Tag: 200-300

Halogenation of N-substituted p-quinone imines and p-quinone oxime esters: IV. Chlorination and bromination of N-arylsulfonyl-2(3)-methyl(2-chloro)-1,4-benzoquinone monoimines was written by Avdeenko, A. P.;Konovalova, S. A.. And the article was included in Russian Journal of Organic Chemistry in 2006.Application of 1146-43-6 This article mentions the following:

The addition of halogens to N-arylsulfonyl-1,4-benzoquinone imines (e.g. N-(4-oxo-2,5-cyclohexadien-1-ylidene)benzenesulfonamide), which exist in a solution as Z and E isomers, is controlled by steric factors. Z-E isomerization strongly affects the stability of cyclohexene structures formed by halogenation of 1,4-benzoquinone imines. The halogenation of N-arylsulfonyl-1,4-benzoquinone imines is accompanied by prototropic rearrangement. The halogenation of analogous phenols, e.g. N-(4-hydroxyphenyl)benzenesulfonamide, which were also obtained in the halogenation of the quinone imines, was also examined In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Application of 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents was written by He, Xiao-Yun. And the article was included in Monatshefte fuer Chemie in 2021.Reference of 383-31-3 This article mentions the following:

Pd(OAc)₂/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride reacted effectively with nucleophile and provided extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C-F bond. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Reference of 383-31-3).

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Reference of 383-31-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mechanism of H₂O₂/bleach activators and related factors was written by Liu, Kai;Yan, Kelu;Sun, Gang. And the article was included in Cellulose (Dordrecht, Netherlands) in 2019.HPLC of Formula: 10543-57-4 This article mentions the following:

Abstract: A mechanism of H₂O₂/bleach activator bleaching systems was proposed by using H₂O₂/tetraacetylethylenediamine (TAED) system as a model. HO· concentrations of the system under different pH conditions was measured by using benzenepentacarboxylic acid as a fluorescent probe. Computational anal. of bond enthalpies of H₂O₂ and peracids revealed that HO· should be the most effective agent in bleaching process, and peracids formed in H2O2/bleach activator bleaching systems could more easily produce HO^·. The formation of peracids in H₂O₂/TAED system depends on the pH values of bleaching solutions and a nucleophilic substitution of the acid derivative by peroxide anion (HOO^–). Charge d. on carbonyl carbons of bleach activators affects the formation of peracids as well, which was proven from these compounds of TAED, tetraacetylhydrazine, N-[4-(triethylammoniomethyl)-benzoyl]-caprolactam chloride, phthalimide, N-acetylphthalimide and nonanoyloxybenzene sulfonate. It is likely that the charge densities on carbonyl carbon of amide bleach activators should be larger than 0.185. For ester bleach activators, the results were also investigated by activation energy, Gibbs free energy and Hansen solubility parameters. In addition, the ecotoxicity of bleach activators has been evaluated by ECOSAR program. Potential bleach activators can be designed and explored according to these results instead of large amounts of exptl. data. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4HPLC of Formula: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tuning Synergistic Effect of Au-Pd Bimetallic Nanocatalyst for Aerobic Oxidative Carbonylation of Amines was written by Duan, Hui;Zeng, Yongfei;Yao, Xin;Xing, Pengyao;Liu, Jia;Zhao, Yanli. And the article was included in Chemistry of Materials in 2017.Electric Literature of C13H24N2O This article mentions the following:

The activation and utilization of carbon monoxide is of crucial importance to C₁ chem. Various catalytic transformation processes have been developed and studied in the last century, and oxidative carbonylation of amines is one of them. Catalysts that have been identified to date for the oxidative carbonylation of amines generally show relatively low activity and/or selectivity. Herein, a metal-organic framework (MOF), i.e., MOF-253 prepared from AlCl₃·6H₂O and 2,2′-bipyridine-5,5′-dicarboxylic acid, was employed as a support of gold-palladium bimetallic nanoparticles (Au-Pd/MOF) for the oxidative carbonylation of amines under mild conditions. Compared to palladium or gold monometallic catalysts, higher catalytic activity (turnover frequency up to 2573 h^-1) and selectivity in the carbonylation of amines were achieved by Au-Pd/MOF bimetallic catalysts through adjusting the molar ratio of gold and palladium within the framework. A breathing effect of Au-Pd/MOF in the catalytic process was further observed from kinetic profiles and powder X-ray diffraction for the first time. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Electric Literature of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Electric Literature of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones was written by Khramtsova, Ekaterina E.;Lystsova, Ekaterina A.;Khokhlova, Evgeniya V.;Dmitriev, Maksim V.;Maslivets, Andrey N.. And the article was included in Molecules in 2021.HPLC of Formula: 2387-23-7 This article mentions the following:

The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is a valuable scaffold in drug discovery. The replacement of the 3-oxy fragment in 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones-based compounds with a 3-amino one (3-amino analogs of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, 3-amino-1,5-dihydro-2H-pyrrol-2-ones) can play a crucial role in their biol. effect. Thus, approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones are of significant interest. We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported approaches (reactions of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones with amines). The developed approach is based on the thermal decomposition of 1,3-disubstituted urea derivatives of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, which were prepared via their reaction with carbodiimides. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

(2-Ethylhexyl)sodium: A Hexane-Soluble Reagent for Br/Na-Exchanges and Directed Metalations in Continuous Flow was written by Harenberg, Johannes H.;Weidmann, Niels;Wiegand, Alexander J.;Hoefer, Carla A.;Annapureddy, Rajasekar Reddy;Knochel, Paul. And the article was included in Angewandte Chemie, International Edition in 2021.Electric Literature of C10H10F3NO2 This article mentions the following:

We report the on-demand generation of hexane-soluble (2-ethylhexyl)sodium (1) from 3-(chloromethyl)heptane (2) using a sodium-packed-bed reactor under continuous flow conditions. Thus, the resulting solution of 1 is free of elemental sodium and therefore suited for a range of synthetic applications. This new procedure avoids the storage of an alkylsodium and limits the handling of metallic sodium to a min. (2-Ethylhexyl)sodium (1) proved to be a very useful reagent and undergoes in-line Br/Na-exchanges as well as directed sodiations. The resulting arylsodium intermediates are subsequently trapped in batch with various electrophiles such as ketones, aldehydes, Weinreb-amides, imines, allyl bromides, disulfides and alkyl iodides. A reaction scale-up of the Br/Na-exchange using an in-line electrophile quench was also reported. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Electric Literature of C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Electric Literature of C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease was written by Keenan, Martine;Abbott, Michael J.;Alexander, Paul W.;Armstrong, Tanya;Best, Wayne M.;Berven, Bradley;Botero, Adriana;Chaplin, Jason H.;Charman, Susan A.;Chatelain, Eric;von Geldern, Thomas W.;Kerfoot, Maria;Khong, Andrea;Nguyen, Tien;McManus, Joshua D.;Morizzi, Julia;Ryan, Eileen;Scandale, Ivan;Thompson, R. Andrew;Wang, Sen Z.;White, Karen L.. And the article was included in Journal of Medicinal Chemistry in 2012.Synthetic Route of C9H10BrNO2 This article mentions the following:

We report the discovery of nontoxic fungicide fenarimol (1, I) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogs with low nM IC₅₀s in a T. cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection. Compounds are chem. tractable, allowing rapid optimization of target biol. activity and drug characteristics. Chem. and biol. studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Synthetic Route of C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel one-pot preparation of 5-methoxylated indoline and indole derivatives using a hypervalent iodine(III) reagent was written by Tohma, Hirofumi;Watanabe, Hiroaki;Takizawa, Shinobu;Maegawa, Tomohiro;Kita, Yasuyuki. And the article was included in Heterocycles in 1999.Recommanded Product: 1146-43-6 This article mentions the following:

A novel and efficient one-pot preparation of 5-methoxy-1-tosylindolines and -indoles from N-tosyl-p-anisidines and activated olefins using phenyliodine(III) bis(trifluoroacetate) is described. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Recommanded Product: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Treading Water: Tire Wear Particle Leachate Recreates an Urban Runoff Mortality Syndrome in Coho but Not Chum Salmon was written by McIntyre, Jenifer K.;Prat, Jasmine;Cameron, James;Wetzel, Jillian;Mudrock, Emma;Peter, Katherine T.;Tian, Zhenyu;Mackenzie, Cailin;Lundin, Jessica;Stark, John D.;King, Kennith;Davis, Jay W.;Kolodziej, Edward P.;Scholz, Nathaniel L.. And the article was included in Environmental Science & Technology in 2021.Recommanded Product: 1,3-Dicyclohexylurea This article mentions the following:

Tire tread wear particles (TWP) are increasingly recognized as a global pollutant of surface waters, but their impact on biota in receiving waters is rarely addressed. In the developed U.S. Pacific Northwest, acute mortality of adult coho salmon (Oncorhynchus kisutch) follows rain events and is correlated with roadway d. Roadway runoff exptl. triggers behavioral symptoms and associated changes in blood indicative of cardiorespiratory distress prior to death. Closely related chum salmon (O. keta) lack an equivalent response. Acute mortality of juvenile coho was recently exptl. linked to a transformation product of a tire-derived chem. We evaluated whether TWP leachate is sufficient to trigger the acute mortality syndrome in adult coho salmon. We characterized the acute response of adult coho and chum salmon to TWP leachate (survival, behavior, blood physiol.) and compared it with that caused by roadway runoff. TWP leachate was acutely lethal to coho at concentrations similar to roadway runoff, with the same behaviors and blood parameters impacted. As with runoff, chum salmon appeared insensitive to TWP leachate at concentrations lethal to coho. Our results confirm that environmentally relevant TWP exposures cause acute mortalities of a keystone aquatic species. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Design, synthesis and herbicidal activity of novel sulfonylureas containing monosubstituted pyrimidine moiety was written by Pan, Li;Liu, Zhuo;Chen, You-wei;Li, Yong-hong;Li, Zheng-ming. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2013.Category: amides-buliding-blocks This article mentions the following:

Sulfonylureas, a unique group of herbicides, were extensively applied to controlling a range of weeds in a variety of crops and vegetables. In order to find efficient sulfonylurea herbicides, the title compounds were designed by introducing monosubstituted pyrimidinamines into some well-known sulfonylurea skeletons. A series of sulfonylurea compounds were synthesized and characterized by ¹H NMR and HRMS. Herbicidal activities and IC₅₀ values of the title compounds were determined by Pot plant test and Petri dish test against Brassica napus, Amaranthus retroflexus, Echinochloa crusgalli and Digitaria adscendens. Some compounds exhibited herbicidal activities. Compounds I and II possessed significant inhibition effects against Brassica napus and Amaranthus retroflexus. Further structural modification of novel sulfonylureas containing monosubstituted pyrimidine moiety will be required for improving efficacy against weeds in our laboratory In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6Category: amides-buliding-blocks).

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics