Tag: 200-300

Manganese oxalate – a Bio-inspired bleach catalyst was written by Reinhardt, G.;Best, M.;Ladwig, M.. And the article was included in SOFW Journal in 2011.Reference of 10543-57-4 This article mentions the following:

Sustainability driven trends to lower temperatures and shorter washing times require the use of alternative bleaches in automatic dishwashing applications. α-Manganese oxalate dihydrate, a synthetic analog of the mineral Lindbergite, offers a new proposition for a low temperature bleach catalyst in automatic dishwashing detergents. In combination with sodium percarbonate, the biodegradable catalyst enables tea stain removal at temperatures below 50°C where common bleaches fail. Storage stable co-granules comprising the catalyst in combination with the activator tetraacetyl ethylenediamine offer excellent tea stain removal while ensuring a high level of hygiene even at low temperatures In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors was written by La Regina, Giuseppe;Coluccia, Antonio;Famiglini, Valeria;Pelliccia, Sveva;Monti, Ludovica;Vullo, Daniela;Nuti, Elisa;Alterio, Vincenzo;De Simone, Giuseppina;Monti, Simona Maria;Pan, Peiwen;Parkkila, Seppo;Supuran, Claudiu T.;Rossello, Armando;Silvestri, Romano. And the article was included in Journal of Medicinal Chemistry in 2015.Synthetic Route of C9H10BrNO2 This article mentions the following:

New 1,1′-biphenylsulfonamides were synthesized and evaluated as inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV using acetazolamide (AAZ) as reference compound The 1,1′-biphenylsulfonamides inhibited all the isoforms, with K_i values in the nanomolar range of concentration, and were superior to AAZ against all of them. X-ray crystallog. and mol. modeling studies on the adducts that compound I, the most potent hCA XIV inhibitor of the series (K_i = 0.26 nM), formed with the five hCAs, provided insight into the mol. determinants responsible for the high affinity of this mol. toward the target enzymes. The results pave the way to the development of 1,1′-biphenylsulfonamides as a new class of highly potent hCA XIV inhibitors. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Synthetic Route of C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Removing polysaccharides-and saccharides-related coloring impurities in alkyl polyglycosides by bleaching with the H₂O₂/TAED/NaHCO₃ system was written by Yanmei, Liu;Jinliang, Tao;Jiao, Sun;Wenyi, Chen. And the article was included in Carbohydrate Polymers in 2014.Computed Properties of C10H16N2O4 This article mentions the following:

The effect of H₂O₂/TAED/NaHCO₃ system, namely NaHCO₃ as alk. agent with the (tetra acetyl ethylene diamine (TAED)) TAED-activated peroxide system, bleaching of alkyl polyglycosides solution was studied by spectrophotometry. The results showed that the optimal bleaching conditions about H₂O₂/TAED/NaHCO₃ system bleaching of alkyl polyglycosides solution were as follows: molar ratio of TAED to H₂O₂ was 0.06, addition of H₂O₂ was 8.6%, addition of NaHCO₃ was 3.2%, bleaching temperature of 50-65 °C, addition of MgO was 0.13%, and bleaching time was 8 h. If too much amount of NaHCO₃ was added to the system and maintained alk. pH, the bleaching effect would be greatly reduced. Fixing molar ratio of TAED to H₂O₂ and increasing the amount of H₂O₂ were beneficial to improve the whiteness of alkyl polyglycosides, but adding too much amount of H₂O₂ would reduce the transparency. In the TAED-activated peroxide system, NaHCO₃ as alk. agent and buffer agent, could overcome the disadvantage of producing black precipitates when NaOH as alk. agent. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Computed Properties of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quantification and method validation of dicyclohexylurea content in fosaprepitant dimeglumine drug substance by reverse phase HPLC was written by Kishore, M. V.;Sivarao, T.;Srinivas, K. Rama;Satyendranath, Ch. V.;Kumar, Vundavilli Jagadeesh;Kumar, K. S. R. Pavan;Sreenivas, N.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2020.Computed Properties of C13H24N2O This article mentions the following:

A simple, sensitive, and rapid reverse phase High-Pressure Liquid Chromatog. (HPLC) method was developed and validated for the quantification of residual Dicyclohexylurea in Fosaprepitant dimeglumine drug substance at trace level. The method was optimized on Zorbax Eclipse XDB-C8, 250 mm x 4.6 mm, 5μm with column oven temperature maintaining at 35°C with flow rate at 0.7 mL/min. Mobile Phase was prepared by a mixture of phosphate buffer pH 7.0 ((0.68 g of Potassium dihydrogen orthophosphate in 1000 mL of water) and Acetonitrile in the ratio of 53:47 volume/volume), the injection volume is 20μl, the detector wavelength is 205 nm. The developed, optimized method was further validated in accordance with ICH, and the method is found to be specific, sensitive, accurate, and precise. The Limit of detection (LOD) and Limit of quantification (LOQ) for dicyclohexylurea are 20μg/g and 60μg/g, resp. The method validation exptl. results are discussed in detail in this research paper. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mass spectrometry-based metabolomics approach to reveal differential compounds in pufferfish soups: Flavor, nutrition, and safety was written by Bi, Hongyan;Cai, Dandan;Zhang, Rutan;Zhu, Yiwen;Zhang, Danni;Qiao, Liang;Liu, Yuan. And the article was included in Food Chemistry in 2019.HPLC of Formula: 2387-23-7 This article mentions the following:

Some Eastern Asian countries deem pufferfish – especially its muscle – a culinary delight. Herein, mol. mass fingerprinting of soups prepared by Takifugu flavidus, Takifugu obscurus and Takifugu rubripes was established via matrix-assisted laser desorption/ionization – mass spectrometry (MALDI MS). Soup samples were directly analyzed by MALDI MS to collect mass spectra within 0-700 Da in a quick way, followed by principal component anal. to distinguish the different soups and to find out the distinctive compounds among the soups. High performance liquid chromatog. – tandem MS (HPLC-MS/MS) was applied to identify the compounds Nineteen compounds were identified from the HPLC-MS/MS data by using METLIN database. Through literature mining, we found that these compounds are closely related to the flavor, nutrition, and safety of pufferfish soups. This method can also be used as a facile way to distinguish between different pufferfish fillets when morphol. characters have been damaged or destroyed. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids was written by Niu, Teng;Zhang, Weiming;Huang, Danfeng;Xu, Changming;Wang, Haifeng;Hu, Yulai. And the article was included in Organic Letters in 2009.Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide This article mentions the following:

A powerful reagent, P[NCH₃(OCH₃)]₃, for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH₃(OCH₃)]₃ was heated with aromatic and aliphatic carboxylic acids in toluene. The sterically hindered carboxylic acids can also give the corresponding Weinreb amides in excellent yields. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Poly(vinyl ketone)s by Controlled Boron Group Transfer Polymerization (BGTP) was written by Uehara, Kazuhiro;Wagner, Christine B.;Vogler, Thomas;Luftmann, Heinrich;Studer, Armido. And the article was included in Angewandte Chemie, International Edition in 2010.Application of 192436-83-2 This article mentions the following:

A novel method is presented for controlled radical polymerization of alkyl and aryl vinyl ketones. The process comprises an unprecedented boron group transfer reaction as the key step. Mass spectrometry studies support the suggested mechanism and elucidate possible termination processes. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Application of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides was written by Sun, Deli;Ma, Guobin;Zhao, Xinluo;Lei, Chuanhu;Gong, Hegui. And the article was included in Chemical Science in 2021.Formula: C9H10BrNO2 This article mentions the following:

An asym. Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones I [R¹ = Me, Ph, 2-thienyl, etc.; R² = Me, n-Bu, Bn, etc.; Ar = 4-MeOOCC₆H₄, 2-methoxy-pyridin-5-yl, 2-naphthyl, etc.] was reported. The reaction tolerated a variety of functional groups under mild reaction conditions, which complements current methods. The utility of this work was demonstrated by facile late-stage functionalization of com. drugs. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Formula: C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Formula: C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effects of different activation processes on H₂O₂/TAED bleaching of Populus nigra chemi-thermo mechanical pulp was written by Zhao, Qiang;Sun, Dezhi;Wang, Zhaohong;Pu, Junwen;Jin, Xiaojuan;Xing, Mian. And the article was included in BioResources in 2012.Formula: C10H16N2O4 This article mentions the following:

Tetra acetyl ethylene diamine (TAED) was used as an activator in H₂O₂ bleaching to improve bleaching efficiency. The present work was aimed at confirming different activations for various H₂O₂/TAED bleaching processes, including the addition of acetic anhydride and the step-addition of sodium hydroxide. The results showed that an acetic anhydride dosage of 1%, an acetic anhydride treatment time of 10 min, and an addition time of 45 min were the optimal treatment conditions. The optimum processes of NaOH step-addition treatment in H₂O₂ bleaching and in H₂O₂/TAED bleaching also were confirmed, resp. The o-quinone contents of H₂O₂ bleached lignin and H₂O₂/TAED bleached lignin were determined The results indicated that H₂O₂/TAED bleached lignin has a lower o-quinone content than H₂O₂ bleached lignin, which is one of the reasons for the H₂O₂/TAED bleaching process having better bleaching efficiency than H₂O₂ bleaching. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Formula: C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Formula: C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The wide spectrum high biocidal potency of Bioxy formulation when dissolved in water at different concentrations was written by Dagher, Dori;Ungar, Ken;Robison, Richard;Dagher, Fadi. And the article was included in PLoS One in 2017.Formula: C10H16N2O4 This article mentions the following:

Traditional surface disinfectants that have long been applied in medicine, animal husbandry, manufacturing and institutions are inconvenient at best and dangerous at worst. Moreover, some of these substances have adverse environmental impacts: for example, quaternary ammonium compounds (“quats”) are reproductive toxicants in both fish and mammals. Halogens are corrosive both to metals and living tissues, are highly reactive, can be readily neutralized by metals, and react with organic matter to form toxic, persistent byproducts such as dioxins and furans. Aldehydes may be carcinogenic to both human and animals upon repeated exposures, are corrosive, cross-link living tissues and many synthetic materials, and may lose efficacy when pathogens enzymically adapt to them. Alcs. are flammable and volatile and can be enzymically degraded by certain bacterial pathogens. Quats are highly irritating to mucous membranes and over time can induce pathogen resistance, especially if they are not alternated with functionally different disinfectants. In contrast, peracetic acid (PAA), a potent oxidizer, liberates hydrogen peroxide (itself a disinfectant), biodegrades to carbon dioxide, water and oxygen, and is at least as efficacious as contact biocides e.g., halogens and aldehydes. Nevertheless, the standard form of liquid PAA is highly corrosive, is neutralized by metals and organic matter, gives off noxious odors and must be stored in vented containers. For the reasons stated above, Bioxy formulations were developed, a series of powder forms of PAA, which are odorless, stable in storage and safe to transport and handle. They generate up to 10% PAA in situ when dissolved in water. A 0.2% aqueous solution of Bioxy (equivalent to 200 ppm PAA) effected a 6.76 log reduction in Methicillin-resistant Staphylococcus aureus (MRSA) within 2 min after application. A 5% aqueous solution of Bioxy achieved a 3.93 log reduction in the bovine tuberculosis bacillus Mycobacterium bovis, within 10 min after contact. A 1% solution of Bioxy reduced vancomycin-resistant enterococci (VRE) and Pseudomonas aeruginosa by 6.31 and 7.18 logs, resp., within 3 min after application. A 0.5% solution of Bioxy inactivated porcine epidemic diarrhea virus (PEDV) within 15 min of contact, and a 5% solution of Bioxy realized a 5.36 log reduction in the spores of Clostridium difficile within 10 min of application. In summary, Bioxy is safe and easy to transport and store, poses negligible human, animal and environmental health risks, shows high levels of pathogen control efficacy and does not induce microbial resistance. Further investigations are recommended to explore its use as an industrial biocide. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Formula: C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics