Tag: 200-300

Nitrogen-Doped Porous Molybdenum Carbide and Phosphide Hybrids on a Carbon Matrix as Highly Effective Electrocatalysts for the Hydrogen Evolution Reaction was written by Huang, Yichao;Ge, Jingxuan;Hu, Jun;Zhang, Jiangwei;Hao, Jian;Wei, Yongge. And the article was included in Advanced Energy Materials in 2018.Application of 2387-23-7 This article mentions the following:

The efficient evolution of hydrogen through electrocatalysis is considered a promising approach to the production of clean hydrogen fuel. Platinum (Pt)-based materials are regarded as the most active hydrogen evolution reaction (HER) catalysts. However, the low abundance and high cost of Pt hinders the large-scale application of these catalysts. Active, inexpensive, and earth-abundant electrocatalysts to replace Pt-based materials would be highly beneficial to the production of cost-effective hydrogen energy. Herein, a novel organoimido-derivatized heteropolyoxometalate, Mo4-CNP, is designed as a precursor for electrocatalysts of the HER. It is demonstrated that the carbon, nitrogen, and phosphorus sources derived from the Mo4-CNP mols. lead to in situ confined carburization, phosphorization, and chem. doping on an at. scale, thus forming nitrogen-doped porous molybdenum carbide and phosphide hybrids, which exhibit remarkable electrocatalytic activity for the HER. Such an organically functionalized polyoxometalate-assisted strategy described here provides a new perspective for the development of highly active non-noble metal electrocatalysts for hydrogen evolution. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of activation oxidation system in cleaning of dyed cotton fabric was written by Luo, Deng-hong;Zheng, Qing-kang;Liu, Qing-shu;Pu, Zong-yao. And the article was included in Yinran Zhuji in 2010.HPLC of Formula: 10543-57-4 This article mentions the following:

Activation oxidation system was applied in cleaning procedure of cotton fabric dyed with K type reactive dye. The effects of additives and rinsing condition on decolorization rate of rinsing liquor and cleaning result of dyed fabric were investigated. The results indicated that the color removal rate could reach 58.92% through the application of tetraacetylethylenediamine (TAED)/H₂O₂ activation oxidation system in Reactive Red K-2G. Combination of MgCl₂, (NH₄)₂S₂O₈ and TAED/H₂O₂ had a synergistic effect on the decolorization, which could increase the decolorization rate of Reactive Red K-2G to 91.43%. When the composite oxidation system was applied to the soaping process of cotton fabric, the K/S values and the color differences of the rinsed fabric changed little compared with that of normal rinsed fabric. And the color fastness slightly increased, the color removal rate of rinsing liquor could reach a high level. Besides, oxidation cleaning could decrease the COD_Cr of rinsing effluent by 40%, which was helpful for alleviating the load of wastewater treatment and lowering the total cost of production In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4HPLC of Formula: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A Strategy for Amide to β-Oxo Ester Transformation via N-Alkenoxypyridinium Salts as the Activator and H₂O as the Nucleophile was written by Wu, Nan;Li, Chuang;Mi, Jiajia;Zheng, Yan;Xu, Zhou. And the article was included in Organic Letters in 2020.Safety of 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

N-Alkenoxypyridinium salts were found to be highly active electrophilic reagents that could be used to activate the C-N bond of amides. Both aromatic amides and aliphatic amides could be transformed into the corresponding β-oxo esters with good yields via the combined use of N-alkenoxypyridinium salts and water. The methodol. proceeds under mild reaction conditions and is tolerant of various functional groups in both reaction partners. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Safety of 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Safety of 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and properties of new non-symmetric liquid crystal dimers containing mandelic acid and cyano group was written by Yao, Miao;Chen, Xin-shi;Dong, Liang;Wan, Xin-yi;Xian, Yu-pei;Yao, Dan-shu;Hu, Jian-she;Tian, Mei. And the article was included in Liquid Crystals in 2018.Name: 1,3-Dicyclohexylurea This article mentions the following:

Four non-sym. dimers containing mandelic acid as the chiral core I [R = H, cyano, (4-cyanophenyl)], II were synthesized. Chem. structures and liquid crystal (LC) properties of the dimers were characterised by FTIR, ¹H-NMR, differential scanning calorimetry (DSC), thermogravimetric anal. (TG) and polarised optical microscopy (POM). The results indicated that the rigidity and conformation of the mols. of the dimers played important effects on their mesophase properties. I [R = H] did not display any mesophase, I [R = cyano, (4-cyanophenyl)] exhibited nematic (N) phases, while II displayed cholesteric (ch) phase, which indicated that chiral mandelic acid could induce cholesteric phase, but some attention should be paid to the mol. conformation to obtain cholesteric phase. For the four dimers, melting temperature (Tm) increased first and then decreased, inferring that mol. conformation played a more important effect besides mol. weight and rigidity. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Name: 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Name: 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases was written by Crosignani, Stefano;Pretre, Adeline;Jorand-Lebrun, Catherine;Fraboulet, Gaele;Seenisamy, Jeyaprakashnarayanan;Augustine, John Kallikat;Missotten, Marc;Humbert, Yves;Cleva, Christophe;Abla, Nada;Daff, Hamina;Schott, Olivier;Schneider, Manfred;Burgat-Charvillon, Fabienne;Rivron, Delphine;Hamernig, Ingrid;Arrighi, Jean-Francois;Gaudet, Marilene;Zimmerli, Simone C.;Juillard, Pierre;Johnson, Zoe. And the article was included in Journal of Medicinal Chemistry in 2011.Electric Literature of C8H10FNO2S This article mentions the following:

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound, I, by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with K_i < 10 nM) but also excellent potencies in a human whole blood assay (IC₅₀ < 100 nM; PGD2-induced eosinophil shape change). Addnl. optimization of the pharmacokinetic characteristics led to the identification of several compounds suitable for in vivo testing. Of these, II (R¹ = n-Pr, R² = Me; R¹ = n-Pr, R² = F) were tested in two different pharmacol. models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg). In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Electric Literature of C8H10FNO2S).

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C8H10FNO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rhodium-Catalyzed C-H Olefination of Aryl Weinreb Amides was written by Wang, Yan;Li, Chao;Li, Yan;Yin, Feng;Wang, Xi-Sheng. And the article was included in Advanced Synthesis & Catalysis in 2013.SDS of cas: 116332-61-7 This article mentions the following:

A rhodium(III)-catalyzed oxidative C-H olefination directed by Weinreb amides, a class of well developed versatile building blocks in organic synthesis, has been developed with air as the terminal oxidant. The reactions proceed with excellent reactivity, good functional group tolerance and high yields. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7SDS of cas: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Asymmetric synthesis of aryl/vinyl alkyl carbinol esters via Ni-catalyzed reductive arylation/vinylation of 1-chloro-1-alkanol esters was written by Sun, Deli;Tao, Xianghua;Ma, Guobin;Wang, Jifen;Chen, Yunrong. And the article was included in Chemical Science in 2022.Quality Control of 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

An asym. Ni-catalyzed cross-electrophile coupling approach to prepare enantioenriched aryl/vinyl alkyl carbinol esters RC(O)OC(R¹)R² [R = 4-methylphenyl, iso-Pr, naphthalen-2-yl, etc.; R¹ = 4-(methoxycarbonyl)phenyl, 2H-1,3-benzodioxol-5-yl, cyclopent-1-en-1-yl, etc; R² = Et, 2-phenylethyl, 4-methoxy-4-oxobutyl, etc.] through arylation/vinylation of easily accessible racemic 1-chloro-1-alkanol esters RC(O)OC(Cl)R² with aryl/vinyl electrophiles R¹X (X = Br, I, OTf) was reported. The method features a broad substrate scope as demonstrated by more than 60 examples including the challenging chiral allylic esters. It tolerates a wide array of functional groups including alkenyl, carbonyl and free hydroxyl groups that may not survive in conventional carbonyl reduction and addition methods. The synthetic utility of the present work was showcased by facile preparation of a few key intermediates and the modification of chiral drugs and naturally occurring compounds Finally, an efficient one-pot procedure for this method was described. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Quality Control of 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of biaryl ketones by arylation of Weinreb amides with functionalized Grignard reagents under thermodynamic control vs. kinetic control of N,N-Boc₂-amides was written by Li, Guangchen;Szostak, Michal. And the article was included in Organic & Biomolecular Chemistry in 2020.Recommanded Product: 116332-61-7 This article mentions the following:

A highly efficient method for chemoselective synthesis of biaryl ketones by arylation of Weinreb amides (N-methoxy-N-methylamides) with functionalized Grignard reagents was reported. This protocol offers rapid entry to functionalized biaryl ketones after Mg/halide exchange with i-PrMgCl·LiCl under operationally-simple and practical reaction conditions. The scope of the method was highlighted in >40 examples, including bioactive compounds and pharmaceutical derivatives Collectively, this transition-metal-free approach offers a major advantage over the recently established cross-coupling of amides by oxidative addition of N-C(O) bonds. Considering the utility of amide acylation reactions in modern synthesis, we expect that this method will be of broad interest. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Recommanded Product: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sulfated-Tungstate-Catalyzed Synthesis of Ureas/Thioureas via Transamidation and Synthesis of Forchlorofenuron was written by Wagh, Ganesh D.;Pathare, Sagar P.;Akamanchi, Krishnacharya G.. And the article was included in ChemistrySelect in 2018.Application of 2387-23-7 This article mentions the following:

N, N’-Disubstituted ureas and thioureas were efficiently and expeditiously synthesized by transamidation reaction between unsubstituted or monosubstituted ureas/thioureas and amines under solvent-free condition using sulfated tungstate as a heterogeneous mild solid acid catalyst. This protocol offered several advantages such as wide substrate scope, providing both sym. and unsym. ureas and thioureas, solvent-free reaction, recyclability of the catalyst and a simple work-up procedure. Application of the methodol. was demonstrated through simple and one step synthesis of forchlorofenuron [1-(2-chloropyridine-4-yl)-3-phenylurea] (CPPU), an approved plant growth regulator. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Low-temperature activated bleaching processes and mechanism of cotton fabric was written by Wang, Kuo;Liu, Kai;Yan, Ke-lu. And the article was included in Yinran in 2017.Computed Properties of C10H16N2O4 This article mentions the following:

Low-temperature activators TAED and JML-2 are adopted for cotton bleaching, and the hydroxyl radical (OH·) in TAED/H₂O₂ and JML-2/H₂O₂ systems is detected with a novel fluorescent probe benzenepentacarboxylic acid (BA). The results show that the optimum activated bleaching condition is: 30% H₂O₅ g/L, NaOH 2 g/L, TAED or JML-2 3g/L, bleaching at 70°C for 60 rain. OH · yield in TAED/H₂O₂ system is significantly higher than that in H₂O₂ system. The whiteness of cotton fabric is obviously decreased when the OH · is scavenged in TAED/H₂O₂ system. It proves that OH · plays a significant role in TAED/H₂O₂ system for low-temperature bleaching. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Computed Properties of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics