Tag: 200-300

Bioactive compounds from medicinal plants: Focus on Piper species was written by Mgbeahuruike, E. E.;Yrjonen, T.;Vuorela, H.;Holm, Y.. And the article was included in South African Journal of Botany in 2017.Formula: C14H25NO The following contents are mentioned in the article:

This article reviews new discoveries related to the phytochem. and biol. activities of bioactive compounds from Piper species. It outlines the anticancer, anti-parasitic, and antimicrobial activities of Piper species in relation to drug discovery. The use of bioactive compounds from medicinal plants as therapeutic agents has been an important area in biomedical and natural product research. Piper species are effective medicinal plants used in folk medicine. They have traditionally been used to treat stomach ache, rheumatoid arthritis, diarrhea and other general infections, and their efficacy has been attributed to their bioactive compounds Bioactive compounds and extracts from Piper species have been examined and found to be of clin. importance for both malignant and non-malignant diseases. They have displayed pronounced efficacy as anticancer, antitumor and antimicrobial agents in various pharmacol. studies. They have been reported to possess anti-inflammatory, antioxidant, antibacterial, antifungal, and antimalarial activities. The alkaloids piperine, piperlongumine, guineensine, chabamide and pellitorine, which have been isolated from most Piper species, are able to inhibit the growth of cancer cell lines inducing apoptosis and acting as nuclear export inhibitors. These bioactive compounds can improve the effectiveness of chemotherapeutic drugs with minimal systemic toxicity to normal cells in cancer therapy. Pinoresinol, guineensine and other bioactive compounds from this species exhibited strong antimicrobial efficacy against various microorganisms including pathogenic Vibrio strains, which are often involved in host cell invasion during Vibrio cholera infection. The anticancer, antimicrobial and antimalarial properties of Piper species are compiled to support further exploration of their bioactive compounds for drug discovery. Biomedical and pharmacol. discoveries concerning their anticancer and antimicrobial properties are highlighted here for further clin. applications, which could pave the way for the proper therapeutic use of bioactive compounds and extracts from this plant species. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Formula: C14H25NO).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C14H25NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Anion-recognition studies of a Re(I)-based square containing the dipyridyl-amide ligand was written by Tzeng, Biing-Chiau;Chen, Yen-Fei;Wu, Chia-Chin;Hu, Cho-Chun;Chang, Ya-Ting;Chen, Chang-Kai. And the article was included in New Journal of Chemistry in 2007.Recommanded Product: N1,N2-Di(pyridin-4-yl)oxalamide The following contents are mentioned in the article:

The mol. square [Re(CO)₃Cl(L)]₄ (1) containing the dipyridyl-amide ligand, N,N’-4-dipyridyloxalamide (L), was constructed from Re(CO)₅Cl and L for the purpose of anion-recognition studies. Upon addition of fluoride anions to a THF solution of 1, a remarkable spectral change is observed, and indeed a new absorption band grows at ∼348 nm. The authors reasoned that upon addition of fluoride, the hydrogen bonds between F^– and -NH groups of L would first form and increase the electron densities of nitrogen atoms. This in turn increases the conjugation throughout the L ligand, which is responsible for the new growing absorption band. Finally, a proton-transfer process occurs upon addition of excess F^– anions, corroborated by the ¹H NMR titration experiment due to the occurrence of HF₂^–. The binding constants based on a 1:1 complex (1-X^–, X^– = anions) follow the order: F^– > CN^– > OAc^– > Cl^– > Br^–, PF₆^–, BF₄^–, ClO₄^–, NO₃^– and HSO₄^–. The most electroneg. F^– anion shows the largest binding constant, followed by CN^–, OAc^– and Cl^– anions. The less electroneg. Br^– anion and bigger PF₆^–, BF₄^–, ClO₄^–, NO₃^– and HSO₄^– anions do not show any binding affinity with 1. The control titrations carried out using L and the same series of anions showed that the basicity of anions also possibly lends some contribution to the sensing events. However, the binding affinity of 1 toward various anions can be mostly correlated with the electronegativity as well as cavity size of the mol. square, and hence 1 can be expected to be a sensor for F^–. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Recommanded Product: N1,N2-Di(pyridin-4-yl)oxalamide).

N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: N1,N2-Di(pyridin-4-yl)oxalamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cengiz, Gokhan; Algin Yapar, Evren; Kara, Bilge Ahsen; Sindhu, Rakesh K. published an article in 2021, the title of the article was Comparison and evaluation of pharmacopoeial methods for the assessment of potency of antibiotics.COA of Formula: C8H10N2O3S And the article contains the following content:

The detection and assessment of potency of antibiotics are crucial for the pharmaceutics. The valid methods for microbiol. assays in pharmacopoeias are mainly based on statistical comparison of the data obtained by measuring the cidal activity resulting from the treatment of the antibiotic active ingredient in the composition of the pharmaceutics with the target microorganism. However, it was seen that there is no validated microbiol. method for some active ingredients. Due to microbiol. assays are indispensable methods for determining the potency of some active ingredient groups, the calculation of the potency is performed logarithmically. In either turbidimetric or chromatog. methods, the statistical evaluation of the sample is compared with the standard reference material. Anal. data obtained by chromatog. and chem. methods are linear peak areas and spectrophotometer readings. In microbiol. methods, the data obtained from the analyzes performed to determine the potency of antibiotics are the inhibition zone diameters or turbidimetric turbidity data. In this study, above-mentioned microbiol. assays are compared in the context of the main pharmacopoeias EP, USP, CP, IP and BP, and evaluated in terms of the chromatog. method and classical microbiol. method. It has been observed that chromatog. and chem. methods are not available to determine the potency of some pharmaceutical products containing antibiotics. The examinations made reveal the difficulty of analyzing some active ingredient groups according to chem. and chromatog. methods. For this reason, the importance of method validation studies is increasing in order to analyze active substances that do not have alternative anal. methods with microbiol. and chem. methods. In this study, all validated microbiol. methods were investigated, and it was aimed to determine alternative methods to chromatog. and chem. methods. It was concluded that the realization of new microbiol. methods to be validated by evaluating the methods in all differences would facilitate the study. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to antibiotics pharmacopoeial potency microbiol chem method, Placeholder for records without volume info and other aspects.COA of Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hussein, Ag; Sakr, Hm; Mansour, Am; Ayyad, Rr published an article in 2021, the title of the article was Ulcer index and anti-inflammatory testing of some benzimidazole derivatives.Related Products of 144-80-9 And the article contains the following content:

In this work, we carry out the testing of some Benzimidazole derivatives as anti-inflammatory using Indomethacin 10mg/Kg, diclofenac sodium 7mg/Kg, celecoxib 100mg/Kg and tested compounds of 200mg/Kg. The tested compounds showed anti-inflammatory activity in comparison with the standard reference drugs. In addnl., carrying out the testing of ulcer index for some testing compounds 600mg/Kg comparing with indomethacin 100mg/Kg, the testing revealed indomethacin causes ulcer in stomach of the testing animals, while the testing compounds no ulcerated the stomach of the testing animal. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

The Article related to ulcer index inflammation benzimidazole antiinflammatory, Placeholder for records without volume info and other aspects.Related Products of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Borowiecki, Pawel; Zdun, Beata; Popow, Natalia; Wiklinska, Magdalena; Reiter, Tamara; Kroutil, Wolfgang published an article in 2022, the title of the article was Development of a novel chemoenzymatic route to enantiomerically enriched 尾-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

Efficient chemoenzymic routes toward the synthesis of both enantiomers of adrenergic beta-blockers were accomplished by identifying a central chiral building block, which was first prepared using lipase-catalyzed kinetic resolution (KR, Amano PS-IM) as the asym. step at a five gram-scale (209 mM concentrate). The enantiopure (R)-chlorohydrin (>99% ee) subsequently obtained was used for the synthesis of a series of model (R)-(+)-beta-blockers (i.e., propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol), which were produced with enantiomeric excess in the range of 96-99.9%. The pharmaceutically relevant (S)-counterpart, taking propranolol as a model, was synthesized in excellent enantiomeric purity (99% ee) via acetolysis of the resp. enantiomerically pure (R)-mesylate by using cesium acetate and a catalytic amount of 18-Crown-6, followed by acidic hydrolysis of the formed (S)-acetate. Alternatively, asym. reduction of a prochiral ketone, namely 2-(3-chloro-2-oxopropyl)-1H-isoindole-1,3(2H)-dione, was performed using lyophilized E. coli cells harboring overexpressed recombinant alc. dehydrogenase from Lactobacillus kefir (E. coli/Lk-ADH-Lica) giving the corresponding chlorohydrin with >99% ee. Setting the stereocenter early in the synthesis and performing a 4-step reaction sequence in a 鈥瞣ne-pot two-step鈥?procedure allowed the design of a 鈥瞫tep-economic鈥?route with a potential dramatic improvement in process efficiency. The synthetic method can serve for the preparation of a broad scope of enantiomerically enriched beta-blockers, the chem. structures of which rely on the common 伪-hydroxy-N-isopropylamine moiety, and in this sense, might be industrially attractive. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to adrenergic betha blocker one pot two step procedure, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Xiaoqin; Fang, Zhijuan; He, Xinye; Zhang, Shuqin; Ding, Hongliu; Ye, Hu published an article in 2021, the title of the article was Optimization of 204 veterinary drug residues method and establishing their mass spectrum library.Reference of N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

A multi-class multi-residue anal. method was validated in this paper for simultaneously identifying 204 veterinary drugs in pork by UPLC-QTRAP MS/MS, including sulfonamides, quinolones, 尾-agonists, and nitroimidazoles. MRM-IDA-EPI mode of QTRAP was used to establish a secondary mass spectrum library of these 204 veterinary drugs, which could enhance the qual. anal. of suspect substances. The separation of substances was performed on a C18 column, with a gradient elution of 0.1% formic acid solution in water and methanol. Electrospray ionization (ESI), fast polarity switching, and scheduled MRM mode were used to collect the characterization results. Factors that affected the recovery were delicately optimized, such as solvent proportion, formic acid content, and purification method. We finally determined the extracting method with formic acid-acetonitrile-water (0.1:90:10, v:v:v) and purifying method with Cleanert LipoNo as a package for dispersive solid-phase extraction Matrix effects on the quant. results were also investigated. Some compounds had strong matrix inhibition or enhancement, and the matrix matching external standard method was used to quantify the compounds accurately. The correlation coefficient R2 was over 0.99 within the calibration linearity range for the detected 204 veterinary drugs. The limit of quantification (LOQ) was 0.5 鈭?5 渭g/kg. The recoveries ranged from 61.4% to 118.8% with RSDs of 3.1% to 19.2% (n = 6). The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to veterinary drug residue mass spectrum library, Placeholder for records without volume info and other aspects.Reference of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bawar, Khirsten Marie; Cruz, Leannie Praise; Ilao, Kristine Bernadette; Justiniano, Julianne Mica; Panganiban, Lara Mae; Fabito, Diane Laine; Amayun, Christine Joy; Nas, John Sylvester published an article in 2021, the title of the article was In silico identification of novel compounds as quorum-sensing inhibitors in selected waterborne pathogens.COA of Formula: C13H12N2O And the article contains the following content:

Quorum sensing (QS) is a process involved in producing, detecting, responding, and releasing signaling mols. to maintain physiol. activities of most utilized by both gram-pos. and gram-neg. bacteria in various environmental conditions. This study aims to identify novel compounds that have potential QS inhibitory mechanisms against the gram-pos. bacteria Staphylococcus aureus (S. aureus) and Streptococcus pneumoniae (S. pneumoniae), and the gram-neg. bacteria Salmonella typhi (S. typhi) and Escherichia coli (E. coli). Compounds that are structurally similar to the known QS inhibitors were identified using ligand-based screening. Candidate compounds with 40 to 80% similarity with the known QS inhibitors were further evaluated through mol. docking with the QS-associated enzymes, namely ComA, ComE, LsrF, LsrK, AgrC, AgrA, LsrB, and Hfq. The binding affinity was visualized to identify the different non-covalent binding interactions. Compounds with <-8.0 kcal/mol docking score were considered for evaluation for their distribution coefficient (LogD) at different optimal growth of the bacteria, such as pH 4, 6, 7.4, 7.8, 8, and 9. Out of the 63 compounds evaluated, only three compounds demonstrated a high binding affinity, namely 1-phenyl-3-[5-(phenylcarbamoylamino)naphthalen-1-yl]urea and 1-naphthalen1-yl-3-[5-(naphthalen-1-ylcarbamoylamino)naphthalen-1-yl]urea with ComE of S. pneumoniae and 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one to AgrA of S. aureus. Their high binding affinity may be attributed to the numerous hydrogen bonds and hydrophobic interactions. However, only 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one has comparable LogD value with its QS inhibitor of AgrA, savarin, at the optimal growth pH for S. aureus. These findings suggest that the use of 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a] quinazolin-5(4H)-one may be effective in controlling S. aureus growth probably through inhibition of AgrA. However, further studies are needed to confirm these findings. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to waterborne pathogen quorum sensing inhibitor, Placeholder for records without volume info and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Saluti, Giorgio; Colagrande, Maria Novella; Castellani, Federica; Ricci, Matteo; Diletti, Gianfranco; Scortichini, Giampiero published an article in 2021, the title of the article was Survey on Antibiotic Residues in Egg Samples in Italy.Electric Literature of 144-80-9 And the article contains the following content:

The presence of antibiotic residue in eggs is a current issue due to the increasingly important phenomenon of antibiotic resistance. A multiclass, confirmatory method for the determination of seventy-three antimicrobial agents (amphenicols, cephalosporins, diaminopyrimidines, lincosamides, macrolides, penicillins, pleuromutilins, quinolones, sulfonamides, and tetracyclines) with liquid chromatog. high-resolution mass spectrometry was applied to 200 egg samples collected from 119 Italian farms during the years 2018-2021. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to egg sample antibiotic residue survey italy, Placeholder for records without volume info and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mulualem, Yared Fikadu; Chandravanshi, Bhagwan Singh published an article in 2021, the title of the article was Assessment of metals content of widely used traditional toothbrushes in Addis Ababa, Ethiopia.Computed Properties of 456-12-2 And the article contains the following content:

Traditional toothbrushes are used by the vast majority of people who cannot afford to buy the com. toothbrush and toothpaste. The traditional toothbrushes are generally obtained from any slim woody part of a toothbrush tree. The main purpose of this study was to determine selected metals (Ca, Fe, Mg, Al, Cu, Cr, Ni, Zn, Mn, Pb, and Cd) in traditional toothbrushes obtained from three plants including Ligustrum vulgare L., Phoenix reclinata and Olea africana, which are extensively used in Addis Ababa, Ethiopia, by using microwave plasma-at. emission spectroscopy (MP-AES) after wet digestion. Recoveries of the metals in spiked samples varied from 90.4-107%. The overall mean concentrations determined (mg/kg, dry weight) were in the ranges of Ca (4267-36514) > Fe (131-318) > Al (81.6-224) > Mg (45.6-122) > Zn (27.2-175) > Mn (20.1-29) > Cu (6.6- 20.3) > Cr (6.7-8.9) > Ni (2.6-7.9). Anal. of variance at 95% indicated significant differences in the metals’ contents of three toothbrushes. The results indicated that the selected traditional toothbrushes are good sources of essential metals and free from Pb and Cd. Therefore, the investigated Ethiopian traditional toothbrushes are found to be safe for human use. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to ligustrum vulgare phoenix reclinata olea africana metal toothbrush ethiopia, Mammalian Pathological Biochemistry: Other and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics