Tag: 200-300

A Catalytic Strategy for α,ω-Functionalization: NHC-Mediated Fragmentation/Umpolung Cascades to Access Hydroxytrifluoromethyl Ynones and Allenones was written by Selg, Christoph;Kraft, Fabian B.;Welcke, Linda;Zeitler, Kirsten. And the article was included in ChemCatChem in 2019.HPLC of Formula: 116332-61-7 This article mentions the following:

Herein we report an unprecedented, convenient NHC-catalyzed one-pot cascade reaction to afford α,ω-difunctionalized hydroxytrifluoromethyl alkynones and allenones in a single step. The critical fragile aliphatic aldehydes are introduced by a base-mediated in situ Grob-type fragmentation of their corresponding latent cyclic vinylogous hemiacetal triflate (VHAT) and γ-hydroxy vinyl triflate (GHVT) precursors, avoiding typical problems and losses upon isolation. The ‘demasked’ aldehydes are subsequently trapped by NHC-catalyzed umpolung and further metal-free C-C-cross-coupling to access a broad scope of terminally modified alkynyl or allenyl aliphatic, aromatic and heteroaromatic trifluoromethyl ketones as multifunctionalized, high-value building blocks for advanced synthetic applications. Addnl. synthetic utility of this approach is demonstrated with the possibility for asym. variants using chiral NHC-catalysts. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7HPLC of Formula: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.HPLC of Formula: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and biological evaluation of N-(cyclopropyl)benzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors was written by Heo, Jinyuk;Shin, Hanbo;Lee, Jun;Kim, Taelim;Inn, Kyung-Soo;Kim, Nam-Jung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

A series of hybrid mols. consisting of benzophenone derivatives and N-cyclopropyl-3-methylbenzamide derivatives were synthesized and biol. evaluated as novel p38 mitogen activated protein kinase (MAPK) inhibitors. In particular, the authors found that one compound displayed potent p38α MAPK inhibitory activity (IC₅₀ = 0.027 μM), high kinase selectivity, and significant antiinflammatory activity in THP-1 monocyte cells [i.e., human monocytic leukemia cell line]. The synthesis of the target compounds was achieved by a reaction of N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide with [(hydroxyethoxy)phenyl](bromophenyl)methanone derivatives and analogs. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling Procedure was written by Heijnen, Dorus;Helbert, Hugo;Luurtsema, Gert;Elsinga, Philip H.;Feringa, Ben L.. And the article was included in Organic Letters in 2019.Product Details of 192436-83-2 This article mentions the following:

The synthesis of functionalized (benz)aldehydes, via a two-step, one-pot procedure, is presented. The method employs a stable aluminum hemiaminal as a tetrahedral intermediate, protecting a latent aldehyde, making it suitable for subsequent cross-coupling with (strong nucleophilic) organometallic reagents, leading to a variety of alkyl and aryl substituted benzaldehydes. This very fast methodol. also facilitates the effective synthesis of a ¹¹C radiolabeled aldehyde. Aluminum-ate complexes enable transmetalation of alkyl fragments onto palladium and subsequent cross-coupling. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Product Details of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Oxidation of sulfamethazine by a novel CuS/calcium peroxide/tetraacetylethylenediamine process: High efficiency and contribution of oxygen-centered radicals was written by Li, Yangju;Dong, Haoran;Xiao, Junyang;Li, Long;Chu, Dongdong;Hou, Xiuzhen;Xiang, Shuxue;Dong, Qixia. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands).Reference of 10543-57-4 This article mentions the following:

Calcium peroxide (CP)-based advanced oxidation processes for water decontamination have stimulated considerable attention due to their inherent merits. Herein, a novel tetraacetylethylenediamine (TAED) coupled CuS/CP (i.e., CuS/TAED/CP) process was tentatively employed for the degradation of sulfamethazine (SMT) in water. Exptl. results suggested that peracetic acid (PAA) could be efficiently generated and then activated by CuS in alk. media, achieving 92.1% removal of SMT in 30 min. Identification of reactive oxygen species (ROS) revealed that the available ROS including hydroxyl radical (•OH), singlet oxygen (1O2), and oxygen-centered radicals (R – O•) together accounted for SMT degradation Based on quant. anal. of the relative contribution of involved ROS, R – O• were validated to be the primary reactive species that contributed to 75.2% of SMT removal. Addnl., the role of superoxide radical (O•-2), sulfur species, and calcium hydroxide (Ca(OH)2) were investigated. It was concluded that the O•-2 and reductive sulfur species enabled the promoted redox cycle of Cu species, and the Ca(OH)2 generated from CP favored the efficient generation and activation of PAA. Influencing factors like CP dosage, initial pH, and nontarget matrix constituents were also evaluated. Moreover, degradation pathways of SMT were proposed, and the ecotoxicity of these intermediates was predicted. The present work provides a promising and simple approach for the rapid decontamination of antibiotic-polluted water. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chlorine-free extraction of cellulose from rice husk and whisker isolation was written by Rosa, Simone M. L.;Rehman, Noor;de Miranda, Maria Inez G.;Nachtigall, Sonia M. B.;Bica, Clara I. D.. And the article was included in Carbohydrate Polymers in 2012.Product Details of 10543-57-4 This article mentions the following:

This work reports the isolation of cellulose whiskers from rice husk (RH) by means of an environmental friendly process for cellulose extraction and bleaching. The multistep process begins with the removal of pectin, cutin, waxes and other extractives from rice husk, then an alk. treatment for the removal of hemicelluloses and lignin, and a two-step bleaching with hydrogen peroxide/tetra-acetylethylenediamine (TAED), followed by a mixture of acetic and nitric acids, for further delignification of the cellulose pulp. The techniques of IR absorption spectroscopy (ATR-FTIR), SEM, thermogravimetric anal. (TGA), modulated differential scanning calorimetry (MDSC) and X-ray diffraction (XRD) showed that the overall process is adequate to obtain cellulose with high purity and crystallinity. This cellulose was submitted to sulfuric acid hydrolysis with the aim to isolate the whiskers. They showed the typical elongated rod-like aspect as revealed by transmission electron microscopy (TEM) and at. force microscopy (AFM). In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Product Details of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

EIS study of blister formation on coated galvanized steel in oxidizing alkaline solutions was written by Schachinger, Ernst Dietmar;Braidt, Roland;Strauss, Bernhard;Hassel, Achim Walter. And the article was included in Corrosion Science in 2015.Category: amides-buliding-blocks This article mentions the following:

The performance of polymer coated galvanized steel sheet in alk. solutions with and without saline components containing Na percarbonate as an oxidizing agent was studied by visual inspection, light microscopy and electrochem. impedance spectroscopy (EIS). Ionic species are both, they are necessary to initiate blistering, but also support blister growth. Na percarbonate accelerates blister growth. Detailed studies concerning the effect of temperature and salt concentration were made. Blister growth kinetics was followed by EIS and is in good agreement with visual inspection. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Simulated sunlight-induced photodegradations of triasulfuron and cinosulfuron in aqueous solutions was written by Vulliet, E.;Emmelin, C.;Grenier-Loustallot, M. F.;Paiesse, O.;Chovelon, J. M.. And the article was included in Journal of Agricultural and Food Chemistry in 2002.Safety of 2-(2-Chloroethoxy)benzenesulfonamide This article mentions the following:

To elucidate the photochem. behavior of two sulfonylureas (cinosulfuron and triasulfuron) for which the chem. formulas are relatively close, their photodegradation was studied in water. All experiments were carried out under laboratory conditions using a xenon arc lamp as the source of radiation to simulate environmental conditions. Polychromatic quantum efficiencies were calculated to determine the photochem. pesticide lifetimes at pH 7, and a comparison with hydrolysis lifetimes has been performed. The results obtained showed clearly that at pH 7, photodegradation becomes a more important pathway than chem. degradation HPLC-DAD was used to study the kinetics for both sulfonylureas and their photoproducts, whereas HPLC-MS (ESI in pos. and neg. modes) was used to identify photoproducts. These results suggest that the photodegradation of these two sulfonylureas proceeds via a number of reaction pathways: (1) cleavage of the sulfonylurea bridge; (2) desulfonylation, which can proceed either by a carbon-sulfur cleavage or a nitrogen-sulfur cleavage; (3) O-demethylation of methoxy moieties present on the triazine ring; and (4) O-dealkylation of benzene derivatives In addition, it was found that the desulfonylation represented the main step and that it was wavelength dependent. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6Safety of 2-(2-Chloroethoxy)benzenesulfonamide).

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Safety of 2-(2-Chloroethoxy)benzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quaternary ammonium-functionalized carbon dots for sensitive and selective detection of 2,4,6-trinitrophenol in aqueous medium was written by Gao, Kezheng;Guo, Yaqing;Niu, Qingyuan;Han, Lifeng;Zhou, Liming;Wang, Lizhen. And the article was included in Sensors and Actuators, B: Chemical in 2018.Formula: C13H24N2O This article mentions the following:

A new fluorescence nanosensor for sensitive and selective 2,4,6-trinitrophenol (TNP) detn is reported based on (3-chloro-2-hydroxypropyl)trimethylammonium chloride (CTA) functionalized carbon dots (CTA-CDs). CM-cellulose sodium (CMC)-4,7,10-trioxa-1,13-tridecanediamine (TTDDA) mixture was heated to prep passivated CDs. Then CTA was grafted onto the surface of the passivated CDs by esterification reaction to form quaternary ammonium-functionalized CTA-CDs. Therefore, the CTA-CDs are used as a sensor for the detection of 2,4,6-trinitrophenol (TNP) in water via mol interactions (electrostatic, π-π, and hydrogen bonding interactions) between TNP and CTA-CDs. A limit of detection of the CTA-CDs for TNP in aq soln is 7.04 × 10^-7 mol/L, which is lower than that of the passivated CDs for TNP (3.03 × 10^-6 mol/L). In addition, compared with various org reagents, the CTA-CDs exhibit significantly sensitive and selective sensing towards TNP in aq medium. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Enabling the Cross-Coupling of Tertiary Organoboron Nucleophiles through Radical-Mediated Alkyl Transfer was written by Primer, David N.;Molander, Gary A.. And the article was included in Journal of the American Chemical Society in 2017.Reference of 192436-83-2 This article mentions the following:

The construction of quaternary centers is a common challenge in the synthesis of complex materials and natural products. Current cross-coupling strategies that can be generalized for setting these centers are sparse and, when known, are typically predicated on the use of reactive organometallic reagents. To address this shortcoming a new, photoredox-Ni dual catalytic strategy for the cross-coupling of tertiary organoboron reagents with aryl halides is reported. In addition to details on the cross-coupling scope and limitations, full screening efforts and mechanistic experiments are communicated. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Reference of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Reference of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Oxovanadium(V)-catalyzed amination of carbon dioxide under ambient pressure for the synthesis of ureas was written by Moriuchi, Toshiyuki;Sakuramoto, Takashi;Matsutani, Takanari;Kawai, Ryota;Donaka, Yosuke;Tobisu, Mamoru;Hirao, Toshikazu. And the article was included in RSC Advances in 2021.Related Products of 2387-23-7 This article mentions the following:

Carbon dioxide is regarded as a reliable C1 building block in organic synthesis because of the nontoxic, abundant, and economical characteristics of carbon dioxide. In this manuscript, a com. available oxovanadium(V) compound was demonstrated to serve as an efficient catalyst for the catalytic amination of carbon dioxide under ambient pressure in the synthesis of ureas. The catalytic transformation of chiral amines into the corresponding chiral ureas without loss of chirality was also performed. Furthermore, a gram-scale catalytic urea synthesis under ambient pressure was successfully achieved to validate the scalability of this catalytic activation of carbon dioxide. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics