Tag: 200-300

Simultaneous determination of six marker compounds in Piper nigrum L. and species comparison study using high-performance thin-layer chromatography-mass spectrometry was written by Ramesh, Bokka;Sarma, Vanka Uma Maheswara;Kumar, Katragunta;Babu, Katragadda Suresh;Devi, Potturi Sita. And the article was included in Journal of Planar Chromatography–Modern TLC in 2015.Electric Literature of C14H25NO The following contents are mentioned in the article:

The isolation and characterization of bioactive compounds from medicinal plants is usually a significant challenge in phytochem. anal. because of the natural chem. complexity of plant extracts However, there exists a need for anal. tools which can quant. sep. and characterize the components from these biosources with greater chromatog. selectivity and lesser anal. run times that facilitate the evaluation with enhanced separation profiles. Hyphenation of thin-layer chromatog. (TLC/HPTLC) with mass spectrometry (MS) is an alternative for screening herbal extracts because of its rapid anal. and ability to aid structural characterization with powerful anal. capacity. The aim of the present study was to develop a sophisticated anal. method which utilizes HPTLC-MS coupling for the chromatog. profiling and evaluation of the therapeutically important genus Piper (Piperaceae). In this study, six marker compounds, namely, trichostachine, piperine, 4,5-dihydropiperlonguminine, guineensine, pellitorine, and sesamin were analyzed and quantified in extracts of Piper nigrum L. and compared with those of Piper longum L. and Piper chaba Hunter. All the samples tested showed similar phytochem. profiles, but the contents of the active ingredients varied. Addnl., HPTLC-MS further allowed confirming the identification of the constituents in the analyzed samples with greater chromatog. selectivity where HPTLC facilitated a selective chromatog. resolution, while MS offered an efficient characterization of the target compounds in one anal. run. The study finds a potential utility in adopting HPTLC-MS as a rapid and high throughput method for the efficient quantification and identification of marker compounds from medicinal plants. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Electric Literature of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Electric Literature of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In silico analysis of medicinal plants against Mycobacterium tuberculosis (MTB) was written by Sathish Kumar, R.;Sankaravel, V.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2018.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Tuberculosis (TB) is a deadly infectious disease caused by the Mycobacterium tuberculosis (MTB). Tuberculosis mostly affects the lungs at later stages it also affects other organs. The protein epoxide hydrolase plays a major role in drug metabolism as well as signal processing mol. and therefore has been targeted in the present study. The medicinal plants being a solution for several human ailments, also act as a reservoir for secondary metabolites, has taken its credit as a cure from our ancient times. The compounds reported earlier in the plants Solanum torvum, Piper longum, Morinda citrifolia, Cocos nucifera, Dissotis rotundifolia, Curcuma longa, Aloe vera, Ocimum basillicum, Centella asiatica and Dipterocarpus sublamelatous were analyzed for its possible significant interaction with the target protein using mol. docking studies.The compounds from the plants Solanum torvum, Piper longum, Morinda citrifolia, Cocos nucifera, Dissotis rotundifolia, Curcuma longa, Aloe vera, Ocimum basillicum, Centella asiatica and Dipterocarpus sublamelatous were analyzed using the mol. docking studies ADME-properties, drug-likeness using the Schrodinger software.The docking results were observed which indicated that the compound catechin scored significant G.score of -8.74 Kcal/mol among the other compounds tested. The interactions were observed with amino acid residue tyrosine at two different positions 164 and 272, each of bond length of 2.1Å. The compound Catechin had significant interaction with the target protein, could be further analyzed for stability using mol. dynamics study and in vitro. The future perspective of the study is to determine the stability of the protein-compound complex through dynamics studies. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Identification of interactions between multiple components in Socheongryong-tang using a plant profiling approach was written by Oh, Hyun-A.;Lee, Hyunbeom;Kang, Keon Wook;Im, Ji Hye;Kim, Donghak;Yang, Hyun Ok;Jung, Byung Hwa. And the article was included in Biomedical Chromatography in 2019.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Traditional herbal medicine consists of multiple components. There are interactions among the components, which affect both potency and toxicity. The preparation of herbal medicines can be a cause of interactions between multicomponents in herbs. To demonstrate the differences in multiherb interactions based on the preparation methods, the changes in the active components in the different preparations of Socheongryong-tang (SCRT) were evaluated using metabolomics profiling. We performed multicomponent profiling of the decoction of SCRT (SCRTD) and individual herb mixture (SCRTM) using ultra-high-performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Active compounds from SCRTD and SCRTM were identified using multivariate anal., and the activities between the two groups were compared. We also evaluated the anti-inflammatory effect of SCRT through investigating the protein expression of iNOS and COX-2 in lipopolysaccharide-induced macrophage RAW 264.7 cells in both groups. From the multivariate anal., 53 active compounds that have different intensities between SCRTD and SCRTM were identified. The intensities of those components, such as ephedrines, glycyrrhizic acid, 6-gingerol and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide, which is newly identified in Asiasarum heterotropoides, were mostly higher in SCRTD than in SCRTM, which was related to the anti-inflammatory effect. From the iNOS inhibition test, it was found that SCRTD had a stronger anti-inflammatory effect than SCRTM. It was demonstrated that multicomponent interactions can be changed by the preparation method, and finally the anti-inflammatory effect in SCRT can be affected. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Simultaneous quantification of three amides by gas chromatography time of flight mass spectrometry in extracts of Piper sarmentosum was written by Hussain, Khalid;Ismail, Zhari;Sadikun, Amirin;Ibrahim, Pazilah. And the article was included in Analytical Chemistry: An Indian Journal in 2009.Product Details of 18836-52-7 The following contents are mentioned in the article:

Piper sarmentosum is well known due to its culinary and medicinal properties and has a great potential of commercialization. Herbal standardization is a tedious task mainly due to un-availability or inadequacy of methods and standards, and its lacking is the single biggest hindrance in the acceptance of herbal products in main stream of pharmaceuticals. Therefore, present study aimed to develop an anal. method using gas chromatog. time of flight mass spectrometry for the simultaneous quantification of three amides, which can be used as pharmacol. active anal. markers to standardize the product made from this plant and others containing these compounds Three amides, pellitorine, sarmentine, and sarmentosine isolated and identified previously from fruit of the plant were used as markers to develop and validate the method. Lowest limit of detection (LOD) of the three amides were found to be 0.10, 0.10 and 0.12 ng/mL, resp., at a signal to noise ratio 3:1, whereas the lowest limit of quantification (LOQ) was taken 1.00, 1.00, and 12.00 ng/mL, resp., at a signal to noise ration 10:1. The method was found to be linear (R² = 0.9985 to 0.9995) with RSD < 5%. Intraday and inter day accuracy was found to be 97.40-100.00% with precision (RSD <5%). The percentage recoveries were 97-100% with RSD <5%. The method was found sensitive and reproducible, and applied successfully to quantify the amides in ethanol and supercritical CO₂ extracts of fruit of Piper sarmentosum. The method is found to be simple, fast and easy to perform, and may be helpful for natural product industry as well as natural product scientists to produce standardized extracts and products from the plant. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Product Details of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Product Details of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

From Natural to Synthetic Quorum Sensing Active Compounds: Insights to Develop Specific Quorum Sensing Modulators for Microbe-Plant Interaction was written by Gutierrez-Villagomez, Juan Manuel;Ramirez-Chavez, Enrique;Molina-Torres, Jorge;Vazquez-Martinez, Juan. And the article was included in ACS Symposium Series in 2020.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

It is clear the importance of plant-microbe interactions to accomplish food safety and sustainable agriculture. Many plant-microbe interactions depend on bacterial quorum sensing (QS) systems, so the manipulation of these communication systems could be a powerful instrument to modulate plant development. The search of compounds with the capacity to modulate the microbial communication systems using docking mol. anal. methods along with chromatog. and miniaturized microbiol. techniques offers a robust tool-kit for designing and testing quorum quenching (QQ) active compounds Further, the synthesis of QQ compounds can be achieved by applying enzymic processes with the advantages of lowering costs and generating fewer byproducts. To exemplify these processes, herein, a group of natural compounds known as alkamides and piperamides were tested using mol. docking simulations to detect QQ active compounds against the CviR and LasR QS receptors of Gram-neg. bacteria. The docking results show that some alkamides and piperamides bind specifically to each of the studied QS receptors. The structural anal. of the resp. crystalized-receptor native ligand and the best-docked alkamide/piperamide was used to design acyl amide-like compounds These new acyl amide-like compounds bind more efficiently to the studied QS receptors than the native ligands, according to the docking results. The designed compounds could also potentially modulate plant-microbe interactions related to cellular processes dependent on bacterial QS. The data we describe contributes to the understanding of plant-microbe interactions and investigates methods to modulate plant-microbe interactions that can impact sustainable food production This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bioactive markers based pharmacokinetic evaluation of extracts of a traditional medicinal plant, Piper sarmentosum was written by Hussain, Khalid;Ismail, Zhari;Sadikun, Amirin;Ibrahim, Pazillah. And the article was included in Inventi Impact: Ethnopharmacology in 2012.Reference of 18836-52-7 The following contents are mentioned in the article:

In vitro assays are economical and easy to perform but to establish relevance of their results to real clin. outcome in animals or human, pharmacokinetics is prerequisite. Despite various in vitro pharmacol. activities of extracts of Piper sarmentosum, there is no report of pharmacokinetics. Therefore, the present study aimed to evaluate ethanol extract of fruit of the plant in dose of 500 mg kg^-1 orally for pharmacokinetics. Sprague-Dawley rats were randomly divided into groups 1, 2, and 3 (each n = 6) to study absorption, distribution and excretion, resp. High performance liquid chromatog. (HPLC) with UV detection was applied to quantify pellitorine, sarmentine and sarmentosine in plasma, tissues, feces and urine to calculate pharmacokinetic parameters. Pellitorine exhibited maximum plasma concentration (C_max) 34.77 ng mL^-1 ± 1.040, time to achieve C_max (T_max) 8 h, mean resident time (MRT) 26.00 ± 0.149h and half life (t_1/2) 18.64 ± 1.65 h. Sarmentine showed C_max 191.50 ± 12.69 ng mL^-1, T_max 6h, MRT 11.12 ± 0.44h and t_1/2 10.30 ± 1.98h. Sarmentosine exhibited zero oral bioavailability because it was neither detected in plasma nor in tissues, and in urine. Pellitorine was found to be distributed in intestinal wall, liver, lungs, kidney, and heart, whereas sarmentine was found only in intestinal wall and heart. The cumulative excretion of pellitorine, sarmentine and sarmentosine in feces in 72 h was 0.0773, 0.976, and 0.438 μg, resp. This study shows that pellitorine and sarmentine have good oral bioavailability while sarmentosine is not absorbed from the gastrointestinal tract. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Reference of 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sensory active piperine analogues from Macropiper excelsum and their effects on intestinal nutrient uptake in Caco-2 cells was written by Obst, Katja;Lieder, Barbara;Reichelt, Katharina V.;Backes, Michael;Paetz, Susanne;Geissler, Katrin;Krammer, Gerhard;Somoza, Veronika;Ley, Jakob P.;Engel, Karl-Heinz. And the article was included in Phytochemistry (Elsevier) in 2017.Electric Literature of C14H25NO The following contents are mentioned in the article:

The phytochem. profile of Macropiper excelsum (G.Forst.) Miq. subsp. excelsum (Piperaceae), a shrub which is widespread in New Zealand, was investigated by LC-MS-guided isolation and characterization via HR-ESI-TOF-MS and NMR spectroscopy. The isolated compounds were sensorily evaluated to identify their contribution to the overall taste of the crude extract with sweet, bitter, herbal and trigeminal impressions. Besides the known non-volatile Macropiper compounds, the lignans (+)-diayangambin and (+)-excelsin, four further excelsin isomers, (+)-diasesartemin, (+)-sesartemin, (+)-episesartemin A and B were newly characterized. Moreover, piperine and a number of piperine analogs as well as trans-pellitorine and two homologs, kalecide and (2E,4E)-tetradecadienoic acid N-iso-Bu amide were identified in M. excelsum, some of them for the first time. Methyl(2E,4E)-7-(1,3-benzodioxol-5-yl)hepta-2,4-dienoate was identified and characterized for the first time in nature. Sensory anal. of the pure amides indicated that they contributed to the known chemesthetic effects of Macropiper leaves and fruits. Since the pungent piperine has been shown to affect glucose and fatty acid metabolism in vivo in previous studies, piperine itself and four of the isolated compounds, piperdardine, chingchengenamide A, dihydropiperlonguminine, and methyl(2E,4E)-7-(1,3-benzodioxol-5-yl)hepta-2,4-dienoate, were investigated regarding their effects on glucose and fatty acid uptake by enterocyte-like Caco-2 cells, in concentrations ranging from 0.1 to 100 μM. Piperdardine showed the most pronounced effect, with glucose uptake increased by 83±18% at 100 μM compared to non-treated control cells. An amide group seems to be advantageous for glucose uptake stimulation, but not necessarily for fatty acid uptake-stimulating effects of piperine-related compounds This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Electric Literature of C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Electric Literature of C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1 was written by Olah, Zoltan;Redei, Dora;Pecze, Laszlo;Vizler, Csaba;Josvay, Katalin;Forgo, Peter;Winter, Zoltan;Dombi, Gyorgy;Szakonyi, Gerda;Hohmann, Judit. And the article was included in Phytomedicine in 2017.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:

Transient Receptor Potential Vanilloid 1 (TRPV1) confers noxious heat and inflammatory pain signals in the peripheral nervous system. Clin. trial of resiniferatoxin from Euphorbia species is successfully aimed at TRPV1 in cancer pain management and heading toward new selective painkiller status that further validates this target for drug discovery efforts. Evodia species, used in traditional medicine for hundreds of years, are a recognized source of different TRPV1 agonists, but no antagonist has yet been reported. In a search for painkiller leads, we noted for the first time a TRPV1 antagonist activity in the fresh fruits of Tetradium daniellii (Benn.) T. G. Hartley (syn. Evodia hupehensis Dode). Through a combination of extraction and purification methods with functional TRPV1-specific Ca²⁺ uptake assays (bioactivity-guided fractionation/isolation/purification); we isolated a new painkiller candidate that is a distant structural homolog of capsiate exovanilloids and endovanilloids such as anandamide, but a putative competitive inhibitor of the TRPV1. Four addnl. inactive compounds (N-isobutyl-4,5-epoxy-2E-decadienamide, geranylpsoralen, 8-(7′,8′-epoxygeranyloxy)psoralen, and xanthotoxol) were also co-purified with pellitorine. Their structures were established by extensive 1D- and 2D-NMR spectroscopic anal.¹H- and ¹³C NMR determination of the chem. structure revealed it to be pellitorine, (2E,4E)-N-(2-methylpropyl)deca-2,4-dienamide, which can compete structurally with algesics released in inflammation. In contrast to previous isolates from Evodia species, pellitorine blocked capsaicin-evoked Ca²⁺ uptake with an IC₅₀ of 154 μg/mL (0.69 mM/l). N-Isobutyl-4,5-epoxy-2E-decadienamide and geranylpsoralen, 8-(7′,8′-epoxygeranyloxy)psoralen, and xanthotoxol did not affect the TRPV1. This is the first evidence that pellitorine, an aliphatic alkylamide analog of capsaicin, can serve as an antagonist of the TRPV1 and may inhibit exovanilloid-induced pain. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: (2E,4E)-N-Isobutyldeca-2,4-dienamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A selective and sensitive UFLC-MS/MS method for the simultaneous determination of five alkaloids from Piper longum L. and its application in the pharmacokinetic study of 6-OHDA-induced Parkinson’s disease rats was written by Xu, Rongrong;Zhao, Wenwen;Yu, Lan;Chen, Qijun;Hu, Xiaolu;Ba, Yinying;Chen, Xiaoqing;Wang, Xing;Wu, Xia. And the article was included in RSC Advances in 2019.Recommanded Product: 18836-52-7 The following contents are mentioned in the article:

The alkaloids from Piper longum L. (PLA) mainly contain piperine (PPR), piperlongumine (PPL), Δα,β-dihydropiperlonguminine (DPPL), piperanine (PPRA) and pellitorine (PLTR), which have neuroprotective effects on a 6-OHDA-induced rat model of Parkinson’s disease (PD). To elucidate the pharmacokinetic profiles of these main compounds in PD rats, we developed a rapid, selective and sensitive ultra-fast liquid chromatog.-electronic spray ionization-tandem mass spectrometry (UFLC-ESI-MS/MS) method which was validated for the simultaneous determination of the 5 absorbed compounds in the plasma of 6-OHDA-induced PD rats. The plasma samples were pretreated using a protein precipitation method with methanol/acetonitrile (1 : 1, volume/volume). The analytes and internal standard (IS) were separated on a Phenomenex Gemini C18 column using gradient elution with a mobile phase consisting of acetonitrile and a 0.1% formic acid aqueous solution at a flow rate of 0.5 mL min^-1. The total chromatog. running time was 4.5 min. The detection was performed with pos. electrospray ionization (ESI) using the multiple reaction monitoring (MRM) mode of transitions at m/z 286.2 → 201.2, m/z 274.2 → 201.2, m/z 276.2 → 135.1, m/z 288.2 → 135.1, m/z 224.1 → 168.2, and m/z 472.1 → 436.1 for PPR, PPL, DPPL, PPRA, PLTR and IS, resp. All five analytes showed excellent linearity (R > 0.995) within the concentration range of 0.20-5000 ng mL^-1. The established method was then applied to investigate the pharmacokinetics of multi-components (PPR, PPL, DPPL, PPRA and PLTR) in PD rats after oral administration of PLA. The results showed that no obvious differences were observed in the pharmacokinetic parameters of PPR, PPL, DPPL, PPRA and PLTR in PD rats compared with those in sham rats after oral administration of PLA except for MRTs for PPR, PPL and PLTR. Addnl., the activities of superoxide dismutase (SOD) were related to the concentrations of the multi-components in plasma. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pd(II) complexes with chelating N-(1-alkylpyridin-4(1H)-ylidene)amide (PYA) ligands: Synthesis, characterization and evaluation of anticancer activity was written by Zafar, Muhammad Naveed;Butt, Abdul Mannan;Chaudhry, Gul-e-Saba;Perveen, Fouzia;Nazar, Muhammad Faizan;Masood, Sara;Dalebrook, Andrew Francis;Mughal, Ehsan Ullah;Sumrra, Sajjad Hussain;Sung, Yeong Yik;Muhammad, Tengku Sifzizul Tengku;Wright, Leonard James. And the article was included in Journal of Inorganic Biochemistry in 2021.Quality Control of N1,N2-Di(pyridin-4-yl)oxalamide The following contents are mentioned in the article:

The bidentate N-(1-Alkylpyridin-4(1H)-ylidene)amide (PYA) pro-ligands [H₂L_Bn][Cl]₂ (2), and [H₂L_Me][TfO]₂ (3) were prepared by simple alkylation reactions of the known compound, N,N-di(pyridin-4-yl)oxalamide (H₂L, 1). The Pd(II) complexes, [Pd(L_Bn)₂][Cl]₂ (4), [Pd(L_Me)₂][Cl][TfO] (5), Pd(L_Bn)Cl₂ (6) and Pd(L_Me)Cl₂ (7) were synthesized through reactions between these pro-ligands and suitable Pd(II) substrates in the presence of base. The mol. structures of 3 and 6 were obtained by single crystal x-ray structure determinations Studies of the exptl. and computational DNA binding interactions of 1–7 revealed that overall 4 and 6 have the largest values for the binding parameters K_b and ΔG^o_b. The results showed a good correlation with the steric and electronic parameters obtained by quant. structure activity relation (QSAR) studies. In-vitro cytotoxicity studies against four different cell lines showed that the human breast cancer cell lines MCF-7, T47D and cervical cancer cell line HeLa had either higher or similar sensitivities towards 4, 6 and 2, resp., compared to cisplatin. In general, the cytotoxicity of the compounds, represented by IC₅₀ values, decreased in the order 4 > 6 > 2 > 5 > 3 > 1 > 7 in cancer cell lines. Apoptosis contributed significantly to the cytotoxic effects of these anticancer agents as evaluated by apoptosis studies. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Quality Control of N1,N2-Di(pyridin-4-yl)oxalamide).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of N1,N2-Di(pyridin-4-yl)oxalamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics