Tag: 200-300

On August 15, 2022, Tan, Haiguang; Sun, Feifei; Abdallah, Mohamed F.; Li, Jianxun; Zhou, Jinhui; Li, Yi; Yang, Shupeng published an article.Category: amides-buliding-blocks The title of the article was Background ions into exclusion list: A new strategy to enhance the efficiency of DDA data collection for high-throughput screening of chemical contaminations in food. And the article contained the following:

Foods contaminated with hazardous compounds, could pose potential risks for human health. To date, there is still a big challenge in accurate identification. In this study, a novel data-dependent acquisition (DDA) approach, based on a combination of inclusion list and exclusion list, was proposed to acquire more effective MS/MS spectra. This strategy was successfully applied in a large-scale screening survey to detect 50 mycotoxins in oats, 155 veterinary drugs in dairy milk, and 200 pesticides in tomatoes. Compared with traditional acquisition modes, this new strategy has higher detection rate, particularly at ultra-low concentration by eliminating background influence, thereby generating the MS/MS spectra for more potential hazardous materials instead of matrix interference. Addnl., the obtained MS/MS spectra are simpler and more likely to be traced back than DIA. Moreover, this new strategy would be more comprehensively applied in food safety monitoring with the improvement of HRMS and post-acquisition techniques. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Category: amides-buliding-blocks

The Article related to throughput screening chem contamination food, data acquisition, food safety, high-resolution mass spectrometer, non-targeted screening, Placeholder for records without volume info and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2022, Shinde, Jivan; Bhimrao Patil, Prakash; Kavala, Veerababurao; Yao, Ching-Fa published an article.Related Products of 102-07-8 The title of the article was Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine. And the article contained the following:

The synthesis of unsym. urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsym. urea derivatives synthesis in Et acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to urea derivative copper acylazide secondary amine catalysis, curtius rearrangement, copper catalyst, green solvent, unsymmetrical urea, Placeholder for records without volume info and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Song, Mengke; Song, Dandan; Jiang, Longfei; Zhang, Dayi; Sun, Yingtao; Chen, Guoen; Xu, Huijuan; Mei, Weiping; Li, Yongtao; Luo, Chunling; Zhang, Gan published an article.Synthetic Route of 144-80-9 The title of the article was Large-scale biogeographical patterns of antibiotic resistome in the forest soils across China. And the article contained the following:

Soil is a reservoir of environmental resistomes. Information about their distribution, profiles, and driving forces in undisturbed environments is essential for understanding and managing modern antibiotic resistance genes (ARGs) in human disturbed environments. However, knowledge about the resistomes in pristine soils is limited, particularly at national scale. Here, we conducted a national-scale investigation of soil resistomes in pristine forests across China. Although the antibiotics content was low and ranged from below limit of detection (LOD) to 0.290 渭g/kg, numerous detected ARGs conferring resistance to major classes of modern antibiotics were identified and indicated forest soils as a potential source of resistance traits. ARGs ranged from 6.20 x 10-7 to 2.52 x 10-3 copies/16S-rRNA and were predominated by those resisting aminoglycoside and encoding deactivation mechanisms. Low abundance of mobile genetic elements (MGEs) and its scarcely pos. connections with ARGs suggest the low potential of horizontal gene transfer. The geog. patterns of ARGs and ARG-hosts in pristine forest soils were mainly driven by soil physiochem. variables and followed a distance-decay relationship. This work focusing on pristine soils can provide valuably new information for our understanding of the ARGs in human disturbed environments. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9

The Article related to gene expression antibiotic resistance forest soil, antibiotic resistome, distribution, driving force, forest soils, national scale, Placeholder for records without volume info and other aspects.Synthetic Route of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Chibwe, Leah; Parrott, Joanne L.; Shires, Kallie; Khan, Hufsa; Clarence, Stacey; Lavalle, Christine; Sullivan, Cheryl; O鈥睟rien, Anna M.; De Silva, Amila O.; Muir, Derek C. G.; Rochman, Chelsea M. published an article.Synthetic Route of 102-07-8 The title of the article was A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow. And the article contained the following:

The ecol. impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high-resolution liquid chromatog. Orbitrap mass spectrometry to characterize the toxicity and chem. mixture of organic chems. associated with tire particle leachates. We assessed: 1) exposure to tire particle leachates after leaching for 1-, 3-, and 10-d; and 2) the effect of the presence and absence of small tire particulates in the leachates. We observed a decrease in embryonic heart rates, hatching success, and lengths, as well as an increase in the number of embryos with severe deformities and diminished eye and body pigmentation, after exposure to the leachates. Overall, there was a pattern whereby we observed more toxicity in the 10-d leachates, and greater toxicity in unfiltered leachates. Redundancy anal. showed that several benzothiazoles and aryl-amines were correlated with the toxic effects observed in the embryos. These included benzothiazole, 2-aminobenzothiazole, 2-mercaptobenzothiazole, N,N鈥?diphenylguanidine, and N,N鈥?diphenylurea. However, many other chems. characterized as unknowns are likely to also play a key role in the adverse effects observed Our study provides insight into the types of chems. likely to be important toxicol. drivers in tire leachates, and improves our understanding of the ecotoxicol. impacts of tire wear particles. Environ Toxicol Chem 2021;00:1-10. 2021 The Authors. Environmental Toxicol. and Chem. published by Wiley Periodicals LLC on behalf of SETAC. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to pimephales chem mixture tire wear particle toxicol, complex chemical mixtures, fathead minnow, tire toxicity, tire wear particles, Placeholder for records without volume info and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tian, Min; Zhou, Shenzhi; Li, Wei; Li, Jiaru; Yang, Lan; Peng, Ying; Zheng, Jiang published an article in 2021, the title of the article was Metabolic activation of aegeline mediated by CYP2C19.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacol. activities. As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. Nevertheless, the mechanisms of AGL-induced hepatotoxicity remain unclear. This study was conducted to identify reactive metabolite(s), to determine related metabolic pathways, and define the possible association of the bioactivation with AGL cytotoxicity. A demethylation metabolite (M1) and a GSH conjugate (M2) were detected in rat liver microsomal incubations containing AGL and GSH. The two metabolites were both found in bile of rats and rat primary hepatocytes after AGL administration. Recombinant P 450 enzyme incubations showed that CYP2C19 was the principal enzyme catalyzing this metabolic activation. Ticlopidine, a selective inhibitor of CYP2C19, decreased the formation of M1 and M2 in hepatocytes and attenuated the susceptibility of hepatocytes to the cytotoxicity of AGL. The results suggest that AGL was metabolized to a p-quinone methide intermediate which could in part participate in AGL-induced cytotoxicity. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline cytochrome p metabolic activation, aegeline, cyp2c19, cytotoxicity, metabolic activation, quinone methide intermediate, Placeholder for records without volume info and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dykhanov, N. N.; Ryzhkova, T. S.; Khaletskii, A. M. published an article in 1967, the title of the article was Ammonolysis of isomeric chlorobenzensulfonamides.Application of 97-09-6 And the article contains the following content:

Heating o-ClC6H4SO2NH2 (I) with 15 moles NH3 (as 30% solution in water) to 200° in the absence of catalysts failed to give any reaction. However, in the presence of Cu2O, ammonolysis took place at 145-50° to give 5-6% o-H2NC6H4SO2NH2 (II) and a polymeric mass (III). Hydrolysis of III with 40% H2SO4 gave o-H2NC6H4SO3H and II. Presence of an alkyl substituent on the amino group of I prevents the formation of a polymer. Thus, ammonolysis of o-ClC6H4SO2NHMe in the presence of Cu+ at 155-60° gave ∼80% o-H2NC6H4SO2NHMe. Also ammonolysis of m-ClC6H4SO2NH2 gave ∼80% m-H2NC6H4SO2NH2 and no polymer. Formation of II was explained by postulating the existence of an intermediate Cu+ complex of the average composition [ClC6H4SO2NH2.CuCl.2H2O],which at 200° nearly instantaneously decompose to III. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ionescu, Maria; Panea, Ioan published an article in 1967, the title of the article was Infrared spectra of some sulfamides.Synthetic Route of 97-09-6 And the article contains the following content:

A series of sulfamides were pelletized with KBr (1:300 mg./mg.), and the ir spectra were determined The data were tabulated for the bands corresponding to νs–…C, νs–…N, νs–…O, and The first 3 bands at 1090, 1050, and 1030 cm.-1, resp., are present in the spectra of the arylsulfamides in the 1100-1000-cm.-1 range, in addition to the bands corresponding to the νβ-CH of the substituted benzene nucleus. In many cases, these bands coupled with each other or with addnl. bands. The band at 913 cm.-1 in I was used for quant. anal. The ir spectrum of the equimol. mixture of I and its isomer showed that it was additive, each vibration (even of the same bond but in different connection) manifesting its presence by a corresponding maximum Determinations, by using various amounts of I and II and measuring the extinction by the base line method, verified the rectilinear correlation between extinction and concentration of I, when the latter is >90%, but if it is <60% the error is >>2.8%. 16 references. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Synthetic Route of 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Synthetic Route of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kavalek, Jaromir; Socha, Jaromir published an article in 1968, the title of the article was Quinoxaline series. V. Preparation of 3-hydroxy-2-methyl-6-chloroquinoxaline and 3-hydroxy-2-methyl-6-sulfamoylquinoxaline.Reference of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

The title compounds I are potential fungicides and therapeutic agents. Thus, 17.2 g. 2-nitro-4-chloroaniline and 15.3 g. DL-MeCHBrCO2H was heated at 120° 40 hrs., the product extracted with hot aqueous NH4OH, and the extract made acid with HCl to give 4.86 g. N-(2-nitro-4-chlorophenyl)-DL-alanine, m. 162-3° (MeOH), which was hydrogenated in MeOH solution over Raney Ni, the product oxidized in 4% NaOH solution with 30% H2O2 on a steam bath and the material purified on Al2O3 to yield 11% I (R = Cl), m. 274-5°. A suspension of 7.1 g. 3-nitro-4-chlorobenzenesulfonamide, 11.2 g. NaHCO3, and 8.1 g. DL-alanine in 20 ml. MeOH and 15 ml. H2O gave on heating 48 hrs. at 90-100° 7.75 g. N-(2-nitro-4-sulfamoylphenyl)-DL-alanine, m. 233.5-6.0°, which was portionwise added to a boiling mixture of FeSO4.7H2O and 5% aqueous NH4OH. After 15 min., the mixture was filtered, the filtrate made acid, and the separated crude amide of 3-hydroxy-2-methyl-1,2-dihydro-6-quinoxalinesulfonic acid, m. 235-9°, dropwise treated with 30% aqueous H2O2 and kept 1 hr. on a steam bath to yield 69% I (R = SO2NH2), m. 325.5-7.0°. By an alternative route, I (R = SO2NH2) was obtained in 92% yield by treating amide of 4-amino-3-nitrobenzenesulfonic acid in aqueous NH4OH at 80° with a solution of FeSO4 and allowing to react the resulting 1,2-diamino-4-benzenesulfonamide, m. 173-5°, at 65° with an aqueous solution of pyruvic acid. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Reference of 3-Nitro-4-chlorobenzenesulfonamide

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Reference of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chatterjee, Asima; Chaudhuri, Narayan Aditya published an article in 1957, the title of the article was New synthesis of β-hydroxy-β-(p-methoxyphenyl)ethylamine and aegelin, the alkaloid of Aegle marmelos correa.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

KCN and HCl (sp. gr. 1.85) added alternately in small quantities to anisaldehyde cooled in a freezing mixture gave anisaldehyde cyanohydrin (I), m. 67°. I was smoothly reduced by LiAlH4 (65% yield) to DL-β-hydroxy-β-(p-methoxyphenyl)ethylamine (II). Dry HCl gas added to II dissolved in Et2O gave II.HCl, m. 172-3°. An ethereal solution of II added to an ethereal solution of trans-cinnamoyl chloride (III) gave DL-trans-N-[β-hydroxy-β-(p-methoxyphenyl)] ethyl cinnamide (IV), m. 178-9°, identical with aegelin; this was confirmed by infrared spectra and Rf values. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Conroy, Harold; Bernasconi, Raymond; Brook, Peter R.; Ikan, Raphael; Kurtz, Roberta; Robinson, Keith W. published an article in 1960, the title of the article was Structure of echitamine.Related Products of 456-12-2 And the article contains the following content:

Accumulated data favor formulation of echitamine (I) in compatability with the theory of alkaloid biogenesis and in close resemblance to intermediates of the strychnine-vomicine group. Echitamine chloride (II), C22H29ClN2O4, ν 1740, shows no infrared N+-H peak and no :C:N+: absorption at 1680 cm.-1 The aqueous solution is neutral, apparent pKa 11, and treatment with aqueous NaOH gives I, C22H28N2O4, readily crystallized as the C6H6 solvate, m. 139-40° (transition at 98-101°). The 60 Mc. high resolution nuclear magnetic resonance (n.m.r.) spectrum gives intense singlets at τ 6.30, 7.76 for O-Me and N-Me, indicating that I is not a quaternary ammonium hydroxide; a doublet at τ 8.39 for allylic C-Me; a 1,3,3,1 sym. quartet at τ 4.56 for the olefinic proton; and a one-proton singlet near τ 5.1 ascribed to a single OH group. Formation of I α-methiodide, m. 226-9° (decomposition) (absolute alc.), with 2 N-Me groups indicates normal behavior as a tertiary base. The reconversion of I to II is sufficiently slow at 25° so that titration of I gives a pKa 7.8 in 60% aqueous alc. and this hysteresis is well accommodated by the equilibrium I ⇌ II. II treated with Me3COK in absolute Me3COH yields alloechitamine (III), C21H26NO3, m. 191° (MeOH), ν 1736, 1689 cm.-1, n.m.r, spectra showing presence of O-Me, N-Me, and MeCH: groups; MeI salt, showing loss of 1689 cm.-1 peak due to transannular interaction. I in alc. hydrogenated with Pt gives a high yield of echitinolide (IV), C21H26N2O3, m. 140-4° (Et2O), m. 154-7° (C6H6), pKa, 5.4 (60% alc.), n.m.r. τ 7.53 (singlet, N-Me), 7.76 (singlet, C-Me), 8.48 (doublet, C-Me), ν 1742 cm.-1; O-monoacetate, m. 210-14°, 1754 cm.-1 IV heated with HCl gives an isomer, isoechitinolide (V), m. 149-54° (Et2O), ν 1754 cm.-1 I and II show almost identical ultraviolet absorption [λ 235, 295 mμ (log ε 3.93, 3.55)], even in strongly alk. solution IV and V absorb at longer wave lengths [λ 248, 309 mμ (log ε 3.91, 3.55)] but acidification causes downward displacement. All compounds with low wave length absorption have Na equatorial with respect to the C carbocyclic six-membered ring, whereas absorption above 240 mμ (and 300 mμ) can be consistently related with structures in which Na has axial conformation. The Hofmann degradation of IV MeI salt gives the methine, C22H30N2O4, reduced by Zn-HCl to the lactone, deoxyneodihydroechitamine methine, λ247, 307 mμ (log ε 3.97, 3.59), unchanged in acidic solution The Zn dust and Se degradations leading to echitamyrine and dimethylpyrrolo-2′,3′;3,4-quinoline might proceed through the intermediate (VI) which could arise from the iminium cation of IV by 1,2 migration of the indoline α-C. It is suggested that the specific biogenetic derivation of I involves the precursor (VII) in Mannich cyclization. (CA 53, 22033i). A close relation to the quaternary alkaloid C-fluorocurarine is apparent, and the noncyclized system retaining the CO2H residue is present in corynoxeine and rhyncophylline. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Related Products of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics