Tag: 200-300

Synthesis and biological activity of 2,5-diaminobenzoic acids stimulating the biosynthesis of prostaglandins was written by Kosary, J.;Szabo, I. K.;Kasztreiner, E.. And the article was included in Pharmazie in 1982.Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide The following contents are mentioned in the article:

Twenty-two diaminobenzoates [I; R = NH₂; R¹ = OH, OMe, OEt, NH₂, cyclopropylamino, PhCH₂NH, Et₂N(CH₂)₂NH; R² = cyclopropyl, Bu, cyclohexyl, aryl, Et₂N(CH₂)₂; R³ = H, Bu; or NR²R³ = morpholino] (II) were prepared by reduction (H, Pd/C) of the corresponding I (R = NO₂). II are potent activators of prostaglandin synthetase (from sheep seminal vesicles) and play an important role in the biosynthesis of prostaglandins. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alkamides from Piper longum and Piper nigrum as inhibitors of IL-6 action was written by Lee, Seung Woong;Kim, Myo Sun;Park, Mi Hye;Park, Su-Jin;Lee, Woo Song;Chang, Jong Sun;Rho, Mun-Chual. And the article was included in Bulletin of the Korean Chemical Society in 2010.COA of Formula: C14H25NO The following contents are mentioned in the article:

Blocking of IL-6 has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine the potential effects of alkamides isolated from P. longum and P. nigrum on IL-6 induced Stat3 activation and identify the structure-activity relationship of these alkamides in human hepatoma cells. Among 10 alkamides isolated from P. longum and P. nigrum, compounds 6, 7 and 9 were identified as strong inhibitors of IL-6 action, which inhibit IL-6 induced Stat3-dependent luciferase activities. These inhibitory activities were pos. influenced by the presence of piperidine moiety. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7COA of Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.COA of Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Column Chromatography-Free Solution-Phase Synthesis of a Natural Piper-Amide-like Compound Library was written by Kim, Sumin;Lim, Chaemin;Lee, Sukjin;Lee, Seokwoo;Cho, Hyunkyung;Lee, Joo-Youn;Shim, Dong Sup;Park, Hee Dong;Kim, Sanghee. And the article was included in ACS Combinatorial Science in 2013.Recommanded Product: 18836-52-7 The following contents are mentioned in the article:

We have achieved an efficient solution-phase parallel synthesis of a library of natural Piper-amide-like compounds from the bifunctional β-phosphono-N-hydroxy-succinimidyl ester intermediate. The primary important feature in our study is the construction of natural-product-like mols. through the adaptation of sophisticated organic reactions that create water-soluble byproducts for a chromatog.-free purification This simple and efficient method rapidly provides a combinatorial library of high yield and purity. The library was evaluated against GPCR targets to demonstrate its potential use as a tool for drug discovery and in chem. biol. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Identification and Synthesis of New Volatile Molecules Found in Extracts Obtained from Distinct Parts of Cooked Chicken was written by Delort, Estelle;Velluz, Alain;Frerot, Eric;Rubin, Mark;Jaquier, Alain;Linder, Simon;Eidman, Kirk F.;MacDougall, Brian S.. And the article was included in Journal of Agricultural and Food Chemistry in 2011.Recommanded Product: 18836-52-7 The following contents are mentioned in the article:

Several chicken parts (skin, fat, juice) were cooked in different ways (roasting, simmering) and investigated sep. for their volatile composition In-depth GC/MS anal. of the sep. fractions revealed several unknown mols. Mass spectra interpretation allowed us to identify nine mols. for the first time in chicken, including cyclic aldehydes, cyclic ketones, and new δ-lactones containing an unsaturated linear chain. Identification was confirmed by chem. synthesis followed by comparison of the mass spectra and linear retention indexes. The natural occurrence of five of these mols. is reported here for the first time in a natural product. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

One Pot Regioselective Synthesis of a Small Library of Dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles Rearrangement was written by Zhao, Yongmei;Dai, Qiaoling;Chen, Zhi;Zhang, Qihui;Bai, Yongcheng;Ma, Chen. And the article was included in ACS Combinatorial Science in 2013.Computed Properties of C14H11ClN2O3 The following contents are mentioned in the article:

A facile and efficient method has been developed for the synthesis of a small library of dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles rearrangement. Compounds were obtained in excellent isolated yields (70%-92%) under metal-free conditions. E.g., in presence of KOH in DMF, reaction of 2-chlorobenzamide derivative (I) with 2-BrC₆H₄SH gave 72% dibenzo[b,f][1,4]thiazepin-11(10H)-one derivative (II). More specifically, this transition metal-free process relates to an environmentally friendly, economical, and efficient method for preparing benzoic-fused seven-membered lactams. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Computed Properties of C14H11ClN2O3).

N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Computed Properties of C14H11ClN2O3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical constituents from Piper boehmeriifolium (Miq.) Wall. ex C. DC was written by Liu, Tie;Liang, Qian;Zhang, Xin-Min;Li, Gen-Qian;Xu, Bo;Xu, Wen-Hui. And the article was included in Biochemical Systematics and Ecology in 2017.COA of Formula: C14H25NO The following contents are mentioned in the article:

The chem. investigation of whole plants Piper boehmeriifolium (Miq.) Wall. ex C. DC. led to the isolation of 22 compounds, including two lignans (1-2), sixteen amide alkaloids (3-18), one diterpene (19), two monoterpenes (20-21), and one phenylpropanoid (22). Their structures were elucidated by extensive spectroscopic analyses including NMR, MS, and by comparison with the literature. Compounds 1-2, 6-7, 11-12, 14, and 17-22 were firstly isolated from P. boehmeriifolium, while compounds 2, and 19-20 were isolated from Piper genus for the first time. The chemotaxonomic significance of these isolated compounds is discussed. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7COA of Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.COA of Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A new approach to the synthesis of pellitorine was written by Ishbaeva, A. U.;Shakhmaev, R. N.;Zorin, V. V.. And the article was included in Bashkirskii Khimicheskii Zhurnal in 2011.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The stereoselective method for the synthesis of natural alkaloid pellitorine – (2E,4E)-N-isobutyldeca-2,4-dienamide has been developed using nonphosphine Mizoroki-Heck reaction. A cross-coupling reaction of (E)-1-iodohept-1-ene, obtained by hydroalumination-iodination 1-heptyne, with N-isobutylacrylamide, synthesized by amidation of the acryloyl chloride by isobutylamine, in the presence of Pd(OAc)₂, base and tetrabutylammonium chloride in DMF afforded target product in high yield with insignificant content of isomeric compounds (∼1%). The overall yield of pellitorine calculated from 1-heptyne is 79%. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alkaloids from Piper sarmentosum and Piper nigrum was written by Ee, G. C. L.;Lim, C. M.;Lim, C. K.;Rahmani, M.;Shaari, K.;Bong, C. F. J.. And the article was included in Natural Product Research in 2009.Application of 18836-52-7 The following contents are mentioned in the article:

Detailed chem. studies on the roots of Piper sarmentosum and Piper nigrum have resulted in several alkaloids. The roots of P. sarmentosum gave a new aromatic compound, 1-(nitrosoimino)methyl-2,4,5-trimethoxybenzene (1). Piper nigrum roots gave pellitorine (2), (E)-1-[3′,4′-(methylenedioxy)cinnamoyl]piperidine (3), 2,4-tetradecadienoic acid iso-Bu amide (4), piperine (5), sylvamide (6), cepharadione A (7), piperolactam D (8) and paprazine (9). Structural elucidation of these compounds was achieved through NMR and MS techniques. Cytotoxic activity screening of the plant extracts indicated some activity. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cp*Rh-Based Heterometallic Metallarectangles: Size-Dependent Borromean Link Structures and Catalytic Acyl Transfer was written by Huang, Sheng-Li;Lin, Yue-Jian;Hor, T. S. Andy;Jin, Guo-Xin. And the article was included in Journal of the American Chemical Society in 2013.Related Products of 53118-43-7 The following contents are mentioned in the article:

Cp^*Rh-based functional metallarectangles were synthesized from metallaligands, e.g., [Cu(opba)]^2- [opba = o-phenylenebis(oxamato)]. Enlargement of one linker gives two novel Borromean link architectures. All these complexes are intact in solution, as evident from ESI-MS spectroscopic anal. Arising from the combination of open Cu centers and favorable cavity space, {(Cp^*Rh)₄(bpe)₂[Cu(opba)·2MeOH]₂}4(OTf)·6MeOH shows extraordinary catalytic abilities with high efficiency and wide substrate selectivity in the acyl-transfer reaction. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Related Products of 53118-43-7).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 53118-43-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chemical constituents in Piper longum L. (I) was written by Wu, Xia;Yu, Zhibin;Ye, Yunhua;Zhou, Yawei. And the article was included in Zhongcaoyao in 2008.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The chem. constituents from in Piper longum L. were separated and purified by column chromatog. with silica gel, RP-C₁₈, Sephadex LH-20, and their structures were identified by ESI-MS, ¹H-NMR, and ¹³C-NMR. Ten compounds were obtained and identified as: piperine (I), Me piperate (II), guineensine (III), phenylpropionic acid (IV), pipercide (V), piperanine (VI), pellitorine (VII), (E)-4-[(2-methylpropyl)amino]-4-oxo-2-butenoic acid (VIII), pipernonaline (IX), and β-sitosterol (X), resp. Compound II, IV, and VIII were isolated from this plant for the first time. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics