Tag: 200-300

Ionic (Co)Organocatalyst with (Thio)Urea Anion and Tetra-n-butyl Ammonium Cation for the Polymerization of γ-Butyrolactone was written by Ge, Fang;Wang, Zhe;Zhu, Yanyun;Wang, Xiaowu. And the article was included in Macromolecular Chemistry and Physics in 2020.Category: amides-buliding-blocks This article mentions the following:

An effective ionic organocatalyst system is developed for the challenging ring-opening polymerization (ROP) of γ-butyrolactone (GBL) at low temperature The catalysts are prepared by dehydration reaction between tetra-Bu ammonium hydroxide (TBAOH) and (thio)ureas at ambient temperature, and utilized with or without extra benzyl alc. (BnOH) initiator. The solid-state structure of TUA-3 comprising thiourea anion is characterized by X-ray diffraction anal. Typically, a mixture of cyclic and linear poly(GBL) with low mol. weights (5000-1600 g mol^-1) and slightly narrow mol. distribution ETH (1.2-1.4) is obtained by single base with/without combination with (thio)ureas. Interestingly, solely linear high-mol.-weight poly(GBL) (10 400 g mol^-1) can be achieved by a synergistic effect of TBAOH/N,N’-isopropylthiourea in the presence of BnOH. The obtained poly(GBL) is characterized with NMR spectroscopy and matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS). Mechanistic studies reveal different polymerization initiation steps in this reported catalyst system, which leads to poly(GBL) with divergent end groups. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Category: amides-buliding-blocks).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bromination of 4-arenesulfonamidophenols and -1-naphthols and N-(arylsulfonyl)-1,4-benzo(naphtho)quinone 4-imines was written by Avdeenko, A. P.;Velichko, N. V.. And the article was included in Zhurnal Organicheskoi Khimii in 1992.Product Details of 1146-43-6 This article mentions the following:

2,3,6-Tribromo-N-arylsulfonyl-1,4-benzoquinon-4-imines are formed by bromination of 4-arenesulfonamidophenols and N-arylsulfonyl-1,4-benzoquinon-4-imines, but in the case of 4-arenesulfonamido-1-naphthols and N-arylsulfonyl-1,4-naphthoquinon-4-imines only 2-bromo-N-arylsulfonyl-1,4-naphthquinon-4-imines are formed. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Product Details of 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Innovative bleaching active system which could improve bleaching performance was written by Song, Rong-hua. And the article was included in Zhongguo Xidi Yongpin Gongye in 2013.Recommanded Product: 10543-57-4 This article mentions the following:

An effective low temperature bleaching active granule Peractive Perfect Clean (PPC) was developed based on TAED, which contains tetraacetylethylenediamine (TAED) and decanoyloxy benzoate (DOBA). Compared with TAED, low temperature stain removing effect, especially removing oil stain, of PPC was more effective. DOBA was gentler to color than TAED. PPC could effectively sterilize at 20°C. Soaking under 21°C for 15°C, the degerming abilities of PPC on Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Trichophyton rubrum were the highest, and the removal rate on Trichophyton rubrum reached 99.9%. Peractive PPC could effectively improve the comprehensive performance of the laundry products. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and antiviral effect of p-alkylbenzenesulfonamide derivatives was written by Tsuji, Tadakazu;Kawabata, Junzo;Kobayashi, Sachiko;Ueda, Takeo. And the article was included in Chemical & Pharmaceutical Bulletin in 1964.HPLC of Formula: 1146-43-6 This article mentions the following:

p-Alkylbenzenesulfonamide derivatives were synthesized by the reaction of p-alkyl- or p-alkoxybenzenesulfonyl chloride with amine or ammonia, and the compounds were recrystallized from dilute EtOH. Lower alkyl and alkoxyl groups introduced into benzenesulfonamide gave rise to in vitro activity on poliomyelitis virus (Lansing strain). Mice were inoculated intracerebrally with poliomyelitis virus prior to intravenous injections of the tested derivative Only p-toluenesulfonamide and N-phenyl-p-toluenesulfonamide showed in vivo activity on viral multiplication. N-Phenyl-p-toluenesulfonamide required repeated daily administrations of 11 mg./kg. for 3-5 days to demonstrate effectiveness. None of the derivatives was effective against Japanese encephalitis (Nakayma strain) or influenza A virus (PR-8 strain). In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6HPLC of Formula: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.HPLC of Formula: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies was written by Phelan, James P.;Wiles, Rebecca J.;Lang, Simon B.;Kelly, Christopher B.;Molander, Gary A.. And the article was included in Chemical Science in 2018.Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

Two synergistic approaches to the facile assembly of complex α-trifluoromethyl alkenes are described. Using α-trifluoromethyl-β-silyl alcs. as masked trifluoromethyl alkenes, cross-coupling or related functionalization processes at distal electrophilic sites can be executed without inducing Peterson elimination. Subsequent Lewis acidic activation affords functionalized α-trifluoromethyl alkenes. Likewise, the development of a novel α-trifluoromethylvinyl trifluoroborate reagent complements this approach and allows a one-step cross-coupling of (hetero)aryl halides to access a broad array of complex α-trifluoromethyl alkenes. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lewis Acid Assisted Broensted Acid Catalysed Decarbonylation of Isocyanates: A Combined DFT and Experimental Study was written by Dasgupta, Ayan;van Ingen, Yara;Guerzoni, Michael G.;Farshadfar, Kaveh;Rawson, Jeremy M.;Richards, Emma;Ariafard, Alireza;Melen, Rebecca L.. And the article was included in Chemistry – A European Journal in 2022.Formula: C13H24N2O This article mentions the following:

An efficient and mild reaction protocol for the decarbonylation of isocyanates was developed using catalytic amounts of Lewis acidic boranes. The electronic nature (electron withdrawing, electron neutral, and electron donating) and the position of the substituents (ortho/meta/para) bound to isocyanate controls the chain length and composition of the products formed in the reaction. Detailed DFT studies were undertaken to account for the formation of the mono/di-carboxamidation products and benzoxazolone compounds In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes was written by Orsi, Douglas L.;Douglas, Justin T.;Sorrentino, Jacob P.;Altman, Ryan A.. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 1146-43-6 This article mentions the following:

Gem-Difluoroalkenes represent valuable synthetic handles for organofluorine chem.; however, most reactions of this substructure proceed through reactive intermediates prone to eliminate a fluorine atom and generate monofluorinated products. Taking advantage of the distinct reactivity of gem-difluoroalkenes, we present a cobalt-catalyzed regioselective unsym. dioxygenation of gem-difluoroalkenes using phenols and mol. oxygen, which retains both fluorine atoms and provides β-phenoxy-β,β-difluorobenzyl alcs. Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O₂/phenol and quenched by the Co-based catalyst. This mechanism enables the retention of both fluorine atoms, which contrasts most transition-metal-catalyzed reactions of gem-difluoroalkenes that typically involve defluorination. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Recommanded Product: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rapid and Simple Identification and Quantification of Components in Detergent Formulations by Nuclear Magnetic Resonance Spectroscopy was written by Hansen, Svend Hoime;Damhus, Ture;Brask, Jesper. And the article was included in Journal of Surfactants and Detergents in 2020.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

A rapid, inexpensive, and simple high-resolution NMR spectroscopic method is outlined for determining the content of surfactants and other low-mol.-weight organic compounds in detergent formulations. With simple sample preparation, quant. results can be obtained from an internal standard and/or the method can be used as a fingerprint anal. of the surfactant composition The NMR sample is prepared by suspending the detergent sample in deuterated acetic acid and thus dissolving surfactants and other organic compounds Any content of carbonate will be liberated as CO₂, whereas other inorganic materials are removed by centrifugation. From one-dimensional ¹H and two-dimensional HSQC NMR spectra, the surfactant components and low-mol.-weight organic compounds can be identified from reference spectra. Intensities of signature signals in the one-dimensional ¹H NMR spectrum are used for quantification by comparing with an internal standard Furthermore, it is demonstrated how ³¹P NMR can be used to identify and quantify phosphonate-type chelators. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effective approach to ureas through organocatalyzed one-pot process was written by Wang, Mingliang;Han, Jilai;Si, Xiaojia;Hu, Yimin;Zhu, Jidong;Sun, Xun. And the article was included in Tetrahedron Letters in 2018.Reference of 2387-23-7 This article mentions the following:

An efficient approach to N,N’-unsym. substituted ureas ArN(R¹)C(O)NH(R²) (R¹ = H; R² = n-Bu, c-hexyl, Bn, etc.; Ar = 4-MeC₆H₄, 4-MeOC₆H₄, 4-F₃CC₆H₄, 3-BrC₆H₄) has been developed through the ammonolysis of N-Boc protected anilines with amines prompted by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). Moreover, a convenient protocol for the synthesis of the sym. N,N’-substituted ureas RNHC(O)NHR (R = Ph, 2-ClC₆H₄, 4-IC₆H₄, etc.) by one-pot diammonolysis of Boc₂O with amines catalyzed by DABCO has also been achieved. With broad substrate scope and mild conditions, these two methods demonstrate practical preparation of both unsym. and sym. ureas. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Reference of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quantification of organic contaminants in urban stormwater by isotope dilution and liquid chromatography-tandem mass spectrometry was written by Hou, Fan;Tian, Zhenyu;Peter, Katherine T.;Wu, Christopher;Gipe, Alex D.;Zhao, Haoqi;Alegria, Ernesto A.;Liu, Fengmao;Kolodziej, Edward P.. And the article was included in Analytical and Bioanalytical Chemistry in 2019.Formula: C13H24N2O This article mentions the following:

Pollutants transported in urban stormwater runoff induce pervasive water quality degradation in receiving waters. To accurately characterize stormwater quality and treatment system performance across the range of possible contaminant characteristics, comprehensive multi-residue anal. methods are necessary. Here, we developed a solid-phase extraction (SPE) and high-performance liquid chromatog.-tandem mass spectrometry (HPLC-MS/MS) method to quantify representative stormwater-derived organic contaminants across multiple chem. classes, including vehicle-related chems., corrosion inhibitors, industrial chems., pesticides, pharmaceuticals and personal care products, and antioxidants. Extraction conditions, isotope-labeled internal standards, and LC-MS/MS parameters were optimized to enhance recovery, minimize matrix effects, and maximize selectivity and sensitivity. The developed method was sensitive (method quantification limits < 10 ng/L for > 80% of selected analytes) and accurate (mean relative recoveries in the range of 70-130%, with relative standard deviations < 25% for 77% of the analytes) for most of the analytes. The method was used to analyze samples collected from nine urban watersheds during a storm event; 62% of the 39 analytes were detected at least once at concentrations up to 540 ng/L (1,3-diphenylguanidine). Spatial trends in detection and concentration were observed for vehicle-related and industrial chems. that correlated with vehicle traffic. Total concentrations of pesticides suggested that residential uses could be more important sources than agriculture. This study illustrates the pervasive occurrence of a wide variety of stormwater-derived chems. in urban receiving waters and highlights the need to better understand their environmental fate and ecol. implications. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics