Tag: 200-300

On November 30, 2015, Wang, Feng; Fan, Di; Qian, Jun; Zhang, Zhe; Zhu, Jianhua; Chen, Jian published an article.Synthetic Route of 5455-98-1 The title of the article was Preparation and Biodistribution of Technetium-99m-Labeled Bis- Misonidazole (MISO) as an Imaging Agent for Tumour Hypoxia. And the article contained the following:

Diagnosis of tumor hypoxia is an important aspect in determining the course of tumor therapy. In this study, we developed a novel imaging agent, 99mTcethylenedicysteine- bis-misonidazole (99mTc-EC-MISO), for diagnosing tumor hypoxia. We used 2-nitroimidazole as a reactant to synthesize the amino derivative of misonidazole (MISO) in the first step and then conjugated the di-amino derivative of MISO to the chelating agent ethylenedicysteine (EC) for labeling 99mTc in the second step. 99mTc-pertechnetate (99mTcO4 -) was reduced by tin chloride (SnCl2) for radiolabeling. The radiochem. purity was up to 94%. Tissue biodistribution and SPECT/CT imaging studies were conducted on s.c. gliomal tumor-bearing mice. The tumor-to-muscle ratio in the 99mTc-EC-MISO group increased with time, up to 4.6 at 4 h after injection. SPECT/CT imaging confirmed that the tumors could be visualized clearly with 99mTc-EC-MISO at 2 h. By introducing a second 2-nitroimidazole redox center, an apparent hypoxic accumulation of this novel 99mTc-labeled imaging agent in the tumor was observed The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

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Yuguda, Yakubu Magaji; Pandey, Rishikesh; Chavhan, Mayur Meghashyam; Mitra, Disha; Vijay, Aswathy; Ahmad, Sajjad; Daya, Minerva L.; Kumar, Shivam published an article in 2022, the title of the article was In-silico analysis for the confirmation of insulin receptor as a target for reported GLUT4 anti-diabetic natural compounds.HPLC of Formula: 456-12-2 And the article contains the following content:

There are 425 million people with diabetes in the World. There will be 629 million people with diabetes in the World in 2045. The insulin receptor controls glucose homeostasis, a physiol. mechanism that can lead to diabetes and cancer if disrupted. This study aimed to confirm the Insulin Receptor target for reported GLUT4 anti-diabetic natural compounds based on their pharmacokinetic properties, toxicity prediction, mol. docking, target anal., similar FDA approved drugs prediction, and mol. dynamic simulation. We selected 24 compounds on the basis of their mode of action from the anti-diabetic natural compounds database (ADNCD). Initially, we performed ADME anal. for the selected 24 compounds Among these 24 compounds, it has been found that 18 compounds followed the Lipinski Rule of Five. Further, we did a toxicity anal. of those 18 compounds, and it was found that 15 compounds were toxic in nature. We performed mol. docking against the Insulin Receptor (PDB ID: 1IR3) of the rest of the 3 compounds after ADME and toxicity anal. To understand the dynamic motions of the ligand-protein complex, we perform a root mean square fluctuation anal. We also checked the similarity of Apigenin from the FDA-approved drugs, but no similar mol. was found. It has been found that Apigenin was selected as the best compound as it showed the lowest binding energy and satisfied all our study parameters. Our promising findings based on preliminary and in-silico anal. need to be validated further by in-vitro and in-vivo studies. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

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On February 28, 2022, Varani, Tania; Abdouss, Majid; Azerang, Parisa; Tahghighi, Azar published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Acetylenic Sulfones and Acetylenic Sulfonamide Analogs: A Novel and Preferable Antimicrobial Drugs Based on Computational Strategies. And the article contained the following:

This study was done to report virtual screening and mol. docking studies of sulfacetamide derivatives as new antimicrobial drugs, belonging to the pharmacol. class of sulfonamides. For this purpose, sulfonamide functional groups from a library of chem. structures were converted into acetylenic sulfone and acetylenic sulfonamide functional groups to introduce a new class of antimicrobial drugs with mechanisms of action of dihydropteroate synthase inhibitors (DHPS). Initially, a library of compounds containing approx. 170 acetylenic sulfone ligands was created by similarity search method, and a library containing 170 acetylenic sulfonamide ligands was designed to be administered as new inhibitors. After designing, their mol. docking energies were calculated by three software programs including Arguslab4.0.1, AutoDock Vina and Molegro Virtual Docker and the results were compared in terms of binding energy. Although acetylenic sulfonamide compounds showed better results, acceptable results were observed in both groups of compounds Adsorption, distribution, metabolism and excretion (ADME) properties of acetylenic sulfones/acetylenic sulfonamide analogs were also analyzed using the admetSAR program. These new derivatives can be used in drug improvement processes for the treatment of antibacterial infections after performing further studies. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to cetylenic sulfonamide antimicrobial drug computational strategy, Placeholder for records without volume info and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

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Tam, Nguyen Minh; Pham, Minh Quan; Nguyen, Huy Truong; Hong, Nam Dao; Hien, Nguyen Khoa; Quang, Duong Tuan; Thu Phung, Huong Thi; Ngo, Son Tung published an article in 2021, the title of the article was Potential inhibitors for SARS-CoV-2 Mpro from marine compounds.Related Products of 144-80-9 And the article contains the following content:

Preventing the biol. activity of SARS-CoV-2 main protease using natural compounds is of great interest. In this context, using a combination of AutoDock Vina and fast pulling of ligand simulations, eleven marine fungi compounds were identified that probably play as highly potent inhibitors for preventing viral replication. In particular, four compounds including M15 (3-O-(6-O-伪-L-arabinopyranosyl)-尾-D-glucopyranosyl-1,4-dimethoxyxanthone), M8 (wailupemycins H), M11 (cottoquinazolines B), and M9 (wailupemycins I) adopted the predicted ligand-binding free energy of -9.87, -9.82, -9.62, and -9.35 kcal mol-1, resp., whereas the other adopted predicted ligand-binding free energies in the range from -8.54 to -8.94 kcal mol-1. The results were obtained using a combination of Vina and FPL simulations. Notably, although, AutoDock4 adopted higher accurate results in comparison with Vina, Vina is proven to be a more suitable technique for rapidly screening ligand-binding affinity with a large database of compounds since it requires much smaller computing resources. Furthermore, FPL is better than Vina to classify inhibitors upon ROC-AUC anal. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

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On February 15, 2022, Kumar Bishoyi, Ajit; Mahapatra, Monalisa; Sahoo, Chita Ranjan; Kumar Paidesetty, Sudhir; Nath Padhy, Rabindra published an article.Computed Properties of 144-80-9 The title of the article was Design, molecular docking and antimicrobial assessment of newly synthesized p-cuminal-sulfonamide Schiff base derivatives. And the article contained the following:

Antibiotic resistance of bacteria and fungi has been brewing for decades and has now surfaced as a potential public health emergency, globally. Thus, newer potent drug candidates are needed urgently to overcome antibiotic-resistant episodes. As an attempt to overcome the antimicrobial multi-drug resistance problems, a new series of p-cuminal sulfonamide Schiff base congeners 3a-3h were designed, synthesized, and their structures confirmed by several spectral studies. The antimicrobial activities assessment of obtained products was carried out against pathogenic bacteria Staphylococcus aureus, Streptococcus pyogenes, Methicillin-resistant Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and against pathogenic fungi Candida tropicalis and Trichophyton rubrum. Among them, 3b exhibited significant inhibition of all the strains of bacteria with MIC as 3.12渭g/mL and the compound 3e exhibited the most promising control against both C. tropicalis and T. rubrum (MIC 6.25渭g/mL) in comparison to Ketoconazole as well as good inhibition against both S. aureus and MRSA at MIC 6.25 渭g/mL The presence of sulfamoyl and azomethine groups and some of heteroaryl rings in individual mols. could have increased the antibacterial actions, while the antifungal action could be attributed to the presence of guanyl and acetyl groups in the mol. structure. Furthermore, in silico investigation and drug-likeness have been ascertained with biol. targets. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Computed Properties of 144-80-9

The Article related to cuminal schiff base reaction sulfanilamide antimicrobial sars, Placeholder for records without volume info and other aspects.Computed Properties of 144-80-9

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Ray, Avishikta; Mishra, Rakhi; Singh, Anju; Biswal, Pramod K.; Yadav, Reenu; Ghatuary, Shailesh Kumar published an article in 2020, the title of the article was Phytochemistry, pharmacology and ethnomedicinal properties of Aegle marmelos.Electric Literature of 456-12-2 And the article contains the following content:

A review. Aegle marmelos is widely used by the traditional healers for treatments of various diseases like diarrhea, dysentery, diabetes, ulcer, inflammation etc. The variety of secondary metabolites are present in this plant which impart its medicinal uses. Further number of active constiuetns has been isolated from the Aegle marmelos. Present review focused on traditional uses, phytochem., pharmacol. and toxicol. of Aegle marmelos to support potential scope for advance ethnopharmacol. study. The extract of Aegle marmelos is reported to have numerous significant pharmacol. activities like antihyperglycemic, anti-inflammatory, antipyretic, analgesic, anticonvulsant, antihistaminic, anxiolytic, antidepressant, antioxidant, hepatoprotective, antimicrobial, analgesic, antifungal, neuroprotective etc evaluated by using various animal models. The present study summaries selected scientific evidence on phytochem., pharmacol. properties and ethnomedicinal uses of Aegle marmelos. The data was gathered via the Internet (using Scopus, PubMed, Google Scholar, Elsevier, Springer, Science Direct, Researchgate and Web of Science) as well as from libraries and local books. The aim of the current review article is to compile all the relevant published information regarding traditional uses, phytochem. and therapeutic potential of Aegle marmelos. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Electric Literature of 456-12-2

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On August 1, 2022, Dou, Shuzhen; Lu, Jiaxin; Chen, Qiye; Chen, Chunning; Lu, Nan published an article.HPLC of Formula: 144-80-9 The title of the article was High-density Si nanopillars modified with Ag nanoislands: Sensitive SALDI-MS chip for sulfonamides. And the article contained the following:

In recent years, the abuse of antibiotics has brought adverse effects on water environment and food safety, to monitor the antibiotic content in water and foodstuffs is imperative for environmental protection and human health. In this work, a chip, composed of high-d. Si nanopillars and Ag nanoislands, is prepared for sensitive detection of sulfonamides with surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). In this chip, the high-d. Si nanopillars can absorb laser energy efficiently and promote electron transfer as antennas; the Ag nanoislands can enhance the thermal effect; the formation of the Schottky barrier and the conductive nanolayer between Si/Ag can extend the lifetime of electrons and promote electron tunneling effect. Therefore, the heterostructure presents high detection sensitivity (the limit of detection of sulfamethazine is as low as 3 amol); in addition, the satisfactory coefficients of determination (> 0.99) show that the chip is applicable for rapid quantification of sulfonamides. Further, the sulfacetamides spiked in milk and lake water can be sensitively identified and rapidly quantified. The prepared chip presents a considerable potential for food and environment monitoring. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

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On December 15, 2019, Sahu, Satya Narayan; Pattanayak, Subrat Kumar published an article.Product Details of 456-12-2 The title of the article was Molecular docking and molecular dynamics simulation studies on PLCE1 encoded protein. And the article contained the following:

Phospholipase C epsilon gene (PLCE1) is encoded the 1-phosphatidylinositol 4,5- bisphosphate phosphodiesterase 蔚-1 protein. This protein is characterized by the fetal onset of enormous proteinuria following by severe steroid resistance nephrotic syndrome (SRNS). The mutation position is located on the PIPLC_X domain of PLCE1 encoded protein. Mol. docking study was carried out between aegeline, berberine, diterpenoid, roseoside phytochems. with wild type and mutant of the PIPLC_X domain of the PLCE1 gene encoded protein. From the mol. docking study, it was found that, due to mutation the binding energy was decreased for aegeline, berberine diterpenoid and roseoside with mutant PLCE1 at S1484L compared to wildtype. To achieve the depth anal., we extended our study by performing the mol. dynamic simulation of 100 ns on wild type and the mutant (S1484L) model of above said domain of the studied protein. In the MD simulation study, we analyzed the result obtained from root mean square deviation, root mean square fluctuation, radius of gyration, solvation accessible surface area, hydrogen bond number and principal component anal. These dynamical behavior results of wild type protein show similar behavior with mutant protein. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

The Article related to mol docking dynamic simulation plce1 phospholipase c epsilon, Enzymes: Structure-Conformation-Active Site and other aspects.Product Details of 456-12-2

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On December 31, 2020, Piotrowska-Niczyporuk, Alicja; Bajguz, Andrzej; Kotowska, Urszula; Zambrzycka-Szelewa, Elzbieta; Sienkiewicz, Aneta published an article.Related Products of 102-07-8 The title of the article was Auxins and Cytokinins Regulate Phytohormone Homeostasis and Thiol-Mediated Detoxification in the Green Alga Acutodesmus obliquus Exposed to Lead Stress. And the article contained the following:

Abstract: Phytohormones, such as auxins and cytokinins, take part in the integration of growth control and stress response, but their role in algal adaptation to heavy metal remains to be elucidated. The current research indicated that lead (Pb), one of the most toxic metals in nature, causes severe depletion of endogenous cytokinins, auxins, and gibberellin and an increase in abscisic acid content in the green alga Acutodesmus obliquus. Exogenous auxins and cytokinins alleviate Pb toxicity through the regulation of the endogenous phytohormones鈥?levels. Exogenously applied auxins provoked the coordinated activation metal tolerance mechanisms leading to the increase in phytochelatin synthase activity and accumulation of phytochelatins and their precursors, which are essential for Pb sequestration. On the other hand, phytochelatin synthesis decreased in algal cells treated with cytokinins. Significant changes in the levels of low mol. weight metabolites, mainly involved in metal chelation and glutathione synthesis pathway under the influence of phytohormones in algal cells growing in the presence of Pb stress, were observed This is the first report showing that auxins and cytokinins are important regulatory factors in algal adaptation strategies to heavy metal stress based on thiol-mediated compounds and the maintenance of phytohormone homeostasis. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

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Benkaddour, Rajae; Ben Ali, Naouar; Hamdoun, Ouafaa; Badoc, Alain; Azaroual, Latifa; Martin, Patrick; Lamarti, Ahmed published an article in 2022, the title of the article was Micropropagation and acclimatization of common Oregano (Origanum vulgare L. Subsp. vulgare) by shoot tip culture.SDS of cas: 102-07-8 And the article contains the following content:

Origanum vulgare L. is a com. valued species with remarkable biol. properties. It is subject to over-exploitation practices that seriously threaten its sustainability for future generations. Thus, micropropagation serves as a tool for the protection and domestication of this species. In this study, we established an in vitro vegetative propagation protocol for Origanum vulgare. This is done through the axillary bud technique by carrying out various tests. Six culture media (MS, MSm, N30K, SD, SH and B5) were tested. Therefore, SD was chosen for the following experiments Seven cytokinins (adenine (Ad), N6-(2-isopentenyl) (2i.p.), zeatin (Zeat), kinetin (Kin), benzyladenine (BAP), 1,3-diphenylurea (DPU) and thidiazuron (TDZ) at 5 concentrations (0.44, 1.33, 2.22, 3.11 and 4.44 渭M/L) were evaluated. Thus, Kin at 3.11 渭M allowed high regeneration of vitroplants, optimal elongation, total rooting of explants, maximum bud multiplication, and absence of hyperhydric explants. In fact, the integration of auxins (indole-3-acetic acid (IAA), indole-3-butyric acid (IBA), and 1-naphthaleneacetic acid (NAA)) into the culture medium and their combinations with 3.11 渭M Kinetin contributed to the optimization of the root part. Thus, it was improved in particular in the case of 3.11 渭M Kin and 6.27 渭M IBA. Three polyamines (Putrescine, Spermidine and Spermine) at different concentrations (1.134, 3.402, 5.67, 7.938 and 11.34 渭M/L) combined at 3.11 渭M Kin and 6.27 渭M IBA were tested. In fact, 1.304 渭M putrescine was considered to be the most suitable for in vitro culture of explants, since it allowed optimal propagation of buds and roots, also a high rate of regeneration and rhizogenesis. GA3 at 1.15 渭M combined with 3.11 渭M Kin and 6.27 渭M IBA permitted maximum bud multiplication. The acclimatization was carried out successfully using vitroplants showing good foliar and root development. Thus, three months after acclimatization, the seedlings were transferred into large pots under natural light and temperature conditions. Almost all acclimatized plants developed flowers in the first year between May and July. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8

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