Tag: 200-300

Efficient and general one-pot synthesis of β-chloro-β-trifluoromethylated enones from 3,3,3-trifluoropropyne was written by Jeon, Sung Lan;Kim, Dae Ho;Son, Jang Bae;Jeong, In Howa. And the article was included in Bulletin of the Korean Chemical Society in 2006.Product Details of 116332-61-7 This article mentions the following:

CF₃CCH reacted with Weinreb amides in BuLi/THF to give CF₃CCl:CHCOR [R = (un)substituted Ph, 1-naphthalenyl, 2-furanyl, cyclohexyl] as E-Z mixtures In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Product Details of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Product Details of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Oxidative Catalytic Spiroketalization Leading to Diastereoselective Synthesis of Spiro[benzofuran-2,1′-isochromene]s was written by Qiu, Jiang-Kai;Hao, Wen-Juan;Li, Guigen;Jiang, Bo. And the article was included in Advanced Synthesis & Catalysis in 2018.Application of 1146-43-6 This article mentions the following:

One-pot, two-step silver-catalyzed spiroketalization of the in-situ generated quinone imine ketals (QIKs) with β-alkynyl ketones was established, enabling multiple C-O and C-C bond-forming reactions to access densely functionalized spiro[benzofuran-2,1′-isochromene] derivatives with generally good yields. The use of β-alkynyl ketones bearing alkyl and aryl groups located at the α-position of the carbonyl group led to highly diastereoselective spiro[chromane-2,1′-isochromene] derivatives The reaction featured broad substrate scope, mild oxidative catalytic conditions and excellent diastereoselectivity. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Application of 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application of 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cyclodimerization of isocyanates promoted by one large vertex metallaborane was written by Ma, Pei;Spencer, James T.. And the article was included in Polyhedron in 2018.Related Products of 2387-23-7 This article mentions the following:

The 10-vertex Manganese-decaborane [nido-6-Mn(CO)₃B₉H₁₃][NMe₄] was found to act as an efficient catalyst for the synthesis of ureas I [R = allyl, n-Bu, cyclohexyl, Ph, Bn] via cyclodimerization of isocyanates under photo-irradiation conditions. The reaction yields were comparable with other metal catalyst reported in literature. Compound I [R = Ph] was characterized by X-ray crystallog. study and reaction mechanism was also proposed. The results are very encouraging as they represent first examples of a large metallaborane compound to catalyze the cyclodimerization of isocyanates. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The investigation of oxidative bleaching performance of peripherally Schiff base substituted tri-nuclear cobalt-phthalocyanine complexes was written by Sen, Pinar;Yildiz, S. Zeki. And the article was included in Inorganica Chimica Acta in 2017.Name: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

This study covers the functional complexes of tetrakis [4-(salicylhydrazone)phenoxy] phthalocyaninato cobalt (II) (5) which was the macro mol. Schiff base ligand and synthesized through a multistep reaction sequence starting first with the cyclotetramerization of 4-[4-(1,3-Dioxolan-2-yl)phenoxy]-phthalonitrile (2). Then, the de-protection of tetra acetal groups of Tetrakis[4-(1,3-dioxolan-2-yl)phenoxy]phthalocyaninato cobalt (II) (3) to the aldehyde functionality in acetic acid/FeCl₃ system to yield the Tetrakis(4-formylphenoxy)phthalocyaninato cobalt(II) (4) and then its condensation with salicylhydrazide gave to 5. Finally, CoPc-bis(salicylhydrazone)phenoxymanganese (III) (6), CoPc-bis(salicylhydrazone) phenoxycobalt(III) (7) and CoPc-bis (salicylhydrazone)phenoxy nickel(II) (8) were synthesized using with the related MnCl₂·4H₂O, CoCl₂·6H₂O, Ni(CH₃COO)₂ salt in basic conditions in DMF. FTIR, UV-visible, MS spectra and elemental anal. were applied to characterize to prepared compounds The bleaching performances of the prepared phthalocyanine compounds (3–8) were examined by the degradation of Morin as the hydrophilic dye which characterized the wine stains on the fabrics. Progress of the degradations in the catalysts (3–8)/H₂O₂ combination in basic aqueous solution conditions was investigated by using online spectrophotometric method (OSM). The prepared catalysts showed better bleaching performance at 25° than to that of tetraacetylethylenediamine (TAED) bleach activator com. used in powder detergent formulations. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Name: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors was written by Kishore Kumar, G. D.;Chavarria, Gustavo E.;Charlton-Sevcik, Amanda K.;Arispe, Wara M.;MacDonough, Matthew T.;Strecker, Tracy E.;Chen, Shen-En;Siim, Bronwyn G.;Chaplin, David J.;Trawick, Mary Lynn;Pinney, Kevin G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Formula: C9H10BrNO2 This article mentions the following:

A small library of 36 functionalized benzophenone thiosemicarbazone analogs was prepared by chem. synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. The six most active inhibitors of cathepsin L (IC₅₀ < 85 nM) in this series were I (R = 2-F, 3-F₃C, 4-F, 2,3-F₂, 3,5-F₂, 2,3,4,5-F₄). These six analogs were selective for their inhibition of cathepsin L vs. cathepsin B (IC₅₀ > 10,000 nM). The most active analog in the series, thiosemicarbazone I (R = 2-F), also efficiently inhibited cell invasion of the DU-145 human prostate cancer cell line. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Formula: C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′Râ€? or, equivalently, an acyl (alkanoyl) group RC(=O)âˆ?joined to an amine group. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kinetics and hydrolysis mechanism of triasulfuron was written by Braschi, Ilaria;Calamai, Luca;Cremonini, Mauro Andrea;Fusi, Paolo;Gessa, Carlo;Pantani, Ottorino;Pusino, Alba. And the article was included in Journal of Agricultural and Food Chemistry in 1997.Quality Control of 2-(2-Chloroethoxy)benzenesulfonamide This article mentions the following:

The hydrolysis of the sulfonylurea herbicide triasulfuron [(2-(2-chloroethoxy)-N-[[4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide] was studied in aqueous buffers of pH values 2, 3, 4, 5, 6, 7, and 9. The reaction was of first-order and pH-dependent. Triasulfuron was more persistent in neutral or weakly basic than in acidic solution Five metabolites have been isolated and identified. At all pH values studied, the primary pathway of degradation was the cleavage of the sulfonylurea bridge. However, minor degradation pathways have also been observed like O-demethylation and opening of the triazine ring. The product distribution was pH-dependent. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6Quality Control of 2-(2-Chloroethoxy)benzenesulfonamide).

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)Nâ€?is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cmâˆ?. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of 2-(2-Chloroethoxy)benzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The use of TAED in the last phase of CMP peroxide bleaching was written by Zeinaly, Farhad;Tabrizi, Ali Kazemi;Shakhes, Jalal;Zeinali, Nooshin. And the article was included in Nordic Pulp & Paper Research Journal in 2017.Category: amides-buliding-blocks This article mentions the following:

The alk. peroxide process is one of the bleaching processes used to bleach high-yield pulps. The two disadvantages concerning the bleaching of these pulps are pulp color reversion at the end of bleaching process, and the incomplete consumption of the peroxide. The effect of using TAED (tetra acetyl ethylene diamine), as an activator in the last phase of bleaching, on the process, as well as on the bleached pulp properties was the target of the present study. Single-stage alk. peroxide process was applied for bleaching of mixed hardwood chemi-mech. pulp (CMP, 85% yield). The treatments involved three different charges of peroxide (1.5, 2 and 3%) and of alkali (1.12, 1.5 and 2.25%, sodium hydroxide), with and without addition of TAED during the last phase of bleaching i.e. the last 10 min. The results indicated that the bleached pulp brightness and the bleaching process selectivity increased with the increase of the chems. charge, but with a descending tendency. The use of TAED, not only reduced the level of the alk. darkening, but also produced further improvement in the brightness and selectivity, and a reduction in the effluent COD load. Furthermore, the residual peroxide levels in TAED-activated treatments were low and negligible. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

N,N-Dialkyl-p-halobenzenesulfonamides: their insecticidal properties and joint action with DDT was written by Ascher, K. R. S.. And the article was included in Rivista di Parassitologia in 1963.Reference of 383-31-3 This article mentions the following:

A series of para substituted N,N-dialkylbenzenesulfonamides (I) was tested as to their inherent toxicity and their joint action with DDT on resistant and susceptible housefly (Musca domestica vicina) strains. The most toxic compounds on tarsal contact were p-chloro and p-fluoro substituted with maximum potency in the N,N-di-Pr derivatives Knockdown was higher at 28-29° than at 24°. Toxicity was greater for the normal than for the resistant strain. Tests of the gaseous phase action showed the F compounds had better fumigant action than the resp. Cl compounds No synergism was found when I compounds combined with DDT were used on normal flies. Synergism was evident in the Cl series, especially the N,N-di-Et derivative, on the resistant strain. Synergism was also obtained using DDE which indicated that the synergism was a support effect for the toxic action of the substituted benzenesulfonamides. 48 references. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Reference of 383-31-3).

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 383-31-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Establishing an ultrasound-assisted activated peroxide system for efficient and sustainable scouring-bleaching of cotton/spandex fabric was written by Li, Qing;Ni, Lijie;Wang, Jiacheng;Quan, Heng;Zhou, Yuyang. And the article was included in Ultrasonics Sonochemistry in 2020.Name: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

This study presents a high-efficient and cost-effective ultrasound-assisted strategy for one-bath one-step scouring and bleaching of cotton/spandex fabric using sodium percarbonate (SPC) and tetraacetylenediamine (TAED) couple. SPC plays both roles of pH regulator and H₂O₂ donor to initiate the peracetic acid (PAA) release from TAED. The significance and interaction effects of operating parameters (TAED concentration, temperature and time) on the WI (Whiteness Index) of fabrics were investigated through a central composite design. The bleaching mechanism was studied by exploring the relationship between WI and PAA and hydroxyl radical (HO·) concentrations The mech. and dyeing performances of treated fabrics were also evaluated. Results show that temperature exerted a significant impact on WI followed by TAED concentration and time. The PAA concentration decreased and HO· concentration increased upon the temperature rise. Both PAA and HO· were significant to upgrade WI and ultrasound was effective in enhancing their bleaching efficiency. The fabric treated only with 15 mmol/L TAED and 10 mmol/L SPC at 40° for 40 min under ultrasound could achieve a WI of 68.6 (43% higher than greige fabric), which was almost equivalent to that of the fabric treated at 60° without ultrasound. This verifies the contribution of ultrasound technol. in reducing bleaching temperature for energy-saving purpose. Moreover, the treated fabric displayed less than 5% tensile strength loss, having a marginal impact on the apparel performance. The wettability of fabric was greatly improved leading to a good dyeing performance. Encouraging results demonstrate the high efficiency of the ultrasound-assisted pre-treatment process of cotton/spandex fabric, which contributes to the sustainable production of textiles. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Name: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-step process for bio-scouring and peracetic acid bleaching of cotton fabric was written by El Shafie, Amira;Fouda, Moustafa M. G.;Hashem, Mohamed. And the article was included in Carbohydrate Polymers in 2009.SDS of cas: 10543-57-4 This article mentions the following:

In this study, we investigated the utilization of peracetic acid (PAA) formed in situ from reaction of tetraacetylethylenediamine (TAED) with sodium perborate to affecting simultaneous desizing and bleaching whereas cellulase, pectinase and their mixture were utilized to affect bio-scouring. In this regards, two parallel studies were designed, the first were, sep. desizing either with PAA or ammonium persulfate followed by bio-scouring and PAA bleaching in one step. The second sets of experiments were involved one-step process for desizing, bio-scouring and PAA bleaching. Residual starch, fabric wettability, residual wax content retained tensile strength elongation at break and fabric whiteness index were taken as a measure of the extent of cotton desizing, scouring and bleaching. Results obtained show that, cotton fabric bleached with PAA and either cellulase or pectinase enzyme shows excellent wettability and acceptable whiteness index (WI). This indicated that the combination between PAA and either cellulase or pectinase enzyme did not detract from the effectiveness these enzyme towards bio-scouring or the effectiveness of PAA towards low temperature bleaching of cotton fabric. The optimum bleaching recipe consists of utilizing a bath containing 25 g/L, TAED; 15 g/L, sodium perborate; 2 g/L, pectinase and 5 g/L Egyptol (non-ionic wetting agent) and the treatment was carried out at 60 °C for 90 min. Desizing with PAA prior to bio-scouring and bleaching enhances the WI to 73.5 the retained tensile strength remain at 85.5%. One-step process for desizing, bio-scouring and PAA was also feasible, which involved treatment the loomstate cotton fabric with the same recipe. Although, the fabric bleached with one-step process shows lower WI compared with two-step processes, but its wettability was excellent and no detectable residual starch was found. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4SDS of cas: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics