Tag: 200-300

New nitro-benzo[c]phenanthridine and indolopyridoquinazoline alkaloids from Zanthoxylum atchoum was written by Akoua Yao-Kouassi, Philomene;Caron, Catherine;Ramiarantsoa, Harisolo;Prost, Elise;Harakat, Dominique;Le Magrex-Debar, Elisabeth;Gangloff, Sophie C.;Ahibo Coffy, Antoine;Zeches-Hanrot, Monique. And the article was included in Comptes Rendus Chimie in 2015.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The first phytochem. investigation of the roots of Zanthoxylum atchoum has led to the isolation of two new nitro-benzo[c]phenanthridine alkaloids 6-nitronitidine (1) and 6-nitro-8-methoxy-7,8-dihydronitidine (2), two new salts of indolopyridoquinazoline alkaloids 3-hydroxy-8,13-dihydro-14-methyl-5-oxo-7H-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-14-ium (3) and its zwitterionic form 3-phenolate-8,13-dihydro-14-methyl-5-oxo-7H-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-14-ium (4) along with 18 (5-22) known compounds Their chem. structures were elucidated by spectroscopic anal. including 1D and 2D NMR and MS techniques. This is the first report of the nitro group on the biosynthesis of the natural benzo[c]phenantridine alkaloids. Compound 2 exhibited potent antibacterial activity against Staphylococcus aureus with MIC₅₀ = 4 μg·mL^-1. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides was written by Matsuda, Hisashi;Ninomiya, Kiyofumi;Morikawa, Toshio;Yasuda, Daisuke;Yamaguchi, Itadaki;Yoshikawa, Masayuki. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The 80% aqueous acetone extract from the fruit of Piper chaba (Piperaceae) was found to have hepatoprotective effects on -galactosamine (-GalN)/lipopolysaccharide-induced liver injury in mice. From the Et acetate-soluble fraction, three new amides, piperchabamides E, G, and H, 33 amides, and four aromatic constituents were isolated. Among the isolates, several amide constituents inhibited -GalN/tumor necrosis factor-α (TNF-α)-induced death of hepatocytes, and the following structural requirements were suggested: (i) the amide moiety is essential for potent activity; and (ii) the 1,9-decadiene structure between the benzene ring and the amide moiety tended to enhance the activity. Moreover, a principal constituent, piperine, exhibited strong in vivo hepatoprotective effects at doses of 5 and 10 mg/kg, po and its mode of action was suggested to depend on the reduced sensitivity of hepatocytes to TNF-α. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A new benzophenanthridine alkaloid and other bioactive constituents from the stem bark of Zanthoxylum heitzii was written by Wangensteen, Helle;Ho, Giang Thanh Thi;Tadesse, Margey;Miles, Christopher O.;Moussavi, Nastaran;Mikolo, Bertin;Malterud, Karl Egil. And the article was included in Fitoterapia in 2016.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Heitziquinone (7), a new benzophenanthridine alkaloid, together with five known compounds; isoarnottianamide (5), rhoifoline B (6), isobauerenol (8), 6-hydroxypellitorine (9) and sylvamide (10), were isolated as minor compounds from the hexane extract of stem bark from Zanthoxylum heitzii. Four previously reported compounds (1-4) were found, as well. Compounds 5 and 7 were both found to exist as 4:1 mixtures of two atropisomers. The structures were elucidated by 1D and 2D NMR spectroscopy and by mass spectrometry. Compounds 5-10 were identified for the first time in this species, and they are all rare natural compounds Pellitorine (4), one of the main compounds from the hexane bark extract, was found to be responsible for the brine shrimp larvae toxicity (LC₅₀ 37 μM, 8 μg/mL) of the crude extract (LC₅₀ 24 μg/mL). Low cytotoxicity against a macrophage cell line was observed This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Piper longum Linn.-a fruit contains potential inhibitors of COVID-19 main protease based on molecular docking was written by Sivaraj, S.;Rangaraj, S.;Suguna, A.. And the article was included in World Journal of Pharmaceutical Research in 2020.Formula: C14H25NO The following contents are mentioned in the article:

A new coronavirus (nCoV) identified as the etiol. agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan. Currently there is no clin. approved antiviral drug or vaccine available and effective treatment options remain very limited. Here, we have studied the virtual interaction between COVID-19 main protease (Mpro-PDB ID: 6LU7) and ten bioactive compounds of Piper longum by mol. docking using Autodock 4.2. It was identified that Piperundecalidine, a phytoconstituent present in fruit of Piper longum as potential inhibitor of COVID-19 Mpro which shows higher binding affinity (-9.54 kcal/mol) than the lead tideglusib (-8.48 kcal/mol). However, these data need further in vitro and in vivo evaluation to use against 2019-nCoV. This was the first report on phytoconstituents of Piper longum as potential inhibitor of COVID-19 Mpro using mol. docking studies. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400 was written by Kudale, Vishal Suresh;Wang, Jeh-Jeng. And the article was included in Green Chemistry in 2020.Electric Literature of C13H11BrN2O The following contents are mentioned in the article:

A novel and an efficient route for synthesis of methyl-arylquinazolinones I [R = H, 8-Me, 7-Cl; R¹ = Ph, 4-MeOC₆H₄, 2-ClC₆H₄, etc.] and acetylated heteroarenes II [Ar = 2-quinolyl, 3-CN-2-pyridyl, 1,3-benzothiazol-2-yl, etc.] via methylation and acetylation of aza-heteroarenes using PEG-400 under O₂ and TsOH·H₂O for the first time by tuning the reaction conditions using a different set of starting materials was described. The key features of current protocol were oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance and a broad substrate scope. The potential applicability of designed methodol. was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug mols. by a one-pot strategy. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Electric Literature of C13H11BrN2O).

2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Electric Literature of C13H11BrN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A Bridge Too Far: Testing the Limits of Polypyridyl Ligands in Bridging Soluble Subunits of a Coordination Polymer was written by Beddoe, Samuel V. F.;Fitzpatrick, Anthony J.;Price, Jason R.;Mallo, Neil;Beves, Jonathon E.;Morgan, Grace G.;Kitchen, Jonathan A.;Keene, Tony D.. And the article was included in Crystal Growth & Design in 2017.HPLC of Formula: 53118-43-7 The following contents are mentioned in the article:

Starting with a coordination polymer, {[Cu(L)]₂}_n (1 where H₂L = salicylidene-2-aminophenol), the authors have explored the ability of polypyridyl ligands (P) to bridge the monomer complex to form nine {[Cu(L)]₂(P)} complexes. The identity and solution stability of the [Cu(L)] units was studied through a novel combined UV-visible/EPR experiment and it is a stable supramol. building unit for the construction of discrete complexes and coordination polymers. The reorganization of [Cu(L)] units to a new coordination polymer on addition of 4,4′-bipyridine markedly changes the connectivity of the structure and the magnitude of the antiferromagnetic interactions through reorientation of the Cu(II) orbitals. The authors also present the structure of 1, 80 years after its synthesis was first reported. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7HPLC of Formula: 53118-43-7).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 53118-43-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Preparation of bioactive amide compounds from black pepper by countercurrent chromatography and preparative HPLC was written by Jin, Yongyang;Qian, Dengyong;Du, Qizhen. And the article was included in Industrial Crops and Products in 2013.SDS of cas: 18836-52-7 The following contents are mentioned in the article:

Amide compounds are the major bioactive substances in black pepper. Black pepper extracts were fractionated by high-speed countercurrent chromatog. resulting in three compounds: dehydropipernonaline, piperine and (2E,4E,12Z)-N-isobutyl-octadecatrienamide, and four fractions which were separated by preparative HPLC to yield ten purified compounds: retrofractamide-A, (2E,4E)-N-isobutyl-decadienamide, retrofractamide-C, piperoleine A, dehydropiperoleine A, retrofractamide-B, piperoleine B, pipernonaline, pipercyclobutanamides A and (2E,4E,14Z)-N-isobutyleicosa-2,4,14-trienamide as identified by ESI-MS and NMR anal. The results of the present study indicated that HSCCC is an effective technique for the preparation of bioactive amide compounds from black pepper. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7SDS of cas: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Search for β-Secretase Inhibitors from Natural Spices was written by Matsumura, Shinichi;Murata, Kazuya;Yoshioka, Yuri;Matsuda, Hideaki. And the article was included in Natural Product Communications in 2016.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

The growing number of Alzheimer’s disease (AD) patients prompted us to seek effective natural resources for the prevention of AD. We focused on the inhibition of β-secretase, which is known to catalyze the production of senile plaque. Sixteen spices used in Asian countries were selected for the screening. Among the extracts tested, hexane extracts obtained from turmeric, cardamom, long pepper, cinnamon, Sichuan pepper, betel, white turmeric and aromatic ginger showed potent inhibitory activities. Their active principles were identified as sesquiterpenoids, monoterpenoids, fatty acid derivatives and phenylpropanoids using GC-MS analyses. The chem. structures and IC₅₀ values of the compounds are disclosed. The results suggest that long-term consumption of aromatic compounds from spices could be effective in the prevention of AD. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: A comparative study with fruits, pericarp, stalks and leaves was written by Yu, Lan;Hu, Xiaolu;Xu, Rongrong;Ba, Yinying;Chen, Xiaoqing;Wang, Xing;Cao, Bing;Wu, Xia. And the article was included in Food Chemistry in 2022.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Piper nigrum L. is commonly used worldwide and its pericarp, stalks, leaves will be major wastes materials. 42 amide alkaloids were identified in black, white pepper and pericarp by UHPLC-LTQ-Orbitrap HRMS method, followed by 40 constituents in stalks and 36 constituents in leaves. 8 amide alkaloids were reported for the first time in P. nigrum. An ultra-high-performance supercritical fluid chromatog. (UHPSFC)-MS method was firstly applied to simultaneously determine 9 characteristic constituents (piperine, piperlonguminine, piperanine, pipercallosine, dehydropipernonaline, pipernonatine, retrofractamide B, pellitorine and guineensine). The most abundant compound in each extract was piperine with a concentration from 0.10 to 12.37 mg/g of dry weight The fruits, pericarp and leaves extracts could improve cell viability in 6-OHDA-induced SK-N-SH and SH-SY5Y cells. The results showed the characteristics of amide alkaloids of different parts of P. nigrum and evaluated their neuroprotective activities. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Separation of Piper kadsura using preparative Supercritical Fluid Chromatography Combined with Preparative Reversed-Phase Liquid Chromatography was written by Xin, Huaxia;Dai, Zhuoshun;Cai, Jianfeng;Ke, Yanxiong;Feng, Jiatao;Fu, Qing;Jin, Yu;Liang, Xinmiao. And the article was included in Chromatographia in 2018.SDS of cas: 18836-52-7 The following contents are mentioned in the article:

We have developed a separation strategy that employed preparative supercritical fluid chromatog. (prep-SFC) combined with preparative reversed-phase liquid chromatog. (prep-RPLC) to purify compounds from Piper kadsura. The complexity of the sample was effectively reduced by two steps of prep-SFC. The key exptl. parameters of prep-SFC were systematically optimized, including an “average-pressure rule” scaling-up method for adjustment of the back pressure of the system. A mixed modifier consisting of ethanol/n-hexane was applied to provide a stable elution. Prep-RPLC was subsequently adopted to purify the SFC fractions due to its good orthogonality with SFC. Furthermore, chiral SFC was used to sep. the structural analogs. As a result, 14 compounds with high purity were obtained from one fraction, including three pairs of diastereoisomers. These data indicate that the separation strategy using prep-SFC combined with prep-RPLC is an effective tool to sep. complex samples such as natural products. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7SDS of cas: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.SDS of cas: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics