Tag: 200-300

Synthesis and structure of 3-amino-4-heteroaryl-1(2H)isoquinolones was written by Nemazanyi, A. G.;Volovenko, Y. M.;Silaeva, T. A.;Kornilov, M. Yu.;Babichev, F. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1991.SDS of cas: 83909-69-7 The following contents are mentioned in the article:

A one-step preparation of the title compounds I (R = H, Me, CH₂Ph, Ph, 2-FC₆H₄; Ar = 2-azahetaryl) by a cyclocondensation of 2-Cl,5-(NO₂)C₆H₃CONHR with ArCH₂CN in K₂CO₃/DMF is reported. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7SDS of cas: 83909-69-7).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.SDS of cas: 83909-69-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Aqueous phase mono-protection of amines and amino acids as N-benzyloxycarbonyl derivatives in the presence of β-cyclodextrin was written by Kumar, V. Pavan;Reddy, M. Somi;Narender, M.;Surendra, K.;Nageswar, Y. V. D.;Rao, K. Rama. And the article was included in Tetrahedron Letters in 2006.SDS of cas: 887757-51-9 The following contents are mentioned in the article:

A simple and selective protection of amines/amino acids with Cbz-Cl was achieved in aqueous phase with catalytic amounts of β-cyclodextrin in high yields at room temperature This reaction proceeds without the formation of any byproducts and has advantages over existing methods. This study involved multiple reactions and reactants, such as Benzyl (3-hydroxypropyl)(methyl)carbamate (cas: 887757-51-9SDS of cas: 887757-51-9).

Benzyl (3-hydroxypropyl)(methyl)carbamate (cas: 887757-51-9) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.SDS of cas: 887757-51-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stereoselective synthesis of natural (2E,4E)-dienamides and their synthetic analogs was written by Shakhmaev, R. N.;Ishbaeva, A. U.;Zorin, V. V.. And the article was included in Russian Journal of Organic Chemistry in 2012.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

A procedure was developed for stereoselective synthesis of a number of naturally occurring (2E,4E)-dienamides and their analogs via palladium-catalyzed reaction of (1E)-1-iodoalk-1-enes with acrylamides. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of 1,3-dienes by extrusion was written by Grainger, R. S.;Jervis, P. J.. And the article was included in Science of Synthesis in 2009.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

A review of methods to prepare 1,3-dienes by extrusion. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Self-Assembly of Molecular Borromean Rings from Bimetallic Coordination Rectangles was written by Huang, Sheng-Li;Lin, Yue-Jian;Li, Zhen-Hua;Jin, Guo-Xin. And the article was included in Angewandte Chemie, International Edition in 2014.Recommanded Product: 53118-43-7 The following contents are mentioned in the article:

In contrast to conventional stepwise synthesis of mol. Borromean rings, a self-assembly synthetic method which proceeds without the aid of a template was developed. In the formation of mol. rectangles, by adjustment of the long-arm length of the rectangles, size-dependent Borromean-link frameworks were constructed. Both the shortest length of two arms and the relative proportion of the length of the long arm to that of the short arm play a key role in the formation of Borromean rings. DFT calculations were used to provide theor. support for the formation of discrete interlocked frameworks. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Recommanded Product: 53118-43-7).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 53118-43-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical constituents from twigs of Piper hancei was written by Lei, Hai-peng;Chen, Xian-qiang;Qiao, Chun-feng;Liu, Yang;Zhao, Jing. And the article was included in Zhongyaocai in 2014.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The chem. constituents from the twigs of Piper hancei were investigated. The chem. constituents were isolated and purified by means of chromatog. techniques including silica gel, Sephadex LH-20 and preparative RP-HPLC. Their structures were elucidated on the basis of physicochem. properties and spectral anal. Eight compounds were isolated and identified as 4-allylpyrocatechol (I), piperlonguminine (II), d-sesamin (III), β-sitosterol (IV), pellitorine (V), piperolactam A (VI) and piperolactam D (VII), resp. Compound I, III, VI and VII are isolated from Piper hancei for the first time. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells was written by Zhang, Hailong;Matsuda, Hisashi;Nakamura, Seikou;Yoshikawa, Masayuki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Recommanded Product: 18836-52-7 The following contents are mentioned in the article:

Several amide constituents (piperlonguminine and retrofractamides A, B, and C) from the fruit of Piper chaba promoted adipogenesis of 3T3-L1 cells. Among them, retrofractamide A was the most active and significantly increased the amount of adiponectin released into the medium and the uptake of 2-deoxyglucose into the cells. Retrofractamide A also increased mRNA levels of adiponectin, peroxisome proliferator-activated receptor γ2 (PPARγ2), glucose transporter 4 (GLUT4), and insulin receptor substrate 1 (IRS-1), but did not act as a PPARγ agonist different from troglitazone. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Structurally diversified synthesis of 2,3-dihydroquinazolin-4-(1H)-ones from 2-aminobenzamides and 1,2-dicarbonyl compounds in ionic liquids catalyzed by iodine was written by Wang, Jie;Zhang, Mei-Mei;Wang, Xiang-Shan. And the article was included in Research on Chemical Intermediates in 2017.Recommanded Product: 34489-85-5 The following contents are mentioned in the article:

A green procedure for the rapid diversification of quinazolin-4-(1H)-one scaffolds is described in this paper. Various types of 1,2-dicarbonyl compounds are treated with 2-aminobenzamides in ionic liquids catalyzed by iodine and unexpectedly afford structurally diversified single-quinazoline derivatives The recyclability of the ionic liquids makes this protocol to be an environmentally benign procedure. A total of 39 quinazolin-4-(1H)-one scaffolds were synthesized via a green procedure of 1,2-dicarbonyl compounds and 2-aminobenzamides in ionic liquids catalyzed by iodine. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Recommanded Product: 34489-85-5).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 34489-85-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cyclopiperettine, a new amide from Piper nigrum was written by Ren, Jie;Zeng, Ting;Ali, Zulfiqar;Wang, Mei;Bae, Jiyeong;Chittiboyina, Amar G.;Wang, Wei;Li, Shunxiang;Khan, Ikhlas A.. And the article was included in Natural Product Communications in 2017.Product Details of 18836-52-7 The following contents are mentioned in the article:

Cyclopiperettine, a new amide, was isolated from essential oil of Piper nigrum L. together with ten known compounds, including amides, monoterpenoids, and sesquiterpenoids. The structure of cyclopiperettine was established by 1D- and 2D- NMR and GC-MS techniques. Known compounds were identified as α-humulene, β-caryophyllene, caryophyllenol-II, β-elemene, elemol, 1-terpinen-4-ol, nerolidol, pellitorine, piperolein B and piperine. The crude oil and isolated compounds exhibited no antimicrobial activity against seven microbial strains up to 20 μg/mL. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Product Details of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pellitorine, a potential anti-cancer lead compound against HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum was written by Ee, Gwendoline Cheng Lian;Lim, Chyi Meei;Rahmani, Mawardi;Shaari, Khozirah;Bong, Choon Fah Joseph. And the article was included in Molecules in 2010.Product Details of 18836-52-7 The following contents are mentioned in the article:

Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3′,4′-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid iso-Bu amide (5). These compounds were isolated using chromatog. methods and their structures were elucidated using MS, IR, and NMR techniques. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Product Details of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Product Details of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics