Tag: 200-300

Electrooxidative and Regioselective C-H Azolation of Phenol and Aniline Derivatives was written by Feng, Pengju;Ma, Guojian;Chen, Xiaoguang;Wu, Xing;Lin, Ling;Liu, Peng;Chen, Tianfeng. And the article was included in Angewandte Chemie, International Edition in 2019.Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:

A general and practical protocol was developed for the regioselective C-H azolation of phenol and aniline derivatives by electrooxidative cross-coupling [e.g., 4-methoxyphenol + pyrazole → 4-methoxy-2-(1H-pyrazol-1-yl)phenol (97%)]. The reaction occurs under metal-, oxidant-, and reagent-free conditions, allowing access to a wide variety of synthetically useful heteroarene derivatives The reaction also tolerates a broad range of functional groups and is amenable to gram-scale synthesis. Finally, a preliminary mechanistic study indicated that a radical-radical-combination pathway might be involved in the coupling reaction. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bleaching process of cashmere with sodium percarbonate was written by Li, Zhi-gang. And the article was included in Maofang Keji in 2014.Application of 10543-57-4 This article mentions the following:

Sodium percarbonate is a kind of environmental friendly mild bleaching agent, the cashmere fiber bleaching process has not been applied. In this paper, through the test of bleaching process, the feasibility of sodium percarbonate on bleaching cashmere. The exptl. results show that, when the process conditions are: sodium percarbonate dosage 15 g/L, use NaOH to adjust the pH value of 8, the dosage of TAED 1.5 g/L, oxygen bleaching stabilizer 2 g/L, bleaching temperature 55°C, bleaching time 40 min. Compared with the conventional hydrogen peroxide bleaching, single fiber strength is slightly higher, up to 3.87 cN, whiteness values are slightly low, but also achieves 80 above, good bleaching effect. It provides the theory reference for the dyeing and finishing enterprises cashmere bleaching process improvement. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and mass spectrometry of some a-dialkylaminoalkylphenols structurally related to certain antiparasitic agents was written by El-Mouafi, Hamdi M. R.. And the article was included in Egyptian Journal of Pharmaceutical Sciences in 1991.Category: amides-buliding-blocks This article mentions the following:

Condensation of aminohydroxybenzenemethanamine derivatives (Mannich bases), e.g. I with 3-chloro-2-(2-pyridyl)-1-indenone gave the [[[(dialkylamino)methyl]hydroxyphenyl]amino](2-pyridyl)indenone II. Mannich reaction of N-(4-hydroxyphenyl)benzenesulfonamide with formaldehyde and diethylamine gave the [[(dialkylamino)methyl]hydroxyphenyl]benzenesulfonamide III. The mass spectrum of III was discussed. The antiparasitic activity of these compounds was not reported. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Category: amides-buliding-blocks).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wool micro powder as a metal ion exchanger for the removal of copper and zinc was written by Atef El-Sayed, Amr;Salama, Mohamed;Kantouch, Abdel Aziz Mohamed. And the article was included in Desalination and Water Treatment in 2015.Reference of 10543-57-4 This article mentions the following:

Waste wool fibers (WF) were oxidized and ball milled to enhance the exchanging ability toward some metal ions, namely copper and zinc. Wool fibers were oxidized with hydrogen peroxide and tetraacetylethylenediamine, followed by grinding process. Optimization of the exchanging medium with regard to the metal ion concentration, pH, and exchanging time was performed. It was observed that the ability of the wool powder (WP) and oxidized wool powder (OWP) to exchange greater amount of metal ions than the ordinary waste wool fibers. Mostly, current results verify a significant ability of the OWP to exchange copper and zinc ions from their aqueous medium. Nevertheless, the ability of all wool substrates used to exchange copper is more than their ability to exchange zinc, and as the pH of the exchanging medium increases, the uptake % of both copper and zinc ions by WF or WP increases to reach its maximum at pH 6. The efficiency of WF, WP, or OWP to adsorb copper and zinc ions after a number of adsorption/desorption tests was also studied. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Selectivity in tosylation of p-aminophenol was written by Kurita, Keisuke. And the article was included in Chemistry & Industry (London, United Kingdom) in 1982.SDS of cas: 1146-43-6 This article mentions the following:

Tolylsulfonylation of p-H₂NC₆H₄OH with p-MeC₆H₄SO₂Cl in CH₂Cl₂ containing Et₃N at 25° for 2 h gave 81% p-MeC₆H₄SO₃C₆H₄NH₂–p (I), 6% p-MeC₆H₄SO₃C₆H₄(NHO₃SC₆H₄Me-p)-p (II), and 4% p-HOC₆H₄NHO₃SC₆H₄Me-p (III). With Me₃COK as base only 32% I was obtained. When pyridine was used III was the major product (76%), only 1 and 14% of I and II, resp., being obtained. In the presence of the weak base AcNMe₂, or in the absence of base, III was the sole product. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6SDS of cas: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.SDS of cas: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Investigation of a homogeneous activating ozonation method in the rinsing procedure of cotton fabric dyed with reactive dye was written by Mao, Ya-Hong;Guan, Yu;Luo, Deng-Hong;Zheng, Qing-Kang;Feng, Xi-Ning;Wang, Xiu-Xing. And the article was included in Coloration Technology in 2011.Computed Properties of C10H16N2O4 This article mentions the following:

The textile dyeing process requires the consumption of large quantities of water, which includes huge amounts of colored wastewater. Usually the rinsing of dyed fabric and the treating of the dyeing house wastewater are separated The two independent processes not only increase the difficulty of wastewater treatment but also increase the costs of the treatment. In this paper, the ozone/tetraacetylethylenediamine active oxidation technol. was employed to rinse dyed fabric and to decolorise the rinsing wastewater simultaneously. The effects of the rinsing conditions on the decolorisation ratio and the COD Cr value of treated wastewater, and the K/S value, color difference, tensile strength and fastness of dyed samples were investigated. The results indicated that the decolorisation ratio of the rinsing effluent was greater than 80% and the COD Cr value decreased more than 58% by the ozone/tetraacetylethylenediamine rinsing process compared with that of traditional rinsing processes. Furthermore, the curve of decolorisation kinetics was in good agreement with a pseudo-first-order kinetic model. In addition, the decolorisation mechanism was also discussed after UV-visible and ultra performance liquid chromatograph-mass spectrometry analyses of the degraded dye mol. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Computed Properties of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Computed Properties of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

N-(2-(1H-indol-3-yl)ethyl)-2-(2-fluoro-[1,1”-biphenyl]-4-yl)propanamide was written by Manolov, Stanimir;Ivanov, Iliyan;Bojilov, And Dimitar. And the article was included in Molbank in 2021.Electric Literature of C13H24N2O This article mentions the following:

N-(2-(1H-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1”-biphenyl]-4-yl)propanamide were prepared by a reaction between tryptamine and flurbiprofen, applying N,N”-dicyclohexylcarbodiimide, as a coupling agent. The obtained new amide has a fragment similar to Brequinar, a compound used in SARS-CoV-2 treatment trials. The newly synthesized compound was fully analyzed and characterized via ¹H, ¹³C-NMR, UV, IR, and mass spectral data. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Electric Literature of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Electric Literature of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot sequential combination of multi-component and multi-catalyst: synthesis of 5-aminobenzofurans from aminophenol and ketene acetals was written by Yang, Cheng-Wen;Bai, Yue-Xia;Zhang, Ni-Tao;Zeng, Cheng-Chu;Hu, Li-Ming;Tian, Hong-Yu. And the article was included in Tetrahedron in 2012.Electric Literature of C13H13NO3S This article mentions the following:

The reaction between p-aminophenols and various ketene acetals in the presence of hypervalent iodine is described. The results show that 2- and 3-substituted 5-sulfonamidobenzofurans, e.g., I, are obtained in moderate to good yields from p-aminophenols and ketene acetals. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Electric Literature of C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

PEGylated ethyl cellulose micelles as a nanocarrier for drug delivery was written by Singam, Amarnath;Killi, Naresh;Patel, Pratikshkumar R.;Gundloori, Rathna V. N.. And the article was included in RSC Advances in 2021.Product Details of 2387-23-7 This article mentions the following:

Natural polymers provide a better alternative to synthetic polymers in the domain of drug delivery systems (DDSs) because of their renewability, biocompatibility, and low immunogenicity; therefore, they are being studied for the development of bulk/nanoformulations. Likewise, current methods for engineering natural polymers into micelles are in their infancy, and in-depth studies are required using natural polymers as controlled DDSs. Accordingly, in our present study, a new micellar DDS was synthesized using Et cellulose (EC) grafted with polyethylene glycol (PEG); it was characterized, its properties, cell toxicity, and hemocompatibility were evaluated, and its drug release kinetics were demonstrated using doxorubicin (DOX) as a model drug. Briefly, EC was grafted with PEG to form the amphiphilic copolymers EC-PEG1 and EC-PEG2 with varying PEG concentrations, and nano-micelles were prepared with and without the drug (DOX) via a dialysis method; the critical micelle concentrations (CMCs) were recorded to be 0.03 mg mL-1 and 0.00193 mg mL-1 for EC-PEG1 and EC-PEG2, resp. The physicochem. properties of the resp. nano-micelles were evaluated via various characterization techniques. The morphologies of the nano-micelles were analyzed via transmission electron microscopy (TEM), and the average size of the nano-micelles was recorded to be ∼80 nm. In vitro, drug release studies were done for 48 h, where 100% DOX release was recorded at pH 5.5 and 52% DOX release was recorded at pH 7.4 from the micelles. In addition, cytotoxicity studies suggested that DOX-loaded micelles were potent in killing MDA-MB-231 and MCF-7 cancer cells, and the blank micelles were non-toxic toward cancerous and normal cells. A cellular uptake study via fluorescence microscopy indicated the internalization of DOX-loaded micelles by cancer cells, delivering the DOX into the cellular compartments. Based on these studies, we concluded that the developed material should be studied further via in vivo studies to understand its potential as a controlled DDS to treat cancer. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Product Details of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Microbicidal action of heat, detergents and active oxygen bleach as components of laundry hygiene was written by Brands, Britta;Brinkmann, Angelina;Bloomfield, Sally;Bockmuehl, Dirk P.. And the article was included in Tenside, Surfactants, Detergents in 2016.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

It is known that decreasing temperatures in laundry can have a significant impact on the hygiene efficacy of laundering. This study used suspension tests to investigate the microbicidal effects of heat, detergent, and activated oxygen bleach and their contributions to laundry hygiene. Heat at 60° contributes significantly to the microbicidal action, while detergent only has limited effects. Activated oxygen bleach strongly enhances the microbicidal action and thus has the potential to compensate for the loss of antimicrobial efficacy due to temperature decrease. This effect varied with the test strain and the temperature, and further work is needed to determine whether it is possible to achieve a hygiene effectiveness equivalent to that at 60° across both fungal and bacterial strains. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics