Tag: 100-200

The author of 《Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols》 were Reed-Berendt, Benjamin G.; Morrill, Louis C.. And the article was published in Journal of Organic Chemistry in 2019. HPLC of Formula: 70-55-3 The author mentioned the following in the article:

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcs. to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield). After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Journal of the American Chemical Society included an article by Chen, Pan-Pan; Lucas, Erika L.; Greene, Margaret A.; Zhang, Shuo-Qing; Tollefson, Emily J.; Erickson, Lucas W.; Taylor, Buck L. H.; Jarvo, Elizabeth R.; Hong, Xin. Product Details of 70-55-3. The article was titled 《A Unified Explanation for Chemoselectivity and Stereospecificity of Ni-Catalyzed Kumada and Cross-Electrophile Coupling Reactions of Benzylic Ethers: A Combined Computational and Experimental Study》. The information in the text is summarized as follows:

Ni-catalyzed C(sp3)-O bond activation provides a useful approach to synthesize enantioenriched products from readily available enantioenriched benzylic alc. derivatives The control of stereospecificity is key to the success of these transformations. To elucidate the reversed stereospecificity and chemoselectivity of Ni-catalyzed Kumada and cross-electrophile coupling reactions with benzylic ethers, a combined computational and exptl. study is performed to reach a unified mechanistic understanding. Kumada coupling proceeds via a classic cross-coupling mechanism. Initial rate-determining oxidative addition occurs with stereoinversion of the benzylic stereogenic center. Subsequent transmetalation with the Grignard reagent and syn-reductive elimination produce the Kumada coupling product with overall stereoinversion at the benzylic position. The cross-electrophile coupling reaction initiates with the same benzylic C-O bond cleavage and transmetalation to form a common benzylnickel intermediate. However, the presence of the tethered alkyl chloride allows a facile intramol. SN2 attack by the benzylnickel moiety. This step circumvents the competing Kumada coupling, leading to the excellent chemoselectivity of cross-electrophile coupling. These mechanisms account for the observed stereospecificity of the Kumada and cross-electrophile couplings, providing a rationale for double inversion of the benzylic stereogenic center in cross-electrophile coupling. The improved mechanistic understanding will enable design of stereoselective transformations involving Ni-catalyzed C(sp3)-O bond activation. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Wessig, Pablo; John, Leonard; Mertens, Monique published 《Extending the Class of [1,3]-Dioxolo[4.5-f]benzodioxole (DBD) Fluorescent Dyes》.European Journal of Organic Chemistry published the findings.COA of Formula: C4H9NO2 The information in the text is summarized as follows:

Synthetic routes to a collection of new fluorescent dyes are described, which are based on the [1,3]-dioxolo[4.5-f]benzodioxole (DBD) core. By introducing different electron withdrawing groups in 4- and 8-position of the DBD moiety the emission wavelength could be adjusted over a large spectral range from blue to orange light. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1COA of Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Diehl, Julian; Brueckner, Reinhard published 《Synthesis of Enantiomerically Pure β-Hydroxy Ketones via β-Keto Weinreb Amides by a Condensation/Asymmetric-Hydrogenation/Acylation Sequence》.European Journal of Organic Chemistry published the findings.Product Details of 78191-00-1 The information in the text is summarized as follows:

An established route to enantiomerically pure β-hydroxy ketones proceeds through the asym. hydrogenation of β-keto esters, an ester/amide exchange, and the use of the resulting β-hydroxy amide for the acylation of an organometallic compound The authors shortened this route by showing that β-keto Weinreb amides are hydrogenated with up to 99% ee in the presence of [Me2NH2]+{[RuCl(S)-BINAP]2(μ-Cl)3}- (0.5 mol-%) at room temperature/5 bar. These Weinreb amides were prepared by seemingly obvious yet unprecedented condensations of lithiated N-methoxy-N-methylacetamide with carboxylic chlorides (51-87% yield). The resulting β-hydroxy Weinreb amides were used for the acylation of organolithium and Grignard reagents. They thus gave enantiomerically pure β-hydroxy ketones (28 examples). A selection of these compounds gave anti-1,3-diols after another C:O bond hydrogenation, or syn-1,3-diols by a Narasaka-Prasad reduction In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Product Details of 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Product Details of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《The chemistry of N-substituted benzotriazoles. Part 20. Mono-N-tert-butylation of aromatic and heteroaromatic amines》 was published in Journal of the Chemical Society in 1989. These research results belong to Katritzky, Alan R.; Vanden Eynde, Jean Jacques. Related Products of 70298-88-3 The article mentions the following:

Adducts R1CH(1-benzotriazolyl)NHR2, (R1 = Pr, CHMe2, CMe3, R2 = 2-, 3-pyridyl, Ph, 4-methyl-2-pyridyl, 5-chloro-2-pyridyl, 3-ClC6H4, 3-, 4-O2NC6H4), readily available from aldehydes, primary aromatic or heteroaromatic amines, and benzotriazole are converted by H2O2-SeO2 into mixtures of R1CONHR2 and HCONR1R2 in proportions which depend rationally on the nature of the R1 group. For R1 = CMe3, the formamide Me3CNR2CHO is formed in satisfactory yields, thus enabling the title reaction to be achieved. After reading the article, we found that the author used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Related Products of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Related Products of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Miletin, Miroslav; Dolezal, Martin; Opletalova, Veronika; Hartl, Jiri; Kral’ova, Katarina; Machacek, Milos published an article in Molecules [online computer file]. The title of the article was 《Some anilides of 2-alkylthio- and 2-chloro-6-alkylthio-4-pyridinecarboxylic acids: synthesis and photosynthesis-inhibiting activity》.Computed Properties of C6H4Cl2N2O The author mentioned the following in the article:

Many compounds containing a -CONH- group display photosynthesis-inhibiting activity. Based on this structural feature, a group of anilides of 2-alkylthio- (I) or 2-chloro-6-alkylthio-4-pyridinecarboxylic acids (II) was synthesized. The prepared compounds were tested for their inhibition of the oxygen evolution rate (OER) in spinach chloroplasts. A quasi-parabolic dependence between photosynthesis-inhibiting activity and the lipophilicity of the compounds was determined The inhibitory activity of compounds I was higher than that of II for comparable lipophilicity values. The results came from multiple reactions, including the reaction of 2,6-Dichloroisonicotinamide(cas: 89281-13-0Computed Properties of C6H4Cl2N2O)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Computed Properties of C6H4Cl2N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lawson, Edward C.; Santulli, Rosemary J.; Dyatkin, Alexey B.; Ballentine, Scott A.; Abraham, William M.; Rudman, Sandra; Page, Clive P.; de Garavilla, Lawrence; Damiano, Bruce P.; Kinney, William A.; Maryanoff, Bruce E. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent》.Category: amides-buliding-blocks The author mentioned the following in the article:

The α4β1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent α4β1 antagonists that the authors evaluated for safety and efficacy, compound (I) was selected as a lead candidate for antiasthma therapy by the inhalation route. The authors devised an optimized stereoselective synthesis to facilitate the preparation of a sufficiently large quantity of I for assessment in vivo. Administration of I to allergen-sensitive sheep by inhalation blocked the late-phase response of asthma and abolished airway hyper-responsiveness at 24 h following the antigen challenge. Addnl., the recruitment of inflammatory cells into the lungs was inhibited. Administration of I to ovalbumin-sensitized guinea pigs i.p. blocked airway resistance and inhibited the recruitment of inflammatory cells. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dichloroisonicotinamide(cas: 89281-13-0Category: amides-buliding-blocks)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2011,Angewandte Chemie, International Edition included an article by Zhang, Min; Imm, Sebastian; Baehn, Sebastian; Neumann, Helfried; Beller, Matthias. Recommanded Product: 2-Hydroxy-N-phenylacetamide. The article was titled 《Synthesis of α-amino acid amides: ruthenium-catalyzed amination of α-hydroxy amides》. The information in the text is summarized as follows:

An efficient ruthenium-catalyzed amination of α-hydroxy acid derivatives is reported. Using a variety of amines, including anilines, primary and secondary aliphatic amines, and ammonia, a wide range of amino acid amides was obtained from α-hydroxy amides or esters. Combination of Ru3(CO)12 and 1,2-bis(dicyclohexylphosphino)ethane was the best catalyst system. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Recommanded Product: 2-Hydroxy-N-phenylacetamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《H-*BEA Zeolite-Catalyzed Nucleophilic Substitution in Allyl Alcohols Using Sulfonamides, Amides, and Anilines》 was written by Ohtsuki, Akimichi; Aoki, Shunsuke; Nishida, Ryo; Morita, Sachiko; Fujii, Takeshi; Okumura, Kazu. Computed Properties of C7H9NO2SThis research focused onzeolite catalyst nucleophilic substitution allyl alc sulfonamide amide aniline. The article conveys some information:

Herein, the authors report a novel zeolite-catalyzed nucleophilic substitution in allyl alcs. The product yield was improved upon the addition of NaOTf (0.05 mol-%) using the studied zeolites. The highest yields were observed using H-*BEA(Si/Al2 = 40)/NaOTf. The scope of the reaction with respect to the nucleophile was examined using 1,3-diphenylprop-2-ene-1-ol as a model substrate under optimized reaction conditions. p-Substituted aryl sulfonamides bearing electron-rich or electron-deficient substituents, alkyl sulfonamides, and heteroaryl sulfonamides undergo the amidation reaction to produce their corresponding allyl sulfonamides in good yield. Amides and anilines exhibited low activity under the optimized conditions, however, performing the reaction at 90° produced the target product. The scope of the allyl alc. was studied using p-toluenesulfonamide as the nucleophile and the reaction proceeded with a variety of allylic alcs. To probe the practical utility of the H-*BEA-catalyzed amidation reaction, a gram-scale reaction was performed using 1.01 g (4.8 mmol) of allyl alc., which afforded the target product in 88% yield. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Alkyne Versus Ynamide Reactivity: Regioselective Radical Cyclization of Yne-Ynamides》 was written by Dutta, Shubham; Mallick, Rajendra K.; Prasad, Rangu; Gandon, Vincent; Sahoo, Akhila K.. COA of Formula: C7H9NO2SThis research focused onyne tethered ynamide thiophenol regioselective radical cyclization; thioaryl pyrrole preparation; 4-thioaryl-pyrroles; 5-exo-dig cyclization; alkynes; radical cyclization; ynamides. The article conveys some information:

Ynamides are typically more reactive than simple alkynes and olefins. However, a serendipitous observation revealed a rare case where the reactivity of simple alkynes exceeds that of ynamides. This led to the development of a unique sulfur-radical-triggered cyclization of yne-tethered ynamides, which involves attack of the alkyne by a thiyl radical followed by cyclization with the ynamide. A wide range of novel 4-thioaryl pyrroles that could tolerate common functional moieties and N-protecting groups were expediently constructed by this strategy. The current method contrasts with the typical cyclization of yne-ynamides, which involves the attack of the alkyne moiety by the ynamide core. Control experiments and DFT calculations supported the participation of the sulfur radical in the reaction and the regioselective cyclization. The synthetic potential of the substituted pyrroles is also discussed. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics