an example of the implementation, and the result shows that QSAR studies of structure patterns can provide an estimate of the activity as well as a detailed relationship between activity and structure. From the performance of overall procedure, such a stepwise scheme is demonstrated to be feasible and effective to mine a database of toxic chems.2-Hydroxy-N-phenylacetamide(cas: 4746-61-6HPLC of Formula: 4746-61-6) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.HPLC of Formula: 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Science of the Total Environment included an article by Ding, Xinliang; Zhu, Jingying; Wang, Xiaoxiao; Zhou, Weijie; Wu, Keqin; Zhou, Zhu; Zhou, Kun; Wu, Di; Jiao, Jiandong; Xia, Yankai; Wang, Xinru. SDS of cas: 683-57-8. The article was titled 《Different cytotoxicity of disinfection by-product haloacetamides on two exposure pathway-related cell lines: Human gastric epithelial cell line GES-1 and immortalized human keratinocyte cell line HaCaT》. The information in the text is summarized as follows:

Humans are exposed to disinfection byproducts (DBPs) mainly through drinking water ingestion and dermal contact. As an emerging class of nitrogenous DBPs (N-DBPs), haloacetamides (HAcAms) have been found to have significantly higher cytotoxicity than regulated DBPs. In this study, we investigated the cytotoxicity of HAcAms on two exposure pathway-related cell lines: human gastric epithelial GES-1 cells and immortalized keratinocytes HaCaT. Our results showed that the ranking order of cytotoxicity of 13 HAcAms was different between HaCaT and GES-1 cells. In addition, the 50% inhibitive concentration in HaCaT was 1.01-3.29 times that in GES-1. Further comparison among GES-1, HaCaT and CHO cell lines confirmed that different cell lines exhibited different sensitivity to the same compound Importantly, HAcAms showed 5.83-7.13 × 104 times higher toxicity than the well-clarified DBP chloroform, clearly demonstrating the increased toxicity of HAcAms. Finally, using a novel high-content screening (HCS) anal., we found that 39.29% of chlorinated HAcAms, 42.86% of brominated HAcAms and 16.07% of iodinated HAcAms significantly affected at least one of the cell-health parameters, such as nuclear size, membrane permeability, mitochondrial membrane potential, or cytochrome c release, in GES-1 or HaCaT cells. Thus, brominated HAcAms appear to have stronger effects under the sublethal exposure dose, possibly causing cytotoxicity via apoptosis. Together, our study provides new insights to the toxicity of HAcAms and a comprehensive toxicol. dataset for health risk assessment. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8SDS of cas: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.SDS of cas: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Synthesis and anticonvulsant activity of 3-alkoxycarbonylaminomethylcarbonylamino-4-benzoylpyridines》 was published in Drug Design and Delivery in 1990. These research results belong to Fiakpui, Charles Y.; Namchuk, Mark N.; Knaus, Edward E.. Computed Properties of C10H14N2O The article mentions the following:

3-Alkoxycarbonylaminomethylcarbonylamino-4-(arylcarbonyl)pyridines I (R1 = aryl; R2 = tert-Bu or CH2Ph; R3 = H or Me) or II, in which the chlorophenyl ring of dipeptidylaminobenzophenones is replaced by a pyridyl ring were synthesized and evaluated as anticonvulsants using s.c. pentylenetetrazole (scPTZ) and maximal electroshock (MES) induced seizure screening tests. The substituent on the aryl ring of the 4-arylcarbonyl moiety was a determinant of activity in both tests, the potency order of substituents being generally 2-F > 2-H > 2-Cl. Compounds possessing a 3-benzyloxycarbonylaminomethylcarbonylamino substituent exhibited moderate activity in the scPTZ test, whereas all 3-tert-butoxycarbonylaminomethylcarbonylamino derivatives were inactive. The test results in the scPTZ screen suggest that the 3-benzyloxycarbonylaminomethylcarbonyl(N-methyl)amino compounds may undergo biotransformation, at least in part, to pyrido[3,4-e]-1,4-diazepin-2-ones. 3-Alkoxycarbonylaminomethylcarbonyl(N-methyl)amino-substituted compounds were always more potent than analogous 3-alkoxycarbonylaminomethylcarbonylamino-substituted compounds in the scPTZ test, whereas they were equipotent in the MES screen. Following oral administration, 3-benzyloxycarbonylaminomethylcarbonyl(N-methyl)amino-4-(2-chlorobenzoyl)pyridine exhibited a potency greater that that of valproic acid but less than that of clonazepam in the rat scPTZ screening test. 3-Benzyloxycarbonylaminomethylcarbonylamino-4-(2-fluorobenzoyl)pyridine was the most potent compound in the rat oral MES screening test, exhibiting an activity greater than that of clonazepam but less than that of phenytion. The 3-alkoxycarbonylaminomethylcarbonylamino-4-(arylcarbonyl)pyridines had moderate affinity for the benzodiazepine receptor site(s); the IC50s in displacing 10 nM [3H]flunitazepam were in the 0.37-15.11 μM range (clonazepam = 0.003 μM). In the experimental materials used by the author, we found 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Computed Properties of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Constructions of 2D-Metallamacrocycles Using Half-Sandwich RuII2 Precursors: Synthesis, Molecular Structures, and Self-Selection for a Single Linkage Isomer》 was written by Shanmugaraju, Sankarasekaran; Bar, Arun Kumar; Joshi, Sachin A.; Patil, Yogesh P.; Mukherjee, Partha Sarathi. Related Products of 64479-78-3 And the article was included in Organometallics on April 11 ,2011. The article conveys some information:

Coordination-driven self-assembly of oxalato-bridged half-sandwich p-cymene Ru complex [Ru2(μ-η4-C2O4)(MeOH)2(η6-p-cymene)2](O3SCF3)2 (1a) with several ditopic donors (La-Ld) in MeOH affords bi- and tetranuclear metallamacrocycles (2a and 3-5). Similarly, the combination of 2,5-dihydroxy-1,4-benzoquinonato (dhbq)-bridged binuclear complex [Ru2(μ-η4-C6H2O4)(MeOH)2(η6-p-cymene)2](O3SCF3)2 (1b) with a flexible bidentate amide linker (La) in 1:1 molar ratio gave the corresponding tetranuclear complex 2b. All the macrocycles were isolated as their triflate salts in high yields and were fully characterized by various spectroscopic techniques. Finally, the mol. structures of all the assemblies were determined unambiguously by single-crystal X-diffraction anal. The combination of acceptor 1a or 1b with an unsym. linear ditopic donor La results in a self-sorted linkage isomeric (head-to-tail) macrocycle (2a or 2b) despite the possibility of formation of two different isomeric macrocycles (head-to-head or head-to-tail) due to different connectivity of the donor. Mol. structures of the complexes 2a and 2b showed tetranuclear rectangular geometry with dimensions of 5.51 Å × 13.29 Å for 2a and 7.91 Å × 13.46 Å for 2b. In both cases, two binuclear RuII2 building blocks are connected by a μ-N-(4-pyridyl)isonicotinamide donor in a head-to-tail fashion. Surprisingly, the macrocycle 2a loses one counteranion and cocrystallizes with monodeprotonated 1,3,5-trihydroxybenzene via strong intermol. π-π stacking and H bonding. The tweezer complex 3 showed strong fluorescence in solution, and it showed fluorescence sensing toward nitroarom. compounds A fluorescence study demonstrated a marked quenching of the initial fluorescence intensity of the macrocycle 3 upon gradual addition of trinitrotoluene and exhibits significant fluorescence quenching response only for nitroarom. compounds compared to various other aromatic compounds tested. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Related Products of 64479-78-3 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 70-55-3In 2021 ,《Rhodium(III)-Catalyzed Aryl Borrowing Amination of Diaryl Methanols Containing Pyridine-Directing Groups》 appeared in Advanced Synthesis & Catalysis. The author of the article were Liu, Zheng-Qiang; Tao, Jing; Zhuang, Xin; Hong, Chuan-Ming; Luo, Zhen; Wu, Yu-Fei; Li, Qing-Hua; Liu, Tang-Lin. The article conveys some information:

The rhodium(III)-catalyzed aryl borrowing amination of various diaryl methanols with sulfonamides was developed. The amination of alcs. via C-C bond activation was less developed and remains a challenge. These aryl borrowing reactions feature mild reaction conditions, good functional group tolerance and compatibility with a wide range of alcs., overall comprising an atom- and step-economic procedure. Mechanistic studies indicated that a rhodacycle complex exist during the aryl borrowing amination reaction. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics