Tag: 200-300

Bourdais, Jacques; Meyer, Francois published an article in 1961, the title of the article was 1,3-Benzenedisulfonamides as carbonic anhydrase inhibitors.SDS of cas: 97-09-6 And the article contains the following content:

4,5,6-XYZC6H(SO2Cl)2 (I) were prepared from the appropriate benzene derivatives and ClSO3H, and converted to the corresponding diamides (II) by boiling with concentrated aqueous NH3. The following I were prepared (X, Y, Z, % yield, and m.p. given): Me, H, H, 85, 52°; H, COCl, H, 51, 90; OH, Me, H, 47, 85-6°; Cl, Me, H, 45, 78°; Me, H, Cl, 64, 122-5°; Cl, H, Cl, 75, 122-3°; Cl, H, F, 36, 105°; Cl, Me, Cl, 41, 163-4°; Cl, Cl, Cl, 31, 178°. II prepared were (X, Y, Z, % yield, m.p., pK1 and pK2 determined in H2O + 15% MeOH at 20°, and carbonic anhydrase inhibitory activity relative to 1.0 for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide given): Me, H, H, 57, 189°, 9.3, 10.3, 0.33; CO2H (by KMnO4 oxidation of the corresponding Me compound), H, H, 22, 283°, 9.51, 10.66, 0.025; H, CONH2, H, 85, -, 8.93, 10.02, 0.33; Cl, Me, H, 36, 235°, 8.97, 10.14, 0.25; Me, H, Cl, 31, 247°, 8.98, 10.1, 0.63; Cl, H, Cl, 53, 265°, 8.52, 9.78, 1.67; Cl, H, F, 38, 229°, 8.55, 9.76, 1.0; NH2, H, Cl, 64, 254-5°, 9.34, 10.36, 0.025; Cl, Me, Cl, 39, 296-7°, 8.80, 9.98, 0.125; Cl, Cl, Cl, 30, 295°, 8.73, 9.51, 2.0; NH2, Me, Cl, 64, 282-3°, -, -, -. Also prepared were (compound, % yield, m.p., pK1, pK2, and inhibitory activity as above): 4,3,1-Cl(O2N)C6H3SO2Cl, 92, 56, -, -, -; 4,3,1-Cl(O2N)C6H3SO2NH2, 64, 176°, 9.18, -, 0.33; 1,3,4,6-Cl2C6H2(SO2NHMe)2, 51, 186°, 9.83, 10.63, 0.025. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lavrishchev, V. A.; Kretov, A. E. published an article in 1962, the title of the article was Reaction of unsymmetric substituted ureas on melting with 4-chloro-3-nitrophenyl alkyl(aryl) sulfones and sulfonamides.Name: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

cf. CA 55, 18646h. Fusion of a sulfone or sulfonamide of general type 4,3-Cl(O2N)C6H3SO2R or 4,3-Cl(R2NSO2)C6H3NO2, resp., with unsym. substituted ureas in 1:4 molar ratio at 200° gave after treatment with EtOH some cyanuric acid and the following amines (urea derivative and the product shown, resp.): methylurea, 4-methylsulfonyl-2-nitrophenylmethylamine m. 190-1°, dimethylurea, 4-methylsulfonyl-2-nitrophenyldimethylamine m. 135-6°; phenylurea, 4-methylsulfonyl-2-nitrodiphenylamine m. 133-4°; p-anisylurea, 4-methylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 168-9°; p-ethoxyphenylurea, 4-methylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 130-1°; methylurea, 4-N-methylsulfonamido-2-nitrophenylmethylamine m. 180-1°; dimethylurea, 4-N-methylsulfonamido-2-nitrophenyldimethylamine m. 158-9°; p-anisylurea, 4-N-methylsulfonamido-2-nitro-4′-methoxydiphenylamine m. 170-1°; p-ethoxyphenylurea, 4-N-methylsulfonamido-2-nitro-4′-ethoxydiphenylamine m. 179-80°; methylurea, 4-N-dimethylsulfonamido-2-nitrophenylmethylamine m. 149-50°; dimethylurea, 4-N-dimethylsulfonamido-2-nitrophenyldimethylamine m. 103-4°; p-anisylurea, 4-N-dimethylsulfonamido-2-nitro-4′-methoxydiphenylamine m. 124-5°; p-ethoxyphenylurea, 4-N-dimethylsulfonamido-2-nitro-4′-ethoxydiphenylamine m. 126-7°; methylurea, 4-sulfonamido-2-nitrophenylmethylamine m. 212-13°; dimethylurea, 4-sulfonamido-2-nitrophenyldimethylamine m. 147-8°; methylurea, 4-phenylsulfonyl-2-nitrophenylmethylamine m. 154-5°; dimethylurea, 4-phenylsulfonyl-2-nitrophenyldimethylamine m. 104-5°; phenylurea, 4-phenylsulfonyl-2-nitrodiphenylamine m. 147-8°; p-anisylurea, 4-phenylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 153-4°; p-ethoxyphenylurea, 4-phenylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 139-40°; methylurea, 4-benzylsulfonyl-2-nitrophenylmethylamine m. 182-3°; dimethylurea, 4-benzylsulfonyl-2-nitrophenyldimethylamine m. 121.5-2.5°; phenylurea, 4-benzylsulfonyl-2-nitrodiphenylamine m. 182.5-3°; p-anisylurea, 4-benzylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 185-6°; p-ethoxyphenylurea, 4-benzylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 162.5-3.5°; dimethylurea, 2-N-methylsulfonamido-4-nitrophenyldimethylamine m. 127-8°. p-Phenetidine and 4-chloro-3-nitrophenyl methyl sulfone fused as above gave product, m. 130-1°, identical with 4-methylsulfonyl-2-nitro-4′-ethoxydiphenylamine shown above. 4-N-Dimethylsulfonamido-2-nitrophenyldimethylamine, m. 103-4°, was also prepared according to Eliel and Nelson (CA 50, 11965c); E. and N. reported 182-3°. Yields of the above amines are best with 1:4 reactant ratio; equimolar mixtures gave lower yields. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Name: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chatterjee, Asima; Bose, Sukumar published an article in 1952, the title of the article was The active principles of the leaves of Aegle marmelos.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

cf. C.A. 43, 2993g. From the leaves of Aegle marmelos have been isolated skimmianine (I) and a sterol, aegelin (II), C18H18O4. I is characterized by the preparation of 7 salts and by its ultraviolet absorption spectrum. II from EtOAc, then Me2CO or EtOH, m. 174-5°. It gives a yellow Liebermann-Burchard test, a yellow-to-pink Salkowsky test, and a red Lifschütz test. II with Ac2O-pyridine gives a mono-Ac derivative m. 159-60°. Se dehydrogenation of II gives no identifiable product. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1955, the title of the article was Structure of aegelin.Computed Properties of 456-12-2 And the article contains the following content:

cf. C.A. 47, 10544g. Analysis showed the formula of aegelin (I) to be C18H19ON3; it is neutral with one OMe and one OH but no NMe or CMe. Oxidation (C.A. 43, 1386i) gave aegelone (II), C18H17O3N, m. 159-60° and hydrogenation (PtO2 in HOAc) gave dihydroaegelin (III). Similarly, hydrogenation of II afforded dihydroaegelone (IV), m. 126-7°. Hydrolysis (H2O-EtOH-HCl) of I gave NH3, PhCH:CHCO2H (and its Et ester) and a little p-MeOC6H4CHO. The following structures are proposed: p-MeOC6H4CH(OH)CH2NHCOCH:CHPh for I, p-MeOC6H4COCH2NHCOCH:CHPh for II, p-MeOC6H4CH(OH)CH2NHCO(CH2)2Ph for III, and p-MeOC6H4COCH2NHCO(CH2)2Ph for IV. These structures have been confirmed by the alk. condensation of p-MeOC6H4CH(OH)CH2NH2 or p-MeOC6H4COCH2NH2 with PhCH:CHCOCl or Ph(CH2)2COCl. The products were identified by mixed m.p. The ultraviolet absorption curves of natural and synthetic I are identical. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 2022, Gao, Hui; Zhao, Fuqiang; Li, Ruijing; Jin, Shuaichen; Zhang, Haibo; Zhang, Keyu; Li, Shisheng; Shu, Qin; Na, Guangshui published an article.COA of Formula: C8H10N2O3S The title of the article was Occurrence and distribution of antibiotics and antibiotic resistance genes in water of Liaohe River Basin, China. And the article contained the following:

Surface water environment is an important repository of antibiotics and antibiotic resistance genes (ARGs). It is of great significance to study the occurrence and distribution of antibiotics and ARGs in surface water environment. In this study, the Liaohe River Basin, China was taken as the study area, and the concentrations of antibiotics and ARGs in water were investigated by HPLC-MS/MS and HT-qPCR. The results showed that a total of 53 antibiotics of 6 types were detected in water, and the pollution level was at ND∼331.64 ng/L, where PCG was the highest. Totally 164 ARGs and 10 mobile genetic elements (MGEs) were detected in the water, and the absolute abundances were at 2.18 × 104∼3.95 × 107 copies/L and 1.82 × 105-3.78 × 107 copies/L, resp. The multidrug and aminoglycoside were the dominant ARG types. Amoxicillin, erythromycin, anhydroerythromycin and ofloxacin posed certain ecol. risks for sensitive aquatic organisms. In spatial distribution, the pollution of antibiotics and ARGs in the Daliao River system was higher than that in the Liaohe River system. There was a significant pos. correlation between total concentrations of antibiotics and total relative abundance of ARGs (r = 0.66, p < 0.05). The co-occurrence of multiple antibiotics promoted the pollution and spread of ARGs. In addition, the total relative abundance of MGEs and ARGs showed a significant pos. correlation (r = 0.946, p < 0.01), and MGEs played an important role in the occurrence and evolution of ARGs in water. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to antibiotic resistance gene occurrence distribution water hplc ms, Water: Analysis and other aspects.COA of Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2021, Low, Kyleyoung; Chai, Layching; Lee, Choonweng; Zhang, Gan; Zhang, Ruijie; Vahab, Vaezzadeh; Bong, Chuiwei published an article.Formula: C8H10N2O3S The title of the article was Prevalence and risk assessment of antibiotics in riverine estuarine waters of Larut and Sangga Besar River, Perak. And the article contained the following:

Abstract: Antibiotics released into the environment through anthropogenic activities exert selective pressure, driving bacteria towards increasing antimicrobial resistance. The prevalence of antibiotics and the ecol. risks posed in the riverine estuarine of Larut River and Sangga Besar River, which included wastewater effluents from hospital, zoo, and poultry slaughterhouse sources were investigated. Solid phase extraction (SPE) followed by high-performance liquid chromatog. tandem mass chromatog. (HPLC-MS/MS) were used to extract and quantify the antibiotic residues from 22 antibiotics belonging to six major antibiotic classes (sulfonamide, macrolide, fluoroquinolone, phenicol, trimethoprim, and tetracycline). Sixteen antibiotic residues were detected with concentrations ranging from limit of detection (LOD) to 1 262.3 ng/L. Fluoroquinolones and macrolides were the most frequently detected compounds Erythromycin, clarithromycin, and ofloxacin detected in hospital and zoo effluents posed a high risk to algae while tetracycline had low to medium ecol. risks toward all the relevant organisms from aquatic environments (algae, invertebrate Daphnia magna, and fish). The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to antibiotic risk assessment riverine estuarine water perak, Water: Analysis and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guo, Yaoguang; Liu, Zhiyuan; Lou, Xiaoyi; Fang, Changling; Wang, Pu; Wu, Genying; Guan, Jie published an article in 2021, the title of the article was Insights into antimicrobial agent sulfacetamide transformation during chlorination disinfection process in aquaculture water.Name: N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

Antibiotic addition and chlorination are two common processes in fishery culture. Antibiotic residues not only pollute aquaculture water, but are also one of the potential precursors of disinfection byproducts (DBPs) during chlorination. The degradation kinetics, products identification and reaction mechanism of sulfacetamide (SFA), a new sulfonamides antibiotics, and potential formation of haloacetic acids (HAAs) in chlorination were explored. The results showed that the degradation of SFA followed pseudo first-order kinetic model, and chlorinating agent dose, pH of water, water temperature, NH4+, HCO3- and humic acid (HA) had various effects on the degradation of SFA and the yields of HAAs. The presence of Br- accelerated both the degradation rate of SFA and more formation of Br-DBPs. Through the identification of intermediate products, we proposed the transformation pathway of SFA during the chlorination disinfection process. Namely, in this NaClO disinfection system, the C-S bond between the sulfonyl group and benzene ring, and S-N bond between sulfonyl and acylamino of SFA were broken, and then the primary formed groups were further oxidized to produce intermediates, such as chloroanilines and chlorophenols. And then chlorophenols were subsequently chlorinated to form toxic HAAs. The present study might be of significance for the evaluation of effective degradation of SFA and potential production of halogenate-DBPs (H-DBPs) during the chlorination disinfection process in aquaculture water. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Name: N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to sulfacetamide chlorination disinfection degradation, Water: Analysis and other aspects.Name: N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Xi; Zhang, Zhi; Zhang, Lu; Fan, Weiying; Yang, Chao; Li, Enhua; Du, Yun; Wang, Xuelei published an article in 2021, the title of the article was Inconsistent seasonal variation of antibiotics between surface water and groundwater in the Jianghan Plain: Risks and linkage to land uses.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

Antibiotics are widely used in humans and animals, but their transformation from surface water to groundwater and the impact of land uses on them remain unclear. In this study, 14 antibiotics were systematically surveyed in a complex agricultural area in Central China. Results indicated that the selected antibiotic concentrations in surface waters were higher in winter (average: 32.7 ng/L) than in summer (average: 17.9 ng/L), while the seasonal variation in groundwaters showed an opposite trend (2.2 ng/L in dry winter vs.8.0 ng/L in summer). Macrolides were the predominant antibiotics in this area, with a detected frequency of over 90%. A significant correlation between surface water and groundwater antibiotics was only observed in winter (R2=0.58). This study further confirmed the impact of land uses on these contaminants, with optimal buffer radii of 2500 m in winter and 500 m in summer. Risk assessment indicated that clarithromycin posed high risks in this area. Overall, this study identified the spatiotemporal variability of antibiotics in a typical agricultural area in Central China and revealed the impact of land uses on antibiotic pollution in aquatic environments. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to antibiotic surface water groundwater, antibiotic pollution, honghu lake, land use, optimal buffer, risk assessment, antibiotics, environmental risk assessment, groundwaters, nitrates role: pol (pollutant), occu (occurrence), ph, redox potential, surface waters, temperature, turbidity and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Yata, Noboru; Kamada, Akira; Aoki, Masaru published an article in 1969, the title of the article was Biological activities of drugs. VIII. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Hansch-Fujita’s method was applied to a structure-activity anal. of 22 sulfonamide derivatives with an inhibitory activity against carbonic anhydrase. Electronic parameters such as Hammett’s σ factor, ΔpKa, Dppm and Δfr , and hydrophobic parameters such as π, πc and β were employed. ΔpKa, Δppm, Δfr, π, πc and β were derived from dissociation constant, NM R chem. shift of sulfamoyl protons, S:O valence-force constant, n-oc tyl alc.-H2O partition coefficient, CHCl3-H2O partition coefficient and association constant to albumin, resp. This anal. proved to be useful in predicting not only the activity of substituted benzenesulfonamides except o-substituted derivatives but also that of 1,3,4-thiadiazole-5-sulfonamide derivatives The activity of o-substituted derivatives was satisfactorily predicted with the use of polar parameter σ* and steric constant ES. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to sulfonamides carbonic anhydrase, carbonic anhydrase sulfonamides, structure activity antienzymes, activity structure antienzymes, antienzymes structure activity, sulfonamides role: biol (biological study) and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Aoki, Masaru; Kamada, Akira; Yata, Noboru published an article in 1969, the title of the article was Biological activities of drugs. VI. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors. 1.Application of 97-09-6 And the article contains the following content:

A study was made of the correlation of carbonic anhydrase inhibitory activity with the chem. structures of 19 derivatives of benzenesulfonamide and 3 heterocyclic sulfonamides, with reference to the physicochem. properties of the compounds A linear correlation was observed for Hammett’s σ factor against pKa, chem. shift of the sulfamoyl protons, and valence-force constant of the S:O bond. Inhibitory activity increased with a decrease of pKa, and with an increase of Hammett’s σ factor, chem. shift of the sulfamoyl protons, and the S:O valence-force constant of the sulfamoyl group. A close correlation was also found between the inhibitory activity and water solubility of the unionized mols. of benzenesulfonamides except for p-CH3NH and o-NO2 derivatives The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to structure activity drug, sulfonamides biol activity, carbonic anhydrase inhibitor, enzyme inhibitor structure, benzenesulfonamides enzyme, sulfonamides role: biol (biological study) and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics