Tag: 200-300

Kraft pulp bleaching with a P-stage catalyzed by both bicarbonate and TAED was written by Das, N.;Bose, S. K.;Francis, R. C.. And the article was included in Tappi Journal in 2019.Formula: C10H16N2O4 This article mentions the following:

Peroxide bleaching of softwood and hardwood (eucalypt) kraft pulps was performed in solutions of sodium bicarbonate (NaHCO₃), sodium carbonate (Na₂CO₃), and sodium hydroxide (NaOH). The conventional P stage (hydrogen peroxide + sodium hydroxide; H₂O₂ + NaOH) was the most effective brightening system without an addnl. activator. However, peroxide activation by bicarbonate anion (HCO₃^–) was obvious in all cases where NaHCO₃ or Na₂CO₃ was used. When N,N,N’,N’-tetraacetylethylenediamine (TAED) was added to the bleaching system, Na₂CO₃ as the alkali source afforded equal or slightly higher bleached brightness compared to NaOH usage for both the softwood and hardwood pulps. This outcome is attributed to simultaneous peroxide activation by HCO₃^– and TAED. When applied to the eucalypt pulp, the H₂O₂/Na₂CO₃/TAED bleaching system also decreased the brightness loss due to thermal reversion. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Formula: C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and Investigation of Therapeutic Potential of Isoform-Specific HDAC8 Inhibitors for the Treatment of Cutaneous T Cell Lymphoma was written by Umamaheswari, Appavoo;Puratchikody, Ayarivan;Hari, Natarajan. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2019.Related Products of 2387-23-7 This article mentions the following:

The aim of this paper was to synthesis and evaluates HDAC8 isoform specific inhibitors. Based on the preliminary report on the design and in-silico studies of 52 hydroxamic acid derivatives bearing multi-substituent heteroaromatic rings with chiral amine linker, five compounds were shortlisted and synthesized by microwave assisted approach and high yielding synthetic protocol. A series of in-vitro assays in addition to HDAC8 inhibitory activity was used to evaluate the synthesized compounds Serine derivatives I [R = H, MeO, OH; R¹ = H, Br; R² = Me, NH₂, MeO] and II exerted the anti-proliferative activities against CTCL cell lines at 20- 100 μM concentrations Both the compounds I and II exhibited μM inhibitory activity against HDAC8. The compound I [R = OH, R¹ = Br, R² = Me] displayed remarkable HDAC8 selectivity superior to that of the standard drug, SAHA with an IC50 at 0.1μM. Simple modifications at different portions of pharmacophore in the hydroxamic acid analogs were effective for improving both HDAC8 inhibitory activity and isoform selectivity. Potent and highly isoform-selective HDAC8 inhibitors were identified. These findings were expedient for further development of HDAC8-selective inhibitors. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Potassium tert-butoxide-mediated metal-free synthesis of sulfonamides from sodium sulfinates and N,N-disubstituted formamides was written by Bao, Xiaodong;Rong, Xiaona;Liu, Zhiguo;Gu, Yugui;Liang, Guang;Xia, Qinqin. And the article was included in Tetrahedron Letters in 2018.Category: amides-buliding-blocks This article mentions the following:

A new protocol was developed for KO-t-Bu mediated metal-free direct S-N bond formation from sodium sulfinates and formamides as amine sources. This protocol provided a simple and green approach for the preparation of sulfonamide derivatives RSO₂NR¹R² [R = 2-thienyl, Ph, 1-naphthyl, etc.; R¹ = Me, Et, Bn; R² = Me, Et; R¹R₂ = (CH₂)₅, (CH₂)₂O(CH₂)₂] from sodium sulfinates and N,N-disubstituted formamides. The reaction utilized readily available starting materials under metal-free conditions, thus providing an alternative and attractive route to sulfonamides. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Category: amides-buliding-blocks).

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Enzymatic desizing, bioscouring and enzymatic bleaching of cotton fabric with glucose oxidase was written by Mojsov, Kiro. And the article was included in Journal of the Textile Institute in 2019.Recommanded Product: 10543-57-4 This article mentions the following:

The sized cotton fabric was enzymically desized, scoured and bleached with an enzyme mixture of starch degrading enzymes, pectinases and glucose oxidases (GOxs) was added to generate hydrogen peroxide (HP). In this study, enzyme selection and process optimization was made in order to increase the glucose content of the desizing liquor of a starch-sized cotton fabric. The highest glucose concentration of 4175 mg/L was measured in one-bath containing mixture of α-amylase, amyloglucosidase and pectinase and GOx produced 758 mg/L peroxide. This combination was used in further bleaching processes. For bleaching, hydrogen peroxide was converted into peracetic acid (PAA) by incorporating the bleach activator tetraacetylethylenediamine (TAED). Whiteness values, water absorbency, polymerization degree and tenacity at maximum load were measured on pre-treated samples. The total organic carbon (TOC), COD (COD), biol. oxygen demand (BOD₅), the biol. degradability (BOD₅/COD) and the final pH values were measured on residual pre-treatment baths. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of N-aryl substituted p-toluenesulphonamides via nickel catalyzed amidation reaction and their antibacterial, antifungal and antioxidant activities evaluation was written by Izuchukwu, Ugwuja Daniel;Chris, Okoro Uchechukwu;Izuchukwu, Ugwu David. And the article was included in Pakistan Journal of Pharmaceutical Sciences in 2018.Recommanded Product: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:

In present study nickel catalyzed synthesis of N-(aryl) substituted p-toluene sulfonamides is reported. Substituted p-toluene sulfonamides were obtained by coupling 4-methylbenezenesulfonamide with various readily available aryl halides via Buchwald-Hartwig cross-coupling reaction. The new compounds were screened for antibacterial and antifungal activities against Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coll, Staphylococcus aureus, salmonella typhi, candida albicans and Aspergillus niger using agar diffusion technique. The sulfonamides were further screened for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl, Ferrous sulfate lipid per oxidation and Ferric reducing antioxidant power. Tests such as acute toxicity, liver function and kidney function was also carried out on the synthesized compounds In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Recommanded Product: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reaction of some N-substituted 1,4-benzoquinone imines with sodium arenesulfinates was written by Konovalova, S. A.;Avdeenko, A. P.;Marchenko, I. L.. And the article was included in Russian Journal of Organic Chemistry in 2014.Safety of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:

N-Arylsulfonyl, N-aroyl, and N-[arylsulfonylimino(phenyl)methyl] derivatives of 1,4-benzoquinone imine reacted with sodium arenesulfinates to give 1,4-, 1,6-, and 6,1-addition products which were formed according to two concurrent paths: direct nucleophilic addition of arenesulfinate anion to neutral quinone imine mol. and radical ion addition of arenesulfinate radical to radical anion derived from quinone imine. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Safety of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Safety of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-Pot Trifluoromethylative Functionalization of Amides: Synthesis of Trifluoromethylated Bis(indolyl)arylmethanes and Triarylmethanes was written by Pandey, Vinay Kumar;Anbarasan, Pazhamalai. And the article was included in Journal of Organic Chemistry in 2017.Category: amides-buliding-blocks This article mentions the following:

Efficient and general one-pot trifluoromethylative functionalization of amides has been accomplished for the synthesis of various trifluoromethylated bis(indolyl)arylmethane, utilizing trifluoromethyltrimethylsilane and substituted indoles as nucleophiles. The developed reaction involves the in situ generation and trapping of a trifluoromethylated iminium ion, derived from the trifluoromethylated hemiaminal of amide, with various substituted indoles. This method has been successfully extended to the synthesis of diverse trifluoromethylated triarylmethanes employing phenols as nucleophiles. Furthermore, the potential of the method was demonstrated via the two-step synthesis of a trifluoromethylated analog of a hypolipidemic and anti-obesity agent. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Category: amides-buliding-blocks).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One-pot synthesis of 1,2,4-oxadiazoles from chalcogen amino acid derivatives under microwave irradiation was written by Wolf, Lucas;Mayer, Joao C. P.;Quoos, Natalia;Sauer, Andre C.;Schwab, Ricardo S.;Rodrigues, Oscar E. D.;Dornelles, Luciano. And the article was included in Tetrahedron in 2021.Recommanded Product: 1,3-Dicyclohexylurea This article mentions the following:

A series of sulfur- and selenium-bearing, amino acid-derived 1,2,4-oxadiazoles were obtained by a simple procedure. The method consists of EDC-promoted coupling of chalcogen amino acid derivatives with arylamidoximes in acetone, followed by solvent removal and microwave irradiation in water medium. Influence of amidoxime substituents, of the chalcogen atom and of the amino acid side chain is discussed. The results showed this to be a fast, easy and effective method to obtain these compounds, with good functional-group tolerance, potentially favoring future applications in organic synthesis. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Low temperature bleaching and dyeing properties of modified cellulose fabrics with triazine derivative was written by Xie, Kongliang;Hu, Chuanguo;Zhang, Xufang. And the article was included in Carbohydrate Polymers in 2012.SDS of cas: 10543-57-4 This article mentions the following:

Cellulose fabrics were modified with triazine derivative containing multi-cationic groups, 2,4,6-tri [(2-hydroxy-3-trimethyl-ammonium)propyl]-1,3,5-triazine chloride (Tri-HTAC). Low temperature bleaching of modified cellulose fabrics with tetra acetyl ethylene diamine (TAED), tetra acetyl glycineurea (TAGU) or (N-[4-triethylammoniomethyl]-benzoyl) caprolactam chloride (TBCC) as H₂O₂ activator was investigated. Bleaching properties and mechanisms of three activators were discussed. The dyeing properties and colorimetric data of the bleaching fabrics were investigated. The results show that the modified cellulose fabrics with Tri-HTAC could be bleached with hydrogen peroxide at low temperature, using activators. All whiteness indexes and wettabilities of modified fabrics under low temperature bleaching conditions were significantly higher than those of control samples. The exhaustion of the bleached modified fabrics was significant higher than that of unmodified cellulose fabric. Color degree of all bleaching fabrics with activators was also improved. The fastnesses of bleached fabrics were excellent. The quality of modified fabrics bleached under low temperature activator systems was improved. It has potential application in new composites and cleaner production of cellulose biomaterials. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4SDS of cas: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.SDS of cas: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Antioxidant and angiotensin-I converting enzyme inhibitory activities of phenolic extracts and fractions derived from three phenolic-rich legume varieties was written by Zhang, Yan;Pechan, Tibor;Chang, Sam K. C.. And the article was included in Journal of Functional Foods in 2018.Name: 1,3-Dicyclohexylurea This article mentions the following:

Lentil, black soybean and black turtle bean are commonly consumed legumes of different genera, containing high phenolic contents, which are effective antioxidants and angiotensin-I converting enzyme (ACE) inhibitors. However, these legumes’ phenolic compositions and ACE inhibition ability have not been compared. Crude water extract (CE) was semi-purified (SPE) and fractionated using column chromatog. Results showed that purification and fractionation could substantially increase phenolic contents and antioxidant capacities. Heating and variety had great effect on phenolic substances, antioxidant potential and mass yield of extracts and fractions. Only crude extracts showed potent ACE inhibitory activity. Black turtle bean’s ACE inhibition potential was largely reduced by cooking. The order from low to high in terms of ACE inhibitory activity was black turtle bean < lentil < black soybean. Identification and quantification of individual phenolic compounds by UV spectroscopy and LC-MSⁿ anal. confirmed 18, 22, and 14 compounds, resp., for the three legumes. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Name: 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics