Tag: 200-300

The sydnone ring as an ortho-director of lithiation. 2. Dilithiation of 3-phenylsydnone and regiospecific o-aryl acylation using N-methoxy-N-methylamides was written by Turnbull, Kenneth;Sun, Congcong;Krein, Douglas M.. And the article was included in Tetrahedron Letters in 1998.Product Details of 192436-83-2 This article mentions the following:

Readily available 3-phenylsydnone reacts with butyllithium-TMEDA to form a dilithio species which can be regiospecifically acylated at the ortho-aryl position using N-methoxy-N-methylamides. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Product Details of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Intermolecular 1,4-Carboamination of Conjugated Dienes Enabled by Cp*Rh^III-Catalyzed C-H Activation was written by Pinkert, Tobias;Wegner, Tristan;Mondal, Shobhan;Glorius, Frank. And the article was included in Angewandte Chemie, International Edition in 2019.Computed Properties of C9H10BrNO2 This article mentions the following:

A protocol for the three-component 1,4-carboamination of dienes is described. Synthetically versatile Weinreb amides were coupled with 1,3-dienes and readily available dioxazolones as the nitrogen source using [Cp*RhCl₂]₂-catalyzed C-H activation to deliver the 1,4-carboaminated products. This transformation proceeds under mild reaction conditions and affords the products with high levels of regio- and E-selectivity. Mechanistic investigations suggest an intermediate Rh^III-allyl species is trapped by an electrophilic amidation reagent in a redox-neutral fashion. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Computed Properties of C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Computed Properties of C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of N-derivatives of p-quinonimines was written by Titov, E. A.;Avdeenko, A. P.. And the article was included in Zhurnal Organicheskoi Khimii in 1972.Formula: C13H13NO3S This article mentions the following:

N,2-Bis(benzenesulfonyl)- and N-benzenesulfonyl-2-chloro-1,4-naphthaquinone imine and N-benzenesulfonyl-2,6-dichloro-1,4-benzoquinone imine were prepared in ≤95.5% yield by treating the corresponding sulfonamido phenols with either HNO3 or NaNO2-HOAc. -PhSO2NHC10-H6OH-1 was converted to 54.2% 4-benzenesulfonamido-1,2-naphthoquinone by the former procedure and 65.0% N-benzenesulfonyl-1,4-naphthoquinone imine by the latter. N-(2,4-Dinitrophenyl)-4-aminophenol was oxidized by Pb(OAc)4 in HOAc to the corresponding quinone imine, which gave N-(2,4-dinitrophenyl)-2-chloro-4-aminophenol (I) with HCl-HOAc; N-(2,4-dinitrophenyl)-2,6-dichloro-4-aminophenol and -1,4-benzoquinone imine were prepared analogously from I. -Benzenesulfonamido- and 4-(p-toluenesulfonamido)-2-nitrophenol were prepared by nitration of the parent sulfonamido phenols using NaNO2-HOAc. -Benzenesulfonamido- and 1-(p-toluenesulfonamido)naphthalene gave mixtures of the resp. 2- and 4-nitro derivatives with HCl-NaNO2, with the latter predominating. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Formula: C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Formula: C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists was written by Jang, Yoon Kyung;Lee, Kyu Myung;Jung, Kwan-Young;Kang, Seung Kyu;Pagire, Suvarna H.;Lee, Jun Mi;Pagire, Haushabhau S.;Kim, Kwang Rok;Bae, Myung Ae;Lee, Hohjai;Rhee, Sang Dal;Ahn, Jin Hee. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Recommanded Product: 192436-83-2 This article mentions the following:

A series of N-methoxyamide derivatives was identified and evaluated as GPR119 agonists. Several N-methoxyamides with thienopyrimidine and pyridine scaffolds showed potent GPR119 agonistic activities. Among them, compound I displayed good in vitro activity and potency. Moreover, compound I lowered glucose excursion in mice in an oral glucose tolerance test and increased GLP-1 secretion in intestinal cells. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An integrated framework for designing formulated products was written by Zhang, Lei;Fung, Ka Yip;Zhang, Xiang;Fung, Ho Ki;Ng, Ka Ming. And the article was included in Computers & Chemical Engineering in 2017.Synthetic Route of C10H16N2O4 This article mentions the following:

Formulated products are created by mixing various ingredients together. They are com. produced for drugs, cosmetics, cleaning agents, lubricants and many others. The design of formulated products is diverse and multidisciplinary in nature; physico-chem. properties, product microstructure, product quality, and all other related areas have to be considered integratively. Various types of data, methods and tools are needed to tackle formulated product design problems to achieve an optimal design. In this study, an integrated framework as well as the design steps are proposed for the design of all kinds of formulated products including liquids, solids, emulsions, etc. Strategies for the selection of different modeling methods such as rule-based methods, model-based methods, experiments and databases are also presented. A multi-layer knowledge library is proposed to store all the information needed in the design of formulated products. Case studies of battery electrolyte and laundry detergent are given to illustrate the design framework. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Synthetic Route of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Synthetic Route of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Comparative study on application of cationic glutin agent and TAED in cotton fabric bleaching was written by Tang, Jun-ling;Wang, Xue-yan. And the article was included in Yinran Zhuji in 2015.Related Products of 10543-57-4 This article mentions the following:

A self-made cationic glutin agent and a com. bleaching activator tetraacetylethylenediamine (TAED) were added to the hydrogen peroxide bleaching bath resp., then two new bleaching systems were set up. Whiteness, capillary effect, strength and dyeing effect of cotton fabric treated by the new bleaching systems and traditional system were compared. The results showed that the cationic glutin agent was better than com. bleaching activator TAED in application, it was not only beneficial to promote the effect of hydrogen peroxide bleaching, but also improve the capillary effect and dyeing performances of bleached cotton fabric. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Related Products of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis and biological activity of novel sulfonylurea derivatives containing dimethoxymethyl-substituted pyrimidine moiety was written by Chen, Wei;Wei, Wei;Liu, Ming;Hua, Xuewen;Li, Yuxin;Li, Yonghong;Zhang, Xiao;Li, Zhengming. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2015.Category: amides-buliding-blocks This article mentions the following:

Sulfonylureas (SUs) as one kind of the most active herbicides targeted on acetolactate synthase (ALS). ALS was found not only in plants, but also in fungi and bacteria. In order to study the multi-biol. activity of sulfonylurea (SU), a series of novel SU derivatives containing dimethoxymethyl pyrimidine moiety were designed and synthesized according to bioisosteric principles. The bioassay results indicated that the title compounds exhibited favorable herbicidal activity. Compounds I (R = Cl, CO₂Me) showed 100% pre-emergence inhibition activity against Brassica napus at the dosage of 75 g/ha, which was near to that of Monosulfuron and Chlorsulfuron (100%). In addition, some of the title compounds also exhibited moderate antifungal activity. Compounds I (R = CF₃) and II showed over 80% antifungal activity against three fungi in vitro at the concentration of 50 mg/L, and closed to that of Chlorothalonil and Carbendazim. It provided useful information for designing new SUs with highly herbicidal activity and fungicidal activity. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6Category: amides-buliding-blocks).

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

N,N,N-Trimethyl-5-[(2,3,5,6-tetrafluorophenoxy)carbonyl]pyridin-2-aminium trifluoromethanesulfonate a precursor for the synthesis of 2,3,5,6-tetrafluorophenyl 6-[¹⁸F]-fluoronicotinate was written by Davis, Ryan A.;Fettinger, James C.. And the article was included in Acta Crystallographica, Section C: Structural Chemistry in 2018.Product Details of 2387-23-7 This article mentions the following:

The synthesis, recrystallization, and X-ray deterimination of N,N,N-trimethyl-5-[(2,3,5,6-tetrafluorophenoxy)carbonyl]pyridin-2-aminium trifluoromethanesulfonate (PyTFP-precursor), C₁₅H₁₃F₄N₂O₂⁺·CF₃SO₃^–, is described. This triflate salt precursor is required for the synthesis of 2,3,5,6-tetrafluorophenyl 6-[¹⁸F]-fluoronicotinate ([¹⁸F]FPyTFP), a prosthetic group used to radiolabel peptides for positron emission tomog. (PET), as peptides are increasingly being used as PET-imaging probes in nuclear medicine. Radiolabeling of peptides is typically done using a ‘prosthetic group’, a small synthon to which the radioisotope is attached in the first step, followed by attachment to the peptide in the second step. During the synthesis of the PyTFP-precursor, displacement of a Cl atom with trimethylamine gas and anion replacement with a triflate counter-ion is critical, as incomplete replacement would hinder radioisotopic incorporation of nucleophilic fluorine-18 and result in diminished radiochem. yields. The structural determination of the PyTFP-precursor by X-ray crystallog. helped confirm the anion exchange of chloride with triflate. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Product Details of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Using Oxone and TAED activator in non-chlorine bleaching of soda bagasse pulp was written by Zeinaly, Farhad;Gabov, Konstantin;Kanani Sula, Hadi;Babavand, Arash;Fardim, Pedro. And the article was included in Nordic Pulp & Paper Research Journal in 2019.Synthetic Route of C10H16N2O4 This article mentions the following:

Bagasse fiber has been used in the production of bleached chem. pulp by the Pars paper company. In this company, a conventional three-stage sequence of hypochlorite, alk. extraction and second hypochlorite (HEH) is applied in pulp bleaching. Pulp bleaching is one of the most important environmental pollutant stages in the pulp and paper industry. In this research, the bleaching of soda bagasse pulp by applying oxone and TAED-activator in non-chlorine bleaching sequences has been investigated. The unbleached pulp, with kappa number of 20, 955 mL/g viscosity and 37% brightness, was prepared from Pars Paper Company. Results indicated that, the TAED at the first and second stages were more effective than in the oxone stages. Moreover, the sequences, which contained TAED- and oxone-second-stage, could reach the min. level of kappa (1.7), but the highest brightness (80%) was attained by using only TAED with a comparatively high level of pulp viscosity (752). In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Synthetic Route of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot synthesis of N,N’-dialkylureas via carbonylation of amines with CO₂ applying Y_0.08Zr_0.92O_1.96 mixed oxide (YSZ-8) as a heterogeneous catalyst was written by Sun, Dalei;Xie, Kaihong;Fang, Yanxiong;Yang, Xianghua. And the article was included in Catalysts in 2018.Quality Control of 1,3-Dicyclohexylurea This article mentions the following:

One-pot synthesis of N,N’-dialkylureas were successfully achieved from catalytic carbonylation of aliphatic primary amines with CO₂ as the carbon source and Y_0.08Zr_0.92O_1.96 mixed oxide (Yttria-stabilized zirconia, YSZ-8) as the heterogeneous catalyst. The yield of the target product was obtained up to 80.60% from a 48 h reaction with an aliphatic primary amine and 3.0 MPa CO₂ in N-methyl-2-pirrolidinone at 160 °C. A multi-pronged mechanistic study was carried out where factors that might influence the reaction efficiency were studied, including catalyst structure, substrates basicity, CO₂ pressure, solvent polarity and reaction time. The presence of oxygen vacancies in YSZ-8 was found to be essential for the carbonylation process by creating addnl. reduction potential for the activation of CO₂ which would lead to the key intermediate species. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Quality Control of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Quality Control of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics