Tag: 200-300

The overexpression of the SAPB of Bacillus pumilus CBS and mutated sapB-L31I/T33S/N99Y alkaline proteases in Bacillus subtilis DB430: New attractive properties for the mutant enzyme was written by Zarai Jaouadi, Nadia;Jaouadi, Bassem;Aghajari, Nushin;Bejar, Samir. And the article was included in Bioresource Technology in 2012.Related Products of 10543-57-4 This article mentions the following:

The sapB gene encoding for Bacillus pumilus CBS protease (SAPB) and the triple mutated sapB-L31I/T33S/N99Y gene were cloned and overexpressed in the protease-deficient Bacillus subtilis DB430 using an Escherichia coli-Bacillus shuttle vector pBSMuL2. The 34,625.13 and 34,675.11-Da enzymes were purified from the culture supernatant of B. subtilis expressing the wild-type and mutated genes, resp. The purified proteases showed the same N-terminal sequences and biochem. properties of those expressed in E. coli. Further investigations demonstrated that, compared to wild-type and other proteases, SAPB-L31I/T33S/N99Y had the highest catalytic efficiency and the best degree of hydrolysis. The mutant enzyme was also noted to exhibit a number of newly explored properties that are highly valued in the marketplace, namely considerable stability to detergents, higher resistance towards organic solvents, and potent dehairing ability. Overall, the findings indicated that SAPB-L31I/T33S/N99Y is a promising candidate for future use in a wide range of industrial and com. applications. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Related Products of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists was written by Mittapalli, Gopi Kumar;Vellucci, Danielle;Yang, Jun;Toussaint, Marion;Brothers, Shaun P.;Wahlestedt, Claes;Roberts, Edward. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Product Details of 383-31-3 This article mentions the following:

Highly potent and selective small mol. neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit mol. N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 1-R-4-[hydroxy(diphenyl)methyl]piperidines [R = CSNHC₆H₄SO₂NMe₂-4] (CYM 9484) and [R = CO₂C₆H₄SO₂NEt₂-4] (CYM 9552) with IC₅₀ values of 19 nM and 12 nM resp. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Product Details of 383-31-3).

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 383-31-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Use of nitrogen centered peroxide activators to increase the brightening potential of peroxide II. optimized conditions was written by Hu, Q. Y.;Daneault, C.;Robert, S.. And the article was included in Cellulose Chemistry and Technology in 2011.Reference of 10543-57-4 This article mentions the following:

This work focuses on a new TAED/H₂O₂ bleaching system on spruce-balsam thermomech. pulp, at low consistency. The experiments show that the TAED/H₂O₂ system improves the brightness of the softwood thermo-mech. pulp significantly (6% ISO), compared to the peroxide system alone. For each fixed molar ratio of TAED/H₂O₂, there is an optimum range for alkali addition, for achieving a maximum brightness gain of the thermomech. pulp, a well-defined linear correlation being found between the TAED/H₂O₂ molar ratio and the optimal alkali charge. An optimal TAED/H₂O₂ ratio is obtained at 0.7, slightly higher than the theor. value of 0.5, as due to the saponification reaction of TAED. TAED/H₂O₂ results in pulps being slightly more susceptible to light-induced yellowing in the UV and visible regions of the spectrum, at very long irradiation times. Short term light-induced yellowing is approx. the same for both kinds of pulps. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis, characterisation and catalytic studies of nano zinc oxide-alumina for displacement reaction on carbonyldiimidazole was written by Sumathi, S.;Balaganesh, M.;Balasubramanian, K. K.. And the article was included in Rasayan Journal of Chemistry in 2020.Category: amides-buliding-blocks This article mentions the following:

Nano zinc oxide supported on alumina was prepared by chem. method and calcined at 300°C. The calcined material was characterized by UV-Visible spectroscopy, Infra-Red spectroscopy, X-Ray Diffraction technique, SEM, Thermogravimetric anal. and Porosimetry. The catalytic activity studies on alumina supported zinc oxide for the synthesis of disubstituted ureas through displacement reaction on carbonyldiimidazole are hitherto unreported. Thus, alumina supported nano zinc oxide was tested for its catalytic activity in the displacement reaction of carbonyldiimidazole with cyclohexylamine. While, the above reaction when carried out at room temperature, afforded 1,3-Dicyclohexyl urea, as the sole product in 88% yield in 20 h, at 80°C, 1,3-dicyclohexyl urea was obtained in 80% yield, in 4 h. Reusable and safer catalysts, reaction at room temperature, simple workup and product with good yield and purity are the merits of this process. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Category: amides-buliding-blocks).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Targeted folate-conjugated pluronic P85/poly(lactide-co-glycolide) polymersome for the oral delivery of insulin was written by Xie, Shuang;Gong, Yan C.;Xiong, Xiang Y.;Li, Zi L.;Luo, Yue Y.;Li, Yu P.. And the article was included in Nanomedicine (London, United Kingdom) in 2018.Application In Synthesis of 1,3-Dicyclohexylurea This article mentions the following:

To explore the better efficacy of targeted folic acid (FA)-Pluronic 85-poly(lactide-co-glycolide) (FA-P85-PLGA) polymersome in oral insulin delivery. The cytotoxicity of the polymers, in vitro qual. and quant. cellular uptake and the internalization mechanism of insulin-loaded FA-P85-PLGA and PLGA-P85-PLGA polymersomes were studied with the human colon adenocarcinoma cells (Caco-2 cells). Their pharmacodynamics and pharmacokinetics properties were also studied with diabetic rats. Polymersomes have shown good biocompatibility. Polymersomes are mainly localized within the cytoplasm of Caco-2 cells from fluorescence microscopy images. FA-P85-PLGA exhibited higher cellular uptake than PLGA-P85-PLGA polymersomes and free fluorescein isothiocyanate-labeled insulin (FITC-insulin) did. The uptake process of targeted polymersomes included clathrin- and caveolae-mediated endocytosis, macropinocytosis and the folate receptor-mediated endocytosis. Insulin-loaded FA-P85-PLGA showed better hypoglycemic effects than insulin-loaded PLGA-P85-PLGA. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application In Synthesis of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boosting catalytic activity of δ-MnO₂ through potassium incorporation for efficient carbonylation of amines by carbon dioxide was written by Sun, Dalei;Peng, Liang;Yang, Yating;Fang, Yanxiong;Ping Jiang, San;Shao, Zongping. And the article was included in Journal of Catalysis in 2022.Recommanded Product: 2387-23-7 This article mentions the following:

The synthesis of N,N’-dialkylurea from carbonylation of amines with CO₂ over δ-MnO₂ catalyst is a highly attractive green route, however, the catalytic performance of δ-MnO₂ is still far from satisfied. Here, we report a new strategy for fine tuning the physicochem. properties of δ-MnO₂ through KOH hydrothermal activation, resulting in superior catalytic performance with N,N’-dialkylurea yield as high as 77.09% using NMP as solvent at 160°C for 4 h, as compared to only 43.41% for the pristine δ-MnO₂. The yield is further boosted to 92.02% by using PEG 400 as solvent. Systematic anal. based on characterization techniques reveals such superior catalytic performance is closely related to, on the one hand, the potassium-incorporation and catalysis induced modification of the concentration of vacancies of both oxygen and Mn, on the other hand, PEG 400 as solvent is favorable to both absorbance of CO₂ and stability of carbamic acids intermediates. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System was written by Kumar, Naveen;Zhao, Haoqi Nina;Awoyemi, Olushola;Kolodziej, Edward P.;Crago, Jordan. And the article was included in Environmental Science & Technology in 2021.SDS of cas: 2387-23-7 This article mentions the following:

Current aquatic toxicity assessments usually focus on targeted analyses coupled with toxicity testing to determine the impacts of complex mixtures on aquatic organisms. However, based on this approach alone, it is sometimes difficult to explain observed toxicity from the selected chem. analytes. Recent anal. advances such as high-resolution mass spectrometry (HRMS) can improve the characterizations of the chem. composition of complex mixtures, but the intensive labor required to produce confident identifications limits its utility in high-throughput screening. In the present study, we evaluated a rapid workflow to predict potential toxicity signatures of complex water samples based on high-throughput, tentative HRMS identifications derived from database matching, followed by identification of chem.-ligand interactions and pathway identification. We tested the workflow with water samples from the effluent-dominated Lubbock Canyon Lake System (LCLS). Results across all sites showed that predicted toxicity signatures had little variation when correcting for HRMS false-pos. rates. The most common pathways across sites were gonadotropin-releasing hormone receptor and α-adrenergic receptor signaling. Alterations to the predicted pathways were successfully observed in larval zebrafish exposures to LCLS water samples. These results may allow researchers to better utilize rapid assessments of HRMS data for the assessment of adverse impacts on aquatic organisms. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.SDS of cas: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hemin-Catalyzed Oxidative Phenol-Hydrazone [3+3] Cycloaddition Enables Rapid Construction of 1,3,4-Oxadiazines was written by Zuo, Honghua;Qin, Jingyang;Zhang, Wentao;Bashir, Muhammad Adnan;Yu, Qile;Zhao, Weining;Wu, Guojiao;Zhong, Fangrui. And the article was included in Organic Letters in 2020.Application of 1146-43-6 This article mentions the following:

Herein, we present a hemin-catalyzed oxidative phenol-hydrazone [3+3] cycloaddition that accommodates a broad spectrum of N-arylhydrazones, a class of less exploited 1,3-dipoles due to their significant Lewis basicity and weak tendency to undergo 1,2-prototropy to form azomethine imines. It renders expedient assembly of diversely functionalized 1,3,4-oxadiazines with excellent atom and step economy. Preliminary mechanistic studies point to the involvement of a one-electron oxidation pathway, which likely differs from the base-promoted aerobic oxidative scenario. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Application of 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Influence of bleach activators in removing different soils from cotton fabric was written by Tavcer, Petra Forte. And the article was included in Fibres & Textiles in Eastern Europe in 2020.Product Details of 10543-57-4 This article mentions the following:

The influence of adding Sodium Perborate Tetrahydrate (NaPB) and tetraacetylethylenediamine (TAED) on the efficiency of removing soils from cotton fabric was evaluated in the study. NaPB as inorganic peroxide and TAED as a bleach activator were added to a com. washing powder agent. Four standard soils applied on cotton fabric (EMPA standard soiled fabrics) were used in the study, i.e. 101 – carbon black/olive oil, 114 – red wine, 116 – blood/milk/ink and 160 – chocolate. The washing of fabrics was conducted in accordance with the SIST EN ISO 105-C06 standard at 40, 60 and 90°C in Launder-Ometer apparatus The washing efficiency was evaluated by determining the CIE L* color coordinates of the unwashed and washed fabric samples, and the difference in ΔL* color coordinates among them. The results showed that NaPB and TAED improve the efficiency of washing for two standard soils, have no effect on one, and deteriorate the washing results of one standard soil. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Product Details of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Product Details of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Evaluation of microplastic release caused by textile washing processes of synthetic fabrics was written by De Falco, Francesca;Gullo, Maria Pia;Gentile, Gennaro;Di Pace, Emilia;Cocca, Mariacristina;Gelabert, Laura;Brouta-Agnesa, Marolda;Rovira, Angels;Escudero, Rosa;Villalba, Raquel;Mossotti, Raffaella;Montarsolo, Alessio;Gavignano, Sara;Tonin, Claudio;Avella, Maurizio. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2018.Computed Properties of C10H16N2O4 This article mentions the following:

A new and more alarming source of marine contamination has been recently identified in micro and nanosized plastic fragments. Microplastics are difficult to see with the naked eye and to biodegrade in marine environment, representing a problem since they can be ingested by plankton or other marine organisms, potentially entering the food web. An important source of microplastics appears to be through sewage contaminated by synthetic fibers from washing clothes. Since this phenomenon still lacks of a comprehensive anal., the objective of this contribution was to investigate the role of washing processes of synthetic textiles on microplastic release. In particular, an anal. protocol was set up, based on the filtration of the washing water of synthetic fabrics and on the anal. of the filters by SEM. The quantification of the microfibre shedding from three different synthetic fabric types, woven polyester, knitted polyester, and woven polypropylene, during washing trials simulating domestic conditions, was achieved and statistically analyzed. The highest release of microplastics was recorded for the wash of woven polyester and this phenomenon was correlated to the fabric characteristics. Moreover, the extent of microfibre release from woven polyester fabrics due to different detergents, washing parameters and industrial washes was evaluated. The number of microfibres released from a typical 5 kg wash load of polyester fabrics was estimated to be over 6,000,000 depending on the type of detergent used. The usage of a softener during washes reduces the number of microfibres released of more than 35%. The amount and size of the released microfibres confirm that they could not be totally retained by wastewater treatments plants, and potentially affect the aquatic environment. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Computed Properties of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics