Tag: 100-200

Peng, Tian-Yu; Xu, Zhe-Yuan; Zhang, Feng-Lian; Li, Bin; Xu, Wen-Ping; Fu, Yao; Wang, Yi-Feng published an article in Angewandte Chemie, International Edition. The title of the article was 《Dehydroxylative Alkylation of α-Hydroxy Carboxylic Acids Derivatives via a Spin-Center Shift》.Application In Synthesis of 2-Hydroxy-N-phenylacetamide The author mentioned the following in the article:

A strategically distinct dehydroxylative alkylation reaction of α-hydroxy carboxylic acid derivatives I (Ar1 = 4-NCC6H4, 4-EtO2CC6H4, 2-pyridyl, etc.) with alkenes is developed. The reaction starts with the attack of a 4-dimethylaminopyridine (DMAP)-boryl radical to the carbonyl oxygen atom, followed by a spin-center shift (SCS) to trigger the C-O bond scission. The resulting α-carbonyl radicals couple with a wide range of alkenes to furnish various alkylated products II (Ar1 = 4-NCC6H4, 4-EtO2CC6H4, 2-pyridyl, etc.; R = n-Bu, Ph, 3-MeC6H4, etc.) . This strategy allows for the efficient conversion of a wide array of α-hydroxy amides and esters derived from several biomass mols. and natural products to value-added compounds Exptl. and computational studies verified the reaction mechanism. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application In Synthesis of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Application In Synthesis of 2-Hydroxy-N-phenylacetamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase》 was written by Massari, Serena; Bertagnin, Chiara; Pismataro, Maria Chiara; Donnadio, Anna; Nannetti, Giulio; Felicetti, Tommaso; Di Bona, Stefano; Nizi, Maria Giulia; Tensi, Leonardo; Manfroni, Giuseppe; Loza, Maria Isabel; Sabatini, Stefano; Cecchetti, Violetta; Brea, Jose; Goracci, Laura; Loregian, Arianna; Tabarrini, Oriana. Application of 683-57-8This research focused ontriazolopyrimidine carboxamide preparation antiviral SAR viral protein PB1; Influenza virus; PA-PB1 heterodimerization; Protein-protein interaction; RNA-Dependent RNA polymerase. The article conveys some information:

In search for new anti-Influenza viruses (Flu) drugs, authors have focused on viral RNA-dependent RNA polymerase (RdRP) developing disruptors of PA-PB1 subunits interface with the best compounds characterized by cycloheptathiophene-3-carboxamide and 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide scaffolds. By merging these moieties, two very interesting hybrid compounds were recently identified, starting from which, in this paper, a series of analogs were designed and synthesized. In particular, a thorough exploration of the cycloheptathiophene-3-carboxamide moiety led to acquire important SAR insight and identify new active compounds showing both the ability to inhibit PA-PB1 interaction and viral replication in the micromolar range and at non-toxic concentrations For few compounds, the ability to efficiently inhibit PA-PB1 subunits interaction did not translate into anti-Flu activity. Chem./phys. properties were investigated for a couple of compounds suggesting that the low solubility of compound I, due to a strong crystal lattice, may have impaired its antiviral activity. Finally, computational studies performed on compound II, in which the Ph ring suitably replaced the cycloheptathiophene, suggested that, in addition to hydrophobic interactions, H-bonds enhanced its binding within the PAC cavity. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Application of 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application of 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 70-55-3In 2020 ,《Highly Regio-, Diastereo- and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines through Palladium-Catalyzed [4+3] Cycloaddition Reactions》 was published in Angewandte Chemie, International Edition. The article was written by Trost, Barry M.; Zuo, Zhijun. The article contains the following contents:

A novel Pd0-catalyzed asym. [4+3] annulation reaction of two readily accessible starting materials was developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo- and enantioselectivtities, leading to valuable tetrahydroazepines, e.g., I and benzo[b]oxepines, e.g., II. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.SDS of cas: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C7H9NO2SIn 2019 ,《Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides》 appeared in Angewandte Chemie, International Edition. The author of the article were Marcyk, Paul T.; Jefferies, Latisha R.; Abu Salim, Deyaa I.; Pink, Maren; Baik, Mu-Hyun; Cook, Silas P.. The article conveys some information:

A simple iron-based catalyst system for the mild, direct conversion of secondary and tertiary alcs. to sulfonamides was described. Starting from enantioenriched alcs., the intramol. variant proceeded with stereoinversion to produced enantioenriched 2- and 2,2-subsituted pyrrolidines I [R = Me, n-Pr, i-Bu, 4-MeOC6H4] and indolines II [R1 = i-Bu, n-hexyl, CH2(4-MeOC6H4), etc.; Y = H, F, MeO, CF3], without prior derivatization of the alc. or solvolytic conditions. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Thangavelu, Sangeetha; Balasubramanian, Balamuralikrishnan; Palanisamy, Sampathkumar; Shanmugam, Velayuthaprabhu; Natchiappan, Senthilkumar; Kalibulla, Syed Ibrahim; Rathinasamy, Baskaran; Arumugam, Vijaya Anand published an article in South African Journal of Botany. The title of the article was 《Characterization and phytoconstituents of Petroselinum crispum (Mill) and Coriandrum sativum (Linn) and their impacts on inflammation-An in vitro analysis against human adenocarcinoma cells with molecular docking》.Application In Synthesis of N-Methoxy-N-methylacetamide The author mentioned the following in the article:

Petroselinum crispum (Mill) and Coriandrum sativum (Linn) are common culinary herbs enriched with a wide range of nutrients and minerals. The phytochems. found in these plants as secondary metabolites are useful against a variety of clin. diseases such as inflammation, diabetes, and cancer. The current study used in vitro studies on adenocarcinoma human alveolar basal epithelial (A549) cells to identify the phytochem. compounds present in the petroleum ether, methanol, and aqueous extracts of P. crispum and C. sativum leaves, as well as to depict the influence of these herbs in wound healing and inflammation. In all, 1761 compounds have been found in the leaf extracts of P. crispum and C. sativum, and the identified compounds have been tested in silico against binding receptors such as CD36 and antitrypsin receptors to determine their binding affinity. The extracts had lower IC50 values on A549 cells, suggesting lower toxicity, as well as substantially faster cell migration after treatment with P. crispum and C. sativum extracts, compared to untreated cells, implying that the extracts have high anti-inflammatory activity. Among P. crispum and C. sativum extracts, the healing of the wound was faster when treated with the extracts of P. crispum. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Georgakopoulos, Nikolaos; Talapatra, Sandeep; Dikovskaya, Dina; Dayalan Naidu, Sharadha; Higgins, Maureen; Gatliff, Jemma; Ayhan, Aysel; Nikoloudaki, Roxani; Schaap, Marjolein; Valko, Klara; Javid, Farideh; Dinkova-Kostova, Albena T.; Kozielski, Frank; Wells, Geoffrey published an article in Journal of Medicinal Chemistry. The title of the article was 《Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode》.Category: amides-buliding-blocks The author mentioned the following in the article:

Inhibitors of Kelch-like ECH-associated protein 1 (Keap1) increase the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) by stalling its ubiquitination and degradation This enhances the expression of genes encoding proteins involved in drug detoxification, redox homeostasis, and mitochondrial function. Nrf2 activation offers a potential therapeutic approach for conditions including Alzheimer’s and Parkinson’s diseases, vascular inflammation, and chronic obstructive airway disease. Non-electrophilic Keap1-Nrf2 protein-protein interaction (PPI) inhibitors may have improved toxicity profiles and different pharmacol. properties to cysteine-reactive electrophilic inhibitors. Here, we describe and characterize a series of Ph bis-sulfonamide PPI inhibitors that bind to Keap1 at submicromolar concentrations Structural studies reveal that the compounds bind to Keap1 in a distinct “”peptidomimetic”” conformation that resembles the Keap1-Nrf2 ETGE peptide complex. This is different to other small mol. Keap1-Nrf2 PPI inhibitors, including bicyclic aryl bis-sulfonamides, offering a starting point for new design approaches to Keap1 inhibitors. The experimental part of the paper was very detailed, including the reaction process of 2-Bromoacetamide(cas: 683-57-8Category: amides-buliding-blocks)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Internal Nucleophilic Catalyst Mediated Cyclisation/Ring Expansion Cascades for the Synthesis of Medium-Sized Lactones and Lactams》 were Lawer, Aggie; Rossi-Ashton, James A.; Stephens, Thomas C.; Challis, Bradley J.; Epton, Ryan G.; Lynam, Jason M.; Unsworth, William P.. And the article was published in Angewandte Chemie, International Edition in 2019. Application In Synthesis of N-Methoxy-N-methylacetamide The author mentioned the following in the article:

A strategy for the synthesis of medium-sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the need for the high-dilution conditions usually associated with medium-ring cyclisation protocols, as the reactions operate exclusively via kinetically favorable “”normal””-sized cyclic transition states. This same feature also enables biaryl-containing medium-sized rings to be prepared with complete atroposelectivity by point-to-axial chirality transfer. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Wang, Shitao; Sawada, Tomohisa; Ohara, Kazuaki; Yamaguchi, Kentaro; Fujita, Makoto published 《Capsule-Capsule Conversion by Guest Encapsulation》.Angewandte Chemie, International Edition published the findings.Recommanded Product: 78191-00-1 The information in the text is summarized as follows:

Guest-induced M18L6-M24L8 capsule-capsule conversion is reported. Both capsules are composed of PdII ethylenediamine units (M) and 1,3,5-tris(3,5-pyrimidyl)pyrimidine (L), and form trigonal bipyramidal (M18L6) and octahedral (M24L8) closed-shell structures with huge hydrophobic inner spaces. The M18L6 trigonal bipyramid is converted to the M24L8 octahedron through encapsulation of large aromatic guests, with the latter capsule possessing a cavity volume three times larger than the former. Despite the dynamic properties of the capsule host, the encapsulated guests are difficult to extract and were thus isolated from the external environment. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Valverde-Munoz, Francisco Javier; Bartual-Murgui, Carlos; Pineiro-Lopez, Lucia; Munoz, M. Carmen; Real, Jose Antonio published their research in Inorganic Chemistry on August 5 ,2019. The article was titled 《Influence of Host-Guest and Host-Host Interactions on the Spin-Crossover 3D Hofmann-type Clathrates {FeII(pina)[MI(CN)2]2}·xMeOH (MI = Ag, Au)》.Name: N-(Pyridin-4-yl)isonicotinamide The article contains the following contents:

The synthesis, structural characterization and magnetic properties of two new isostructural porous 3-dimensional compounds {FeII(pina)[MI(CN)2]2}·xMeOH (x = 0-5; pina = N-(pyridin-4-yl)isonicotinamide; MI = AgI and x ∼ 5 (1·xMeOH); MI = AuI and x ∼ 5 (2·xMeOH)) are presented. The single-crystal x-ray diffraction analyses revealed that the structure of 1·xMeOH (or 2·xMeOH) presents two equivalent doubly interpenetrated 3-dimensional frameworks stabilized by both argentophilic (or aurophilic) interactions and interligand C=O···HC H-bonds. Despite the interpenetration of the networks, these compounds display accessible void volume capable of hosting up to five mols. of MeOH which interact with the host pina ligand and establish an infinite lattice of H bonds along the structural channels. The magnetic studies showed that solvated complexes 1·xMeOH and 2·xMeOH display two- and four-step hysteretic thermally driven spin transitions, resp. However, when these compounds lose the MeOH mols., the magnetic behavior changes drastically giving place to gradual spin conversions evidencing the relevant influence of the guest mols. on the spin-crossover properties. Importantly, since the solvent desorption takes place following a single-crystal-to-single-crystal transformation, empty structures 1 and 2 (x = 0) could be also determined allowing the authors to evaluate the correlation between the structural changes and the modification of the magnetic properties triggered by the loss of MeOH mols. After reading the article, we found that the author used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Name: N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Name: N-(Pyridin-4-yl)isonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 2,6-DichloroisonicotinamideOn March 31, 2000, Miletin, Miroslav; Hartl, Jiri; Dolezal, Martin; Odlerova, Z.; Kralova, K.; Machacek, Milos published an article in Molecules [Electronic Publication]. The article was 《Synthesis of some 2,6-disubstituted 4-amidopyridines and -thioamidopyridines, and their antimycobacterial and photosynthesis-inhibiting activity》. The article mentions the following:

A group of 26 new 2-halo-6-alkylthio- and 2,6-bis(alkylthio)-4-carbamoyl- and -thiocsrbamoylpyridines was synthesized. Some of the carbamoylpyridines and all thiocarbamoylpyridines were tested for their antimycobacterial activity against atypical mycobacterial strains. Promising photosynthesis-inhibiting activity was also found for some of the amidopyridines. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dichloroisonicotinamide(cas: 89281-13-0Reference of 2,6-Dichloroisonicotinamide)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of 2,6-Dichloroisonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics