Tag: 200-300

Xiong, Wenzhang et al. published their research in Journal of the American Chemical Society in 2022 | CAS: 1146-43-6

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 1146-43-6

Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature was written by Xiong, Wenzhang;Shi, Qiu;Liu, Wenbo H.. And the article was included in Journal of the American Chemical Society in 2022.Product Details of 1146-43-6 This article mentions the following:

Herein, an efficient and practical approach to prepare phenols from benzoic acids via simple organic reagents at room temperature was reported. This approach was compatible with various functional groups and heterocycles and can be easily scaled up. To demonstrate its synthetic utility, bioactive mols. and unsym. hexaarylbenzenes was prepared by leveraging this transformation as strategic steps. Mechanistic investigations suggest that the key migration step involve a free carbocation instead of a radical intermediate. Considering the abundance of benzoic acids and the utility of phenols, it was anticipated that this method will find broad applications in organic synthesis. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Product Details of 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tuna, Murat et al. published their research in Journal of Molecular Structure in 2022 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Synthetic Route of C10H16N2O4

Synthesis of novel of Mn(II), Co(II), and Cu(II) Schiff base complexes and their high catalytic effect on bleaching performance with H2O2 was written by Tuna, Murat;Ugur, Tugba. And the article was included in Journal of Molecular Structure in 2022.Synthetic Route of C10H16N2O4 This article mentions the following:

Oxidation catalysts are used in a wide range of industrial processes. For instance, stain bleaching in detergents, bleaching of raw cotton and wood pulp, and drying of alkyd-based paint can be given as examples of oxidation catalysts. In this study, Me 2-(((3-hydroxynaphthalene -2-yl) methylene) amino) benzoate synthesized as the structure of a new Schiff base ligand by carrying out over 2-hydroxy-1-naphthaldehyde and Me 2-aminobenzoate. By the reactions of the synthesized Schiff base ligand and Cu(II), Mn(II), and Co(II) acetate salts, their ML2 type complexes were obtained. The structural characterizations of obtained metal ion-Schiff base complexes were performed using FT-IR, 1H-NMR, 13C-NMR, UV-Vis, MALDI-TOF, elemental anal. and m.p. methods. The bleaching performances of the prepared Schiff base complexes were examined by the degradation of morin as a hydrophilic dye that characterizes the wine stains. The bleaching processes of Schiff base complexes in the presence of catalyst and H2O2 in an aqueous solution buffered with Na2CO3/ NaHCO3 at pH: 10.5 were investigated using the online spectrophotometric method. It was found that the prepared catalysts exhibited better bleaching performance at 25°C than that of tetraacetylethylenediamine (TAED) as a bleach activator com. used in powder detergent formulations. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Synthetic Route of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Synthetic Route of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

She, Shan et al. published their research in Inorganic Chemistry in 2018 | CAS: 2387-23-7

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 2387-23-7

A Series of Weakley-type Polyoxomolybdates: Synthesis, Characterization, and Magnetic Properties by a Combined Experimental and Theoretical Approach was written by She, Shan;Gao, Chen;Chen, Kun;Bayaguud, Aruuhan;Huang, Yichao;Wang, Bing-Wu;Gao, Song;Wei, Yongge. And the article was included in Inorganic Chemistry in 2018.Product Details of 2387-23-7 This article mentions the following:

Using the DCC as the dehydrating agent, a series of Weakley-type polyoxomolybdates [Bu4N]3{Ln[Mo5O13(OMe)4(NO)]2} (Ln = Tb, Dy, Ho, Er) were synthesized in one-pot reaction and structurally characterized by elemental, IR, UV-visible anal. and single-crystal x-ray diffraction. Furthermore, the static and dynamic measurements were used to investigate their magnetic performances. Typically, slow relaxation of magnetization was observed for Dy analog with an energy barrier for the reversal of the magnetization of 50 K, which is the highest barrier height observed on the polyoxomolybdates-based SMMs. For a deep understanding of the appearance of the SMM behavior on Weakley-type polyoxomolybdates series, ab initio calculation on {Dy[Mo5O13(OMe)4(NO)]2}3- has been conducted. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Product Details of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Weidmann, Niels et al. published their research in Synthesis in 2021 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 116332-61-7

Halogen-Lithium Exchange of Sensitive (Hetero)aromatic Halides under Barbier Conditions in a Continuous Flow Set-Up was written by Weidmann, Niels;Nishimura, Rodolfo H. V.;Harenberg, Johannes H.;Knochel, Paul. And the article was included in Synthesis in 2021.Application of 116332-61-7 This article mentions the following:

A halogen-lithium exchange reaction of (hetero)aromatic halides performed in the presence of various electrophiles such as aldehydes, ketones, Weinreb amides, and imines using BuLi as exchange reagent and a com. available flow set-up was reported. The organolithiums generated in-situ were instantaneously trapped with various electrophiles (Barbier conditions) resulted in the formation of polyfunctional (hetero)arenes. This method enabled the functionalization of (hetero)arenes containing highly sensitive functional groups such as esters, which were not tolerated in batch conditions. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Application of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Du, Chongyang et al. published their research in Huaxue Xuebao in 2020 | CAS: 2387-23-7

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 2387-23-7

ZnEt2 promoted hydrosilylation of CO2 and formylation or urealation of amines with CO2 as a C1 building block was written by Du, Chongyang;Chen, Yaofeng. And the article was included in Huaxue Xuebao in 2020.SDS of cas: 2387-23-7 This article mentions the following:

Fixation and transformation of CO2 are of the great importance, especially the conversion of CO2 into valuable organic compounds catalyzed by the cheap and biocompatible metal catalysts. Zinc is an abundant, biocompatible and environmentally friendly element. ZnEt2 is com. available, and has been widely used as reducing or transmetalation agent in hydrocarboxylation of unsaturated hydrocarbons with CO2. In these reactions, ZnEt2 is generally used in stoichiometric amount or excess amount This manuscript reports the hydrosilylation of CO2 into methoxysilane promoted by a catalytic amount of ZnEt2 (1.0 mol%), the ZnEt2 promoted formylation or urealation of amines with CO2 as a one-carbon (C1) building block is also described. The hydrosilylation of CO2 into methoxysilane (CH3OSi(OEt)3) with (EtO)3SiH as a hydrosilylation reagent is affected by CO2 pressure, ZnEt2 amount, reaction temperature and reaction time. Under the reaction conditions of 1.0 MPa CO2 (the initial CO2 pressure) and 1.0 mol% ZnEt2, the yield of methoxysilane is up to ca. 90% after 7 h at 90°C, and no solvent is used for this reaction. In the presence of organic amine, the reaction gives formamide or urea instead of methoxysilane. Under 1.5 MPa CO2, 1.0 mol% ZnEt2, 2.4 equivalent (EtO)3SiH and 100°C, a series of secondary amines, both the aromatic ones and the aliphatic ones, can be formylated into formamides. In the formylation of N-methylanilines with different substituents at para-position, the isolated yields of the formylation products are in the order of OMe≈Me>H>F>Cl≈Br>CF3>NO2, indicating the electron-donating group at the para-position of the N-methylanilines is benefit for the formylation reaction. When primary amines are used as the substrates, the reactions prefer to produce urea derivatives under the same reaction conditions. In the urealation reaction, the electronic effect is not as significant as that in the formylation reaction. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Spicka, Nina et al. published their research in Fibers and Polymers in 2015 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Enzymatic scouring and low-temperature bleaching of fabrics constructed from cotton, regenerated bamboo, poly(lactic acid), and soy protein fibers was written by Spicka, Nina;Zupin, Ziva;Kovac, Janez;Forte Tavcer, Petra Eva. And the article was included in Fibers and Polymers in 2015.Category: amides-buliding-blocks This article mentions the following:

In the present study, fabrics constructed from cotton, regenerated bamboo, poly(lactic acid), and soy protein fibers were scoured with pectinase enzymes, bleached with different bleaching processes using peracetic acid (PAA), and conventionally bleached with hydrogen peroxide (HP). The enzymic scouring and bleaching with PAA have been chosen in order to minimize fiber damage and to perform the processes in more benign conditions. PAA was added to the bleaching bath in the form of a com. solution or it was produced in situ in the presence of HP with the addition of a bleach activator, tetraacetylethylenediamine (TAED), or arylesterase enzymes. The conventional process was performed at 90° in highly alk. pH media, and the bleaching processes with PAA were performed at 65° in neutral to slightly alk. pH media. The results revealed that after the enzymic scouring, the hydrophilicity of the fabrics is adequate. Compared with the cotton fibers, the regenerated bamboo and especially the poly(lactic) acid and soy protein fibers are significantly damaged during conventional HP bleaching. By contrast, bleaching with PAA revealed a strong whitening ability that is comparable to that of conventional bleaching with HP but with substantially reduced fiber damage. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Hong et al. published their research in Yinran in 2011 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 10543-57-4

Low temperature peroxide bleaching of cotton fabric activated with monoacetyl guanidine was written by Wang, Hong;Cao, Ji-liang. And the article was included in Yinran in 2011.Product Details of 10543-57-4 This article mentions the following:

Bleaching of cotton fabric is carried out with hydrogen peroxide/acetylguanidine (ACG) activation system. Factors of activator types, ACG dosage, bleaching temperature and time as well as pH value on bleaching effects are investigated, and compared to those with hydrogen peroxide or hydrogen peroxide/tetraacetylethylenediamine (TAED) systems. Results show that cotton fabric treated at 60 °C for 60 min with hydrogen peroxide (30%) 3 g/L, ACG 1.6 g/L, pH value about 8, features high whiteness. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Product Details of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Artoni, Riccardo et al. published their research in Granular Matter in 2014 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Effective wall slip in chutes and channels: experiments and discrete element simulations was written by Artoni, Riccardo;Santomaso, Andrea. And the article was included in Granular Matter in 2014.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

Wall slip is an important phenomenon for the flow of granular materials in chutes and channels. The appearance of a slip velocity at the wall critically affects wall stresses and flow profiles, and particularly the total flowrate. In this work we show, through numerical simulations and experiments, that the global slip phenomenon at a wall has peculiar features which deviate significantly from simple sliding behavior. At first we present exptl. data for the vertical chute flow which highlight that wall slip depends on many operating and system variables such as flow rate, material properties, wall properties. Secondly, we resume a large campaign of numerical data performed in 2D with polygonal particles, and try to analyze the effect of material properties, contact parameters, operating variables, different flow configurations, on the slip phenomenon. The numerical campaign allowed to identify the main parameters affecting the wall slip behavior of a numerical model of granular flow, providing the ingredients for the creation of a framework for the description of wall slip. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Suzuki, Hirotsugu et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C10H10F3NO2

Dealkoxylation of N-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis was written by Suzuki, Hirotsugu;Shiomi, Takahiro;Yoneoka, Kenji;Matsuda, Takanori. And the article was included in Organic & Biomolecular Chemistry in 2020.Computed Properties of C10H10F3NO2 This article mentions the following:

Lewis acid-assisted palladium-catalyzed dealkoxylation of N-alkoxyamides has been developed. This reaction proceeded smoothly with a range of N-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramol. hydride source. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Computed Properties of C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reverdin, Frederic et al. published their research in Arch. sci. phys. nat. gen. in 1907 | CAS: 1146-43-6

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C13H13NO3S

The Nitration of Some Derivatives of p-Aminophenol, (Continued) was written by Reverdin, Frederic;Dinner, Fritz. And the article was included in Arch. sci. phys. nat. gen. in 1907.Electric Literature of C13H13NO3S This article mentions the following:

The nitration of acetyl and benzoyl derivatives of the hydroxy- and amino- groups of sulphotoluene were studied. 1-o-Acetyl-4-N-toluenesulphoneamino phenol, m. 138-139°, by acetylation of N-toluenesulphoneaminophenol (J. pr. Chem., [2] 51, 438), easily saponifiable, with HNO3, sp. gr. 1.52, at 0° to 10°, yielded dinitrotoluenesulphoneaminophenol, C7H7SO2NH(1)C6H2(NO2)2(2,6)(OH)(4), m. 157-158°, the structure following from the fact that heating with concentrate H2SO4 gave dinitroammophenol, m. 231°, C6H2(OH)(NO2)2NH2(1)(3)(5)(4). Nitration preceded saponification, since the free phenol could not be nitrated. Nitration with HNO3 and H2SO4 in acetic anhydride caused decomposition and formation of nitroaminophenols. 1-o-Benzoyl-4-N-toluenesulphoneaminophenol, m. 170°, on nitration yielded a tetranitro derivative, m. 189-190°, probably C6H2(1)OC7H4ONO2(3,5)(NO2)7(4)NHSO2CH3C2H3NO2, with HNO3 and H2SO4, nitroaminophenols were formed. 1-o-toluene-p-sulphone-4-acetylaminophenol, m. 146° (Ber., 34, 237), on nitration yielded a mononitro-, m. 146°, or a dinitroderivative, m. 134°, for the latter acetic anhydride must be present, the structures of which were proved by saponification. With stronger acids, saponification took place at the same time as nitration. 1-o-Toluenesulphone-4-N-benzoylaminophenol, m. 218°, gave a trinitroderivative, m. 145-150°, 1 nitro group in the ring, 2 in the side chains, together with small quantities of mono- and dinitroderivatives. The colors of the various nitroaminophenols with soda served to identify them. Some conclusions with regard to the directive influence in the nitration of the groups present in the ring are given, the groups on the amino appearing to exert the greatest influence. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Electric Literature of C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics